Ionis Pharmaceuticals, Inc. (IONS) vs Praxis Precision Medicines, Inc. (PRAX)

Ionis Pharmaceuticals, Inc. and Praxis Precision Medicines, Inc. are both Biotechnology companies. Ionis Pharmaceuticals, Inc. and Praxis Precision Medicines, Inc. are of similar size ($7.9B and $7.4B). Praxis Precision Medicines, Inc. grew revenue faster over the last twelve months: 249.5% against −7.41%. Praxis Precision Medicines, Inc. has the higher net margin (0.00% vs −64.7%) and the lower return on invested capital (−40.6% vs 0.00%). Across the 17 metrics below, Praxis Precision Medicines, Inc. leads on 12 and Ionis Pharmaceuticals, Inc. on 5.

Valuation

Metric IONS PRAX Biotechnology median
P/E n/m n/m 7.88
P/S 8.42 956.32 11.47
P/B 16.74 6.10 2.52
Price to free cash flow n/m n/m 21.16
EV/EBITDA n/m n/m 0.74
EV/Sales 8.11 867.63 10.73
Earnings yield (7.78%) (4.61%) (28.84%)
Free cash flow yield (7.71%) (3.74%) (23.03%)

Profitability

Metric IONS PRAX Biotechnology median
Gross margin 98.17% 100.00% 65.16%
Operating margin (68.00%) 0.00% 0.00%
Net margin (64.66%) 0.00% 0.00%
Free cash flow margin (64.93%) 0.00% 0.00%
Return on equity (105.50%) (38.86%) (57.72%)
Return on assets (18.90%) (36.80%) (49.22%)
Return on invested capital 0.00% (40.58%) 0.00%

Growth

Metric IONS PRAX Biotechnology median
Revenue growth (TTM) (7.41%) 249.53% 5.64%
EPS growth (last fiscal year) 21.71% (32.03%) —
Revenue growth, 5-year CAGR 5.29% — 8.40%
Net income growth, 5-year CAGR 0.00% 0.00% 0.00%

Health

Metric IONS PRAX Biotechnology median
Debt to equity 3.07 0.00 0.00
Current ratio 7.89 15.73 4.73
Net debt to EBITDA 2.39 1.82 0.96

Dividend

Metric IONS PRAX Biotechnology median
Dividend yield — — 2.10%
Payout ratio 0.00 0.00 0.00

Size

Metric IONS PRAX Biotechnology median
Market cap 7.39b 7.87b 162.10m

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