Arrowhead Pharmaceuticals, Inc. (ARWR) vs Ionis Pharmaceuticals, Inc. (IONS)

Arrowhead Pharmaceuticals, Inc. and Ionis Pharmaceuticals, Inc. are both Biotechnology companies. Arrowhead Pharmaceuticals, Inc. is the larger, with a market value of $8.3B against $7.3B — 1.1× the size. Arrowhead Pharmaceuticals, Inc. grew revenue faster over the last twelve months: 16.1% against −7.41%. Arrowhead Pharmaceuticals, Inc. has the higher net margin (−47.8% vs −64.7%) and the higher return on invested capital (0.00% vs 0.00%). Across the 17 metrics below, Arrowhead Pharmaceuticals, Inc. leads on 13 and Ionis Pharmaceuticals, Inc. on 4.

Valuation

Metric ARWR IONS Biotechnology median
P/E n/m n/m 8.50
P/S 11.97 8.13 9.71
P/B 17.20 16.15 2.13
Price to free cash flow n/m n/m 20.82
EV/EBITDA n/m n/m 0.64
EV/Sales 10.87 7.82 9.21
Earnings yield (4.03%) (8.06%) (33.15%)
Free cash flow yield (0.94%) (7.99%) (25.50%)

Profitability

Metric ARWR IONS Biotechnology median
Gross margin 100.00% 98.17% 65.16%
Operating margin (33.82%) (68.00%) 0.00%
Net margin (47.79%) (64.66%) 0.00%
Free cash flow margin (11.22%) (64.93%) 0.00%
Return on equity (64.91%) (105.50%) (56.36%)
Return on assets (18.32%) (18.90%) (48.04%)
Return on invested capital 0.00% 0.00% 0.00%

Growth

Metric ARWR IONS Biotechnology median
Revenue growth (TTM) 16.13% (7.41%) 6.02%
EPS growth (last fiscal year) 99.80% 21.71% 30.26%
Revenue growth, 5-year CAGR 56.63% 5.29% 9.41%
Net income growth, 5-year CAGR 0.00% 0.00% 0.00%

Health

Metric ARWR IONS Biotechnology median
Debt to equity 1.85 3.07 0.00
Current ratio 5.90 7.89 4.72
Net debt to EBITDA (5.70) 2.39 0.96

Dividend

Metric ARWR IONS Biotechnology median
Dividend yield — — 0.09%
Payout ratio — — —

Size

Metric ARWR IONS Biotechnology median
Market cap 8.26b 7.33b 135.18m

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