Axsome Therapeutics, Inc. (AXSM) vs Ionis Pharmaceuticals, Inc. (IONS)

Axsome Therapeutics, Inc. and Ionis Pharmaceuticals, Inc. are both Biotechnology companies. Axsome Therapeutics, Inc. is the larger, with a market value of $8.5B against $7.3B — 1.2× the size. Axsome Therapeutics, Inc. grew revenue faster over the last twelve months: 56.9% against −7.41%. Axsome Therapeutics, Inc. has the higher net margin (−24.7% vs −64.7%) and the higher return on invested capital (0.00% vs 0.00%). Across the 16 metrics below, Axsome Therapeutics, Inc. leads on 9 and Ionis Pharmaceuticals, Inc. on 7.

Valuation

Metric AXSM IONS Biotechnology median
P/E n/m n/m 8.50
P/S 10.48 8.13 9.71
P/B 97.71 16.15 2.13
Price to free cash flow n/m n/m 20.82
EV/EBITDA n/m n/m 0.64
EV/Sales 10.23 7.82 9.21
Earnings yield (2.39%) (8.06%) (33.15%)
Free cash flow yield (0.88%) (7.99%) (25.50%)

Profitability

Metric AXSM IONS Biotechnology median
Gross margin 93.24% 98.17% 65.16%
Operating margin (23.96%) (68.00%) 0.00%
Net margin (24.68%) (64.66%) 0.00%
Free cash flow margin (9.27%) (64.93%) 0.00%
Return on equity (245.10%) (105.50%) (56.36%)
Return on assets (27.35%) (18.90%) (48.04%)
Return on invested capital 0.00% 0.00% 0.00%

Growth

Metric AXSM IONS Biotechnology median
Revenue growth (TTM) 56.87% (7.41%) 6.02%
EPS growth (last fiscal year) 38.56% 21.71% 30.26%
Revenue growth, 5-year CAGR — 5.29% 9.41%
Net income growth, 5-year CAGR 0.00% 0.00% 0.00%

Health

Metric AXSM IONS Biotechnology median
Debt to equity 1.52 3.07 0.00
Current ratio 1.43 7.89 4.72
Net debt to EBITDA 1.29 2.39 0.96

Dividend

Metric AXSM IONS Biotechnology median
Dividend yield — — 0.09%
Payout ratio — — —

Size

Metric AXSM IONS Biotechnology median
Market cap 8.47b 7.33b 135.18m

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