Stoke Therapeutics, Inc.

STOK Healthcare Biotechnology

Stoke Therapeutics, Inc.’s revenue for fiscal 2025 (year ended December 2025) was $184.4 million, up 404.5% from fiscal 2024. In the quarter to June 2026, revenue fell 32.5%, EPS fell 132.5% and free cash flow fell 129.0%, each against the same quarter a year earlier.

24.17 0.44 −1.79%
Market cap
$1.6B
P/E
0.0×
Fwd P/E
−9.1×
Dividend yield
—
F-score
5/9
Altman Z
16.42
Beneish M
0.76
Dividend safety
n/a

Insider Decisions trades per month

Total sells 8.77
Totals in millions of $.
Dec 25 Mar 26 Jun 26 Sep 26
Buy — — — — — — — — — — — —
Sell 3 8 — — 9 1 1 2 1 4 — 2
Insider Ownership 18.98%

Capital & Financial Ratios $m

Market Cap 1,590.00
Revenue 27.59
Net Income (207.90)
Free Cash Flow (180.68)
Net Debt (292.82)
Current Ratio 7.69 (at or above 1.5: strong)
Debt/Equity 0.00 (at or below 0.5: strong)
P/E ratio 0.00
Fwd P/E (9.13) (negative: loss-making)
P/S ratio 57.84 (above 10: high)
P/B ratio 4.62
Past 5Y EPS Growth —
This Y EPS Growth (2,936.76%) (below 0%: weak)
Next Y EPS Growth 1.42%
Next Y revenue growth (82.64%) (below 0%: weak)
Next 5Y EPS Growth (24.20%) (below 0%: weak)

Green and red mark values outside typical ranges. How we judge →

Valuation vs history

P/S against its own 10 years 79.60%
10-year low 10-year high
P/B against its own 10 years 69.69%
10-year low 10-year high
EV/Sales against its own 10 years 80.14%
10-year low 10-year high

Dividends

Payout Ratio —
Annual Dividend Rate —
Annual Dividend Yield —
total individual payouts
2025 Powerpack
2024 Powerpack
2023 Powerpack
2022 Powerpack
2021 Powerpack
2020 Powerpack
2019 Powerpack
predictions special payouts not included in total or ratios

Assets vs Liabilities $m

2023 2024 2025 Q'26
Cash 201 217 285 293
Receivables 0 2 8 9
Inventory — — — —
Other 3 2 4 6
215 233 306 323
2023 2024 2025 Q'26
Payables 2 2 5 5
ST’ Debt — — — —
Other — — — —
31 40 58 42

Compound Annual Growth %

10y 5y 3y
Sales — — 145.89%
Cash Flow — 0.00% 0.00%
Earnings — 0.00% 0.00%
Book Value — 4.26% 24.00%

Revenue $m

Mar Jun Sep Dec Year
’26 6 9 — — —
’25 159 14 11 1 184
’24 4 5 5 23 37
’23 5 (2) 3 3 9
Fiscal quarters ending in the months shown.

Operating Cash Flow $m

Mar Jun Sep Dec Year
’26 (61) (57) — — —
’25 132 (25) (30) (30) 46
’24 (25) (17) (22) (23) (87)
’23 (21) (22) (17) (21) (81)
’22 32 (20) (22) (22) (32)
’21 (20) (16) (15) (16) (67)
’20 (11) (10) (11) (11) (42)
Fiscal quarters ending in the months shown.

Free Cash Flow $m

Mar Jun Sep Dec Year
’26 (61) (59) — — —
’25 132 (26) (30) (31) 45
’24 (25) (18) (22) (23) (87)
’23 (22) (23) (18) (21) (83)
’22 32 (21) (24) (23) (36)
’21 (20) (16) (15) (16) (68)
’20 (11) (10) (11) (11) (43)
Fiscal quarters ending in the months shown.

EPS $

Mar Jun Sep Dec Year
’26 (0.79) (0.93) — — —
’25 1.90 (0.40) (0.65) (0.97) (0.12)
’24 (0.57) (0.46) (0.47) (0.18) (1.65)
’23 (0.53) (0.69) (0.55) (0.60) (2.38)
’22 (0.66) (0.63) (0.66) (0.65) (2.60)
’21 (0.46) (0.60) (0.61) (0.66) (2.34)
’20 (0.34) (0.39) (0.41) (0.42) (1.56)
Fiscal quarters ending in the months shown.

Target Price Range

Analyst price targets

Recommendation Rating

1
1Buy 2 3Hold 4 5Sell

Ten years at a glance Fiscal years to December

Group Line 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 Trend 2026e 2027e 2028e
Price, $
Price, $ Low — — — 19.21 15.82 17.76 6.88 3.35 4.09 5.35

Analyst estimates 2026–2028

Powerpack
High — — — 39.04 64.54 71.58 26.60 14.00 17.58 38.69
People
People Employees — — 44 56 79 102 117 110 128 170
Revenue/emp, $m — — 0.00 0.00 0.00 0.00 0.11 0.08 0.29 1.08
Income, $m
Income, $m Revenue — — — — — — 12 9 37 184
Gross margin, % — 0.00 0.00 0.00 0.00 0.00 100.00 100.00 100.00 100.00
EBT — (6) (13) (32) (52) (86) (101) (105) (89) (7)
EBT margin, % — 0.00 0.00 0.00 0.00 0.00 (814.73) (1,192.47) (243.42) (3.73)
Net income — 0 (13) (32) (52) (86) (101) (105) (89) (7)
Depreciation — 0 0 0 1 1 1 2 1 1
Per share, $
Per share, $ Revenue — 0.00 0.00 0.00 0.00 0.00 0.32 0.20 0.68 3.11
Earnings — (0.17) (17.65) (1.80) (1.56) (2.34) (2.60) (2.38) (1.65) (0.12)
Cash flow — (0.16) (15.46) (1.73) (1.26) (1.82) (0.82) (1.84) (1.61) 0.77
Capex — 0.00 (1.30) (0.09) (0.03) (0.03) (0.10) (0.04) 0.00 (0.01)
Free cash flow — (0.16) (16.76) (1.82) (1.29) (1.85) (0.92) (1.88) (1.61) 0.76
Book value — (0.04) 148.13 12.49 8.54 5.93 4.75 3.63 4.24 5.95
Shares, m — 33 1 18 33 37 39 44 54 59
Valuation, ×
Valuation, × P/E — — — — — — 0.00 0.00 0.00 0.00
P/S — — — — — — 28.50 29.36 16.30 10.19
P/B — — — — — — 1.91 1.62 2.60 5.33
EV/Sales — — — — — — 9.99 6.43 10.36 8.65
EV/FCF — — — — — — (3.46) (0.68) (4.35) 35.51
Cash, $m
Cash, $m Operating cash flow — (5) (11) (31) (42) (67) (32) (81) (87) 46
Capex — 0 (1) (2) (1) (1) (4) (2) 0 (1)
Free cash flow — (5) (12) (33) (43) (68) (36) (83) (87) 45
Balance, $m
Balance, $m Working capital — (2) 104 222 283 212 213 185 193 248
Total debt — 3 — — 0 5 5 — — —
Net debt — 1 (105) (222) (287) (220) (230) (201) (217) (285)
Shareholders’ equity — (1) 105 224 286 218 185 160 229 352
Returns, %
Returns, % ROA — (10.11) (23.29) (19.22) (19.84) (31.97) (40.84) (43.23) (35.60) (2.00)
ROIC — 0.00 0.00 (1,139.44) 0.00 0.00 0.00 0.00 (525.92) (19.12)
ROE — (10.71) (24.13) (19.62) (20.47) (34.06) (50.20) (60.80) (45.80) (2.37)
Negative figures in brackets.

All 10 years →

Fiscal years to Dec 2025 · latest quarter Jun 2026

Charts ten years each

Stoke Therapeutics, Inc. vs peers in Biotechnology (Q) = latest quarter vs a year earlier

Company Market cap P/E Fwd P/E Revenue growth (Q) EPS growth (Q) FCF growth (Q) Gross margin (Q) EBIT margin (Q) Compare
ZBIO Zenas BioPharma, Inc. $1.7B — (loss-making) — (loss-making) — n/m −37.12% (below 0%: shrinking) 100.00% (10,765.90%) Compare
OCUL Ocular Therapeutix, Inc. $1.6B — (loss-making) — (loss-making) +0.12% (above 0%: growing) n/m −25.35% (below 0%: shrinking) 85.08% (609.34%) Compare
STOK Stoke Therapeutics, Inc. $1.6B — (loss-making) — (loss-making) −32.51% (below 0%: shrinking) n/m −128.97% (below 0%: shrinking) 100.00% (701.65%)
NTLA Intellia Therapeutics, Inc. $1.6B — (loss-making) — (loss-making) −46.23% (below 0%: shrinking) n/m +15.05% (above 0%: growing) 100.00% (1,472.25%) Compare
GPCR Structure Therapeutics Inc. Sponsored ADR $1.6B — (loss-making) — — n/m −119.15% (below 0%: shrinking) 0.00% 0.00% Compare
QURE uniQure N.V. $1.6B — (loss-making) — (loss-making) +11.00% (above 0%: growing) n/m +27.66% (above 0%: growing) 94.01% (893.73%) Compare
KRSA Korsana Biosciences, Inc. $1.5B — (loss-making) — (loss-making) −43.24% (below 0%: shrinking) n/m −184.69% (below 0%: shrinking) 100.00% 0.00% Compare
MAZE Maze Therapeutics, Inc. $1.5B — (loss-making) — — n/m +50.21% (above 0%: growing) 100.00% 0.00% Compare
ABSI Absci Corporation $1.5B — (loss-making) — (loss-making) −46.37% (below 0%: shrinking) n/m −71.74% (below 0%: shrinking) 100.00% (10,741.51%) Compare
Median of peers $1.6B — — −43.24% — −31.23% 100.00% (751.53%)

All 614 Biotechnology stocks →

Stoke Therapeutics, Inc. (STOK) key facts

  • Concern: Stoke Therapeutics, Inc. reported a net loss of $6.9 million, or a loss of $0.12 per share, for fiscal 2025.
  • Strength: Stoke Therapeutics, Inc.’s revenue for fiscal 2025 (year ended December 2025) was $184.4 million, up 404.5% from fiscal 2024.
  • Stoke Therapeutics, Inc. (STOK) is a Biotechnology company in the Healthcare sector, listed on Nasdaq.
  • As of October 16, 2026, STOK traded at $24.17, a market capitalization of $1.6 billion.
  • Trailing earnings are negative, so a P/E ratio is not meaningful; the stock trades at 57.8× sales.
  • Return on equity was −2.37% and debt-to-equity 0.00.
  • Its Piotroski F-score is 5 out of 9 and its Altman Z-score is 16.42 (safe zone) for fiscal 2025.

Source: company filings (standardised) and stockrow calculations.

Stoke Therapeutics, Inc. (STOK) Latest News

10 Aug

stockrow.com/STOK · Data as of Jun 30, 2026 · For information only; not investment advice. · © 2026 stockrow.com