Agios Pharmaceuticals, Inc. AGIO

32.58 (0.32) (0.97%) as of 25 Sep
Market cap
$2.0B
P/E
0.0×
Growth Flags show if company had growth for consecutive years

Insider Decisions

Total sells 4.70
in millions of $
Nov 25 Feb 26 May 26 Aug 26
Buy — — — — — — — — — — — —
Sell 3 2 5 1 — 7 6 — — 1 1 —
Insider Ownership 2.08%

Capital & Financial Ratios

Market Cap 2,000.00
Revenue 98.34
Net Income (411.29)
Free Cash Flow (365.25)
Net Debt (617.58)
Current Ratio 10.22
Debt/Equity 0.00
P/E ratio 0.00
P/S ratio 19.71
P/B ratio 1.89
Past 5Y EPS Growth (0.98%)
This Y EPS Growth 20.22%
Next Y EPS Growth 34.94%
Next 5Y EPS Growth 37.77%
in millions of $

Dividends

Payout Ratio 0.00
Annual Dividend Rate —
Annual Dividend Yield —
total individual payouts
2025 Powerpack
2024 Powerpack
2023 Powerpack
2022 Powerpack
2021 Powerpack
2020 Powerpack
2019 Powerpack
2017 Powerpack
predictions in italic, special payouts not included in total or ratios

Assets vs Liabilities

2023 2024 2025 Q'26
Cash 777 894 854 618
Receivables 3 4 11 20
Inventory 19 28 33 30
Other — — — —
834 966 942 718
2023 2024 2025 Q'26
Payables 10 17 18 16
ST’ Debt — — — —
Other — — — —
68 81 82 70
in millions of $

Compound Annual Growth

10y 5y 3y
Sales (1.89%) (14.45%) 55.97%
Cash Flow 0.00% 0.00% 0.00%
Earnings 0.00% 0.00% 0.00%
Book Value 13.21% 24.46% 2.72%

Revenue

Mar Jun Sep Dec Year
’26 21 45 — — —
’25 9 12 13 20 54
’24 8 9 9 11 36
’23 6 7 7 7 27
’22 1 6 4 4 14
’20 87 37 35 44 203
’19 30 26 26 35 118
in millions of $ · fiscal quarters ending in the months shown

Operating Cash Flow

Mar Jun Sep Dec Year
’26 (119) (57) — — —
’25 (111) (77) (88) (96) (373)
’24 (100) (73) (84) (133) (390)
’23 (95) (67) (62) (72) (296)
’22 (98) (74) (71) (66) (309)
’21 (121) (117) (85) (84) (407)
’20 (105) (68) (68) (49) (291)
in millions of $ · fiscal quarters ending in the months shown

Free Cash Flow

Mar Jun Sep Dec Year
’26 (120) (59) — — —
’25 (112) (78) (90) (97) (377)
’24 (100) (73) (85) (134) (391)
’23 (95) (67) (61) (73) (296)
’22 (101) (76) (71) (65) (313)
’21 (122) (118) (85) (89) (413)
’20 (110) (72) (73) (50) (305)
in millions of $ · fiscal quarters ending in the months shown

EPS

Mar Jun Sep Dec Year
’26 (1.69) (1.69) — — —
’25 (1.55) (1.93) (1.78) (1.85) (7.12)
’24 (1.45) (1.69) 16.22 (1.74) 11.64
’23 (1.47) (1.51) (1.64) (1.72) (6.33)
’22 (1.74) (1.68) (1.49) 0.67 (4.23)
’21 26.95 (1.41) (1.56) (1.74) 26.55
’20 (0.59) (1.31) (1.43) (1.41) (4.74)
fiscal quarters ending in the months shown

Target Price Range

Analyst price targets

Recommendation Rating

1.6
1Buy 2 3Hold 4 5Sell
2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 2026 2027 2028
33.50 39.24 41.63 28.36 27.77 29.21 16.75 19.80 20.96 22.24

Analyst estimates 2026–2028

Powerpack
Low Price
67.74 72.73 99.82 68.94 56.75 62.16 35.12 31.56 62.58 46.00
High Price
287 382 482 536 562 392 393 386 488 540
Employees
0 0 0 0 0 0 0 0 0 0
Revenue/Emp
70 43 94 118 203 — 14 27 36 54
Revenue
100.00% 100.00% 98.52% 84.79% (9.24%) 0.00% 88.03% 89.26% 88.59% 88.26%
Gross Margin
(198) (315) (346) (301) (329) (357) (232) (352) 718 (414)
EBT
(283.97%) (731.60%) (366.61%) (255.62%) (162.06%) 0.00% (1,627.82%) (1,312.63%) 1,967.15% (765.89%)
EBT Margin
(198) (315) (346) (411) (327) 1,605 (232) (352) 674 (413)
Net Income
6 6 3 5 13 16 7 2 (9) (2)
Depreciation
1.79 0.92 1.64 1.97 2.95 0.00 0.26 0.48 0.64 0.93
Revenue/Sh
(5.07) (6.75) (6.03) (6.86) (4.74) 26.55 (4.23) (6.33) 11.86 (7.12)
Earnings/Sh
0.99 (6.12) (5.30) (6.18) (4.21) (6.74) (5.65) (5.32) (6.86) (6.43)
Cash Flow/Sh
(0.25) (0.10) (0.12) (0.20) (0.20) (0.09) (0.07) 0.01 (0.03) (0.07)
Capex/Sh
0.73 (6.22) (5.42) (6.38) (4.42) (6.83) (5.72) (5.31) (6.89) (6.51)
Free CF/Sh
9.16 8.06 11.97 10.68 5.79 21.37 20.09 14.57 27.13 20.58
Book Value/Sh
39 47 57 60 69 60 55 56 57 58
Shares
0.00 0.00 0.00 0.00 0.00 — 0.00 0.00 2.79 0.00
PE Ratio
24.20 64.81 28.05 24.30 14.71 — 105.92 47.37 51.15 29.21
PS Ratio
4.72 7.42 3.85 4.47 7.48 — 1.37 1.57 1.21 1.32
PB Ratio
16.45 54.95 21.85 19.51 11.90 — 55.99 20.68 28.33 14.52
EV/Sales
40.13 (8.15) (6.62) (6.01) (7.93) — (2.54) (1.88) (2.64) (2.08)
EV/FCF
39 (285) (304) (371) (291) (407) (309) (296) (390) (373)
Op' Cash Flow
(10) (5) (7) (12) (14) (6) (4) 0 (2) (4)
Capex
29 (290) (311) (383) (305) (413) (313) (296) (391) (377)
FCF
471 350 520 519 542 1,004 770 766 884 860
Working Cap'
— — — 1 0 0 72 — — —
Total Debt
(541) (424) (585) (564) (573) (1,020) (711) (777) (894) (854)
Net Debt
359 376 688 641 400 1,292 1,101 811 1,541 1,193
Sh' Equity
(38.20%) (51.02%) (46.99%) (47.05%) (37.55%) 140.11% (17.32%) (32.36%) 51.82% (27.89%)
ROA
0.00% 0.00% (221.60%) (258.99%) 0.00% (86.88%) (62.40%) (717.72%) (41.11%) (87.12%)
ROIC
(56.41%) (85.73%) (65.10%) (61.97%) (62.95%) 189.74% (19.37%) (36.83%) 57.29% (30.20%)
ROE
predictions in italic, sparklines do not include predictions

All 10 years →

Fiscal years to Dec 2025 · latest quarter Jun 2026

Agios Pharmaceuticals, Inc. (AGIO) key facts

  • Agios Pharmaceuticals, Inc. (AGIO) is a Biotechnology company in the Healthcare sector, listed on Nasdaq.
  • Agios Pharmaceuticals, Inc.’s revenue for fiscal 2025 (year ended December 2025) was $54.0 million, up 48.0% from fiscal 2024.
  • Agios Pharmaceuticals, Inc. reported a net loss of $412.8 million, or a loss of $7.12 per share, for fiscal 2025.
  • As of September 25, 2026, AGIO traded at $32.58, a market capitalization of $2.0 billion.
  • Trailing earnings are negative, so a P/E ratio is not meaningful; the stock trades at 19.7× sales.
  • Return on equity was −30.2% and debt-to-equity 0.00.

Source: company filings (standardised) and stockrow calculations.

Agios Pharmaceuticals, Inc. (AGIO) Latest News

News by impact score

Fine-tune

30 Jul

4 transcript

Agios Pharmaceuticals reported strong Mitapivat revenue in its Q2 2026 earnings call. Strong Mitapivat revenue growth signals major positive shift in financial performance and market trajectory.

3 transcript

Agios Pharmaceuticals discussed Q2 financial results, pipeline updates and strategic outlook during its earnings call. Quarterly earnings and guidance updates can moderately shift near-term investor views and valuation.

3 earnings

Agios Pharmaceuticals reported second quarter 2026 financial results and issued a business update. Quarterly financial results and business updates typically produce moderate short-term effects on company valuation and investor views.

29 Jul

4

Agios Pharmaceuticals hits a Tebapivat setback in sickle cell but secures priority review for Mitapivat, positioning the drug as a potential major growth driver. Mitapivat priority review creates significant pipeline and market upside that outweighs the Tebapivat delay.

22 Jul

4

Agios Pharmaceuticals scrapped the Tebapivat SCD program, triggering a nearly 7% drop in AGIO shares. Scrapping the Tebapivat SCD program directly caused a nearly 7% AGIO share price decline, signaling a major pipeline setback.

21 Jul

4

Agios Pharmaceuticals scraps its sickle cell drug programme after disappointing Phase II trial results. Discontinuation of sickle cell drug development due to weak Phase II data reduces pipeline prospects and harms market performance.

4

Agios Pharmaceuticals scraps its sickle cell drug program. Discontinuation removes a key pipeline asset and damages Agios future revenue prospects.

3

AGIO stock declines today as investors react to company-specific developments pressuring shares. Stock decline signals short-term sentiment pressure without shifting long-term fundamentals or strategy.

3

Agios Pharmaceuticals, a Novo Nordisk rival, executed a bearish move likely tied to insider selling or negative stock action that signals weakening investor confidence. Bearish action by AGIO may briefly pressure sentiment and valuation but does not alter core pipeline or long-term competitive position versus Novo.

3

Agios Pharmaceuticals discontinued its sickle cell disease program after Phase 2 trial, triggering a share price tumble. Discontinuation of sickle cell program creates pipeline setback and immediate negative share reaction for Agios.

3

Agios Pharmaceuticals provided an update on its Phase 2 trial of tebapivat in sickle cell disease. Phase 2 trial update on tebapivat may moderately affect Agios pipeline progress and investor views in sickle cell disease.

10 Jul

3

Agios Pharmaceuticals shares rose sharply this week on its emerging role as a direct rival to Novo Nordisk. Stock surge reflects moderate short-term positive sentiment without evidence of fundamental long-term shifts.

9 Jul

4

FDA grants priority review to Agios Pharmaceuticals' mitapivat. Article examines whether AGIO stock offers value following the regulatory decision. FDA priority review accelerates mitapivat approval timeline and can materially lift Agios revenue outlook and valuation.

4

Agios Pharmaceuticals stock rose 13.8% after FDA granted priority review to Mitapivat for sickle cell disease treatment. FDA priority review accelerates Mitapivat path to approval and strengthens Agios position in rare disease market.

8 Jul

4

Agios Pharmaceuticals receives FDA priority review designation for mitapivat in sickle cell disease, lifting the stock price. FDA priority tag for mitapivat in SCD speeds potential approval and revenue opportunity, materially lifting AGIO trajectory.

7 Jul

4

Agios Pharmaceuticals stock surged on FDA-related news. FDA-related regulatory progress directly drove a sharp stock increase and signals material impact on company trajectory.

4

AGIO stock reaches over 7-month highs on FDA catalyst and seasonally strong Q2 earnings estimates driving optimism. FDA catalyst combined with upbeat Q2 estimates signals major upside for AGIO trajectory and sentiment.

4

FDA grants priority review to Agios' sNDA for mitapivat in sickle cell disease. Priority review designation for mitapivat in sickle cell disease signals accelerated path to potential approval and expanded revenue.

3

Agios Pharmaceuticals shares surged as a Novo Nordisk rival, approaching levels where investors may take profits. AGIO share price movement signals short-term sentiment shift without altering core operations or long-term trajectory.

13 Jun

4

Agios presents RISE UP Phase 3 results at EHA 2026 plenary session, highlighting mitapivat's strong anti-hemolytic effects in sickle cell disease. Positive Phase 3 data on mitapivat in sickle cell disease at major conference signals major commercial potential.

3

Agios Pharmaceuticals highlights positive Mitapivat gains while missing sickle cell pain reduction endpoint. Mixed Mitapivat trial outcomes may shift AGIO drug approval prospects and near-term valuation.

3 Jun

4

Tebapivat setback is reframing Agios Pharmaceuticals outlook and trajectory. Tebapivat setback directly hits Agios drug pipeline and alters future prospects.

2 Jun

4

Agios Pharmaceuticals secured global rights to a late-stage candidate targeting rare blood disorders. Global rights to late-stage asset expand pipeline and revenue potential substantially.

1 Jun

4

Agios Pharmaceuticals halts tebapivat development in myelodysplastic syndromes. Halting tebapivat development removes a key pipeline candidate and materially alters Agios' future prospects.

4

Agios Pharmaceuticals secures exclusive global license from Oscotec to develop and commercialize next-generation SYK inhibitor cevidoplenib. Exclusive global license adds next-generation SYK inhibitor to Agios pipeline with full development and commercialization rights.

3

Agios Pharmaceuticals licenses global rights to Oscotec's SYK inhibitor cevidoplenib. Licensing cevidoplenib adds a new SYK inhibitor candidate to Agios' pipeline.

29 May

4

Agios drug fails key test. Key drug test failure will damage AGIO pipeline prospects and market performance.

3

Agios Pharmaceuticals discontinued development of tebapivat in myelodysplastic syndromes, triggering a slide in its stock price. Tebapivat discontinuation removes one pipeline candidate and pressures near-term sentiment for Agios.

3

Agios Pharmaceuticals updated its Phase 2b trial of tebapivat in lower-risk myelodysplastic syndromes. Phase 2b update on tebapivat can shift pipeline progress and near-term sentiment for Agios without guaranteeing major commercial change.

25 May

4

Agios Pharmaceuticals' Pyrukynd receives European approval for thalassemia treatment. European approval expands Pyrukynd's market access and drives material revenue growth for Agios.

stockrow.com/AGIO · Data as of Jun 30, 2026 · For information only; not investment advice. · © 2026 stockrow.com