Xenon Pharmaceuticals Inc.

XENE Healthcare Biotechnology

Xenon Pharmaceuticals Inc.’s revenue for fiscal 2025 (year ended December 2025) was $7.5 million, down 20.5% from fiscal 2022. In the quarter to June 2026, revenue grew 100.7%, EPS fell 3.74% and free cash flow fell 48.6%, each against the same quarter a year earlier. Insiders bought in the last twelve months.

33.55 0.78 −2.27%
Market cap
$3.3B
P/E
0.0×
Fwd P/E
−10.7×
Dividend yield
—
F-score
n/a
Altman Z
37.76
Beneish M
n/a
Dividend safety
n/a

Insider Decisions trades per month

Total buys 1.68
Total sells 21.97
Totals in millions of $.
Dec 25 Mar 26 Jun 26 Sep 26
Buy — — — — — — — — — — 2 —
Sell 1 1 1 — 6 — — 2 — 2 — —
Insider Ownership 7.89%

Capital & Financial Ratios $m

Market Cap 3,320.00
Revenue 16.93
Net Income (409.19)
Free Cash Flow (338.53)
Net Debt (930.69)
Current Ratio 21.02 (at or above 1.5: strong)
Debt/Equity 0.00 (at or below 0.5: strong)
P/E ratio 0.00
Fwd P/E (10.70) (negative: loss-making)
P/S ratio 197.35 (above 10: high)
P/B ratio 2.69
Past 5Y EPS Growth —
This Y EPS Growth (5.62%) (below 0%: weak)
Next Y EPS Growth (1.77%) (below 0%: weak)
Next Y revenue growth (83.24%) (below 0%: weak)
Next 5Y EPS Growth 8.32%

Green and red mark values outside typical ranges. How we judge →

Valuation vs history

P/S against its own 10 years 63.99%
10-year low 10-year high
P/B against its own 10 years 38.78%
10-year low 10-year high
EV/Sales against its own 10 years 58.78%
10-year low 10-year high

Dividends

Payout Ratio —
Annual Dividend Rate —
Annual Dividend Yield —
total individual payouts
2025 Powerpack
2024 Powerpack
2023 Powerpack
2022 Powerpack
2021 Powerpack
2020 Powerpack
2019 Powerpack
2017 Powerpack
predictions special payouts not included in total or ratios

Assets vs Liabilities $m

2023 2024 2025 Q'26
Cash 638 627 549 931
Receivables 1 1 1 2
Inventory — — — —
Other — — — —
645 635 561 946
2023 2024 2025 Q'26
Payables 26 34 40 44
ST’ Debt — — — —
Other — — — —
27 36 42 45

Compound Annual Growth %

10y 5y 3y
Sales 3.15% 89.00% (38.45%)
Cash Flow 0.00% 0.00% 0.00%
Earnings 0.00% 0.00% 0.00%
Book Value 25.29% 27.69% (6.92%)

Revenue $m

Mar Jun Sep Dec Year
’26 — — — — —
’25 8 — — — 8
’22 9 1 0 — 9
’21 4 2 8 4 18
’20 7 13 7 5 32
’19 — — 4 3 7
’17 0 0 0 0 0
Fiscal quarters ending in the months shown.

Operating Cash Flow $m

Mar Jun Sep Dec Year
’26 (89) (95) — — —
’25 (62) (64) (72) (81) (279)
’24 (46) (31) (50) (54) (181)
’23 (34) (33) (48) (35) (151)
’22 (18) (17) (30) (33) (98)
’21 (21) (13) (15) (21) (70)
’20 (13) (11) (11) (13) (48)
Fiscal quarters ending in the months shown.

Free Cash Flow $m

Mar Jun Sep Dec Year
’26 (89) (96) — — —
’25 (62) (64) (72) (82) (280)
’24 (46) (33) (50) (55) (184)
’23 (37) (35) (49) (35) (157)
’22 (19) (17) (31) (34) (101)
’21 (21) (14) (15) (21) (72)
’20 (14) (11) (12) (14) (51)
Fiscal quarters ending in the months shown.

EPS $

Mar Jun Sep Dec Year
’26 (1.17) (1.11) — — —
’25 (0.83) (1.07) (1.15) (1.31) (4.36)
’24 (0.62) (0.75) (0.81) (0.84) (3.01)
’23 (0.63) (0.72) (0.73) (0.64) (2.73)
’22 (0.35) (0.55) (0.57) (0.57) (2.06)
’21 (0.42) (0.51) (0.36) (0.57) (1.77)
’20 (0.22) 0.00 (0.25) (0.34) (0.81)
Fiscal quarters ending in the months shown.

Target Price Range

Analyst price targets

Recommendation Rating

1.2
1Buy 2 3Hold 4 5Sell

Ten years at a glance Fiscal years to December

Group Line 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 Trend 2026e 2027e 2028e
Price, $
Price, $ Low 5.65 2.10 2.70 6.17 7.00 13.23 24.60 27.99 35.53 26.74

Analyst estimates 2026–2028

Powerpack
High 8.75 9.95 15.92 14.95 18.45 36.42 41.39 47.00 50.99 46.60
People
People Employees 94 81 92 104 129 153 213 259 327 370
Revenue/emp, $m 0.02 0.00 0.00 0.07 0.25 0.12 0.04 0.00 0.00 0.02
Income, $m
Income, $m Revenue 2 0 — 7 32 18 9 — — 8
Gross margin, % 100.00 100.00 0.00 100.00 100.00 100.00 100.00 — — 100.00
EBT (23) (31) (35) (42) (29) (79) (125) (183) (238) (345)
EBT margin, % (1,275.49) (9,872.67) 0.00 (609.43) (90.45) (427.88) (1,327.70) 0.00 0.00 (4,598.59)
Net income (23) (31) (34) (42) (29) (79) (125) (182) (234) (346)
Depreciation 1 1 1 1 1 1 2 2 3 3
Per share, $
Per share, $ Revenue 0.12 0.02 0.00 0.26 0.93 0.42 0.16 0.00 0.00 0.09
Earnings (1.48) (1.71) (1.63) (1.54) (0.81) (1.77) (2.06) (2.73) (3.01) (4.36)
Cash flow (1.26) (1.60) (1.79) (0.18) (1.39) (1.59) (1.63) (2.26) (2.33) (3.52)
Capex (0.02) (0.02) (0.03) (0.05) (0.08) (0.05) (0.05) (0.08) (0.04) (0.01)
Free cash flow (1.28) (1.61) (1.81) (0.23) (1.47) (1.64) (1.67) (2.34) (2.37) (3.53)
Book value 4.12 2.00 5.32 3.55 4.96 12.61 11.92 13.87 9.69 7.34
Shares, m 15 18 19 26 35 44 61 67 78 79
Valuation, ×
Valuation, × P/E 0.00 0.00 — 0.00 0.00 0.00 0.00 — — 0.00
P/S 67.45 166.55 — 47.84 16.52 73.92 171.27 — — 209.76
P/B 1.90 1.44 — 4.04 3.25 2.51 3.13 — — 6.11
EV/Sales 31.88 48.02 — 30.14 11.84 45.44 128.33 — — 178.92
EV/FCF (2.90) (0.51) — (35.98) (7.50) (11.71) (16.68) — — (10.82)
Cash, $m
Cash, $m Operating cash flow (20) (29) (35) (5) (48) (70) (98) (151) (181) (279)
Capex 0 0 (1) (1) (3) (2) (3) (6) (3) (1)
Free cash flow (20) (29) (35) (6) (51) (72) (101) (157) (184) (280)
Balance, $m
Balance, $m Working capital 62 41 117 101 167 545 578 618 600 519
Total debt — 7 15 16 3 8 10 — — —
Net debt (64) (37) (104) (126) (177) (552) (592) (638) (627) (549)
Shareholders’ equity 64 36 103 92 171 550 721 928 755 582
Returns, %
Returns, % ROA (34.99) (54.05) (37.52) (29.64) (16.63) (20.25) (18.84) (21.22) (26.58) (48.34)
ROIC 0.00 0.00 0.00 0.00 0.00 0.00 (62.37) (46.16) (136.38) (709.28)
ROE (36.81) (61.51) (48.09) (44.52) (22.60) (21.84) (19.77) (22.12) (27.85) (51.76)
Negative figures in brackets.

All 10 years →

Fiscal years to Dec 2025 · latest quarter Mar 2025

Charts ten years each

Xenon Pharmaceuticals Inc. vs peers in Biotechnology (Q) = latest quarter vs a year earlier

Company Market cap P/E Fwd P/E Revenue growth (Q) EPS growth (Q) FCF growth (Q) Gross margin (Q) EBIT margin (Q) Compare
ARQT Arcutis Biotherapeutics, Inc. $3.7B 131× 196× +59.33% (above 0%: growing) n/m +227.96% (above 0%: growing) 91.58% 12.65% Compare
TLX Telix Pharmaceuticals Limited $3.6B — — — — −44.78% (below 0%: shrinking) — — Compare
TARS Tarsus Pharmaceuticals, Inc. $3.5B — (loss-making) — (loss-making) +69.41% (above 0%: growing) n/m +288.08% (above 0%: growing) 93.03% (11.45%) Compare
VKTX Viking Therapeutics, Inc. $3.5B — (loss-making) — — n/m −165.98% (below 0%: shrinking) 0.00% 0.00% Compare
ACAD ACADIA Pharmaceuticals Inc. $3.4B 8.5× 55.6× +16.40% (above 0%: growing) +12.50% (above 0%: growing) +50.32% (above 0%: growing) 90.81% 12.29% Compare
XENE Xenon Pharmaceuticals Inc. $3.3B — (loss-making) — (loss-making) +100.70% (above 0%: growing) n/m −48.57% (below 0%: shrinking) 100.00% 0.00%
IDYA IDEAYA Biosciences, Inc. $3.3B — (loss-making) — (loss-making) +125.77% (above 0%: growing) n/m −41.09% (below 0%: shrinking) 100.00% (1,380.73%) Compare
CELC Celcuity, Inc. $3.0B — (loss-making) — — n/m −53.27% (below 0%: shrinking) 0.00% 0.00% Compare
DNLI Denali Therapeutics Inc. $2.9B — (loss-making) — (loss-making) −89.74% (below 0%: shrinking) n/m −22.91% (below 0%: shrinking) 97.42% (3,622.11%) Compare
Median of peers $3.4B — — +59.33% — −32.00% 91.58% 0.00%

All 614 Biotechnology stocks →

Xenon Pharmaceuticals Inc. (XENE) key facts

  • Concern: Xenon Pharmaceuticals Inc.’s revenue for fiscal 2025 (year ended December 2025) was $7.5 million, down 20.5% from fiscal 2022.
  • Xenon Pharmaceuticals Inc. (XENE) is a Biotechnology company in the Healthcare sector, listed on Nasdaq.
  • As of October 16, 2026, XENE traded at $33.55, a market capitalization of $3.3 billion.
  • Return on equity was −51.8% and debt-to-equity 0.00.
  • Its Altman Z-score is 37.76 (safe zone) for fiscal 2025.

Source: company filings (standardised) and stockrow calculations.

Xenon Pharmaceuticals Inc. (XENE) Latest News

7 May

Impact 4 · transcript
stockrow.com/XENE · Data as of Mar 31, 2025 · For information only; not investment advice. · © 2026 stockrow.com