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Ionis Pharmaceuticals, Inc. (IONS) vs Rhythm Pharmaceuticals, Inc. (RYTM)

Ionis Pharmaceuticals, Inc. and Rhythm Pharmaceuticals, Inc. are both Biotechnology companies. Rhythm Pharmaceuticals, Inc. is the larger, with a market value of $7.3B against $6.5B — 1.1× the size. Rhythm Pharmaceuticals, Inc. grew revenue faster over the last twelve months: 61.0% against −7.41%. Ionis Pharmaceuticals, Inc. has the higher net margin (−64.7% vs −70.6%) and the higher return on invested capital (0.00% vs 0.00%). Across the 16 metrics below, Ionis Pharmaceuticals, Inc. leads on 8 and Rhythm Pharmaceuticals, Inc. on 8.

Valuation

Metric IONS RYTM Biotechnology median
P/E n/m n/m 10.26
P/S 7.36 25.49 9.18
P/B 14.62 81.36 2.05
Price to free cash flow n/m n/m 24.81
EV/EBITDA n/m n/m 0.65
EV/Sales 7.05 24.35 8.98
Earnings yield (8.90%) (2.79%) (34.89%)
Free cash flow yield (8.83%) (1.78%) (24.52%)

Profitability

Metric IONS RYTM Biotechnology median
Gross margin 98.17% 88.23% 65.16%
Operating margin (68.00%) (66.70%) 0.00%
Net margin (64.66%) (70.63%) 0.00%
Free cash flow margin (64.93%) (29.13%) 0.00%
Return on equity (105.50%) (167.49%) (50.12%)
Return on assets (18.90%) (41.75%) (45.60%)
Return on invested capital 0.00% 0.00% 0.00%

Growth

Metric IONS RYTM Biotechnology median
Revenue growth (TTM) (7.41%) 61.04% 6.26%
EPS growth (last fiscal year) 21.71% 28.34% 29.88%
Revenue growth, 5-year CAGR 5.29% — 9.75%
Net income growth, 5-year CAGR 0.00% 0.00% 0.00%

Health

Metric IONS RYTM Biotechnology median
Debt to equity 3.07 0.00 0.00
Current ratio 7.89 2.78 4.89
Net debt to EBITDA 2.39 2.04 1.01

Dividend

Metric IONS RYTM Biotechnology median
Dividend yield — — 0.41%
Payout ratio — — —

Size

Metric IONS RYTM Biotechnology median
Market cap 6.45b 7.28b 172.11m

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