Upstream Bio, Inc.

UPB

Healthcare Biotechnology

Upstream Bio, Inc.’s revenue for fiscal 2025 (year ended December 2025) was $2.9 million, up 20.4% from fiscal 2024.

Revenue
−17.5%
EPS
+1.35%
Free cash flow
+9.33%

Quarter to June 2026, against a year earlier

3.23 0.02 +0.62%
Market cap
$176.9M
P/E
n/m
Fwd P/E
n/m
Dividend yield
—
F-score
2/9
Net debt / EBITDA
2.1×
Dividend safety
n/a
Dec '25 Dec '24 Dec '23
Piotroski F-Score
2 — —
P/E ratio
0.00 0.00 0.00
Altman Z-Score
60.99 11.46 —
P/S ratio
512.30 317.02 27.97
Altman Z″-Score (non-manufacturers)
25.63 45.58 12.38
P/FCF ratio
0.00 0.00 0.00
Beneish M-Score
(2.81) 6.55 —
P/Operating CF
(47.73) (38.31) (4.76)
P/B ratio
4.30 1.60 0.00
EV/Sales
392.64 118.52 (64.82)
EV/EBITDA
0.00 0.00 2.44
EV/FCF
(8.39) (4.69) 2.77
Current Ratio
26.15 44.63 17.96
Net Debt/EBITDA
2.11 5.93 2.66
Debt/Equity
0.00 0.00 0.00
ROE
(35.43%) (44.07%) 0.00%
ROA
(34.34%) (25.51%) 0.00%
ROIC
0.00% 0.00% 0.00%
Return on Tangible Assets
(42.33%) (16.29%) (34.58%)
Average Days of Receivables
85.43 94.41 15.03
Earnings Yield
(9.83%) (113.24%) (92.05%)
Free Cash Flow Yield
(9.14%) (7.96%) (83.71%)
Free Cash Flow per Share
(2.48) (4.36) (12.89)
Book value per Share
6.31 34.34 36.50
Free Cash Flow
(133.44) (59.68) (38.07)
EV/EBIT
0.00 0.00 2.53
Other line items

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Columns are period end dates · fundamentals updated 26 Oct 2026