Denali Therapeutics Inc.

DNLI Healthcare Biotechnology

Denali Therapeutics Inc.’s revenue for fiscal 2023 (year ended December 2023) was $330.5 million, up 204.7% from fiscal 2022.

Revenue
−94.0%
EPS
+150.3%
Free cash flow
−11.8%
Total debt
−1.89%

Quarter to September 2026, against a year earlier

20.31 0.59 +2.99%
Market cap
$3.2B
P/E
0.0×
Fwd P/E
−7.7×
Dividend yield
—
F-score
4/9
Altman Z
13.78
Beneish M
n/a
Dividend safety
n/a

Denali Therapeutics Inc. (DNLI) Operating margin

Alert me on Operating margin

Denali Therapeutics Inc.'s operating margin over the twelve months to 30 September 2026 was −2,349.0%, down 2349.0 percentage points from fiscal 2025 (0.00%). Over the past ten years it has ranged from −799.1% (fiscal 2019) to 18.7% (fiscal 2020); the current reading is higher than 91% of that period. That is below the Biotechnology industry median of 0.00% and below the Healthcare sector median of 0.00%.

Operating margin, annual

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Annual newest first

Period Operating margin Change (points)
FY2025 0.00% 0.00
FY2024 0.00% 59.51
FY2023 −59.5% 254.65
FY2022 −314.2% 293.62
FY2021 −607.8% (626.47)
FY2020 18.7% 817.79
FY2019 −799.1% (763.20)
FY2018 −35.9% (35.90)
FY2017 0.00% 0.00
FY2016 0.00% 0.00

Quarterly newest first

Period Operating margin Change (points)
Sep 2026 −713.0% 2,909.14
Jun 2026 −3,622.1% (3,622.11)
Mar 2026 0.00% 0.00
Dec 2025 0.00% 0.00
35 more quarters

Against its own ten years

Low −799.1% High 18.7%
Ten-year median 0.00%
Current reading's percentile 4

Operating margin against peers

Company Operating margin
ELVN Enliven Therapeutics, Inc. compare 0.00%
DYN Dyne Therapeutics, Inc. compare 0.00%
CELC Celcuity, Inc. compare 0.00%
VKTX Viking Therapeutics, Inc. compare 0.00%
TARS Tarsus Pharmaceuticals, Inc. compare −102.0%
IDYA IDEAYA Biosciences, Inc. compare −1,267.4%
VRDN Viridian Therapeutics, Inc. compare −1,781.4%
DNLI Denali Therapeutics Inc. −2,349.0%
TLX Telix Pharmaceuticals Limited compare —
Biotechnology industry median 0.00%
Healthcare sector median 0.00%
Market median 0.00%

What Operating margin is

EBIT Margin tells an investor how much operating profit, before interest and taxes, a company keeps from each unit of revenue.

EBIT ÷ Revenue

The full definition of Operating margin →

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