Saturday 17 October 2026
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Silence Therapeutics PLC Sponsored ADR
Silence Therapeutics PLC Sponsored ADR’s revenue for fiscal 2025 (year ended December 2025) was $559,000.00, down 98.7% from fiscal 2024. In the quarter to June 2026, revenue grew 197.2%, EPS grew 54.4% and free cash flow grew 107.0%, each against the same quarter a year earlier.
8.68
0.67
−7.17%
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Target Price Range
Analyst price targets
Free accountTen years at a glance Fiscal years to December
| Group | Line | 2016 | 2017 | 2018 | 2019 | 2020 | 2021 | 2022 | 2023 | 2024 | 2025 | Trend | 2026e | 2027e | 2028e |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Price, $ | |||||||||||||||
| Price, $ | Low | — | — | — | — | 15.00 | 20.50 | 7.80 | 4.55 | 5.81 | 1.97 |
Analyst estimates 2026–2028 Powerpack |
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| High | — | — | — | — | 22.64 | 35.00 | 24.66 | 18.95 | 27.72 | 8.08 | |||||
| People | |||||||||||||||
| People | Employees | — | — | — | 58 | 74 | 105 | 122 | 109 | 116 | 88 | ||||
| Revenue/emp, $m | 0.00 | 0.00 | — | 0.01 | 0.10 | 0.16 | 0.18 | 0.29 | 0.37 | 0.01 | |||||
| Income, $m | |||||||||||||||
| Income, $m | Revenue | 1 | 0 | — | 0 | 7 | 17 | 22 | 32 | 43 | 1 | ||||
| Gross margin, % | 59.74 | (2,606.80) | 0.00 | 0.00 | 31.34 | 39.94 | 37.83 | 59.34 | 72.70 | 61.54 | |||||
| EBT | (13) | (7) | (35) | (38) | (46) | (63) | (59) | (53) | (44) | (89) | |||||
| EBT margin, % | (1,345.71) | (23,599.51) | 0.00 | (9,372.37) | (657.81) | (369.36) | (270.66) | (168.35) | (102.79) | (15,849.91) | |||||
| Net income | (10) | 0 | (31) | 0 | (46) | (63) | (59) | (54) | (45) | (89) | |||||
| Depreciation | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |||||
| Per share, $ | |||||||||||||||
| Per share, $ | Revenue | 0.04 | 0.00 | 0.00 | 0.02 | 0.26 | 0.58 | 0.67 | 0.85 | 0.94 | 0.01 | ||||
| Earnings | (0.15) | (0.12) | (1.35) | (1.32) | (1.53) | (1.83) | (1.56) | (1.45) | (0.99) | (1.89) | |||||
| Cash flow | (0.52) | (0.59) | (1.22) | 0.11 | (0.51) | 0.32 | (1.75) | (1.33) | (1.46) | (1.32) | |||||
| Capex | 0.00 | 0.00 | 0.00 | 0.00 | (0.02) | (0.06) | (0.02) | 0.00 | 0.00 | 0.00 | |||||
| Free cash flow | (0.52) | (0.59) | (1.22) | 0.11 | (0.53) | 0.25 | (1.76) | (1.33) | (1.47) | (1.32) | |||||
| Book value | 2.82 | 3.39 | 2.44 | 1.46 | 0.43 | 0.40 | 0.85 | 0.59 | 2.90 | 1.32 | |||||
| Shares, m | 24 | 28 | 23 | 25 | 27 | 30 | 32 | 37 | 46 | 47 | |||||
| Valuation, × | |||||||||||||||
| Valuation, × | P/E | 0.00 | 0.00 | — | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | ||||
| P/S | 0.00 | 0.00 | — | 0.00 | 0.00 | 20.33 | 21.85 | 21.74 | 7.36 | 513.72 | |||||
| P/B | 12.43 | 12.43 | — | 12.43 | 52.52 | 45.82 | 17.32 | 31.29 | 2.37 | 4.61 | |||||
| EV/Sales | 0.00 | 0.00 | — | 0.00 | 0.00 | 16.50 | 17.78 | 19.57 | 3.95 | 361.63 | |||||
| EV/FCF | (291.34) | (291.34) | — | (291.34) | (108.15) | (36.56) | (6.83) | (12.51) | (2.52) | (3.24) | |||||
| Cash, $m | |||||||||||||||
| Cash, $m | Operating cash flow | (12) | (17) | (29) | 3 | (14) | 9 | (56) | (49) | (68) | (62) | ||||
| Capex | (1) | 0 | 0 | 0 | (1) | (2) | (1) | 0 | 0 | 0 | |||||
| Free cash flow | (12) | (17) | (29) | 3 | (14) | 8 | (57) | (50) | (68) | (62) | |||||
| Balance, $m | |||||||||||||||
| Balance, $m | Working capital | 50 | 78 | 42 | 48 | 65 | 98 | 92 | 81 | 171 | 105 | ||||
| Total debt | — | — | — | 1 | 1 | 0 | 1 | 0 | — | — | |||||
| Net debt | (48) | (79) | (43) | (58) | (50) | (101) | (88) | (69) | (147) | (85) | |||||
| Shareholders’ equity | 67 | 96 | 57 | 36 | 12 | 12 | 27 | 22 | 134 | 62 | |||||
| Returns, % | |||||||||||||||
| Returns, % | ROA | (14.55) | (8.18) | (47.55) | (103.54) | (48.07) | (44.66) | (37.76) | (42.97) | (28.13) | (53.05) | ||||
| ROIC | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | |||||
| ROE | (15.14) | (3.46) | (41.16) | (70.17) | (173.84) | (464.06) | (256.66) | (220.02) | (58.08) | (90.27) | |||||
Negative figures in brackets.
Fiscal years to Dec 2025 · latest quarter Mar 2026
Charts ten years each
Silence Therapeutics PLC Sponsored ADR vs peers in Biotechnology (Q) = latest quarter vs a year earlier
| Company | Market cap | P/E | Fwd P/E | Revenue growth (Q) | EPS growth (Q) | FCF growth (Q) | Gross margin (Q) | EBIT margin (Q) | Compare |
|---|---|---|---|---|---|---|---|---|---|
| ZVRA Zevra Therapeutics, Inc. | $609.9M | 10.5× | 10.5× | +53.25% (above 0%: growing) | −88.71% (below 0%: shrinking) | +670.87% (above 0%: growing) | 96.16% | 42.30% | Compare |
| PHAT Phathom Pharmaceuticals, Inc. | $606.8M | — (loss-making) | — (loss-making) | +88.02% (above 0%: growing) | n/m | +96.86% (above 0%: growing) | 79.68% | (5.34%) | Compare |
| OLMA Olema Pharmaceuticals, Inc. | $601.1M | — (loss-making) | — | — | n/m | −54.33% (below 0%: shrinking) | 0.00% | 0.00% | Compare |
| CRMD CorMedix Inc | $581.5M | 3.0× | 16.5× | +156.52% (above 0%: growing) | +13.79% (above 0%: growing) | +185.90% (above 0%: growing) | 75.66% | 42.10% | Compare |
| SLN Silence Therapeutics PLC Sponsored ADR | $581.1M | — (loss-making) | — (loss-making) | +197.18% (above 0%: growing) | n/m | +106.95% (above 0%: growing) | 97.39% | 0.00% | |
| SGMT Sagimet Biosciences Inc. | $574.7M | — (loss-making) | — (loss-making) | — | n/m | −21.95% (below 0%: shrinking) | 100.00% | 0.00% | Compare |
| DBVT DBV Technologies S.A. | $572.6M | — (loss-making) | — | −53.33% (below 0%: shrinking) | n/m | −56.15% (below 0%: shrinking) | 100.00% | (7,228.57%) | Compare |
| VALN Valneva SE Sponsored ADR | $560.4M | 59.7× | 19.4× | −17.29% (below 0%: shrinking) | n/m | −56.05% (below 0%: shrinking) | 15.29% | (76.67%) | Compare |
| STTK Shattuck Labs, Inc. | $555.0M | — (loss-making) | — (loss-making) | −10.31% (below 0%: shrinking) | n/m | +1.01% (above 0%: growing) | 100.00% | 0.00% | Compare |
| Median of peers | $578.1M | 10.5× | 16.5× | +21.47% | — | −10.47% | 87.92% | 0.00% |
Silence Therapeutics PLC Sponsored ADR (SLN) key facts
- Concern: Silence Therapeutics PLC Sponsored ADR’s revenue for fiscal 2025 (year ended December 2025) was $559,000.00, down 98.7% from fiscal 2024.
- Silence Therapeutics PLC Sponsored ADR (SLN) is a Biotechnology company in the Healthcare sector, traded in the US as an ADR.
- As of October 16, 2026, SLN traded at $8.68, a market capitalization of $581.1 million.
- Return on equity was −90.3% and debt-to-equity 0.00.
- Its Piotroski F-score is 2 out of 9 and its Altman Z-score is −4.82 (distress zone) for fiscal 2025.