Charles River Laboratories International, Inc.

CRL Healthcare Diagnostics & Research

Charles River Laboratories International, Inc.’s revenue for fiscal 2025 (year ended December 2025) was $4.0 billion, down 0.85% from fiscal 2024.

Revenue
−2.20%
EPS
+530.3%
Free cash flow
+16.3%
Total debt
+11.8%

Quarter to September 2026, against a year earlier

313.98 12.31 −3.77%
Market cap
$14.9B
P/E
300×
Fwd P/E
89.2×
Dividend yield
—
F-score
5/9
Altman Z
2.40
Beneish M
−3.11
Dividend safety
n/a

Revenue by segment Fiscal 2024

  • DSA
  • RMS
  • Manufacturing

Every year since 2009 →

Insider Decisions last twelve months

Bought, $m 0.01
Sold, $m 52.07
Trades a month
Jan 26 Apr 26 Jul 26 Oct 26
Buy — — — 1 — — — — — 1 — —
Sell — — — — — — 1 — 9 — 3 —
Insider Ownership 1.26%

Capital & Financial Ratios $m

Size
Market Cap 14,940.00
Revenue ttm 3,976.87
Net income ttm 42.59
Free cash flow ttm 399.63
Net debt Q 2,243.08
Valuation
P/E 300.09 (above 35: high)
Forward P/E 89.20 (above 35: high)
Price / sales 3.77
Forward P/S Powerpack
Price / FCF 37.56
Price / book 4.64
Financial health
Current ratio Q 1.41
Debt / equity Q 0.76
Interest coverage Q 7.10
Growth
Revenue growth Q −2.20% (below 0%: shrinking)
Operating income growth Q +51.45% (above 0%: growing)
EPS, this year +11.48%
EPS, next year A +12.74%
Revenue, next year A −2.45% (below 0%: weak)
EPS, past 5 yrs —
EPS, next 5 yrs A +12.04%

Green and red mark values outside typical ranges; (Q) is the latest quarter, (A) analysts’ estimates. How we judge →

Valuation vs history

P/E against its own 10 years 96.94%
10-year low 10-year high
P/S against its own 10 years 83.94%
10-year low 10-year high
P/B against its own 10 years 54.60%
10-year low 10-year high
EV/Sales against its own 10 years 83.68%
10-year low 10-year high
EV/FCF against its own 10 years 84.56%
10-year low 10-year high

Dividends

Yield
—
Annual rate
—
Payout ratio
—

Assets vs Liabilities $m

2023 2024 2025 Q'26
Cash 277 195 214 200
Receivables 780 721 709 735
Inventory 380 279 299 320
Other 83 106 129 182
1,609 1,403 1,447 1,535
2023 2024 2025 Q'26
Payables 169 140 149 145
ST’ Debt — — — —
Other 203 194 222 229
1,055 994 1,120 1,089

Compound Annual Growth %

10y 5y 3y
Sales 11.41% 6.55% 0.33%
Cash Flow 9.17% 6.18% 5.98%
Earnings 0.00% 0.00% 0.00%
Book Value 15.70% 8.40% 2.07%

Earnings Trends EPS, adjusted, against the consensus

EPS $

Mar Jun Sep Dec Year
’26 (0.30) (0.03) 6.88 — —
’25 0.50 1.06 1.10 (5.62) (2.91)
’24 1.30 1.74 1.33 (4.22) 0.20
’23 2.01 1.89 1.69 3.62 9.22
’22 1.81 2.13 1.88 3.65 9.48
’21 1.20 1.72 2.01 2.67 7.60
’20 1.02 1.34 2.03 2.81 7.20
Fiscal quarters ending in the months shown.

Revenue $m

Mar Jun Sep Dec Year
’26 996 1,004 983 — —
’25 984 1,032 1,005 994 4,015
’24 1,012 1,026 1,010 1,003 4,050
’23 1,029 1,060 1,027 1,013 4,129
’22 914 973 989 1,100 3,976
’21 825 915 896 905 3,540
’20 707 683 743 791 2,924
Fiscal quarters ending in the months shown.

Operating Cash Flow $m

Mar Jun Sep Dec Year
’26 41 180 254 — —
’25 172 205 214 148 738
’24 130 194 252 159 735
’23 109 148 205 221 684
’22 103 149 133 235 620
’21 170 187 175 229 761
’20 69 162 177 138 547
Fiscal quarters ending in the months shown.

Free Cash Flow $m

Mar Jun Sep Dec Year
’26 (15) 149 207 — —
’25 112 169 178 59 518
’24 51 154 213 84 502
’23 3 81 140 143 365
’22 22 67 60 146 295
’21 142 140 119 130 532
’20 43 136 151 51 380
Fiscal quarters ending in the months shown.

Valuation

The price implies free cash flow after share-based pay growing 19.1% a year for ten years. It grew 8.5% a year over the last ten.

Implied
19.1%
10 years, reported
8.5%
Open the model

Target Price Range

Analyst price targets

Recommendation Rating

1.9
1Buy 2 3Hold 4 5Sell

Ten years at a glance Fiscal years to December

Ten-year view Analyst estimates Powerpack
Group Line 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 TTM Sep ’26 Trend 10 yrs 2026e 2027e 2028e Next 3/yr
Income, $m
Income, $m Revenue 1,681 1,858 2,266 2,621 2,924 3,540 3,976 4,129 4,050 4,015 3,977 +10.2% 3,917 4,016 4,251 +1.9%
Gross margin, % 38.30 37.73 37.07 36.56 36.72 37.70 36.79 36.39 32.88 32.96 33.33 (5.3) pt
EBT 223 297 282 304 447 481 623 581 93 (100) (100) n/m
EBT margin, % 13.26 15.99 12.43 11.60 15.29 13.58 15.67 14.08 2.30 (2.48) (2.52) (15.7) pt
Net income 156 125 229 254 365 399 493 480 25 (142) 43 n/m
Per share, $
Per share, $ Revenue 35.76 39.12 47.26 53.79 59.01 70.39 78.25 80.61 78.82 81.01 83.19 +9.5%
Earnings 3.29 2.60 4.72 5.17 7.35 7.77 9.57 9.27 0.20 (2.91) 1.05 n/m
Cash flow 6.74 6.70 9.20 9.87 11.03 15.13 12.19 13.35 14.30 14.88 13.02 +9.2%
Capex (1.18) (1.74) (2.92) (2.88) (3.36) (4.55) (6.39) (6.22) (4.53) (4.42) (4.66) +15.9%
Free cash flow 5.56 4.96 6.28 6.99 7.67 10.58 5.80 7.13 9.76 10.46 8.36 +7.3%
Book value 17.85 22.06 27.53 33.61 42.75 50.48 58.67 70.32 67.48 63.96 67.61 +15.2%
Shares, m 47 47 48 49 50 50 51 51 51 50 49 +0.6%
Valuation, ×
Valuation, × P/E 23.19 42.72 24.08 29.55 34.04 48.49 22.82 25.30 1,025.56 0.00 300.09 127.6
P/S 2.14 2.83 2.39 2.84 4.23 5.35 2.79 2.91 2.34 2.46 3.77 3.0
P/B 4.29 5.02 4.11 4.55 5.84 7.46 3.72 3.33 2.74 3.12 4.64 4.4
EV/Sales 2.80 3.36 3.04 3.47 4.83 6.05 3.41 3.48 2.85 2.94 4.34 3.6
EV/FCF 18.02 26.46 22.91 26.71 37.19 40.24 46.02 39.34 22.99 22.78 43.18 30.3
Cash, $m
Cash, $m Operating cash flow 317 318 441 481 547 761 620 684 735 738 622 +9.8%
Capex (55) (82) (140) (141) (167) (229) (325) (319) (233) (219) (223) +16.5%
Free cash flow 262 236 301 340 380 532 295 365 502 518 400 +7.9%
Balance, $m
Balance, $m Working capital 227 363 340 311 361 241 347 554 409 327 446 +4.1%
Net debt 1,117 981 1,473 1,650 1,751 2,422 2,474 2,370 2,046 1,923 2,243 +6.2%
Shareholders’ equity 839 1,047 1,320 1,638 2,118 2,539 2,981 3,602 3,467 3,170 3,232 +15.9%
Returns, %
Returns, % ROA 6.48 4.37 6.67 5.90 7.15 6.25 6.65 6.01 0.13 (1.97) 0.54 (8.4) pt
ROIC 7.59 8.88 7.42 6.67 6.99 7.43 7.46 6.46 2.58 0.31 1.81 (7.3) pt
ROE 19.63 13.08 19.13 17.04 19.40 16.79 17.62 14.42 0.29 (4.35) 1.21 (24.0) pt
People
People Employees 11,000 11,800 14,700 17,100 18,400 20,000 21,400 21,800 20,100 19,700 — +6.7%
Revenue/emp, $m 0.15 0.16 0.15 0.15 0.16 0.18 0.19 0.19 0.20 0.20 — +3.2%
Negative figures in brackets.
estimates

All 10 years →

Fiscal years to Dec 2025 · latest quarter Sep 2026 · fundamentals updated 5 Nov 2026

Business profile

Updated

Charles River Laboratories helps pharmaceutical and biotechnology companies research potential medicines and test their safety before human trials. It also supplies research animals and related services to laboratories, and products and testing services used to check the quality of manufactured medicines.

Its work covers several stages of non-clinical development. Researchers can use its discovery services to identify and refine potential drug candidates, then use its safety assessment services to investigate possible harmful effects. These studies can use cells or tissues in laboratory tests, as well as animals bred for research. Charles River also performs laboratory analysis to help clients understand how a drug moves through the body.

Where the money comes from and where it goes Fiscal 2024

Fiscal 2024: revenue by segment, and margins
DSA 2,451 60.53%
RMS 829 20.48%
Manufacturing 769 19.00%
Gross margin 32.88%
Operating margin 5.61%
Pre-tax margin 2.30%

Revenue by segment since 2009

Charles River Laboratories International, Inc. vs peers in Diagnostics & Research (Q) = latest quarter vs a year earlier

Company Market cap P/E Fwd P/E Revenue growth (Q) EPS growth (Q) FCF growth (Q) Gross margin (Q) EBIT margin (Q) Compare
ILMN Illumina, Inc. $31.5B 35.6× 46.4× +4.15% (above 0%: growing) +48.98% (above 0%: growing) +49.80% (above 0%: growing) 73.52% 27.02% Compare
LH Labcorp Holdings Inc. $29.5B 29.5× 26.7× +6.92% (above 0%: growing) +3.18% (above 0%: growing) +44.73% (above 0%: growing) 29.08% 10.55% Compare
DGX Quest Diagnostics Incorporated $28.0B 25.0× 24.4× +9.98% (above 0%: growing) +29.36% (above 0%: growing) +6.21% (above 0%: growing) 33.65% 15.47% Compare
GH Guardant Health, Inc. $20.6B — (loss-making) — (loss-making) +36.12% (above 0%: growing) n/m +18.74% (above 0%: growing) 65.42% (36.78%) Compare
MEDP Medpace Holdings, Inc. $17.8B 34.6× 35.8× +8.50% (above 0%: growing) +24.56% (above 0%: growing) −16.59% (below 0%: shrinking) 71.39% 23.12% Compare
RVTY Revvity Inc. $16.8B 71.9× 66.2× +4.29% (above 0%: growing) +2.17% (above 0%: growing) +26.97% (above 0%: growing) 57.43% 13.05% Compare
ICLR ICON PLC $15.1B 34.5× 34.6× −2.86% (below 0%: shrinking) n/m −8.01% (below 0%: shrinking) 24.29% 9.82% Compare
CRL Charles River Laboratories International, Inc. $14.9B 300× 89.2× −2.20% (below 0%: shrinking) +530.30% (above 0%: growing) +16.29% (above 0%: growing) 36.42% 20.62%
QGEN QIAGEN N.V. $10.5B 26.1× 26.0× +0.28% (above 0%: growing) +7.94% (above 0%: growing) +30.45% (above 0%: growing) 63.62% 24.75% Compare
Median of peers $19.2B 34.5× 34.6× +5.61% +16.25% +22.86% 60.53% 14.26%

All 49 Diagnostics & Research stocks →

From the latest earnings call

Updated

  • CEO Birgit Girshick said demand improved in Discovery and Safety Assessment, while reduced proposal discounts would take time to reach revenue.
  • CFO Glenn Coleman said Charles River raised its full-year organic revenue and non-GAAP earnings guidance after its third-quarter performance exceeded its outlook.

Largest institutional holders 13F, quarter to 30 June 2026

Held by institutions 119.06%
Held by the ten largest 57.60%
Holder Shares Stake Change
Vanguard 5.80m 12.15% −145.62k
Fidelity (FMR) 4.24m 8.88% +783.51k
BlackRock 3.80m 7.96% −60.54k
Invesco 2.98m 6.25% +587.53k
HARRIS ASSOCIATES L P 2.24m 4.70% +87.85k
Allspring Global Investments Holdings, LLC 1.91m 3.99% −88.07k
State Street 1.86m 3.91% −9.33k
Dimensional Fund Advisors 1.65m 3.45% −4.03k
T. Rowe Price 1.51m 3.15% +380.23k
ARIEL INVESTMENTS, LLC 1.50m 3.15% +62.02k
13F filings for the quarter to 30 June 2026: long positions in US-listed shares reported by managers with $100m or more, ~45 days after the quarter.

Pay and ownership Proxy statement filed 31 March 2026

Chief executive’s pay

Year Total pay Actually paid $100 invested
2025 15.44m 24.91m 81.00
2024 13.47m 3.10m 74.00
2023 14.10m 20.47m 94.00
2022 13.45m 10.66m 87.00
2021 13.71m 41.20m 147.00

Ownership

Directors and executive officers, together 1.30%
The Vanguard Group, Inc. 12.10%
BlackRock, Inc. 7.10%
Invesco, Ltd. 5.50%
Total pay is as the Summary Compensation Table states it; actually paid revalues the year’s share awards at its end, as the SEC’s pay-versus-performance rule asks. $100 invested is what $100 in the company’s shares at the start of the earliest year shown was worth at each year’s end. Ownership is the proxy’s own table: the directors and officers as a group, and every holder of 5% or more. Read the proxy statement

Charles River Laboratories International, Inc. (CRL) Latest News

4 Nov

23 Oct

14 Oct

Impact 4 · · pharmaceutical-technology.com

CRL metrics, ten years each

stockrow.com/CRL · Data as of Nov 5, 2026 · For information only; not investment advice. · © 2026 stockrow.com