Iovance Biotherapeutics, Inc.

IOVA Healthcare Biotechnology

Iovance Biotherapeutics, Inc.’s revenue for fiscal 2025 (year ended December 2025) was $263.5 million, up 60.6% from fiscal 2024.

Revenue
+80.1%
EPS
+80.0%
Free cash flow
+89.7%

Quarter to September 2026, against a year earlier

7.99 0.25 +3.23%
Market cap
$3.5B
P/E
0.0×
Fwd P/E
−18.9×
Dividend yield
—
F-score
4/9
Altman Z
−2.30
Beneish M
−2.46
Dividend safety
n/a

Iovance Biotherapeutics, Inc. (IOVA) Operating margin

Alert me on Operating margin

Iovance Biotherapeutics, Inc.'s operating margin over the twelve months to 30 September 2026 was −60.8%, up 92.3 percentage points from fiscal 2025 (−153.1%). Over the past ten years it has ranged from −38,735.0% (fiscal 2023) to 0.00% (fiscal 2022); the current reading is higher than 27% of that period. That is below the Biotechnology industry median of 0.00% and below the Healthcare sector median of 0.00%.

Operating margin, annual

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Annual newest first

Period Operating margin Change (points)
FY2025 −153.1% 87.84
FY2024 −240.9% 38,494.07
FY2023 −38,735.0% (38,734.99)
FY2022 0.00% 0.00
FY2021 0.00% 0.00
FY2020 0.00% 0.00
FY2019 0.00% 0.00
FY2018 0.00% 0.00
FY2017 0.00% 0.00
FY2016 0.00% 0.00

Quarterly newest first

Period Operating margin Change (points)
Sep 2026 −19.7% 32.53
Jun 2026 −52.3% 61.20
Mar 2026 −113.5% (28.80)
Dec 2025 −84.7% 56.03
43 more quarters

Against its own ten years

Low −38,735.0% High 0.00%
Ten-year median 0.00%
Current reading's percentile 27

Operating margin against peers

Company Operating margin
ACAD ACADIA Pharmaceuticals Inc. compare 10.2%
XENE Xenon Pharmaceuticals Inc. compare 0.00%
IRON Disc Medicine, Inc. compare 0.00%
EWTX Edgewise Therapeutics, Inc. compare 0.00%
PBLS Parabilis Medicines, Inc. compare 0.00%
TNGX Tango Therapeutics, Inc. compare 0.00%
IOVA Iovance Biotherapeutics, Inc. −60.8%
ABCL AbCellera Biologics Inc. compare −340.3%
RLAY Relay Therapeutics, Inc. compare −2,815.5%
Biotechnology industry median 0.00%
Healthcare sector median 0.00%
Market median 0.00%

What Operating margin is

EBIT Margin tells an investor how much operating profit, before interest and taxes, a company keeps from each unit of revenue.

EBIT ÷ Revenue

The full definition of Operating margin →

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