C4 Therapeutics, Inc.

CCCC Healthcare Biotechnology

C4 Therapeutics, Inc.’s revenue for fiscal 2025 (year ended December 2025) was $35.9 million, up 1.02% from fiscal 2024.

Revenue
−24.6%
EPS
+63.6%
Free cash flow
+17.9%

Quarter to September 2026, against a year earlier

3.12 0.17 +5.76%
Market cap
$362.9M
P/E
0.0×
Fwd P/E
−4.0×
Dividend yield
—
F-score
4/9
Altman Z
−2.16
Beneish M
−2.61
Dividend safety
n/a

Insider Decisions last twelve months

Sold, $m 0.02
Trades a month
Jan 26 Apr 26 Jul 26 Oct 26
Buy — — — — — — — — — — — —
Sell — 1 — — — — — — — — — —
Insider Ownership 16.87%

Capital & Financial Ratios $m

Size
Market Cap 362.93
Revenue ttm 32.28
Net income ttm (91.09)
Free cash flow ttm (79.63)
Net debt Q (205.41)
Valuation
P/E 0.00
Forward P/E (4.02) (negative: loss-making)
Price / sales 13.15 (above 10: high)
Forward P/S Powerpack
Price / FCF 0.00
Price / book 1.86
Financial health
Current ratio Q 5.17 (at or above 1.5: strong)
Debt / equity Q 0.00 (at or below 0.5: strong)
Interest coverage Q 9.48
Growth
Revenue growth Q −24.59% (below 0%: shrinking)
Operating income growth Q +28.52% (above 0%: growing)
EPS, this year +38.06% (at or above 15%: strong)
EPS, next year A −8.42% (below 0%: weak)
Revenue, next year A −26.78% (below 0%: weak)
EPS, past 5 yrs —
EPS, next 5 yrs A +7.06%

Green and red mark values outside typical ranges; (Q) is the latest quarter, (A) analysts’ estimates. How we judge →

Valuation vs history

P/S against its own 10 years 63.45%
10-year low 10-year high
P/B against its own 10 years 74.49%
10-year low 10-year high
EV/Sales against its own 10 years 62.28%
10-year low 10-year high

Dividends

Yield
—
Annual rate
—
Payout ratio
—

Assets vs Liabilities $m

2023 2024 2025 Q'26
Cash 254 245 249 205
Receivables 12 3 2 1
Inventory — — — —
Other — — — —
271 258 258 215
2023 2024 2025 Q'26
Payables 1 1 1 1
ST’ Debt — — — —
Other — — — —
43 45 33 41

Compound Annual Growth %

10y 5y 3y
Sales — 1.61% 4.95%
Cash Flow — 0.00% 0.00%
Earnings — 0.00% 0.00%
Book Value — (1.79%) (3.91%)

Earnings Trends EPS, adjusted, against the consensus

EPS $

Mar Jun Sep Dec Year
’26 (0.20) (0.18) (0.16) — —
’25 (0.37) (0.37) (0.44) (0.18) (1.27)
’24 (0.41) (0.26) (0.35) (0.49) (1.52)
’23 (0.71) (0.73) (0.55) (0.68) (2.67)
’22 (0.65) (0.56) (0.65) (0.76) (2.62)
’21 (0.49) (0.51) (0.51) (0.31) (1.82)
’20 (8.14) (7.31) (17.55) 23.79 (5.83)
Fiscal quarters ending in the months shown.

Revenue $m

Mar Jun Sep Dec Year
’26 6 7 8 — —
’25 7 6 11 11 36
’24 3 12 15 5 36
’23 4 3 11 3 21
’22 8 14 7 3 31
’21 7 10 9 20 46
’20 7 10 8 8 33
Fiscal quarters ending in the months shown.

Operating Cash Flow $m

Mar Jun Sep Dec Year
’26 (30) (2) (26) — —
’25 (33) (12) (31) (22) (99)
’24 (18) (5) (24) (18) (65)
’23 (33) (19) (31) (24) (107)
’22 (27) (22) (28) (29) (106)
’21 (25) (18) (18) (26) (87)
’20 (17) (15) (14) (22) (67)
Fiscal quarters ending in the months shown.

Free Cash Flow $m

Mar Jun Sep Dec Year
’26 (30) (2) (26) — —
’25 (33) (12) (32) (22) (99)
’24 (18) (5) (24) (18) (65)
’23 (34) (19) (31) (24) (109)
’22 (27) (23) (31) (31) (111)
’21 (25) (19) (18) (26) (88)
’20 (17) (14) (15) (22) (68)
Fiscal quarters ending in the months shown.

Target Price Range

Analyst price targets

Recommendation Rating

1.1
1Buy 2 3Hold 4 5Sell

Ten years at a glance Fiscal years to December

Ten-year view Analyst estimates Powerpack
Group Line 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 TTM Sep ’26 Trend 10 yrs 2026e 2027e 2028e Next 3/yr
Income, $m
Income, $m Revenue — — 19 21 33 46 31 21 36 36 32 +9.2% 26 22 19 (18.8%)
Gross margin, % — — 0.00 100.00 100.00 100.00 100.00 100.00 100.00 100.00 100.00 +100.0 pt
EBT — — (16) (33) (67) (84) (128) (131) (105) (105) (91) +31.2%
EBT margin, % — — (81.14) (155.72) (201.72) (183.23) (412.19) (632.17) (295.60) (291.74) (281.85) (210.6) pt
Net income — 0 (16) (34) (66) (84) (128) (132) (105) (105) (91) n/m
Per share, $
Per share, $ Revenue — — 0.46 15.58 2.92 0.99 0.64 0.42 0.51 0.43 0.24 (0.8%)
Earnings — — (0.57) (31.03) (5.83) (1.82) (2.62) (2.67) (1.52) (1.27) (0.72) +12.1%
Cash flow — — (0.40) 40.54 (5.91) (1.89) (2.17) (2.15) (0.94) (1.19) (0.59) +16.7%
Capex — — 0.00 (0.94) (0.06) (0.03) (0.11) (0.03) 0.00 (0.01) 0.00 n/m
Free cash flow — — (0.40) 39.60 (5.97) (1.92) (2.28) (2.19) (0.94) (1.20) (0.59) +16.8%
Book value — — 0.74 (0.71) 24.70 8.46 5.92 4.96 3.11 3.10 1.68 +22.6%
Shares, m — — 42 1 11 46 49 50 69 83 119 +10.2%
Valuation, ×
Valuation, × P/E — — 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.0
P/S — — 1.30 1.30 11.35 32.38 10.03 15.59 7.02 4.40 13.15 10.4
P/B — — 0.00 0.00 1.34 3.81 1.08 1.32 1.16 0.62 1.86 1.2
EV/Sales — — (4.93) (4.93) 0.48 25.89 1.51 4.28 0.67 (1.98) 7.38 2.6
EV/FCF — — 2.66 2.66 (0.24) (13.43) (0.42) (0.82) (0.36) 0.72 (2.97) (1.2)
Cash, $m
Cash, $m Operating cash flow — — (17) 56 (67) (87) (106) (107) (65) (99) (80) +28.6%
Capex — — (3) (1) (1) (1) (5) (2) 0 (1) (1) (19.2%)
Free cash flow — — (17) 54 (68) (88) (111) (109) (65) (99) (80) +28.7%
Balance, $m
Balance, $m Working capital — — 100 63 337 274 243 228 213 225 173 +12.4%
Net debt — — (22) (77) (361) (297) (265) (254) (245) (249) (205) +41.5%
Shareholders’ equity — — 31 (1) 281 390 289 246 216 257 228 +35.1%
Returns, %
Returns, % ROA — — (32.91) (32.16) (25.59) (18.50) (27.34) (32.82) (29.01) (29.63) (30.50) +3.3 pt
ROIC — — 0.00 0.00 0.00 (55.54) (329.60) 0.00 0.00 (894.58) (279.99) (894.6) pt
ROE — — 25.15 44.41 (78.58) (25.03) (37.76) (49.50) (45.58) (44.44) (47.62) (69.6) pt
People
People Employees — — — 88 99 121 146 145 110 104 — +2.8%
Revenue/emp, $m — — 0.00 0.24 0.34 0.38 0.21 0.14 0.32 0.35 — n/m
Negative figures in brackets.
estimates

All 10 years →

Fiscal years to Dec 2025 · latest quarter Sep 2026 · fundamentals updated 5 Nov 2026

C4 Therapeutics, Inc. vs peers in Biotechnology (Q) = latest quarter vs a year earlier

Company Market cap P/E Fwd P/E Revenue growth (Q) EPS growth (Q) FCF growth (Q) Gross margin (Q) EBIT margin (Q) Compare
TECX Tectonic Therapeutic, Inc. $379.7M — (loss-making) — — n/m −46.69% (below 0%: shrinking) 0.00% 0.00% Compare
ALLO Allogene Therapeutics, Inc. $376.6M — (loss-making) — (loss-making) +20,990.91% (above 0%: growing) n/m +17.73% (above 0%: growing) 100.00% (1,011.21%) Compare
LYEL Lyell Immunopharma, Inc. $367.6M — (loss-making) — (loss-making) −80.00% (below 0%: shrinking) n/m −21.82% (below 0%: shrinking) 100.00% (1,609,833.33%) Compare
CCCC C4 Therapeutics, Inc. $362.9M — (loss-making) — (loss-making) −24.59% (below 0%: shrinking) n/m +17.88% (above 0%: growing) 100.00% (290.46%)
ZURA Zura Bio Limited $358.3M — (loss-making) — — n/m −26.22% (below 0%: shrinking) — 0.00% Compare
TRXB TRex Bio Inc. $356.5M — — — — — — — Compare
AVTX Avalo Therapeutics, Inc. $355.6M — (loss-making) — (loss-making) −70.14% (below 0%: shrinking) n/m +75.70% (above 0%: growing) 55.73% 0.00% Compare
RZLT Rezolute, Inc. $352.1M — (loss-making) — — n/m +40.23% (above 0%: growing) 0.00% 0.00% Compare
CTNM Contineum Therapeutics, Inc. $345.9M — (loss-making) — — n/m +10.04% (above 0%: growing) 100.00% 0.00% Compare
Median of peers $357.4M — — −70.14% — +10.04% 77.87% 0.00%

All 621 Biotechnology stocks →

Pay and ownership Proxy statement filed 29 April 2026

Chief executive’s pay

Year Total pay Actually paid $100 invested
2025 2.94m 1.32m 32.37
2024 4.63m 905.03k 61.02
2023 3.79m 4.34m 95.76

Ownership

Directors and executive officers, together 5.60%
Entities Affiliated with OrbiMed Advisors 9.99%
Soleus Capital Management, L.P. 9.99%
Lynx1 Capital Advisors LLC 9.99%
RA Capital Management, L.P. 9.99%
Point72 Asset Management, L.P. 9.99%
Morgan Stanley 8.53%
Bain Capital Life Sciences Investors, LLC 6.56%
Wasatch Advisors LP 5.80%
Total pay is as the Summary Compensation Table states it; actually paid revalues the year’s share awards at its end, as the SEC’s pay-versus-performance rule asks. $100 invested is what $100 in the company’s shares at the start of the earliest year shown was worth at each year’s end. Ownership is the proxy’s own table: the directors and officers as a group, and every holder of 5% or more. Read the proxy statement

C4 Therapeutics, Inc. (CCCC) Latest News

11 Apr

10 Apr

Impact 4 · · pharmaceutical-technology.com

24 Mar

9 Mar

4 Feb

Impact 3 · · GlobeNewswireInsider MonkeyTipRanksMT Newswires

2 Feb

Impact 4 · · Insider MonkeyInsider MonkeyInsider Monkey

30 Dec

Impact 4 · · Simply Wall St.Simply Wall St.Simply Wall St.Simply Wall St.Simply Wall St.Simply Wall St.Simply Wall St.Simply Wall St.

27 Nov

Impact 4 · · Simply Wall St.
stockrow.com/CCCC · Data as of Nov 5, 2026 · For information only; not investment advice. · © 2026 stockrow.com