Ultragenyx Pharmaceutical Inc.

RARE Healthcare Biotechnology

Ultragenyx Pharmaceutical Inc.’s revenue for fiscal 2025 (year ended December 2025) was $673.0 million, up 20.2% from fiscal 2024.

Revenue
+8.13%
EPS
+36.2%
Free cash flow
+12.5%

Quarter to September 2026, against a year earlier

15.49 0.08 −0.51%
Market cap
$1.5B
P/E
0.0×
Fwd P/E
−4.9×
Dividend yield
—
F-score
5/9
Altman Z
−3.57
Beneish M
−2.68
Dividend safety
n/a

Insider Decisions last twelve months

Sold, $m 3.81
Trades a month
Jan 26 Apr 26 Jul 26 Oct 26
Buy — — — — — — — — — — — —
Sell 2 1 1 8 1 3 3 1 2 2 1 —
Insider Ownership 11.67%

Capital & Financial Ratios $m

Size
Market Cap 1,540.00
Revenue ttm 730.00
Net income ttm (524.00)
Free cash flow ttm (447.00)
Net debt Q (266.00)
Valuation
P/E 0.00
Forward P/E (4.87) (negative: loss-making)
Price / sales 2.17
Forward P/S Powerpack
Price / FCF 0.00
Price / book 0.00
Financial health
Current ratio Q 1.40
Debt / equity Q 0.00 (at or below 0.5: strong)
Interest coverage Q (5.50)
Growth
Revenue growth Q +8.13% (above 0%: growing)
Operating income growth Q +35.67% (above 0%: growing)
EPS, this year +21.43% (at or above 15%: strong)
EPS, next year A +108.89% (at or above 15%: strong)
Revenue, next year A +12.94% (at or above 10%: strong)
EPS, past 5 yrs —
EPS, next 5 yrs A +71.02% (at or above 15%: strong)

Green and red mark values outside typical ranges; (Q) is the latest quarter, (A) analysts’ estimates. How we judge →

Valuation vs history

P/S against its own 10 years 1.31%
10-year low 10-year high
EV/Sales against its own 10 years 1.44%
10-year low 10-year high

Dividends

Yield
—
Annual rate
—
Payout ratio
—

Assets vs Liabilities $m

2023 2024 2025 Q'26
Cash 577 610 680 266
Receivables 73 122 158 166
Inventory 34 45 52 59
Other — — — —
732 817 951 544
2023 2024 2025 Q'26
Payables 42 39 31 45
ST’ Debt — — — —
Other 29 54 76 102
280 344 384 389

Compound Annual Growth %

10y 5y 3y
Sales — 19.95% 22.81%
Cash Flow 0.00% 0.00% 0.00%
Earnings 0.00% 0.00% 0.00%
Book Value 0.00% 0.00% 0.00%

Earnings Trends EPS, adjusted, against the consensus

EPS $

Mar Jun Sep Dec Year
’26 (1.84) (0.90) (1.16) — —
’25 (1.57) (1.17) (1.81) (1.29) (5.83)
’24 (2.03) (1.52) (1.40) (1.39) (6.29)
’23 (2.33) (2.25) (2.23) (1.52) (8.25)
’22 (2.19) (2.26) (3.50) (2.16) (10.12)
’21 (2.03) (1.81) (1.08) (1.79) (6.70)
’20 (2.05) 0.41 (1.13) (0.37) (3.07)
Fiscal quarters ending in the months shown.

Revenue $m

Mar Jun Sep Dec Year
’26 136 214 173 — —
’25 139 167 160 207 673
’24 109 147 139 165 560
’23 100 108 98 127 434
’22 80 89 91 103 363
’21 99 87 82 83 351
’20 36 62 81 92 271
Fiscal quarters ending in the months shown.

Operating Cash Flow $m

Mar Jun Sep Dec Year
’26 (197) (97) (43) — —
’25 (166) (109) (91) (100) (466)
’24 (191) (77) (67) (79) (414)
’23 (157) (116) (118) (84) (475)
’22 (118) (77) (95) (90) (380)
’21 (159) (65) (60) (54) (339)
’20 (95) 87 (62) (62) (132)
Fiscal quarters ending in the months shown.

Free Cash Flow $m

Mar Jun Sep Dec Year
’26 (203) (98) (45) — —
’25 (182) (112) (92) (101) (487)
’24 (204) (81) (69) (80) (434)
’23 (182) (133) (122) (86) (522)
’22 (180) (108) (121) (117) (527)
’21 (176) (85) (80) (70) (412)
’20 (109) 83 (66) (84) (176)
Fiscal quarters ending in the months shown.

Target Price Range

Analyst price targets

Recommendation Rating

2.1
1Buy 2 3Hold 4 5Sell

Ten years at a glance Fiscal years to December

Ten-year view Analyst estimates Powerpack
Group Line 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 TTM Sep ’26 Trend 10 yrs 2026e 2027e 2028e Next 3/yr
Income, $m
Income, $m Revenue 0 3 51 104 271 351 363 434 560 673 730 +158.0% 760 997 1,169 +20.2%
Gross margin, % 100.00 99.96 97.77 91.31 97.74 95.44 92.21 89.63 86.25 83.80 82.88 (16.2) pt
EBT (246) (318) (197) (399) (185) (453) (702) (609) (567) (571) (530) +9.8%
EBT margin, % (184,841.35) (12,187.52) (382.75) (385.14) (68.39) (128.91) (193.14) (140.32) (101.25) (84.84) (72.60) +184,756.5 pt
Net income (246) (302) (198) (403) (187) (454) (707) (607) (569) (575) (524) +9.9%
Per share, $
Per share, $ Revenue 0.00 0.06 1.03 1.83 4.45 5.18 5.20 5.90 6.19 6.83 7.15 +132.8%
Earnings (6.21) (7.12) (3.97) (7.12) (3.07) (6.70) (10.12) (8.25) (6.29) (5.83) (5.19) (0.7%)
Cash flow (4.07) (5.98) (5.84) (6.10) (2.17) (5.00) (5.44) (6.46) (4.57) (4.73) (4.28) +1.7%
Capex (0.26) (0.07) (0.08) (0.44) (0.72) (1.08) (2.09) (0.64) (0.22) (0.21) (0.10) (2.1%)
Free cash flow (4.32) (6.05) (5.92) (6.54) (2.89) (6.07) (7.53) (7.10) (4.80) (4.94) (4.38) +1.5%
Book value 11.97 9.03 12.23 11.56 18.97 13.61 5.04 3.75 2.82 (0.81) (3.68) n/m
Shares, m 40 42 50 57 61 68 70 74 91 99 101 +10.7%
Valuation, ×
Valuation, × P/E 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.0
P/S 0.00 767.05 42.03 23.30 31.08 16.22 8.76 8.16 6.80 3.37 2.17 90.7
P/B 5.84 5.46 3.55 3.70 7.30 6.18 9.03 12.86 14.93 0.00 0.00 6.9
EV/Sales 0.00 681.09 33.10 16.02 26.64 14.12 6.70 6.83 5.71 2.36 1.80 79.3
EV/FCF (13.95) (7.24) (5.78) (4.49) (41.00) (12.05) (4.62) (5.68) (7.37) (3.26) (2.94) (10.5)
Cash, $m
Cash, $m Operating cash flow (161) (254) (291) (345) (132) (339) (380) (475) (414) (466) (437) +12.5%
Capex (10) (3) (4) (25) (44) (73) (146) (47) (20) (21) (10) +8.4%
Free cash flow (171) (257) (295) (370) (176) (412) (527) (522) (434) (487) (447) +12.3%
Balance, $m
Balance, $m Working capital 341 199 448 748 1,106 675 623 452 473 567 155 +5.8%
Net debt (382) (234) (460) (755) (1,202) (740) (748) (577) (610) (680) (266) +6.6%
Shareholders’ equity 474 383 609 654 1,154 923 352 275 255 (80) (376) n/m
Returns, %
Returns, % ROA (44.70) (58.59) (32.65) (43.42) (12.89) (27.67) (46.12) (39.98) (38.01) (37.89) (44.08) +6.8 pt
ROIC (167.73) (138.02) (155.57) 0.00 0.00 (130.83) 0.00 0.00 0.00 0.00 0.00 +167.7 pt
ROE (48.93) (70.48) (39.83) (63.79) (20.64) (43.72) (110.96) (193.34) (214.55) (657.14) 285.68 (608.2) pt
People
People Employees 376 520 610 740 893 1,119 1,311 1,276 1,294 1,371 — +15.5%
Revenue/emp, $m 0.00 0.01 0.08 0.14 0.30 0.31 0.28 0.34 0.43 0.49 — +123.4%
Negative figures in brackets.
estimates

All 10 years →

Fiscal years to Dec 2025 · latest quarter Sep 2026 · fundamentals updated 6 Nov 2026

Ultragenyx Pharmaceutical Inc. vs peers in Biotechnology (Q) = latest quarter vs a year earlier

Company Market cap P/E Fwd P/E Revenue growth (Q) EPS growth (Q) FCF growth (Q) Gross margin (Q) EBIT margin (Q) Compare
ABSI Absci Corporation $1.6B — (loss-making) — (loss-making) −46.37% (below 0%: shrinking) n/m −71.74% (below 0%: shrinking) 100.00% (10,741.51%) Compare
SLS SELLAS Life Sciences Group, Inc. $1.6B — (loss-making) — (loss-making) −57.10% (below 0%: shrinking) n/m −3.52% (below 0%: shrinking) 0.00% 0.00% Compare
KLRA Kailera Therapeutics, Inc. $1.6B — (loss-making) — — n/m −325.95% (below 0%: shrinking) — 0.00% Compare
BRVE Braveheart Bio, Inc. $1.6B — — — n/m — — 0.00% Compare
NTLA Intellia Therapeutics, Inc. $1.6B — (loss-making) — (loss-making) −48.03% (below 0%: shrinking) n/m −11.05% (below 0%: shrinking) 100.00% (1,707.73%) Compare
RARE Ultragenyx Pharmaceutical Inc. $1.5B — (loss-making) — (loss-making) +8.13% (above 0%: growing) n/m +12.50% (above 0%: growing) 81.50% (63.58%)
NBTX Nanobiotix S.A. - Sponsored ADR $1.5B — (loss-making) — −71.69% (below 0%: shrinking) n/m −177.26% (below 0%: shrinking) 0.00% 0.00% Compare
PGEN Precigen, Inc. $1.5B 60.3× 20.8× +2,437.58% (above 0%: growing) n/m +140.34% (above 0%: growing) 91.22% 52.13% Compare
NUVB Nuvation Bio Inc. $1.5B — (loss-making) — (loss-making) +242.61% (above 0%: growing) n/m +34.07% (above 0%: growing) 73.46% (93.90%) Compare
Median of peers $1.6B — — −47.20% — −11.05% 82.34% 0.00%

All 621 Biotechnology stocks →

Pay and ownership Proxy statement filed 27 March 2026

Chief executive’s pay

Year Total pay Actually paid $100 invested
2025 11.41m (1.29m) 17.00
2024 13.72m 8.19m 30.00
2023 13.08m 11.29m 35.00
2022 12.14m 3.31m 33.00
2021 9.52m (2.15m) 61.00

Ownership

Directors and executive officers, together 5.20%
The Vanguard Group 8.80%
Total pay is as the Summary Compensation Table states it; actually paid revalues the year’s share awards at its end, as the SEC’s pay-versus-performance rule asks. $100 invested is what $100 in the company’s shares at the start of the earliest year shown was worth at each year’s end. Ownership is the proxy’s own table: the directors and officers as a group, and every holder of 5% or more. Read the proxy statement

Ultragenyx Pharmaceutical Inc. (RARE) Latest News

stockrow.com/RARE · Data as of Nov 6, 2026 · For information only; not investment advice. · © 2026 stockrow.com