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Ionis Pharmaceuticals, Inc. (IONS) vs Oruka Therapeutics, Inc. (ORKA)

Ionis Pharmaceuticals, Inc. and Oruka Therapeutics, Inc. are both Biotechnology companies. Ionis Pharmaceuticals, Inc. and Oruka Therapeutics, Inc. are of similar size ($6.5B and $6.4B). Oruka Therapeutics, Inc. has the higher net margin (0.00% vs −64.7%) and the lower return on invested capital (−40.2% vs 0.00%). Across the 14 metrics below, Oruka Therapeutics, Inc. leads on 11 and Ionis Pharmaceuticals, Inc. on 3.

Valuation

Metric IONS ORKA Biotechnology median
P/E n/m n/m 10.26
P/S 7.36 n/m 9.18
P/B 14.62 5.47 2.05
Price to free cash flow n/m n/m 24.81
EV/EBITDA n/m n/m 0.65
EV/Sales 7.05 n/m 8.98
Earnings yield (8.90%) (2.19%) (34.89%)
Free cash flow yield (8.83%) (1.66%) (24.52%)

Profitability

Metric IONS ORKA Biotechnology median
Gross margin 98.17% 0.00% 65.16%
Operating margin (68.00%) 0.00% 0.00%
Net margin (64.66%) 0.00% 0.00%
Free cash flow margin (64.93%) 0.00% 0.00%
Return on equity (105.50%) (18.30%) (50.12%)
Return on assets (18.90%) (17.76%) (45.60%)
Return on invested capital 0.00% (40.22%) 0.00%

Growth

Metric IONS ORKA Biotechnology median
Revenue growth (TTM) (7.41%) — 6.26%
EPS growth (last fiscal year) 21.71% 52.20% 29.88%
Revenue growth, 5-year CAGR 5.29% — 9.75%
Net income growth, 5-year CAGR 0.00% 0.00% 0.00%

Health

Metric IONS ORKA Biotechnology median
Debt to equity 3.07 0.00 0.00
Current ratio 7.89 38.51 4.89
Net debt to EBITDA 2.39 2.65 1.01

Dividend

Metric IONS ORKA Biotechnology median
Dividend yield — 0.00% 0.41%
Payout ratio — — —

Size

Metric IONS ORKA Biotechnology median
Market cap 6.45b 6.36b 172.11m

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