Cyclerion Therapeutics, Inc. KRSA

31.00 (6.19) (16.64%) as of 25 Sep
Market cap
$1.7B
P/E
0.0×
Growth Flags show if company had growth for consecutive years

Insider Decisions

in millions of $
Nov 25 Feb 26 May 26 Aug 26
Buy — — — — — — — — — — — —
Sell — — — — — — — — — — — —
Insider Ownership 0.00%

Capital & Financial Ratios

Market Cap 1,690.00
Revenue 2.07
Net Income (6.71)
Free Cash Flow (4.52)
Net Debt (1.39)
Current Ratio 0.82
Debt/Equity 0.00
P/E ratio 0.00
P/S ratio 9.08
P/B ratio 3.70
Past 5Y EPS Growth 57.72%
This Y EPS Growth 10.45%
Next Y EPS Growth 17.50%
Next 5Y EPS Growth 59.52%
in millions of $

Dividends

Payout Ratio 0.00
Annual Dividend Rate —
Annual Dividend Yield —
total individual payouts
2023 Powerpack
2022 Powerpack
2021 Powerpack
2020 Powerpack
2019 Powerpack
2018 Powerpack
predictions in italic, special payouts not included in total or ratios

Assets vs Liabilities

2023 2024 2025 Q'26
Cash 8 3 3 1
Receivables — 1 1 —
Inventory — — — —
Other 0 0 0 0
8 4 5 2
2023 2024 2025 Q'26
Payables 1 0 1 2
ST’ Debt — — — —
Other — — — —
2 1 1 2
in millions of $

Compound Annual Growth

10y 5y 3y
Sales — (14.38%) (19.27%)
Cash Flow — 0.00% 0.00%
Earnings — 0.00% 0.00%
Book Value — (31.33%) (4.56%)

Revenue

Mar Jun Sep Dec Year
’26 — — — — —
’25 0 0 1 1 2
’24 — — 0 2 2
’22 1 0 — — 0
’21 0 3 0 1 4
’20 1 1 0 0 2
in millions of $ · fiscal quarters ending in the months shown
value withheld pending a data check

Operating Cash Flow

Mar Jun Sep Dec Year
’26 (1) (1) — — —
’25 (1) (1) 0 (2) (3)
’24 (2) (1) (2) 0 (4)
’23 (6) (7) (7) (2) (21)
’22 (13) (11) (10) (7) (41)
’21 (14) (6) (8) (9) (37)
’20 (29) (14) (15) (14) (72)
in millions of $ · fiscal quarters ending in the months shown

Free Cash Flow

Mar Jun Sep Dec Year
’26 (1) (1) — — —
’25 (1) (1) 0 (2) (3)
’24 (2) (1) (2) 0 (4)
’23 (6) (7) (7) (2) (21)
’22 (13) (11) (10) (7) (41)
’21 (13) (6) (8) (9) (35)
’20 (31) (14) (15) (13) (72)
in millions of $ · fiscal quarters ending in the months shown

EPS

Mar Jun Sep Dec Year
’26 (5.32) (2.87) — — —
’25 (3.92) (0.77) (2.10) (1.33) (7.77)
’24 (4.34) (3.71) (2.03) 1.54 (8.47)
’23 (22.39) (12.81) 19.03 0.43 (15.75)
’22 (41.99) (43.39) (33.59) (22.39) (141.36)
’21 (55.02) (62.98) (36.39) (33.59) (184.74)
’20 (102.17) (97.97) (82.58) (76.98) (358.29)
fiscal quarters ending in the months shown

Target Price Range

Analyst price targets

Recommendation Rating

1
1Buy 2 3Hold 4 5Sell
2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 2026 2027 2028
— — — 236.60 290.78 208.60 49.00 12.25 8.89 8.12

Analyst estimates 2026–2028

Powerpack
Low Price
— — — 3,199.00 1,254.40 966.00 264.60 133.98 66.29 43.75
High Price
— — 143 94 94 32 16 1 1 1
Employees
— — 0 0 0 0 0 0 2 2
Revenue/Emp
— — — 5 2 4 0 — 2 2
Revenue
0.00% 0.00% 0.00% 100.00% 100.00% 100.00% 100.00% — 100.00% 100.00%
Gross Margin
(64) (94) (115) (123) (78) (52) (18) (13) (3) (4)
EBT
0.00% 0.00% 0.00% (2,729.27%) (3,388.59%) (1,310.17%) (6,143.43%) 0.00% (152.85%) (170.11%)
EBT Margin
(64) (94) (115) (123) (78) (52) (44) (5) (3) (4)
Net Income
2 2 2 3 2 0 0 — — —
Depreciation
0.00 0.00 0.00 23.04 10.57 14.09 0.96 0.00 5.56 4.56
Revenue/Sh
(2.32) (3.43) (589.13) (628.41) (358.29) (184.74) (141.36) (15.75) (8.47) (7.77)
Earnings/Sh
(1.82) (2.96) (498.48) (522.57) (333.75) (130.56) (130.79) (63.59) (12.04) (7.29)
Cash Flow/Sh
0.00 (0.05) (17.58) (34.33) 0.08 5.21 0.00 0.00 0.00 0.00
Capex/Sh
(1.82) (3.02) (516.06) (556.90) (333.66) (125.35) (130.79) (63.59) (12.04) (7.29)
Free CF/Sh
(0.25) (0.31) (53.40) 499.64 273.91 172.49 33.66 33.79 24.60 19.98
Book Value/Sh
27 27 0 0 0 0 0 0 0 0
Shares
— — — 0.00 0.00 0.00 0.00 — 0.00 0.00
PE Ratio
— — — 0.00 40.53 17.09 35.13 — 5.11 1.95
PS Ratio
— — — 0.76 1.56 1.40 2.79 — 0.92 0.44
PB Ratio
— — — 0.00 16.84 3.40 18.99 — 3.08 0.39
EV/Sales
— — — 0.19 (0.53) (0.38) (0.40) — (1.70) (0.43)
EV/FCF
(50) (81) (98) (102) (72) (37) (41) (21) (4) (3)
Op' Cash Flow
(1) (1) (3) (7) 0 1 — — — —
Capex
(50) (83) (101) (109) (72) (35) (41) (21) (4) (3)
FCF
(10) (13) (17) 83 42 44 7 6 4 4
Working Cap'
— — — 74 46 — — — — —
Total Debt
— — — (95) (54) (54) (13) (8) (3) (3)
Net Debt
(7) (9) (10) 98 59 48 10 11 9 9
Sh' Equity
(1,360.17%) (2,010.10%) (1,790.88%) (126.89%) (51.55%) (59.12%) (113.88%) (33.47%) (26.64%) (36.07%)
ROA
0.00% 0.00% 0.00% (2,757.52%) (996.29%) 0.00% 0.00% (217.77%) (40.36%) (53.18%)
ROIC
829.25% 1,225.50% 1,212.41% (281.86%) (98.97%) (95.87%) (150.19%) (48.42%) (30.36%) (39.34%)
ROE
predictions in italic, sparklines do not include predictions

All 10 years →

Fiscal years to Dec 2025 · latest quarter Dec 2025

Cyclerion Therapeutics, Inc. (KRSA) key facts

  • Cyclerion Therapeutics, Inc. (KRSA) is a Biotechnology company in the Healthcare sector, listed on Nasdaq.
  • As of September 25, 2026, KRSA traded at $31.00, a market capitalization of $1.7 billion.
  • Return on equity was −39.3% and debt-to-equity 0.00.

Source: company filings (standardised) and stockrow calculations.

Cyclerion Therapeutics, Inc. (KRSA) Latest News

News by impact score

Fine-tune

8 Sep

5

Korsana Biosciences completed its merger with Cyclerion Therapeutics along with the previously announced $380 million private placement. Merger closing combined with $380 million private placement redefines Cyclerion's corporate structure and capital base.

20 Apr

4

Cyclerion Therapeutics (CYCN) merges with Korsana Biosciences to combine resources and advance praliciguat and other candidates in its Alzheimer’s disease pipeline. Merger advances CYCN's Alzheimer’s pipeline through resource combination, marking a major strategic shift with high potential to alter trajectory.

1 Apr

4

Cyclerion Therapeutics, Inc. (CYCN) and Korsana Biosciences announced a definitive merger agreement to combine their operations. Merger agreement with Korsana Biosciences represents a major strategic move that could significantly alter CYCN's trajectory and investor sentiment.

23 Feb

4

Cyclerion Therapeutics, Inc. (CYCN) received positive FDA feedback, paving the way for a Phase 2 trial of CYC-126 in the second half of 2026. Positive FDA feedback clears path for Phase 2 trial of CYC-126, representing a major regulatory milestone that could significantly enhance CYCN's pipeline and market valuation.

17 Feb

4

Cyclerion Therapeutics announces positive FDA feedback aligning CYC-126 Phase 2 proof-of-concept study design with regulatory expectations and forms a Clinical Advisory Board of key opinion leaders to guide development. FDA alignment on Phase 2 design and expert advisory board formation represent major clinical advancement for biotech pipeline core to valuation.

2 Feb

4

Cyclerion Therapeutics, Inc. is undergoing a strategic reset aimed at revitalizing its operations and enhancing its market position. The company is focusing on its core competencies and exploring new opportunities to drive growth. Analysts are optimistic about the potential for improved financial performance and product innovation as Cyclerion implements these changes. The reset is expected to positively influence investor sentiment and the company's trajectory in the competitive landscape. The strategic reset and focus on core competencies are likely to significantly impact Cyclerion's future performance and market positioning.

5 Jan

4

Cyclerion Therapeutics, Inc. has entered a strategic agreement with Medsteer to advance the development of CYC-126, a treatment for treatment-resistant depression. The collaboration aims to initiate a Phase 2 proof-of-concept study, marking a significant step in the company's efforts to address this mental health condition. This partnership is expected to enhance Cyclerion's capabilities in clinical development and potentially improve patient outcomes. The strategic agreement and upcoming Phase 2 study could significantly influence Cyclerion's market position and investor sentiment.

1 Dec

3

Akebia Therapeutics has outlined its strategy for a rare kidney disease drug following a deal with Q32 Bio. The partnership aims to enhance the development of therapies targeting kidney disorders, leveraging Q32 Bio's expertise in immunology. This move is part of Akebia's broader efforts to expand its product pipeline and address unmet medical needs in the renal space. The partnership may enhance Akebia's competitive positioning in the kidney disease market, indirectly affecting Cyclerion's landscape.

11 Nov

3

Insider buying at Cyclerion Therapeutics, Inc. has reached a total of US$525,000, indicating strong confidence from company executives in the future performance of the firm. This significant investment by insiders may reflect their belief in the company's strategic direction and potential growth opportunities. Insider buying suggests confidence in the company's future, which may positively influence market sentiment and performance.

23 Sep

4

Cyclerion Therapeutics, Inc. has announced a strategic relaunch focusing on neuropsychiatric disorders, shifting its business model to prioritize the development of innovative treatments for conditions such as depression and schizophrenia. The company aims to leverage its expertise in neuroscience to address unmet medical needs in this area, enhancing its pipeline and potential market presence. This transformation is expected to position Cyclerion as a leader in neuropsychiatric therapeutics. The strategic relaunch and focus on neuropsychiatric disorders could significantly alter Cyclerion's market positioning and investor sentiment.

5 Feb

3

Cyclerion Therapeutics, Inc. is a pre-revenue biopharmaceutical company with a market cap of $13.46 million, recently filing a $25 million Shelf Registration. Despite being unprofitable and having negative return on equity, the company has reduced losses significantly over the past five years. It faces challenges with less than one year of cash runway and volatile share prices but remains debt-free with short-term assets exceeding liabilities by $2.8 million. The company's financial challenges and recent registration filing indicate a moderately noticeable influence on its future performance.

17 Dec

4

Cyclerion Therapeutics renegotiates license agreements for sGC stimulator assets to generate revenues for future growth. The renegotiated license agreements and potential new assets are expected to significantly alter the company's trajectory and investor sentiment.

7 Aug

4

Regina Graul, Ph.D., promoted to Chief Executive Officer, President, and member of the Board of Directors at Cyclerion Therapeutics, Inc. The appointment of a new CEO and President, along with strategic initiatives to enhance shareholder value, is expected to have a significant impact on Cyclerion's future trajectory and market performance.

4 Dec

4

Regina Graul, Ph.D., appointed as President of Cyclerion Therapeutics, Inc. Appointment of new president and strategic consultant, along with asset sale completion, expected to have significant impact on company's future trajectory and operations.

30 Nov

4

Cyclerion Therapeutics appoints Dina Katabi, Ph.D., and Michael Higgins to its Board of Directors. The addition of experienced leaders with diverse backgrounds is likely to have a significant impact on Cyclerion's future strategic direction and market performance.

28 Nov

3

Insiders at Cyclerion Therapeutics face losses as stock price drops 16% in the last year. Insiders' significant investment loss may moderately impact company's future.

31 Jul

4

Cyclerion Therapeutics, Inc. and Tisento Therapeutics close asset purchase agreement, launching Tisento with $81 million for Phase 2 development of zagociguat in MELAS and other genetic mitochondrial diseases. The acquisition and financing of Tisento with promising clinical data for zagociguat in rare diseases is expected to have a significant impact on Cyclerion's future and market performance.

12 May

4

Cyclerion Therapeutics to sell assets for $81M, CEO transition to new spin-off private company established by shareholders and new investors. The sale of assets, CEO transition, and search for a new leader are significant strategic moves that could alter the company's trajectory.

11 May

4

Cyclerion Therapeutics sells assets to NewCo, CEO to lead NewCo, new board chair elected, completed ADv study, financial results for Q1 2023. Major strategic moves with asset sale, leadership changes, study completion, and financial results expected to significantly impact company's trajectory.

4

Cyclerion Therapeutics signs definitive agreement to sell sGC stimulator assets for $81M to launch new company targeting mitochondrial dysfunction diseases. The agreement to sell assets and launch a new company is a significant strategic move that could fundamentally alter the company's trajectory and investor sentiment.

stockrow.com/KRSA · Data as of Dec 31, 2025 · For information only; not investment advice. · © 2026 stockrow.com