Stoke Therapeutics, Inc. STOK

24.80 (0.49) (1.94%) as of 25 Sep
Market cap
$1.6B
P/E
0.0×

Insider Decisions

Total sells 10.79
in millions of $
Nov 25 Feb 26 May 26 Aug 26
Buy — — — — — — — — — — — —
Sell 3 3 8 — — 9 1 1 2 1 4 —
Insider Ownership 18.98%

Capital & Financial Ratios

Market Cap 1,630.00
Revenue 27.59
Net Income (207.90)
Free Cash Flow (180.68)
Net Debt (292.82)
Current Ratio 7.69
Debt/Equity 0.00
P/E ratio 0.00
P/S ratio 59.35
P/B ratio 4.74
Past 5Y EPS Growth 1.74%
This Y EPS Growth (2,915.96%)
Next Y EPS Growth 2.20%
Next 5Y EPS Growth (24.20%)
in millions of $

Dividends

Payout Ratio 0.00
Annual Dividend Rate —
Annual Dividend Yield —
total individual payouts
2025 Powerpack
2024 Powerpack
2023 Powerpack
2022 Powerpack
2021 Powerpack
2020 Powerpack
2019 Powerpack
predictions in italic, special payouts not included in total or ratios

Assets vs Liabilities

2023 2024 2025 Q'26
Cash 201 217 285 293
Receivables 0 2 8 9
Inventory — — — —
Other 3 2 4 6
215 233 306 323
2023 2024 2025 Q'26
Payables 2 2 5 5
ST’ Debt — — — —
Other — — — —
31 40 58 42
in millions of $

Compound Annual Growth

10y 5y 3y
Sales — — 145.89%
Cash Flow — 0.00% 0.00%
Earnings — 0.00% 0.00%
Book Value — 4.26% 24.00%

Revenue

Mar Jun Sep Dec Year
’26 6 9 — — —
’25 159 14 11 1 184
’24 4 5 5 23 37
’23 5 (2) 3 3 9
in millions of $ · fiscal quarters ending in the months shown

Operating Cash Flow

Mar Jun Sep Dec Year
’26 (61) (57) — — —
’25 132 (25) (30) (30) 46
’24 (25) (17) (22) (23) (87)
’23 (21) (22) (17) (21) (81)
’22 32 (20) (22) (22) (32)
’21 (20) (16) (15) (16) (67)
’20 (11) (10) (11) (11) (42)
in millions of $ · fiscal quarters ending in the months shown

Free Cash Flow

Mar Jun Sep Dec Year
’26 (61) (59) — — —
’25 132 (26) (30) (31) 45
’24 (25) (18) (22) (23) (87)
’23 (22) (23) (18) (21) (83)
’22 32 (21) (24) (23) (36)
’21 (20) (16) (15) (16) (68)
’20 (11) (10) (11) (11) (43)
in millions of $ · fiscal quarters ending in the months shown

EPS

Mar Jun Sep Dec Year
’26 (0.79) (0.93) — — —
’25 1.90 (0.40) (0.65) (0.97) (0.12)
’24 (0.57) (0.46) (0.47) (0.18) (1.65)
’23 (0.53) (0.69) (0.55) (0.60) (2.38)
’22 (0.66) (0.63) (0.66) (0.65) (2.60)
’21 (0.46) (0.60) (0.61) (0.66) (2.34)
’20 (0.34) (0.39) (0.41) (0.42) (1.56)
fiscal quarters ending in the months shown

Target Price Range

Analyst price targets

Recommendation Rating

1
1Buy 2 3Hold 4 5Sell
2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 2026 2027 2028
— — — 19.21 15.82 17.76 6.88 3.35 4.09 5.35

Analyst estimates 2026–2028

Powerpack
Low Price
— — — 39.04 64.54 71.58 26.60 14.00 17.58 38.69
High Price
— — 44 56 79 102 117 110 128 170
Employees
— — 0 0 0 0 0 0 0 1
Revenue/Emp
— — — — — — 12 9 37 184
Revenue
— 0.00% 0.00% 0.00% 0.00% 0.00% 100.00% 100.00% 100.00% 100.00%
Gross Margin
— (6) (13) (32) (52) (86) (101) (105) (89) (7)
EBT
— 0.00% 0.00% 0.00% 0.00% 0.00% (814.73%) (1,192.47%) (243.42%) (3.73%)
EBT Margin
— 0 (13) (32) (52) (86) (101) (105) (89) (7)
Net Income
— 0 0 0 1 1 1 2 1 1
Depreciation
— 0.00 0.00 0.00 0.00 0.00 0.32 0.20 0.68 3.11
Revenue/Sh
— (0.17) (17.65) (1.80) (1.56) (2.34) (2.60) (2.38) (1.65) (0.12)
Earnings/Sh
— (0.16) (15.46) (1.73) (1.26) (1.82) (0.82) (1.84) (1.61) 0.77
Cash Flow/Sh
— 0.00 (1.30) (0.09) (0.03) (0.03) (0.10) (0.04) 0.00 (0.01)
Capex/Sh
— (0.16) (16.76) (1.82) (1.29) (1.85) (0.92) (1.88) (1.61) 0.76
Free CF/Sh
— (0.04) 148.13 12.49 8.54 5.93 4.75 3.63 4.24 5.95
Book Value/Sh
— 33 1 18 33 37 39 44 54 59
Shares
— — — — — — 0.00 0.00 0.00 0.00
PE Ratio
— — — — — — 28.50 29.36 16.30 10.19
PS Ratio
— — — — — — 1.91 1.62 2.60 5.33
PB Ratio
— — — — — — 9.99 6.43 10.36 8.65
EV/Sales
— — — — — — (3.46) (0.68) (4.35) 35.51
EV/FCF
— (5) (11) (31) (42) (67) (32) (81) (87) 46
Op' Cash Flow
— 0 (1) (2) (1) (1) (4) (2) 0 (1)
Capex
— (5) (12) (33) (43) (68) (36) (83) (87) 45
FCF
— (2) 104 222 283 212 213 185 193 248
Working Cap'
— 3 — — 0 5 5 — — —
Total Debt
— 1 (105) (222) (287) (220) (230) (201) (217) (285)
Net Debt
— (1) 105 224 286 218 185 160 229 352
Sh' Equity
— (10.11%) (23.29%) (19.22%) (19.84%) (31.97%) (40.84%) (43.23%) (35.60%) (2.00%)
ROA
— 0.00% 0.00% (1,139.44%) 0.00% 0.00% 0.00% 0.00% (525.92%) (19.12%)
ROIC
— (10.71%) (24.13%) (19.62%) (20.47%) (34.06%) (50.20%) (60.80%) (45.80%) (2.37%)
ROE
predictions in italic, sparklines do not include predictions

All 10 years →

Fiscal years to Dec 2025 · latest quarter Jun 2026

Stoke Therapeutics, Inc. (STOK) key facts

  • Stoke Therapeutics, Inc. (STOK) is a Biotechnology company in the Healthcare sector, listed on Nasdaq.
  • Stoke Therapeutics, Inc.’s revenue for fiscal 2025 (year ended December 2025) was $184.4 million, up 404.5% from fiscal 2024.
  • Stoke Therapeutics, Inc. reported a net loss of $6.9 million, or a loss of $0.12 per share, for fiscal 2025.
  • As of September 25, 2026, STOK traded at $24.80, a market capitalization of $1.6 billion.
  • Trailing earnings are negative, so a P/E ratio is not meaningful; the stock trades at 59.3× sales.
  • Return on equity was −2.37% and debt-to-equity 0.00.

Source: company filings (standardised) and stockrow calculations.

Stoke Therapeutics, Inc. (STOK) Latest News

News by impact score

Fine-tune

23 Sep

3

Stoke Therapeutics appointed Bo Cumbo to its Board of Directors, adding commercial experience as zorevunersen advances for Dravet syndrome toward potential FDA approval and commercialization. Cumbo, CEO of Solid Biosciences since 2022 and former Sarepta leader who helped launch Duchenne therapies, replaces Edward Kaye, M.D., who has retired from Stoke’s Board after joining in 2017 and serving as CEO until March 2025; Kaye will advise through the transition. Ian F. Smith said Cumbo’s track record in rare pediatric medicines strengthens the board as Stoke targets an early 2028 FDA decision. Cumbo’s career includes leadership roles at Sarepta, Vertex, Gilead, GlaxoSmithKline and UCB, and he sits on Vor Bio and Climb Bio boards. Stoke’s TANGO approach and zorevunersen, an antisense oligonucleotide to boost NaV1.1 in brain cells, with a Biogen collaboration granting rights outside the U.S.; Stoke retains U.S./Canada/Mexico rights. Zorevunersen is in Phase 3; regulatory outcomes pending. Board appointment adds experienced commercial leadership that could influence future commercialization efforts for zorevunersen.

3 Sep

4

Stoke Therapeutics and Biogen presented long-term clinical data supporting the disease-modifying potential of zorevunersen for Dravet syndrome at the 16th European Epilepsy Congress. Positive long-term data on zorevunersen bolsters STOK's lead candidate and strengthens its competitive position in Dravet syndrome.

1 Sep

4

Stoke Therapeutics and Biogen presented clinical data from studies of Zorevunersen for Dravet syndrome at the 16th European Epilepsy Congress. Clinical data presentations advance Zorevunersen development as Stoke's lead asset under Biogen partnership.

21 Aug

3

JPMorgan initiated coverage on Stoke Therapeutics with an Overweight rating, triggering an immediate rise in the company's shares. Analyst initiation with Overweight rating lifts near-term sentiment and share price without changing core operations or fundamentals.

17 Aug

4

Stoke Therapeutics Dravet syndrome trial exceeded enrollment target with zero dropouts. Over-enrollment with full retention signals strong execution and patient demand for lead Dravet program.

10 Aug

3 transcript

Stoke Therapeutics held its Q2 2026 earnings call to report financial results and provide operational updates. Quarterly earnings calls deliver financial metrics and guidance that can moderately shift near-term investor sentiment and stock movement.

7 Aug

3

Stoke Therapeutics files a shelf registration for 2 million shares, enabling potential future equity issuances to raise capital. Shelf filing supports capital raising that influences share structure and financial flexibility without shifting core operations.

4 Aug

3 transcript

Stoke Therapeutics, Inc. conducted its Q2 2026 earnings call covering financial results, operational updates and forward outlook. Quarterly earnings call delivers financial results and guidance that can moderately shift near-term investor views.

3

Stoke Therapeutics reported a strong cash position during its Q2 2026 earnings call. Positive cash position update offers moderate support for ongoing biotech development without indicating major strategic shifts.

3 Aug

3 transcript

Stoke Therapeutics Q2 earnings call covered financial results, pipeline updates and strategic outlook. Quarterly earnings updates influence near-term financial views and sentiment without major strategic shifts.

3

Stoke Therapeutics reported a Q2 loss while exceeding revenue estimates. Q2 earnings with a loss offset by revenue beat can moderately shift near-term stock movement and sentiment.

3

Stoke Therapeutics reported second quarter 2026 financial results and provided business updates. Quarterly financial results and business updates can shift short-term investor sentiment and valuation for the company.

14 Jul

3

Ionis has initiated dosing in a Phase I/II clinical study for Dravet Syndrome. Competitor progress in Dravet Syndrome directly affects Stoke Therapeutics positioning and market perception in the same indication.

30 Jun

4

Stoke Therapeutics completed enrollment of 162 patients in the Phase 3 EMPEROR study of zorevunersen for Dravet syndrome treatment. Phase 3 enrollment completion advances lead candidate zorevunersen toward potential approval and alters company trajectory.

1 Jun

3

Stoke Therapeutics reported Q1 financial results and provided business updates. Q1 results and business updates offer standard performance details likely to produce moderate investor reaction.

11 May

4

Analysts are bullish on Stoke Therapeutics (STOK) stock following recent positive results. Bullish analyst sentiment post-recent results indicates significant potential uplift to STOK's market performance and investor confidence.

9 May

3

Stoke Therapeutics, Inc. (STOK) released Q1 earnings call highlights covering financial results, pipeline progress on genetic disease therapies, and strategic updates. Q1 earnings highlights detail financials and clinical developments with moderate potential to affect STOK's performance and investor views.

7 May

3

Stoke Therapeutics, Inc. (STOK) reported a Q1 net loss but surpassed revenue estimates. Q1 revenue beat despite net loss moderately influences financial performance and market sentiment.

3

Stoke Therapeutics announced first quarter 2026 financial results and provided business updates. Quarterly financial results and business updates affect financial performance and investor sentiment moderately.

6 Apr

3

Stoke Therapeutics, Inc. (STOK) switches auditors, drawing scrutiny to governance practices in the biotech sector. Auditor switch signals potential governance issues, moderately impacting investor sentiment and stock performance.

1 Apr

5

Biogen, after a $5.6B buyout, targets early-stage assets, positioning Stoke Therapeutics (STOK) as a potential acquisition candidate amid biotech M&A activity. Biogen's pursuit of early-stage assets signals major acquisition potential for STOK, capable of fundamentally redefining its valuation and prospects.

27 Mar

4

Stoke Therapeutics (STOK) stock surged 340% as its Chair sold $174,000 in shares. A 340% stock surge delivers significant short-term market boost and investor attention, despite minor insider selling.

6 Mar

4

Stoke Therapeutics (STOK) published clinical data in the New England Journal of Medicine and announced a 2027 FDA filing timeline, prompting analysis of potential investor reactions ranging from optimism on efficacy to concerns over the extended timeline. NEJM data validates clinical progress while the 2027 FDA timeline sets a clear regulatory path, significantly impacting STOK's valuation and market trajectory.

4 Mar

5

The New England Journal of Medicine published first data demonstrating potential disease modification in Dravet syndrome from Stoke Therapeutics' investigational therapy. NEJM publication of first disease-modifying data in Dravet syndrome fundamentally redefines STOK's competitive position in genetic epilepsies.

4

New England Journal of Medicine publishes first data demonstrating potential for disease modification in Dravet Syndrome for Stoke Therapeutics, Inc. NEJM publication of positive Dravet Syndrome data marks major clinical advancement with strong potential to lift company trajectory and investor sentiment.

15 Feb

4

Stoke Therapeutics highlights durable efficacy gains in Dravet syndrome from STK-001, announces Phase 3 trial timeline, and introduces new autosomal dominant optic atrophy (ADOA) program at a summit. Phase 3 advancement in lead Dravet program and new ADOA initiative mark significant pipeline progress poised to drive stock performance and competitive positioning.

11 Feb

4

Stoke Therapeutics, Inc. (STOK) is highlighted among high growth tech stocks in the US as of February 2026, showcasing its innovative approaches in biotechnology and potential for significant market impact. The company is recognized for its advancements in RNA-targeted medicines, which could lead to transformative treatments for various diseases. Investors are closely monitoring STOK's developments, as its growth trajectory aligns with broader trends in the biotech sector, emphasizing the importance of technological innovation in driving market performance. Stoke's advancements in RNA-targeted therapies are likely to significantly influence its market position and investor sentiment.

4

Stoke Therapeutics, Inc. has announced the dosing of the first patient in a Phase 1 study for STK-002, a potential disease-modifying treatment for Autosomal Dominant Optic Atrophy (ADOA). This milestone marks a significant step in the development of STK-002, which aims to address the underlying genetic cause of ADOA, a rare inherited optic nerve disorder that leads to vision loss. The initiation of a Phase 1 study for a potential treatment of a rare genetic disorder could significantly impact Stoke Therapeutics' future and market performance.

4 Feb

3

Stoke Therapeutics, Inc. (STOK) is scheduled to present at the Guggenheim Emerging Outlook: Biotech Summit 2026. This event will provide an opportunity for the company to showcase its advancements and strategic direction in the biotechnology sector, potentially attracting investor interest and enhancing its market presence. Participation in a prominent biotech summit may enhance visibility and investor sentiment, but the overall impact on the company's trajectory is expected to be limited.

27 Jan

4

Anchor Line Partners has secured a 98,500 square-foot lease for Stoke Therapeutics, Inc. in Waltham, MA, supporting the company's growth and expansion efforts. This new space is expected to facilitate the development of innovative therapies for neurological diseases, aligning with Stoke's mission to advance its research and operational capabilities. Securing a significant lease for expansion is a strategic move that can enhance operational capacity and support future growth initiatives.

stockrow.com/STOK · Data as of Jun 30, 2026 · For information only; not investment advice. · © 2026 stockrow.com