Tyra Biosciences, Inc. TYRA

21.76 (0.65) (2.90%) as of 25 Sep
Market cap
$1.5B
P/E
0.0×
Insider Buys alert about insiders buying in the last 12 month

Insider Decisions

Total buys 0.02
Total sells 10.59
in millions of $
Nov 25 Feb 26 May 26 Aug 26
Buy — — — — — — — — — — — 1
Sell — 3 2 1 1 1 — — — — — —
Insider Ownership 30.64%

Capital & Financial Ratios

Market Cap 1,540.00
Revenue —
Net Income (148.56)
Free Cash Flow (109.90)
Net Debt (353.94)
Current Ratio 14.91
Debt/Equity 0.00
P/E ratio 0.00
P/S ratio 0.00
P/B ratio 4.07
Past 5Y EPS Growth (73.69%)
This Y EPS Growth (31.94%)
Next Y EPS Growth (5.58%)
Next 5Y EPS Growth (16.83%)
in millions of $

Dividends

Payout Ratio 0.00
Annual Dividend Rate —
Annual Dividend Yield —
total individual payouts
2025 Powerpack
2024 Powerpack
2023 Powerpack
2022 Powerpack
2021 Powerpack
2020 Powerpack
2019 Powerpack
predictions in italic, special payouts not included in total or ratios

Assets vs Liabilities

2023 2024 2025 Q'26
Cash 203 341 256 354
Receivables — — — —
Inventory — — — —
Other — — — —
212 347 265 367
2023 2024 2025 Q'26
Payables 5 1 1 2
ST’ Debt — — — —
Other — — — —
15 15 18 25
in millions of $

Compound Annual Growth

10y 5y 3y
Sales — — —
Cash Flow — 0.00% 0.00%
Earnings — 0.00% 0.00%
Book Value — 0.00% 0.17%

Revenue

Year
in millions of $ · fiscal quarters ending in the months shown

Operating Cash Flow

Mar Jun Sep Dec Year
’26 (33) (31) — — —
’25 (25) (24) (22) (24) (95)
’24 (22) (10) (18) (20) (70)
’23 (10) (10) (17) (14) (50)
’22 (9) (17) (12) (12) (50)
’21 (5) (4) (6) (9) (24)
’20 (1) (2) (5) (3) (8)
in millions of $ · fiscal quarters ending in the months shown

Free Cash Flow

Mar Jun Sep Dec Year
’26 (33) (31) — — —
’25 (25) (24) (22) (24) (95)
’24 (22) (11) (18) (20) (70)
’23 (10) (10) (17) (14) (51)
’22 (9) (17) (12) (12) (51)
’21 (5) (5) (6) (9) (24)
’20 (1) (2) (5) (3) (8)
in millions of $ · fiscal quarters ending in the months shown

EPS

Mar Jun Sep Dec Year
’26 (0.64) (0.69) — — —
’25 (0.47) (0.47) (0.50) (0.57) (2.01)
’24 (0.35) (0.32) (0.41) (0.43) (1.51)
’23 (0.28) (0.31) (0.49) (0.53) (1.62)
’22 (0.36) (0.36) (0.30) (0.31) (1.32)
’21 (2.10) (2.43) (0.72) (0.24) (1.91)
’20 (0.03) (0.04) (1.47) — (6.05)
fiscal quarters ending in the months shown

Target Price Range

Analyst price targets

Recommendation Rating

1.2
1Buy 2 3Hold 4 5Sell
2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 2026 2027 2028
— — — — — 11.37 4.93 6.55 11.24 6.42

Analyst estimates 2026–2028

Powerpack
Low Price
— — — — — 31.36 14.27 19.74 29.60 26.41
High Price
— — — — 16 25 38 49 60 87
Employees
— — — — 0 0 0 0 0 0
Revenue/Emp
— — — — — — — — — —
Revenue
— — — 0.00% 0.00% 0.00% 0.00% — — —
Gross Margin
— — — (4) (9) (26) (55) (69) (86) (120)
EBT
— — — 0.00% 0.00% 0.00% 0.00% 0.00% 0.00% 0.00%
EBT Margin
— 0 — (4) (9) (26) (55) (69) (86) (120)
Net Income
— — — 0 0 0 0 0 1 1
Depreciation
— — — 0.00 0.00 0.00 0.00 0.00 0.00 0.00
Revenue/Sh
— — — (0.10) (6.05) (1.91) (1.32) (1.62) (1.51) (2.01)
Earnings/Sh
— — — (0.06) (5.03) (1.72) (1.20) (1.17) (1.22) (1.60)
Cash Flow/Sh
— — — 0.00 (0.20) (0.05) (0.01) (0.02) (0.01) 0.00
Capex/Sh
— — — (0.06) (5.24) (1.77) (1.21) (1.19) (1.23) (1.60)
Free CF/Sh
— — — (0.11) (8.84) 21.90 6.16 4.78 6.00 4.35
Book Value/Sh
— — — 43 2 14 42 43 57 60
Shares
— — — — — — — — — —
PE Ratio
— — — — — — — — — —
PS Ratio
— — — — — — — — — —
PB Ratio
— — — — — — — — — —
EV/Sales
— — — — — — — — — —
EV/FCF
— — — (3) (8) (24) (50) (50) (70) (95)
Op' Cash Flow
— — — 0 0 (1) (1) (1) (1) 0
Capex
— — — (3) (8) (24) (51) (51) (70) (95)
FCF
— — — (5) 13 300 252 196 333 247
Working Cap'
— — — 0 28 1 3 — — —
Total Debt
— — — 0 (15) (302) (251) (203) (341) (256)
Net Debt
— — — (5) (14) 302 258 204 343 259
Sh' Equity
— — — (1,539.77%) (112.90%) (16.30%) (19.31%) (28.10%) (29.34%) (37.13%)
ROA
— — — 0.00% 0.00% 0.00% (556.67%) (6,300.84%) (3,807.64%) (2,614.25%)
ROIC
— — — 44.24% 101.59% (18.25%) (19.77%) (29.92%) (31.60%) (39.83%)
ROE
predictions in italic, sparklines do not include predictions

All 10 years →

Tyra Biosciences, Inc. (TYRA) key facts

  • Tyra Biosciences, Inc. (TYRA) is a Biotechnology company in the Healthcare sector, listed on Nasdaq.
  • Tyra Biosciences, Inc. reported a net loss of $119.9 million, or a loss of $2.01 per share, for fiscal 2025.
  • As of September 25, 2026, TYRA traded at $21.76, a market capitalization of $1.5 billion.
  • Return on equity was −39.8% and debt-to-equity 0.00.

Source: company filings (standardised) and stockrow calculations.

Tyra Biosciences, Inc. (TYRA) Latest News

News by impact score

Fine-tune

16 Sep

4

Tyra Biosciences' Dabogratinib achieved a 57% complete response rate in a Phase 2 trial, with questions raised on Phase 3 support. Positive Phase 2 efficacy data for core pipeline asset supports major upside in clinical progress and valuation.

14 Sep

4

Tyra Biosciences prices $400 million underwritten public offering of common stock and pre-funded warrants. $400 million capital raise materially extends financial runway and funds pipeline development.

9 Sep

4

Tyra Biosciences released bladder cancer data that disappointed investors. Disappointing bladder cancer data directly weakens Tyra's lead clinical program and damages future prospects.

4

Tyra Biosciences shares drop to 10-month low after mixed bladder cancer trial results. Mixed bladder cancer trial outcomes trigger sharp stock decline signaling major setback for pipeline progress.

4

Tyra Biosciences stock plunges 22% after its bladder cancer pill fails to impress. Bladder cancer pill failure triggers 22% stock drop and damages long-term company prospects.

4

Tyra Biosciences shares fell 30% after Phase 2 dabogratinib data release. Phase 2 dabogratinib data triggered 30% share plunge marking major setback to lead asset and company trajectory.

4

Tyra Biosciences reported initial Phase 2 SURF302 results for dabogratinib, supporting it as the first potential oral innovation in LG IR NMIBC. Positive initial Phase 2 results position dabogratinib as potential first oral therapy for LG IR NMIBC, likely boosting company valuation and trajectory.

4 Sep

4

Tyra Biosciences stock surges toward best day in nearly 10 months after setting date for Phase 2 bladder cancer drug readout. Phase 2 bladder cancer drug readout date sets major catalyst for Tyra Biosciences trajectory and investor sentiment.

4

Tyra Biosciences will host a conference call on September 9, 2026, to present initial results of oral dabogratinib from the SURF302 Phase 2 study for IR NMIBC. Phase 2 data readout for lead oncology candidate can substantially shift valuation and pipeline outlook.

4 Aug

3

Tyra Biosciences released second quarter 2026 financial results and recent highlights. Quarterly results and highlights update financial position and pipeline status.

30 Jun

4

Tyra Biosciences (TYRA) stock faces potential movement ahead of SURF302 trial data release that could determine its position as a biotech opportunity. SURF302 trial readout represents major binary event capable of significantly shifting company trajectory and investor sentiment.

11 Jun

3

Tyra Biosciences faces scrutiny over heavy reliance on dabogratinib as skepticism returns regarding SURF-302 trial outcomes and overall pipeline viability. Doubts on SURF-302 heighten perceived risk from dabogratinib dependence without altering core operations outright.

10 Jun

3

BofA links Tyra Biosciences weak investor sentiment to macro pressures and renewed SURF-302 concerns. BofA note on macro pressures and SURF-302 concerns can sway near-term TYRA sentiment and valuation without altering core operations.

13 May

3

Tyra Biosciences announced first quarter 2026 financial results and recent highlights. Quarterly financial results with recent highlights moderately affect financial performance and investor sentiment.

24 Apr

4

Guggenheim initiates coverage on Tyra Biosciences (TYRA) with a Buy rating, highlighting the strength of lead drug candidate dabogratinib in FGFR3-mutated diseases. Guggenheim's Buy initiation underscores dabogratinib's potential, likely driving positive investor sentiment and stock momentum for TYRA.

4 Apr

4

Tyra Biosciences (TYRA) raised $126 million via stock sale amid late-stage clinical trial progress, prompting valuation analysis highlighting improved financial position and pipeline potential. $126 million stock sale bolsters cash reserves while late-stage trial progress advances key pipeline assets, significantly enhancing TYRA's growth trajectory and investor appeal.

20 Mar

4

Tyra Biosciences (TYRA) stock surged 250% in one year as an investor disclosed a new $10 million position. 250% stock surge and $10 million investor stake signal strong momentum and heightened investor confidence, significantly impacting future market performance.

18 Mar

5

Tyra Biosciences (TYRA) stock surges 288% after a massive capital raise, with one early backer reporting a $14 million exit profit. Massive funding raise fueling 288% stock jump and early investor's $14 million profit fundamentally transforms TYRA's growth trajectory and market position.

3 Mar

3

Tyra Biosciences (TYRA) reported deeper losses amid progress on its lead candidate dabogratinib, prompting questions on whether this duo shifts the company's investment narrative. Deeper losses balanced by dabogratinib advancements create moderate influence on TYRA's financial performance and investor sentiment.

2 Mar

4

Tyra Biosciences narrows dabogratinib focus to non-muscle invasive bladder cancer (NMIBC), discontinues other indications, and teases mid-year NMIBC data readout alongside second-half achondroplasia update. Pipeline refocus and imminent clinical data readouts for NMIBC and achondroplasia serve as major catalysts likely to influence investor sentiment and company trajectory.

3

Tyra Biosciences reported fourth quarter and full-year 2025 financial results alongside recent business highlights. Financial results and highlights moderately influence financial performance, pipeline updates, and investor sentiment.

14 Feb

4

Wedbush raised its price target for Tyra Biosciences (TYRA) to $53 from $37. Wedbush's 43% price target increase reflects heightened analyst optimism, likely driving positive investor sentiment and stock price momentum.

25 Dec

4

Tyra Biosciences, Inc. (TYRA) has been included in a major index, which could enhance its visibility and attract institutional investors. This inclusion is seen as a potential turning point for the company, as it may lead to increased trading volume and interest from larger investment firms. Analysts suggest that this development could positively influence Tyra's market performance and overall institutional support. Index inclusion is likely to significantly enhance institutional interest and trading activity for Tyra Biosciences.

1 Dec

3

Tyra Biosciences, Inc. has appointed Bhavesh Ashar as Chief Operating Officer and Heather Faulds as Chief Regulatory Officer, aiming to enhance its leadership team. Ashar brings extensive experience in operations and strategy, while Faul has a strong background in regulatory affairs, which is expected to support the company's growth and development in the biopharmaceutical sector. Leadership changes can moderately influence operational effectiveness and strategic direction.

20 Nov

4

Tyra Biosciences, Inc. (TYRA) is highlighted among three biotech stocks that Wall Street analysts predict will more than double in value. The company is recognized for its innovative approaches in drug development, particularly in targeted therapies for cancer treatment. Analysts express optimism about its growth potential, driven by promising clinical trial results and a strong pipeline of products. This positive outlook reflects broader trends in the biotech sector, where advancements in technology and increased investment are fostering significant opportunities for companies like Tyra. Promising clinical trial results and a strong product pipeline indicate significant potential for future growth and market performance.

5 Nov

3

Tyra Biosciences, Inc. (TYRA) reported its financial results for the third quarter of 2025, highlighting key metrics such as revenue growth and advancements in its product pipeline. The company emphasized its commitment to developing innovative therapies and provided updates on ongoing clinical trials. Management expressed optimism about future prospects and strategic initiatives aimed at enhancing shareholder value. Revenue growth and product pipeline advancements indicate a moderately noticeable influence on financial performance and competitive positioning.

5 Sep

3

Tyra Biosciences, Inc. is under scrutiny regarding its cash management strategies as it navigates its financial future. Investors are hopeful that the company will utilize its available cash effectively to support growth and innovation. The focus is on how well Tyra can leverage its resources to enhance its market position and drive shareholder value. Effective cash management could moderately influence Tyra's financial performance and competitive positioning.

22 Aug

4

Tyra Biosciences, Inc. has initiated a pediatric study for its treatment targeting achondroplasia, a common form of dwarfism. This study aims to evaluate the safety and efficacy of the treatment in children, expanding the company's research focus and potential market reach in addressing this genetic condition. Initiating a pediatric study for a treatment targeting a prevalent genetic condition could significantly enhance Tyra's market position and investor sentiment.

21 Aug

4

Tyra Biosciences, Inc. has announced the dosing of the first child in its BEACH301 Phase 2 study, which evaluates the efficacy of Dabogratinib (TYRA-300) for treating pediatric achondroplasia. This milestone marks a significant step in the company's efforts to develop treatments for this genetic condition affecting bone growth. The initiation of a Phase 2 study in pediatric patients represents a significant advancement in Tyra's product pipeline and could enhance its market position.

19 Aug

4

Wall Street analysts project a potential upside of 178.82% for Tyra Biosciences, Inc. (TYRA), raising questions about the stock's ability to reach such heights. The analysis highlights factors that could influence the stock's performance, including market conditions and company developments. Investors are keenly observing these projections as they consider the future trajectory of TYRA. Analyst projections indicate significant potential for stock appreciation, which could impact investor sentiment and market dynamics.

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