Stoke Therapeutics, Inc.

STOK Healthcare Biotechnology

Stoke Therapeutics, Inc.’s revenue for fiscal 2025 (year ended December 2025) was $184.4 million, up 404.5% from fiscal 2024.

Revenue
+5.86%
EPS
−65.7%
Free cash flow
−114.9%

Quarter to September 2026, against a year earlier

26.54 0.47 +1.80%
Market cap
$1.7B
P/E
0.0×
Fwd P/E
−6.7×
Dividend yield
—
F-score
5/9
Altman Z
16.42
Beneish M
0.76
Dividend safety
n/a

Insider Decisions last twelve months

Sold, $m 6.51
Trades a month
Jan 26 Apr 26 Jul 26 Oct 26
Buy — — — — — — — — — — — —
Sell 8 — — 9 1 1 2 1 4 — 2 1
Insider Ownership 21.40%

Capital & Financial Ratios $m

Size
Market Cap 1,710.00
Revenue ttm 28.21
Net income ttm (243.20)
Free cash flow ttm (215.72)
Net debt Q (319.19)
Valuation
P/E 0.00
Forward P/E (6.67) (negative: loss-making)
Price / sales 64.12 (above 10: high)
Forward P/S Powerpack
Price / FCF 0.00
Price / book 5.13
Financial health
Current ratio Q 7.24 (at or above 1.5: strong)
Debt / equity Q 0.00 (at or below 0.5: strong)
Interest coverage Q —
Growth
Revenue growth Q +5.86% (above 0%: growing)
Operating income growth Q −79.42% (below 0%: shrinking)
EPS, this year −3,201.67% (below 0%: weak)
EPS, next year A −3.18% (below 0%: weak)
Revenue, next year A −81.17% (below 0%: weak)
EPS, past 5 yrs —
EPS, next 5 yrs A −24.20% (below 0%: weak)

Green and red mark values outside typical ranges; (Q) is the latest quarter, (A) analysts’ estimates. How we judge →

Valuation vs history

P/S against its own 10 years 84.06%
10-year low 10-year high
P/B against its own 10 years 76.68%
10-year low 10-year high
EV/Sales against its own 10 years 85.49%
10-year low 10-year high

Dividends

Yield
—
Annual rate
—
Payout ratio
—

Assets vs Liabilities $m

2023 2024 2025 Q'26
Cash 201 217 285 319
Receivables 0 2 8 10
Inventory — — — —
Other 3 2 4 8
215 233 306 354
2023 2024 2025 Q'26
Payables 2 2 5 4
ST’ Debt — — — —
Other — — — —
31 40 58 49

Compound Annual Growth %

10y 5y 3y
Sales — — 145.89%
Cash Flow — 0.00% 0.00%
Earnings — 0.00% 0.00%
Book Value — 4.26% 24.00%

Earnings Trends EPS, adjusted, against the consensus

EPS $

Mar Jun Sep Dec Year
’26 (0.79) (0.93) (1.08) — —
’25 1.90 (0.40) (0.65) (0.97) (0.12)
’24 (0.57) (0.46) (0.47) (0.18) (1.65)
’23 (0.53) (0.69) (0.55) (0.60) (2.38)
’22 (0.66) (0.63) (0.66) (0.65) (2.60)
’21 (0.46) (0.60) (0.61) (0.66) (2.34)
’20 (0.34) (0.39) (0.41) (0.42) (1.56)
Fiscal quarters ending in the months shown.

Revenue $m

Mar Jun Sep Dec Year
’26 6 9 11 — —
’25 159 14 11 1 184
’24 4 5 5 23 37
’23 5 (2) 3 3 9
Fiscal quarters ending in the months shown.

Operating Cash Flow $m

Mar Jun Sep Dec Year
’26 (61) (57) (63) — —
’25 132 (25) (30) (30) 46
’24 (25) (17) (22) (23) (87)
’23 (21) (22) (17) (21) (81)
’22 32 (20) (22) (22) (32)
’21 (20) (16) (15) (16) (67)
’20 (11) (10) (11) (11) (42)
Fiscal quarters ending in the months shown.

Free Cash Flow $m

Mar Jun Sep Dec Year
’26 (61) (59) (66) — —
’25 132 (26) (30) (31) 45
’24 (25) (18) (22) (23) (87)
’23 (22) (23) (18) (21) (83)
’22 32 (21) (24) (23) (36)
’21 (20) (16) (15) (16) (68)
’20 (11) (10) (11) (11) (43)
Fiscal quarters ending in the months shown.

Target Price Range

Analyst price targets

Recommendation Rating

1
1Buy 2 3Hold 4 5Sell

Ten years at a glance Fiscal years to December

Ten-year view Analyst estimates Powerpack
Group Line 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 TTM Sep ’26 Trend 10 yrs 2026e 2027e 2028e Next 3/yr
Income, $m
Income, $m Revenue — — — — — — 12 9 37 184 28 +145.9% 35 51 136 (9.6%)
Gross margin, % — 0.00 0.00 0.00 0.00 0.00 100.00 100.00 100.00 100.00 100.00 +100.0 pt
EBT — (6) (13) (32) (52) (86) (101) (105) (89) (7) (243) +2.7%
EBT margin, % — 0.00 0.00 0.00 0.00 0.00 (814.73) (1,192.47) (243.42) (3.73) (862.07) (3.7) pt
Net income — 0 (13) (32) (52) (86) (101) (105) (89) (7) (243) n/m
Per share, $
Per share, $ Revenue — 0.00 0.00 0.00 0.00 0.00 0.32 0.20 0.68 3.11 0.41 n/m
Earnings — (0.17) (17.65) (1.80) (1.56) (2.34) (2.60) (2.38) (1.65) (0.12) (3.80) (4.3%)
Cash flow — (0.16) (15.46) (1.73) (1.26) (1.82) (0.82) (1.84) (1.61) 0.77 (3.08) n/m
Capex — 0.00 (1.30) (0.09) (0.03) (0.03) (0.10) (0.04) 0.00 (0.01) (0.08) n/m
Free cash flow — (0.16) (16.76) (1.82) (1.29) (1.85) (0.92) (1.88) (1.61) 0.76 (3.16) n/m
Book value — (0.04) 148.13 12.49 8.54 5.93 4.75 3.63 4.24 5.95 5.16 n/m
Shares, m — 33 1 18 33 37 39 44 54 59 64 +7.7%
Valuation, ×
Valuation, × P/E — — — — — — 0.00 0.00 0.00 0.00 0.00 0.0
P/S — — — — — — 28.50 29.36 16.30 10.19 64.12 21.1
P/B — — — — — — 1.91 1.62 2.60 5.33 5.13 2.9
EV/Sales — — — — — — 9.99 6.43 10.36 8.65 52.81 8.9
EV/FCF — — — — — — (3.46) (0.68) (4.35) 35.51 (6.91) 6.8
Cash, $m
Cash, $m Operating cash flow — (5) (11) (31) (42) (67) (32) (81) (87) 46 (210) n/m
Capex — 0 (1) (2) (1) (1) (4) (2) 0 (1) (5) +24.9%
Free cash flow — (5) (12) (33) (43) (68) (36) (83) (87) 45 (216) n/m
Balance, $m
Balance, $m Working capital — (2) 104 222 283 212 213 185 193 248 305 n/m
Net debt — 1 (105) (222) (287) (220) (230) (201) (217) (285) (319) n/m
Shareholders’ equity — (1) 105 224 286 218 185 160 229 352 353 n/m
Returns, %
Returns, % ROA — (10.11) (23.29) (19.22) (19.84) (31.97) (40.84) (43.23) (35.60) (2.00) (63.42) +8.1 pt
ROIC — 0.00 0.00 (1,139.44) 0.00 0.00 0.00 0.00 (525.92) (19.12) (482.02) (19.1) pt
ROE — (10.71) (24.13) (19.62) (20.47) (34.06) (50.20) (60.80) (45.80) (2.37) (73.62) +8.3 pt
People
People Employees — — 44 56 79 102 117 110 128 170 — +21.3%
Revenue/emp, $m — — 0.00 0.00 0.00 0.00 0.11 0.08 0.29 1.08 — n/m
Negative figures in brackets.
estimates

All 10 years →

Fiscal years to Dec 2025 · latest quarter Sep 2026 · fundamentals updated 5 Nov 2026

Stoke Therapeutics, Inc. vs peers in Biotechnology (Q) = latest quarter vs a year earlier

Company Market cap P/E Fwd P/E Revenue growth (Q) EPS growth (Q) FCF growth (Q) Gross margin (Q) EBIT margin (Q) Compare
MAZE Maze Therapeutics, Inc. $1.8B — (loss-making) — — n/m +50.21% (above 0%: growing) 100.00% 0.00% Compare
MRVI Maravai LifeSciences Holdings, Inc. $1.8B — (loss-making) — (loss-making) +10.14% (above 0%: growing) n/m +123.88% (above 0%: growing) 35.31% (44.97%) Compare
STOK Stoke Therapeutics, Inc. $1.7B — (loss-making) — (loss-making) +5.86% (above 0%: growing) n/m −114.89% (below 0%: shrinking) 100.00% (686.94%)
AGIO Agios Pharmaceuticals, Inc. $1.7B — (loss-making) — (loss-making) +330.01% (above 0%: growing) n/m +32.64% (above 0%: growing) 95.44% (139.32%) Compare
ZBIO Zenas BioPharma, Inc. $1.7B — (loss-making) — (loss-making) — n/m −41.00% (below 0%: shrinking) 100.00% (1,034.09%) Compare
LYCA Lycia Therapeutics Inc. $1.7B — — — — — — — Compare
NRIX Nurix Therapeutics, Inc. $1.6B 6.1× 5.5× +8,426.27% (above 0%: growing) n/m +1,122.10% (above 0%: growing) 100.00% 83.12% Compare
ABSI Absci Corporation $1.6B — (loss-making) — (loss-making) −46.37% (below 0%: shrinking) n/m −71.74% (below 0%: shrinking) 100.00% (10,741.51%) Compare
GENB Generate Biomedicines, Inc. $1.6B — (loss-making) — (loss-making) — n/m −224.24% (below 0%: shrinking) 100.00% (1,134.21%) Compare
Median of peers $1.7B — — +170.08% — +32.64% 100.00% (139.32%)

All 621 Biotechnology stocks →

Pay and ownership Proxy statement filed 22 April 2026

Ownership

Directors and executive officers, together 9.60%
Entities affiliated with FMR LLC 9.00%
Entities affiliated with RTW Investments, L.P. 8.50%
Entities affiliated with Lynx1 Capital Management LP 8.30%
Entities affiliated with Redmile Group, LLC 7.00%
BlackRock, Inc. 6.00%
Entities affiliated with Morgan Stanley & Co. 5.50%
Entities affiliated with Baker Bros. Advisors LP 5.40%
The Toronto-Dominion Bank 5.10%
Ownership is the proxy’s own table: the directors and officers as a group, and every holder of 5% or more. Read the proxy statement

Stoke Therapeutics, Inc. (STOK) Latest News

30 Oct

Impact 3 · · The Motley Fool transcript
Impact 3 · · Moby transcript

10 Aug

Impact 3 · · The Motley Fool transcript

9 May

Impact 3 · · MarketBeat
stockrow.com/STOK · Data as of Nov 5, 2026 · For information only; not investment advice. · © 2026 stockrow.com