Exelixis, Inc.

EXEL Healthcare Biotechnology

Exelixis, Inc.’s revenue for fiscal 2025 (year ended December 2025) was $2.3 billion, up 6.98% from fiscal 2024.

Revenue
+10.2%
EPS
+22.2%
Free cash flow
−4.83%

Quarter to September 2026, against a year earlier

70.09 1.38 +2.01%
Market cap
$16.8B
P/E
19.9×
Fwd P/E
20.2×
Dividend yield
—
F-score
7/9
Altman Z
12.68
Beneish M
−2.61
Dividend safety
n/a

Exelixis, Inc. (EXEL) Operating margin

Alert me on Operating margin

Exelixis, Inc.'s operating margin over the twelve months to 30 September 2026 was 40.2%, up 2.6 percentage points from fiscal 2025 (37.6%). Over the past ten years it has ranged from −326.7% (fiscal 2015) to 51.4% (fiscal 2018); the current reading is higher than 82% of that period. That is above the Biotechnology industry median of 0.00% and above the Healthcare sector median of 0.00%.

Operating margin, annual

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Annual newest first

Period Operating margin Change (points)
FY2025 37.6% 9.71
FY2024 27.9% 18.54
FY2023 9.34% (3.17)
FY2022 12.5% (7.47)
FY2021 20.0% 8.84
FY2020 11.1% (27.04)
FY2019 38.2% (13.22)
FY2018 51.4% 14.73
FY2017 36.7% 51.36
FY2016 −14.7% 311.96

Quarterly newest first

Period Operating margin Change (points)
Sep 2026 40.8% 1.24
Jun 2026 39.5% (1.64)
Mar 2026 41.2% 1.86
Dec 2025 39.3% (0.28)
43 more quarters

Against its own ten years

Low −326.7% High 51.4%
Ten-year median 20.0%
Current reading's percentile 81

Operating margin against peers

Company Operating margin
EXEL Exelixis, Inc. 40.2%
HALO Halozyme Therapeutics, Inc. compare 37.4%
ASND Ascendis Pharma A/S compare 24.8%
ALNY Alnylam Pharmaceuticals, Inc. compare 19.5%
JAZZ Jazz Pharmaceuticals PLC compare 9.03%
SMMT Summit Therapeutics PLC compare 0.00%
INSM Insmed, Inc. compare −37.1%
BBIO BridgeBio Pharma, Inc. compare −38.5%
BNTX BioNTech SE Sponsored ADR compare −79.0%
Biotechnology industry median 0.00%
Healthcare sector median 0.00%
Market median 0.00%

What Operating margin is

EBIT Margin tells an investor how much operating profit, before interest and taxes, a company keeps from each unit of revenue.

EBIT ÷ Revenue

The full definition of Operating margin →

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