stockrowUpstream Bio, Inc.
UPBUpstream Bio, Inc.’s revenue for fiscal 2025 (year ended December 2025) was $2.9 million, up 20.4% from fiscal 2024.
- Revenue
- −17.5%
- EPS
- +1.35%
- Free cash flow
- +9.33%
Quarter to June 2026, against a year earlier
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Upstream Bio, Inc. (UPB) EV/Sales
As of 6 November 2026, Upstream Bio, Inc. (UPB) trades at a EV/Sales of −26.9×. Over the past ten years it has ranged from −72.3× (December 2024) to 495× (January 2026); the current reading is higher than 20% of that period. That is below the Biotechnology industry median of 9.0× and below the Healthcare sector median of 3.6×.
EV/Sales, daily
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Annual newest first
| Period | EV/Sales | Change |
|---|---|---|
| FY2025 | 393× | 231.30% |
| FY2024 | 119× | — |
| FY2023 | −64.8× | — |
Quarterly newest first
| Period | EV/Sales | Change |
|---|---|---|
| Jun 2026 | 36.8× | (37.07%) |
| Mar 2026 | 58.5× | (85.10%) |
| Dec 2025 | 393× | 71.18% |
| Sep 2025 | 229× | 217.33% |
| 7 more quarters | Free account |
Against its own ten years
EV/Sales against peers
| Company | EV/Sales |
|---|---|
| UPB Upstream Bio, Inc. | −26.9× |
| BCYC Bicycle Therapeutics PLC Sponsored ADR compare | −2.3× |
| BBOT BridgeBio Oncology Therapeutics, Inc compare | n/m |
| IVVD Invivyd, Inc. compare | 0.3× |
| CGEN Compugen Ltd. compare | 0.8× |
| WHWK Whitehawk Therapeutics, Inc. compare | 2.5× |
| TRDA Entrada Therapeutics, Inc. compare | 3.6× |
| ACOG Alpha Cognition Inc. compare | 9.2× |
| MDWD MediWound Ltd. compare | 12.6× |
| Biotechnology industry median | 9.0× |
| Healthcare sector median | 3.6× |
| Market median | 2.1× |
What EV/Sales is
EV/Sales tells an investor how the value of a whole company, counting its debt and cash, compares with the sales it brings in.
((Stock Price × Shares (Basic, Weighted) (latest quarter)) + (Long Term Debt (Total) (latest quarter) + Current Part of Debt (latest quarter)) − Cash & Short Term Investments (latest quarter)) ÷ Revenue (TTM)