Zymeworks Inc.

ZYME Healthcare Biotechnology

Zymeworks Inc.’s revenue for fiscal 2025 (year ended December 2025) was $106.0 million, up 38.9% from fiscal 2024. In the quarter to June 2026, revenue fell 90.6%, EPS fell 2,166.7% and free cash flow fell 385.5%, each against the same quarter a year earlier.

25.07 0.68 −2.64%
Market cap
$1.8B
P/E
0.0×
Fwd P/E
16.2×
Dividend yield
—
F-score
7/9
Altman Z
11.56
Beneish M
n/a
Dividend safety
n/a

Insider Decisions trades per month

Total sells 5.03
Totals in millions of $.
Dec 25 Mar 26 Jun 26 Sep 26
Buy — — — — — — — — — — — —
Sell — 1 7 — — — — — — — — 1
Insider Ownership 5.58%

Capital & Financial Ratios $m

Market Cap 1,840.00
Revenue 37.13
Net Income (149.99)
Free Cash Flow (120.54)
Net Debt (270.70)
Current Ratio 6.32 (at or above 1.5: strong)
Debt/Equity 0.00 (at or below 0.5: strong)
P/E ratio 0.00
Fwd P/E 16.20
P/S ratio 49.29 (above 10: high)
P/B ratio 22.77 (above 6: high)
Past 5Y EPS Growth —
This Y EPS Growth 196.74% (at or above 15%: strong)
Next Y EPS Growth (1.86%) (below 0%: weak)
Next Y revenue growth 173.20% (at or above 10%: strong)
Next 5Y EPS Growth 69.06% (at or above 15%: strong)

Green and red mark values outside typical ranges. How we judge →

Valuation vs history

P/S against its own 10 years 79.17%
10-year low 10-year high
P/B against its own 10 years 97.82%
10-year low 10-year high
EV/Sales against its own 10 years 83.37%
10-year low 10-year high

Dividends

Payout Ratio —
Annual Dividend Rate —
Annual Dividend Yield —
total individual payouts
2025 Powerpack
2024 Powerpack
2023 Powerpack
2022 Powerpack
2021 Powerpack
2020 Powerpack
2019 Powerpack
2017 Powerpack
predictions special payouts not included in total or ratios

Assets vs Liabilities $m

2023 2024 2025 Q'26
Cash 374 226 229 271
Receivables 19 56 5 6
Inventory — — — —
Other — — — —
413 300 249 298
2023 2024 2025 Q'26
Payables 46 60 36 27
ST’ Debt — — — —
Other — — — —
56 88 42 47

Compound Annual Growth %

10y 5y 3y
Sales 27.06% 22.16% (36.43%)
Cash Flow 0.00% 0.00% 0.00%
Earnings 0.00% 0.00% 0.00%
Book Value 30.86% (8.11%) (18.33%)

Revenue $m

Mar Jun Sep Dec Year
’26 2 5 — — —
’25 27 49 28 3 106
’24 10 19 16 31 76
’23 36 7 17 17 76
’22 2 5 3 402 412
’21 1 2 4 20 27
’20 8 12 3 16 39
Fiscal quarters ending in the months shown.

Operating Cash Flow $m

Mar Jun Sep Dec Year
’26 (46) (32) — — —
’25 (3) 12 (31) (10) (33)
’24 (38) (25) (6) (42) (110)
’23 (83) (6) (43) 14 (118)
’22 (55) (55) (73) 327 144
’21 (41) (50) (51) (51) (192)
’20 (37) (50) (16) (48) (151)
Fiscal quarters ending in the months shown.

Free Cash Flow $m

Mar Jun Sep Dec Year
’26 (46) (32) — — —
’25 (4) 11 (32) (11) (35)
’24 (38) (26) (7) (42) (113)
’23 (84) (7) (44) 12 (122)
’22 (60) (59) (77) 326 131
’21 (41) (52) (56) (56) (206)
’20 (38) (52) (19) (49) (158)
Fiscal quarters ending in the months shown.

EPS $

Mar Jun Sep Dec Year
’26 (0.59) (0.62) — — —
’25 (0.30) 0.03 (0.26) (0.55) (1.08)
’24 (0.42) (0.49) (0.39) (0.31) (1.62)
’23 (0.37) (0.76) (0.41) (0.20) (1.72)
’22 (1.19) (0.97) (0.72) 4.65 1.90
’21 (0.87) (1.31) (1.25) (0.72) (4.61)
’20 (0.64) (0.77) (1.43) (0.74) (3.58)
Fiscal quarters ending in the months shown.

Target Price Range

Analyst price targets

Recommendation Rating

1
1Buy 2 3Hold 4 5Sell

Ten years at a glance Fiscal years to December

Group Line 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 Trend 2026e 2027e 2028e
Price, $
Price, $ Low — 6.25 7.69 13.96 20.33 14.90 4.11 6.02 7.97 9.03

Analyst estimates 2026–2028

Powerpack
High — 14.25 29.00 45.83 56.73 59.03 17.27 10.99 17.70 28.49
People
People Employees 117 147 183 256 355 458 294 277 286 264
Revenue/emp, $m 0.09 0.35 0.29 0.12 0.11 0.06 1.40 0.27 0.27 0.40
Income, $m
Income, $m Revenue 11 52 53 30 39 27 412 76 76 106
Gross margin, % (234.42) 19.34 (7.37) (292.30) (339.53) (648.70) 49.43 (88.94) (76.43) (29.29)
EBT (39) (10) (34) (146) (180) (212) 135 (119) (117) (80)
EBT margin, % (353.20) (19.25) (64.85) (494.24) (462.43) (795.95) 32.79 (156.87) (152.82) (75.26)
Net income (34) (10) (37) (145) (181) (212) 124 (119) (123) (81)
Depreciation 1 3 4 7 10 10 7 17 11 11
Per share, $
Per share, $ Revenue 0.86 2.44 1.82 0.78 0.77 0.52 6.33 1.10 1.01 1.41
Earnings (2.65) (0.51) (1.26) (3.83) (3.58) (4.11) 1.91 (1.72) (1.62) (1.08)
Cash flow (2.77) 0.01 0.83 (2.15) (3.01) (3.73) 2.21 (1.72) (1.45) (0.44)
Capex (0.43) (0.15) (0.12) (0.36) (0.12) (0.26) (0.20) (0.06) (0.04) (0.03)
Free cash flow (3.20) (0.14) 0.71 (2.52) (3.13) (3.99) 2.01 (1.78) (1.49) (0.47)
Book value 5.33 5.48 6.20 6.46 8.14 4.83 7.56 6.75 4.47 3.56
Shares, m 13 21 29 38 50 52 65 69 76 75
Valuation, ×
Valuation, × P/E 0.00 0.00 0.00 0.00 0.00 0.00 4.24 0.00 0.00 0.00
P/S 15.62 3.26 8.05 58.51 61.13 31.67 1.19 9.40 14.55 18.74
P/B 0.00 1.45 2.37 7.04 5.81 3.39 1.00 1.54 3.28 7.39
EV/Sales 13.59 1.65 4.36 48.58 50.34 23.37 0.06 4.78 11.89 16.58
EV/FCF (3.16) (29.37) 11.15 (14.61) (12.44) (3.03) 0.18 (2.89) (8.02) (49.69)
Cash, $m
Cash, $m Operating cash flow (35) 0 24 (82) (151) (192) 144 (118) (110) (33)
Capex (5) (3) (3) (14) (6) (13) (13) (4) (3) (2)
Free cash flow (41) (3) 21 (96) (158) (206) 131 (122) (113) (35)
Balance, $m
Balance, $m Working capital 30 78 174 229 369 216 449 357 212 206
Total debt 4 0 0 6 6 31 25 — — —
Net debt (36) (88) (200) (299) (426) (253) (492) (374) (226) (229)
Shareholders’ equity 68 116 180 246 410 249 493 465 339 269
Returns, %
Returns, % ROA (57.72) (9.67) (19.42) (47.48) (39.83) (45.68) 23.96 (19.30) (23.51) (20.04)
ROIC (73.91) (19.64) 0.00 0.00 0.00 0.00 11,267.96 (95.36) (75.84) (145.69)
ROE (248.22) (17.42) (24.62) (68.25) (55.08) (64.29) 33.51 (24.78) (30.54) (26.72)
Negative figures in brackets.

All 10 years →

Fiscal years to Dec 2025 · latest quarter Jun 2026

Charts ten years each

Zymeworks Inc. vs peers in Biotechnology (Q) = latest quarter vs a year earlier

Company Market cap P/E Fwd P/E Revenue growth (Q) EPS growth (Q) FCF growth (Q) Gross margin (Q) EBIT margin (Q) Compare
MLYS Mineralys Therapeutics, Inc. $1.9B — (loss-making) — — n/m −7.91% (below 0%: shrinking) — 0.00% Compare
SRPT Sarepta Therapeutics, Inc. $1.9B — (loss-making) 4.4× −34.34% (below 0%: shrinking) n/m −14.48% (below 0%: shrinking) 62.77% 3.31% Compare
ZYME Zymeworks Inc. $1.8B — (loss-making) 16.2× −90.58% (below 0%: shrinking) n/m −385.53% (below 0%: shrinking) (497.71%) (918.95%)
MRVI Maravai LifeSciences Holdings, Inc. $1.8B — (loss-making) — (loss-making) +8.53% (above 0%: growing) n/m +127.57% (above 0%: growing) 40.14% (29.33%) Compare
PVLA Palvella Therapeutics, Inc. $1.8B — (loss-making) — (loss-making) −99.09% (below 0%: shrinking) n/m −136.38% (below 0%: shrinking) 100.00% 0.00% Compare
MESO Mesoblast Limited $1.8B — (loss-making) — −13.41% (below 0%: shrinking) n/m −89.23% (below 0%: shrinking) (353.35%) (909.40%) Compare
URGN Urogen Pharma $1.8B — (loss-making) — (loss-making) +199.22% (above 0%: growing) n/m +17.26% (above 0%: growing) 90.93% 0.15% Compare
XNCR Xencor, Inc. $1.8B — (loss-making) — (loss-making) +17.46% (above 0%: growing) n/m −52.91% (below 0%: shrinking) 100.00% (72.37%) Compare
VIR Vir Biotechnology, Inc. $1.8B — (loss-making) — (loss-making) +19,582.54% (above 0%: growing) n/m +200.47% (above 0%: growing) 100.00% 30.75% Compare
Median of peers $1.8B — — +8.53% — −11.20% 90.93% 0.00%

All 614 Biotechnology stocks →

Zymeworks Inc. (ZYME) key facts

  • Strength: Zymeworks Inc.’s revenue for fiscal 2025 (year ended December 2025) was $106.0 million, up 38.9% from fiscal 2024.
  • Zymeworks Inc. (ZYME) is a Biotechnology company in the Healthcare sector, listed on Nasdaq.
  • As of October 16, 2026, ZYME traded at $25.07, a market capitalization of $1.8 billion.
  • Return on equity was −26.7% and debt-to-equity 0.00.
  • Its Piotroski F-score is 7 out of 9 and its Altman Z-score is 11.56 (safe zone) for fiscal 2025.

Source: company filings (standardised) and stockrow calculations.

Zymeworks Inc. (ZYME) Latest News

stockrow.com/ZYME · Data as of Jun 30, 2026 · For information only; not investment advice. · © 2026 stockrow.com