Shuttle Pharmaceuticals Holdings, Inc. SHPH

4.01 0.01 0.25% as of 25 Sep
Market cap
$15.6M
P/E
34.7×
Insider Buys alert about insiders buying in the last 12 month

Insider Decisions

Total buys 0.18
Total sells 0.50
in millions of $
Nov 25 Feb 26 May 26 Aug 26
Buy — — — — — — — — 1 3 — —
Sell — — — — — — — — — 3 — —
Insider Ownership 0.00%

Capital & Financial Ratios

Market Cap 15.59
Revenue —
Net Income (10.82)
Free Cash Flow (9.44)
Net Debt (1.09)
Current Ratio 0.30
Debt/Equity 0.00
P/E ratio 34.75
P/S ratio 0.00
P/B ratio 0.60
Past 5Y EPS Growth (55.05%)
This Y EPS Growth —
Next Y EPS Growth —
Next 5Y EPS Growth —
in millions of $

Dividends

Payout Ratio —
Annual Dividend Rate —
Annual Dividend Yield —

Assets vs Liabilities

2023 2024 2025 Q'26
Cash 5 2 0 1
Receivables — — — —
Inventory — — — —
Other 0 — — —
6 2 1 2
2023 2024 2025 Q'26
Payables 0 1 1 2
ST’ Debt — — — —
Other — — — —
1 2 8 8
in millions of $

Compound Annual Growth

10y 5y 3y
Sales — — —
Cash Flow — 0.00% 0.00%
Earnings — 0.00% 0.00%
Book Value — 0.00% (33.53%)

Revenue

Year
in millions of $ · fiscal quarters ending in the months shown

Operating Cash Flow

Mar Jun Sep Dec Year
’26 (2) — — — —
’25 (3) (3) (3) (1) (9)
’24 (1) (1) (2) (3) (7)
’23 (1) (2) (2) (1) (6)
’22 (1) 0 (1) (1) (3)
’21 — — 0 0 0
’20 — — — — 0
in millions of $ · fiscal quarters ending in the months shown

Free Cash Flow

Mar Jun Sep Dec Year
’26 (2) — — — —
’25 (3) (3) (3) (4) (13)
’24 (1) (1) (2) (3) (7)
’23 (1) (2) (2) (1) (6)
’22 (1) 0 (1) (1) (3)
’21 — — 0 0 0
’20 — — — — 0
in millions of $ · fiscal quarters ending in the months shown

EPS

Mar Jun Sep Dec Year
’26 (4.30) — — — —
’25 (75.00) (32.90) (10.50) 47.82 (71.60)
’24 (200.00) (240.00) (397.50) 52.83 (825.00)
’23 (140.00) (300.00) (220.00) (200.00) (880.00)
’22 (146.44) (128.27) (200.00) (120.00) (580.00)
’21 — — (46.70) — (247.72)
’20 — — — — (0.07)
fiscal quarters ending in the months shown

Target Price Range

Analyst price targets

Recommendation Rating

1Buy 2 3Hold 4 5Sell
2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 2026 2027 2028
— — — — — — 2,700.00 834.00 145.00 12.60

Analyst estimates 2026–2028

Powerpack
Low Price
— — — — — — 252,520.00 5,740.00 1,236.00 252.50
High Price
— — — — — 5 7 8 9 2
Employees
— — — — — 0 0 0 0 0
Revenue/Emp
— — — — — — — — — —
Revenue
— 0.00% 0.00% — 0.00% 0.00% 0.00% — — —
Gross Margin
— 0 (1) — (1) (1) (5) (7) (9) (12)
EBT
— 0.00% 0.00% — 0.00% 0.00% 0.00% 0.00% 0.00% 0.00%
EBT Margin
— 0 (1) — (1) (1) (5) (7) (9) (12)
Net Income
— 0 0 — 0 0 0 2 1 0
Depreciation
— 0.00 0.00 — 0.00 0.00 0.00 0.00 0.00 0.00
Revenue/Sh
— (0.02) (0.05) — (0.07) (247.72) (580.00) (880.00) (797.50) (71.60)
Earnings/Sh
— (0.01) (0.04) — 0.00 (63.89) (493.78) (744.15) (637.15) (57.89)
Cash Flow/Sh
— 0.00 0.00 — 0.00 0.00 0.00 (2.53) 0.00 (18.66)
Capex/Sh
— (0.01) (0.04) — 0.00 (63.89) (493.78) (746.68) (637.15) (76.55)
Free CF/Sh
— (0.02) 0.00 — (0.12) (346.40) 1,421.83 540.77 61.67 13.76
Book Value/Sh
— 14 14 — 14 0 0 0 0 0
Shares
— — — — — — — — — —
PE Ratio
— — — — — — — — — —
PS Ratio
— — — — — — — — — —
PB Ratio
— — — — — — — — — —
EV/Sales
— — — — — — — — — —
EV/FCF
— 0 (1) — 0 0 (3) (6) (7) (9)
Op' Cash Flow
— — — — 0 — — 0 — (3)
Capex
— 0 (1) — 0 0 (3) (6) (7) (13)
FCF
— 0 0 — (2) (2) 8 5 1 (7)
Working Cap'
— 0 0 — 1 0 1 0 — —
Total Debt
— 0 0 — 1 0 (8) (5) (2) 0
Net Debt
— 0 0 — (2) (2) 8 4 1 2
Sh' Equity
— 0.00% (168.62%) — (155.98%) (209.97%) (145.02%) (90.28%) (216.24%) (180.58%)
ROA
— 0.00% 0.00% — 0.00% 0.00% 0.00% 0.00% 0.00% (387.84%)
ROIC
— 0.00% 487.62% — 109.31% 75.65% (223.05%) (112.37%) (383.83%) (791.04%)
ROE
predictions in italic, sparklines do not include predictions

All 10 years →

Shuttle Pharmaceuticals Holdings, Inc. peers in Drug Manufacturers Specialty & Generic

All 86 Drug Manufacturers Specialty & Generic stocks →

Shuttle Pharmaceuticals Holdings, Inc. (SHPH) key facts

  • Shuttle Pharmaceuticals Holdings, Inc. (SHPH) is a Drug Manufacturers Specialty & Generic company in the Healthcare sector, listed on Nasdaq.
  • As of September 25, 2026, SHPH traded at $4.01, a market capitalization of $15.6 million.
  • Return on equity was −791.0% and debt-to-equity 0.00.

Source: company filings (standardised) and stockrow calculations.

Shuttle Pharmaceuticals Holdings, Inc. (SHPH) Latest News

News by impact score

Fine-tune

28 Aug

3

Shuttle Pharmaceuticals Holdings, Inc. announced receipt of a NASDAQ noncompliance letter. NASDAQ noncompliance letter introduces delisting risk that can pressure stock price and investor sentiment.

1 May

5

Shuttle Pharmaceuticals Holdings, Inc. (SHPH) plans to acquire United Dogecoin to develop a public Dogecoin (DOGE) mining platform. Pivoting from pharmaceuticals to cryptocurrency mining via acquisition fundamentally redefines SHPH's business model and long-term prospects.

27 Mar

4

Shuttle Pharmaceuticals Holdings, Inc. (SHPH) launches autonomous self-reasoning AI agent for scientific workflows. Launching an autonomous AI agent for scientific workflows marks a major strategic tech integration boosting SHPH's R&D capabilities and competitive edge.

26 Mar

4

Shuttle Pharmaceuticals Holdings, Inc. (SHPH) launched an autonomous self-reasoning AI agent designed for scientific workflows. Launching an autonomous self-reasoning AI agent positions SHPH for major gains in R&D efficiency and competitive positioning in pharmaceuticals.

12 Mar

4

E.F. Hutton & Co. served as exclusive placement agent for Shuttle Pharmaceuticals Holdings, Inc. (SHPH)'s $3.5 million public offering. Securing $3.5 million in funding via public offering enables Shuttle Pharmaceuticals to advance operations and R&D, significantly impacting its growth trajectory and market sentiment.

3

Shuttle Pharmaceuticals Holdings, Inc. announced the pricing of a $5.75 million underwritten public offering of 19,166,667 shares at $0.30 per share. The offering is set to close on March 13, 2025, and proceeds will fund a Phase II clinical trial, marketing services, and general corporate purposes. WestPark Capital, Inc. is the Sole Book-Runner for the offering, which is registered with the SEC. Shuttle Pharma focuses on improving cancer treatment outcomes through radiation therapy. The funding from the offering is expected to support key clinical trials and operational activities, which may moderately influence the company's future performance.

3

Shuttle Pharmaceuticals Holdings, Inc. has appointed Christopher Cooper as Interim Co-CEO to enhance its business activities. This leadership change aims to drive the company's strategic initiatives and improve operational performance. Leadership changes can moderately influence operational effectiveness and market perception.

6 Mar

4

Shuttle Pharmaceuticals Holdings, Inc. (SHPH) announced a $3.5 million public offering to raise capital. Public offering of $3.5 million provides significant funding to support R&D and operations, potentially boosting market performance.

18 Dec

4

Shuttle Pharmaceuticals Holdings, Inc. (SHPH) integrates artificial intelligence into its major oncology development initiatives to enhance drug discovery and clinical trials. Incorporating AI into core oncology programs constitutes a major strategic enhancement to innovation and competitive positioning.

21 Nov

4

Shuttle Pharmaceuticals Holdings, Inc. has acquired an AI health platform aimed at enhancing its drug development processes. This strategic move is expected to leverage artificial intelligence to improve patient outcomes and streamline operations. The acquisition aligns with the company's focus on innovative therapies and positions it to better compete in the evolving pharmaceutical landscape. The acquisition of an AI health platform is a significant strategic move that could enhance drug development and competitive positioning.

3 Nov

3

Shuttle Pharmaceuticals Holdings, Inc. has announced a private placement of $2.5 million at an effective price of $4.00 per share, which is above the current market price. This move aims to strengthen the company's financial position and support its growth initiatives. The private placement is expected to provide necessary capital for growth but may have a limited overall effect on the company's trajectory.

22 Oct

4

Shuttle Pharmaceuticals Holdings, Inc. (SHPH) has made significant advancements in its research and development, particularly in the field of psychedelic-assisted therapies. The company is leveraging artificial intelligence to enhance its drug discovery processes, aiming to improve treatment outcomes for various mental health conditions. This innovative approach positions SHPH at the forefront of a rapidly evolving sector, potentially attracting investor interest and partnerships. The integration of AI in their operations could lead to more efficient development timelines and cost reductions, ultimately impacting the company's market performance positively. The integration of AI in drug discovery is a significant strategic move that could enhance SHPH's competitive positioning and market appeal.

4

Shuttle Pharmaceuticals Holdings, Inc. (SHPH) has signed a definitive Letter of Intent (LOI) to acquire Molecule.AI, positioning itself to become the first self-learning biotech company. This acquisition aims to enhance SHPH's capabilities in drug development through advanced artificial intelligence technologies, potentially revolutionizing its approach to biopharmaceutical innovation. The acquisition of Molecule.AI is a significant strategic move that could greatly enhance SHPH's competitive positioning and innovation capabilities.

21 Oct

4

Shuttle Pharmaceuticals Holdings, Inc. has signed a definitive Letter of Intent (LOI) with Molecule.ai to enhance its radiation therapy capabilities. This partnership aims to leverage advanced AI technologies to optimize treatment strategies, potentially transforming radiation into a more effective therapeutic tool. The collaboration is expected to advance Shuttle Pharma's position in the oncology market and improve patient outcomes. The partnership with Molecule.ai is a significant strategic move that could enhance product innovation and market positioning in oncology.

4

Shuttle Pharmaceuticals Holdings, Inc. announced its acquisition of an AI molecular modeling and predictive analytics platform. This strategic move aims to enhance the company's drug development capabilities and improve its competitive position in the pharmaceutical industry. The integration of advanced AI technologies is expected to streamline research processes and potentially lead to more effective treatments. Acquiring an AI platform is a significant strategic move that could enhance drug development and alter the company's competitive landscape.

10 Oct

4

Shuttle Pharmaceuticals Holdings, Inc. has executed a Letter of Intent (LOI) with Molecule.ai to collaborate on the development of artificial intelligence-driven drug discovery and development processes. This partnership aims to enhance Shuttle's capabilities in identifying and optimizing new therapeutic candidates, potentially accelerating the drug development timeline. The collaboration is expected to leverage Molecule.ai's advanced AI technologies to improve the efficiency and effectiveness of Shuttle's pharmaceutical research efforts. The collaboration with Molecule.ai is likely to significantly enhance Shuttle's drug development capabilities and market positioning.

9 Oct

4

Shuttle Pharmaceuticals Holdings, Inc. is set to enter the $3.24 billion AI pharmaceutical market, aiming to leverage artificial intelligence in drug development and enhance its product offerings. This strategic move is expected to position the company favorably within a rapidly evolving sector, potentially increasing its market share and attracting investor interest. Entering the AI pharmaceutical market represents a significant strategic shift that could enhance competitive positioning and financial performance.

14 Aug

4

Shuttle Pharmaceuticals Holdings, Inc. (SHPH) provided a corporate update for the second quarter of 2025, highlighting advancements in its clinical programs and financial performance. The company reported progress in its drug development pipeline and outlined strategic initiatives aimed at enhancing shareholder value. Key milestones were achieved, including updates on ongoing trials and partnerships that may bolster future growth. The management expressed optimism about upcoming opportunities and the overall market landscape. Significant advancements in clinical programs and strategic initiatives are likely to impact future performance and investor sentiment.

24 Jun

3

Shuttle Pharmaceuticals Holdings, Inc. has successfully closed a private placement raising $4.25 million, priced at-the-market. The funds will be used to support the company's ongoing development efforts and operational needs. This financing is expected to enhance the company's financial position and facilitate its strategic initiatives. The private placement provides necessary funding that may support future operations and development, but its overall impact on long-term trajectory remains limited.

20 Jun

3

Shuttle Pharmaceuticals Holdings, Inc. announced a $4.25 million private placement with an accredited investor, issuing 1,180,877 shares of common stock at $3.60 per share. The company plans to use the net proceeds for potential acquisitions, marketing, and general corporate purposes. The offering is expected to close around June 23, 2025, pending customary closing conditions. WestPark Capital, Inc. is the exclusive placement agent. The securities have not been registered under the Securities Act and are offered only to accredited investors, with a registration rights agreement in place for resale. Shuttle Pharma focuses on improving cancer treatment outcomes through radiation therapy. The private placement may provide necessary funding for strategic initiatives, impacting financial performance and product development.

12 Jun

4

Shuttle Pharmaceuticals Holdings, Inc. (SHPH) announced a proposed 25-for-1 reverse stock split to comply with Nasdaq listing requirements. If approved, the number of outstanding shares will decrease from approximately 26.2 million to about 1.05 million. The split will also apply to shares from outstanding RSU grants and warrants, with fractional shares rounded up. This move is part of the company's strategy to strengthen its capital structure. The reverse stock split is a significant strategic move aimed at maintaining compliance with Nasdaq, which could impact investor sentiment and the company's market position.

3

Shuttle Pharmaceuticals Holdings, Inc. announced that a reverse stock split will take effect on June 16, 2025, at 12:01 a.m. Eastern Time. Every 25 shares of the company's common stock will be combined into 1 share, reducing the total from approximately 26.2 million shares to about 1.05 million shares. The common stock will continue to trade under the symbol 'SHPH' on Nasdaq, and the new CUSIP number will be 825693401. This move is part of the company's strategy to comply with Nasdaq's listing requirements and strengthen its capital structure. The reverse stock split is a strategic move that may influence market sentiment and compliance with listing requirements.

4 Jun

4

Shuttle Pharmaceuticals Holdings, Inc. has appointed George Scorsis as the Chairman of the Board of Directors. Scorsis, who has over 25 years of experience in regulated industries, has been a director since February 2025. He aims to leverage the company's radiation sensitizers to improve cancer treatment outcomes, particularly for glioblastoma patients. Shuttle Pharma focuses on enhancing radiation therapy effectiveness while minimizing side effects. The company is committed to developing therapies that increase cancer cure rates and improve patient quality of life. The appointment of a seasoned leader like George Scorsis is expected to significantly influence the company's strategic direction and market positioning.

15 May

4

Shuttle Pharmaceuticals Holdings, Inc. (SHPH) provided a corporate update highlighting progress in its Phase 2 clinical trial of Ropidoxuridine for glioblastoma, with nearly 50% patient enrollment and 84% completion of treatment cycles. The drug is well tolerated, and pharmacokinetic analyses have begun. The company also advanced its Diagnostics subsidiary through a research agreement with UCSF and filed a provisional patent for PSMA-targeted therapies. Three new board members were appointed, and the company strengthened its balance sheet via a public offering. Recent leadership changes include the resignation of Dr. Anatoly Dritschilo and retirement of Michael Vander Hoek. Significant advancements in clinical trials and strategic partnerships are likely to enhance the company's market position and investor sentiment.

8 May

4

Shuttle Pharmaceuticals Holdings, Inc. announced nearly 50% enrollment in its Phase 2 clinical trial of Ropidoxuridine for glioblastoma treatment, with 84% of patients completing all cycles and no significant toxicity reported. The trial aims to identify an optimal dose and demonstrate increased survival compared to historical controls. Conducted at multiple medical centers, the trial's success could redefine glioblastoma care. Shuttle Pharma has received FDA Orphan Drug Designation, potentially granting marketing exclusivity upon approval. The company aims to finalize enrollment later this year, with data readout expected in 2026. Successful trial outcomes could significantly alter treatment standards for glioblastoma, impacting market positioning and investor sentiment.

21 Apr

3

Shuttle Pharmaceuticals Holdings, Inc. (Nasdaq: SHPH) will present at the Planet MicroCap Showcase: VEGAS 2025 on April 23, 2025, at 2:30 p.m. PT. Dr. Anatoly Dritschilo will discuss the ongoing Phase 2 trial of Ropidoxuridine and radiation therapy for glioblastoma, along with advancements in Shuttle Diagnostics for prostate cancer diagnostics. Interested parties can access the live presentation and schedule 1x1 meetings with management at the conference venue in Las Vegas. The presentation may moderately influence investor sentiment and highlight key developments in ongoing clinical trials.

10 Apr

4

Shuttle Pharmaceuticals Holdings, Inc. has filed a provisional patent application for PSMA-Targeted PARP Inhibitor conjugates aimed at enhancing diagnostic and therapeutic programs for prostate cancer. This initiative, developed in collaboration with Dr. Alan Kozikowski, focuses on creating theranostic agents that target prostate cancer cells, improving treatment efficacy while minimizing side effects. The company's subsidiary, Shuttle Diagnostics, is also working on pretreatment diagnostic blood tests for prostate cancer patients, addressing a gap in predictive testing for treatment outcomes. The PSMA ligands are expected to play a significant role in the future of prostate cancer diagnosis and treatment. The patent filing and development of new diagnostic and therapeutic agents represent significant strategic advancements that could enhance the company's market position and investor sentiment.

13 Mar

3

Shuttle Pharmaceuticals Holdings, Inc. announced the closing of a $5.75 million underwritten public offering of 19,166,667 shares at $0.30 per share. The proceeds will fund a Phase II clinical trial for its lead product candidate, marketing services, and general corporate purposes. The offering was conducted by WestPark Capital, Inc. and was registered with the SEC. Shuttle Pharma focuses on improving outcomes for cancer patients treated with radiation therapy. The funding from the offering is expected to support key clinical trials and marketing efforts, which may moderately influence the company's future performance.

26 Feb

4

Shuttle Pharmaceuticals Holdings, Inc. (SHPH) provided a corporate update and reported its financial results for 2024, highlighting advancements in its drug development pipeline and strategic initiatives aimed at enhancing shareholder value. The company emphasized its commitment to innovation and outlined plans for upcoming clinical trials and partnerships to drive growth. Financial metrics showed progress, with increased revenue and reduced losses compared to previous periods, reflecting the effectiveness of its operational strategies. Significant advancements in drug development and strategic initiatives are likely to impact future performance and investor sentiment.

21 Jan

4

Shuttle Pharmaceuticals Holdings, Inc. has achieved a significant milestone in patient enrollment for its Phase 2 clinical trial of Ropidoxuridine, aimed at treating patients with glioblastoma. This advancement is a crucial step in the development of the treatment, which targets a challenging form of brain cancer. Successful patient enrollment in a Phase 2 trial can significantly impact future product development and investor sentiment.

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