MBX Biosciences, Inc. MBX

53.63 (1.76) (3.18%) as of 25 Sep
Market cap
$2.7B
P/E
0.0×
Insider Buys alert about insiders buying in the last 12 month

Insider Decisions

Total buys 1.06
Total sells 2.73
in millions of $
Nov 25 Feb 26 May 26 Aug 26
Buy 2 — — — — 1 — — — — — —
Sell — — — — — — — 3 — — 1 —
Insider Ownership 36.05%

Capital & Financial Ratios

Market Cap 2,670.00
Revenue —
Net Income (104.29)
Free Cash Flow (85.20)
Net Debt (418.58)
Current Ratio 18.08
Debt/Equity 0.00
P/E ratio 0.00
P/S ratio 0.00
P/B ratio 6.25
Past 5Y EPS Growth —
This Y EPS Growth (29.11%)
Next Y EPS Growth (30.11%)
Next 5Y EPS Growth (21.88%)
in millions of $

Dividends

Payout Ratio —
Annual Dividend Rate —
Annual Dividend Yield —

Assets vs Liabilities

2023 2024 2025 Q'26
Cash 81 262 374 419
Receivables — — — —
Inventory — — — —
Other — — — —
83 267 382 428
2023 2024 2025 Q'26
Payables 1 5 3 4
ST’ Debt — — — —
Other — — — —
4 11 15 24
in millions of $

Compound Annual Growth

10y 5y 3y
Sales — — —
Cash Flow — — 0.00%
Earnings — — 0.00%
Book Value — — 0.00%

Revenue

Year
in millions of $ · fiscal quarters ending in the months shown

Operating Cash Flow

Mar Jun Sep Dec Year
’26 (20) (23) — — —
’25 (23) (17) (22) (18) (80)
’24 (11) (13) (15) (16) (55)
’23 — — (21) (11) (32)
in millions of $ · fiscal quarters ending in the months shown

Free Cash Flow

Mar Jun Sep Dec Year
’26 (21) (24) — — —
’25 (23) (18) (22) (19) (82)
’24 (11) (14) (15) (16) (56)
’23 — — (21) (11) (32)
in millions of $ · fiscal quarters ending in the months shown

EPS

Mar Jun Sep Dec Year
’26 (0.51) (0.78) — — —
’25 (0.71) (0.58) (0.63) (0.49) (2.38)
’24 (10.26) (12.61) (2.78) (0.47) (5.82)
’23 — — (9.40) — (31.96)
fiscal quarters ending in the months shown

Target Price Range

Analyst price targets

Recommendation Rating

1.1
1Buy 2 3Hold 4 5Sell
2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 2026 2027 2028
— — — — — — — — 15.31 4.81

Analyst estimates 2026–2028

Powerpack
Low Price
— — — — — — — — 27.50 35.55
High Price
— — — — — — — 36 43 63
Employees
— — — — — — — 0 0 0
Revenue/Emp
— — — — — — — — — —
Revenue
— — — — — — — — — —
Gross Margin
— — — — — — (26) (33) (62) (87)
EBT
— — — — — — 0.00% 0.00% 0.00% 0.00%
EBT Margin
— — — — — — (26) (33) (62) (87)
Net Income
— — — — — — 0 0 0 0
Depreciation
— — — — — — 0.00 0.00 0.00 0.00
Revenue/Sh
— — — — — — (39.18) (31.96) (5.82) (2.38)
Earnings/Sh
— — — — — — (34.67) (31.38) (5.14) (2.19)
Cash Flow/Sh
— — — — — — (0.66) (0.13) (0.08) (0.05)
Capex/Sh
— — — — — — (35.33) (31.51) (5.22) (2.24)
Free CF/Sh
— — — — — — (63.88) (71.12) 24.19 10.11
Book Value/Sh
— — — — — — 1 1 11 37
Shares
— — — — — — — — — —
PE Ratio
— — — — — — — — — —
PS Ratio
— — — — — — — — — —
PB Ratio
— — — — — — — — — —
EV/Sales
— — — — — — — — — —
EV/FCF
— — — — — — (23) (32) (55) (80)
Op' Cash Flow
— — — — — — 0 0 (1) (2)
Capex
— — — — — — (24) (32) (56) (82)
FCF
— — — — — — 41 80 256 366
Working Cap'
— — — — — — — — — —
Total Debt
— — — — — — (42) (81) (262) (374)
Net Debt
— — — — — — (43) (72) 257 369
Sh' Equity
— — — — — — 0.00% (50.38%) (35.11%) (26.61%)
ROA
— — — — — — 0.00% 0.00% 0.00% 0.00%
ROIC
— — — — — — 0.00% 56.60% (66.95%) (27.76%)
ROE
predictions in italic, sparklines do not include predictions

All 10 years →

MBX Biosciences, Inc. (MBX) key facts

  • MBX Biosciences, Inc. (MBX) is a Biotechnology company in the Healthcare sector, listed on Nasdaq.
  • As of September 25, 2026, MBX traded at $53.63, a market capitalization of $2.7 billion.
  • Return on equity was −27.8% and debt-to-equity 0.00.

Source: company filings (standardised) and stockrow calculations.

MBX Biosciences, Inc. (MBX) Latest News

News by impact score

Fine-tune

27 Aug

4

MBX Biosciences dosed the first patient in the pivotal Phase 3 oPTimize trial of once-weekly canvuparatide for hypoparathyroidism. Phase 3 initiation for lead candidate canvuparatide represents major clinical milestone advancing toward potential approval.

6 Aug

3

MBX Biosciences reported second quarter 2026 financial results and corporate highlights. Quarterly results and highlights offer performance updates that may affect near-term market views without major strategic shifts.

13 Jul

3

MBX Biosciences announces executive leadership transition to support next growth phase. Leadership transition moderately influences strategy and operations but does not alter long-term trajectory.

15 Jun

4

MBX Biosciences Phase 2 results prompt reevaluation of its long-term hypoparathyroidism treatment strategy. Phase 2 results for hypoparathyroidism directly shape MBX strategic direction and market trajectory.

12 Jun

4

MBX Biosciences shares declined even though one-year trial results for Canvuparatide proved positive. Positive one-year trial results for Canvuparatide signal potential regulatory progress and pipeline advancement for MBX Biosciences.

4

MBX Biosciences announced one-year data showing sustained benefits of once-weekly Canvuparatide as potential PTH replacement therapy for chronic hypoparathyroidism. Positive one-year clinical data on lead candidate Canvuparatide strengthens prospects for regulatory approval and commercialization.

11 Jun

4

J&J seeks wider Imaavy approval while $300M funds MBX Biosciences rare disease drug launch. $300M backing enables major rare disease drug launch that shifts MBX trajectory and investor outlook.

11 May

4

MBX Biosciences spotlights potential monthly GLP-1 treatments for obesity and advances its pipeline during Obesity Day. Highlighting monthly GLP-1 potential and pipeline progress in the high-stakes obesity market signals major strategic momentum for MBX's growth and investor appeal.

4

MBX Biosciences updates obesity portfolio with initial Phase 1 data for MBX 4291, supporting potential once-monthly dosing. Positive Phase 1 data for once-monthly obesity drug MBX 4291 positions MBX strongly in competitive high-demand market.

7 May

3

MBX Biosciences announced first quarter 2026 financial results and corporate highlights. Quarterly financial results and corporate highlights affect investor sentiment and short-term stock performance.

3

MBX Biosciences, Inc. (MBX) appoints Mark Soued as Chief Commercial Officer and awards him inducement equity grants under Nasdaq rules. Appointment of a Chief Commercial Officer bolsters leadership for commercialization amid MBX's pipeline development.

23 Apr

3

MBX Biosciences to host in-person and virtual Obesity Day on May 11, 2026, to discuss its expanding obesity portfolio. Event signals progress in high-demand obesity portfolio, likely influencing investor sentiment and competitive positioning moderately.

22 Apr

4

Aaron Wealth purchased 1.1 million shares of MBX Biosciences, Inc., placing a substantial bet on the biotech company's prospects. Large 1.1 million share purchase by Aaron Wealth signals strong institutional confidence, likely driving positive investor sentiment and stock performance.

4 Apr

3

MBX Biosciences (MBX) stock undergoes options-driven breakout, signaling potential deeper shifts in its investment narrative. Options-driven breakout likely influences short-term market sentiment and investor positioning without fundamentally altering core operations.

26 Mar

3

MBX Biosciences CEO purchased 18,500 shares as the stock surged 270% over the past year. CEO's share purchase signals confidence after 270% stock rise, likely providing moderate boost to investor sentiment.

16 Mar

4

MBX Biosciences advances Phase 3 trial plans for its rare disease programs and appoints a new Chief Business Officer to sharpen strategic focus on rare diseases. Phase 3 plans represent a major clinical milestone and new CBO enhances business strategy in high-value rare disease space.

12 Mar

4

MBX Biosciences reported fourth quarter and full-year 2025 financial results alongside recent corporate highlights. Quarterly and annual financial results with corporate highlights signal major updates on performance and strategy, poised to sway investor sentiment and trajectory.

10 Mar

3

MBX Biosciences, Inc. (MBX) appoints Karen Basbaum as Chief Business Officer to lead business development, partnerships, and strategic growth initiatives. Appointing a Chief Business Officer bolsters strategic partnerships and business development, moderately influencing competitive positioning.

9 Mar

4

MBX Biosciences announces successful End-of-Phase 2 FDA meeting and provides Phase 3 development plan for once-weekly canvuparatide to treat hypoparathyroidism. Positive FDA End-of-Phase 2 feedback clears path to Phase 3 trials for canvuparatide, de-risking the hypoparathyroidism program and likely driving significant stock gains.

4

MBX Biosciences announces successful End-of-Phase 2 FDA meeting and outlines Phase 3 development plan for once-weekly canvuparatide to treat hypoparathyroidism. Successful FDA meeting clears path to Phase 3 trials for canvuparatide, significantly de-risking the lead asset and enhancing MBX's path to market approval.

7 Mar

4

MBX Biosciences Inc. experiences CFO transition, intensifying scrutiny on funding strategies and execution amid biotech challenges. CFO shift highlights vulnerabilities in funding and execution, key drivers for biotech trajectory and investor confidence.

28 Feb

4

MBX Biosciences targets 2026 as pivotal year with Phase 3 trial initiations, obesity program progress, and $460 million cash runway providing multi-year funding. Phase 3 plans in obesity space plus $460M cash runway represent major clinical milestones and financial stability boosting long-term prospects.

23 Jan

4

MBX Biosciences, Inc. (MBX) has achieved a remarkable 261% total shareholder return over the past year, prompting a reassessment of its valuation. The company's recent performance reflects strong investor interest and potential growth in its product pipeline. Analysts are evaluating the sustainability of this return and the factors contributing to MBX's success, including advancements in its therapeutic offerings and market positioning. As the biotech sector continues to evolve, MBX's strategic initiatives may play a crucial role in its future trajectory. The significant shareholder return indicates strong market interest and potential for future growth, which could alter the company's trajectory.

22 Jan

3

MBX Biosciences, Inc. has appointed Laurie Stelzer to its Board of Directors, where she will serve as the Chair of the Audit Committee. Stelzer brings extensive experience in finance and corporate governance, having held various leadership roles in public companies. Her appointment is expected to enhance the company's financial oversight and strategic direction. The appointment of a new board member with significant experience may moderately influence the company's governance and operational effectiveness.

11 Jan

4

MBX Biosciences, Inc. will present its 2026 outlook and provide a business update at the 44th Annual J.P. Morgan Healthcare Conference. This event is significant for stakeholders as it will outline the company's strategic direction and future plans. The presentation at a major healthcare conference is likely to influence investor sentiment and provide insights into the company's strategic initiatives.

15 Dec

3

MBX Biosciences, Inc. is facing challenges in platform validation as it approaches a critical hypoglycemia data catalyst expected in Q2 2026. Concerns have been raised regarding the potential lack of differentiation in the upcoming data, which could impact the company's competitive positioning and market perception. The anticipated hypoglycemia data may influence MBX's competitive position but is not expected to fundamentally alter its trajectory.

3

MBX Biosciences, Inc. will present at the 44th Annual J.P. Morgan Healthcare Conference on January 13. This event is a significant opportunity for the company to showcase its developments and engage with investors and industry leaders. Participation in a major healthcare conference can enhance visibility and investor interest, potentially impacting market sentiment.

4 Dec

3

MBX Biosciences, Inc. (MBX) experienced a 9.7% decline following a sell recommendation from Goldman Sachs and the exit of MPM Capital from its investment. These developments have raised concerns about the company's future performance and market position, leading to increased scrutiny from investors. The sell call and investment exit are expected to moderately influence investor sentiment and market performance.

3 Dec

4

MBX Biosciences, Inc. faced a significant development as a biotech fund divested $14.8 million in its shares just before crucial milestones expected in 2026. This move raises concerns about investor confidence and the company's future prospects as it approaches key regulatory and product development events. The divestment by a major fund before critical milestones suggests potential shifts in investor sentiment and could significantly impact the company's trajectory.

1 Dec

4

MBX Biosciences, Inc. (MBX) has garnered attention from Wall Street analysts, who project an upside potential of 80.6% for the company's stock. This optimistic outlook is based on recent developments and the company's strategic positioning within the biotech sector. Analysts believe that MBX's innovative approaches and pipeline could significantly enhance its market performance in the near future. Analysts' projections indicate a significant potential for stock appreciation based on strategic developments and market positioning.

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