Seaport Therapeutics, Inc SPTX

 — 
21.52 0.40 1.89% as of 25 Sep
Market cap
$1.1B
P/E
0.0×
Insider Buys alert about insiders buying in the last 12 month

Insider Decisions

Total buys 20.04
in millions of $
Nov 25 Feb 26 May 26 Aug 26
Buy — — — — — — — 1 1 — — —
Sell — — — — — — — — — — — —
Insider Ownership 60.84%

Capital & Financial Ratios

Market Cap 1,130.00
Revenue —
Net Income (177.97)
Free Cash Flow (139.58)
Net Debt (273.31)
Current Ratio 18.00
Debt/Equity 0.00
P/E ratio 0.00
P/S ratio 0.00
P/B ratio 1.79
Past 5Y EPS Growth —
This Y EPS Growth 85.88%
Next Y EPS Growth 41.39%
Next 5Y EPS Growth 55.75%
in millions of $

Dividends

Payout Ratio —
Annual Dividend Rate —
Annual Dividend Yield —

Assets vs Liabilities

2023 2024 2025 Q'26
Cash — 309 216 273
Receivables — — — —
Inventory — — — —
Other — — — —
— 310 223 282
2023 2024 2025 Q'26
Payables — 5 2 6
ST’ Debt — 0 0 —
Other — — — —
— 11 13 16
in millions of $

Compound Annual Growth

10y 5y 3y
Sales — — —
Cash Flow — — —
Earnings — — —
Book Value — — —

Revenue

Year
in millions of $ · fiscal quarters ending in the months shown

Operating Cash Flow

Mar Jun Sep Dec Year
’26 (20) (26) — — —
’25 (20) (15) — (78) (78)
in millions of $ · fiscal quarters ending in the months shown

Free Cash Flow

Mar Jun Sep Dec Year
’26 (20) (26) — — —
’25 (20) (16) — (78) (78)
in millions of $ · fiscal quarters ending in the months shown

EPS

Mar Jun Sep Dec Year
’26 (10.34) (1.78) — — —
’25 (5.65) (6.40) — — (31.54)
fiscal quarters ending in the months shown

Target Price Range

Analyst price targets

Recommendation Rating

1.3
1Buy 2 3Hold 4 5Sell
2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 2026 2027 2028
— — — — — — — — — —

Analyst estimates 2026–2028

Powerpack
Low Price
— — — — — — — — — —
High Price
— — — — — — — — — 58
Employees
— — — — — — — — — 0
Revenue/Emp
— — — — — — — — — —
Revenue
— — — — — — — — — —
Gross Margin
— — — — — — — — (47) (74)
EBT
— — — — — — — — 0.00% 0.00%
EBT Margin
— — — — — — — — (47) (75)
Net Income
— — — — — — — — 0 (2)
Depreciation
— — — — — — — — 0.00 0.00
Revenue/Sh
— — — — — — — — (49.72) (31.54)
Earnings/Sh
— — — — — — — — (31.42) (32.83)
Cash Flow/Sh
— — — — — — — — (0.12) (0.15)
Capex/Sh
— — — — — — — — (31.54) (32.98)
Free CF/Sh
— — — — — — — — 318.64 98.06
Book Value/Sh
— — — — — — — — 1 2
Shares
— — — — — — — — — —
PE Ratio
— — — — — — — — — —
PS Ratio
— — — — — — — — — —
PB Ratio
— — — — — — — — — —
EV/Sales
— — — — — — — — — —
EV/FCF
— — — — — — — — (30) (78)
Op' Cash Flow
— — — — — — — — 0 0
Capex
— — — — — — — — (30) (78)
FCF
— — — — — — — — 299 210
Working Cap'
— — — — — — — — 0 0
Total Debt
— — — — — — — — (309) (216)
Net Debt
— — — — — — — — 300 233
Sh' Equity
— — — — — — — — 0.00% (26.52%)
ROA
— — — — — — — — 0.00% (324.62%)
ROIC
— — — — — — — — 0.00% 127.57%
ROE
predictions in italic, sparklines do not include predictions

All 10 years →

Seaport Therapeutics, Inc (SPTX) key facts

  • Seaport Therapeutics, Inc reported a net loss of $74.9 million, or a loss of $31.54 per share, for fiscal 2025.
  • As of September 25, 2026, SPTX traded at $21.52, a market capitalization of $1.1 billion.
  • Return on equity was 127.6% and debt-to-equity 0.00.

Source: company filings (standardised) and stockrow calculations.

Seaport Therapeutics, Inc (SPTX) Latest News

News by impact score

Fine-tune

22 Sep

4

PureTech Health ended H1 2026 with $220 million in cash, funding runway to 2028. Seaport Therapeutics completed a $260 million NASDAQ IPO, validating the hub-and-spoke model and providing external capital. Gallup Oncology’s LYT200 received FDA Fast Track for relapsed/refractory high-risk MDS and cleared an End of Phase 1 meeting, paving the path to Phase 2 and external financing. The innovation engine remains active, targeting at least three concept-stage programs per year, with new candidates expected in H1 2027. PureTech reiterated capital discipline and plans to return cash to shareholders, guiding go-forward cash burn to $30–$40 million annually from about $90 million when late-stage programs were internal. Sealea has one asset in pivotal Phase 3 and will need additional funding; PureTech reserved about $70 million for Sealea and expects roughly $50 million in royalties/milestones from Cobenfy. STRIDE MDS is mutation-agnostic, with a 30–33 month timeline, and additional programs are in development. Seaport’s $260 million NASDAQ IPO validates the hub-and-spoke model and provides external capital, materially improving funding prospects and investor sentiment around PureTech’s ecosystem and SPTX prospects.

9 Sep

4

Seaport Therapeutics reports positive topline results from Phase 1 driving simulation trial of GlyphAllo in healthy volunteers. Positive Phase 1 trial data advances GlyphAllo development and strengthens pipeline prospects.

3

Seaport Therapeutics announced positive topline results from its Phase 1 driving simulation trial of GlyphAllo in healthy volunteers. Positive Phase 1 results advance GlyphAllo development and may support near-term investor sentiment at Seaport Therapeutics.

20 Aug

4

Seaport Therapeutics completes IPO with major pharma firms including Bristol Myers and Johnson & Johnson monitoring its progress. Interest from leading pharmaceutical companies after IPO signals major strategic opportunities and market momentum for Seaport.

3 Aug

3

Seaport Therapeutics reported second quarter 2026 financial results and highlighted recent corporate and clinical progress. Quarterly results combined with clinical updates produce moderate effects on near-term sentiment and operations.

9 Jun

3

Seaport Therapeutics reported positive multiple-ascending dose data from its Phase 1 proof-of-concept trial of GlyphAgo™ in healthy volunteers. Positive Phase 1 data supports pipeline progress but remains early-stage with limited immediate effects on operations or market position.

8 Jun

3

Seaport Therapeutics reported first quarter 2026 financial results and provided updates on recent corporate developments and clinical progress. Quarterly results with clinical updates offer moderate visibility into operations and pipeline but rarely shift long-term trajectory alone.

3

Seaport Therapeutics reported positive multiple-ascending dose data from its Phase 1 proof-of-concept trial of GlyphAgo™ in healthy volunteers. Positive Phase 1 data for GlyphAgo™ advances Seaport's drug development pipeline.

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