Puma Biotechnology, Inc.
PBYI Healthcare Biotechnology
Puma Biotechnology, Inc.’s revenue for fiscal 2025 (year ended December 2025) was $228.4 million, down 0.91% from fiscal 2024. In the quarter to June 2026, revenue grew 7.75%, EPS grew 33.3%, free cash flow fell 88.5% and total debt fell 79.8%, each against the same quarter a year earlier. Operating cash flow growth for three consecutive years.
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Puma Biotechnology, Inc. (PBYI) P/E ratio
As of 16 October 2026, Puma Biotechnology, Inc. (PBYI) trades at a P/E ratio of 18.2×. Over the past ten years it has ranged from 0.0× (September 2023) to 2,295× (January 2023); the current reading is higher than 92% of that period. That is above the Biotechnology industry median of 8.5× and below the Healthcare sector median of 23.0×.
P/E ratio, daily
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Annual newest first
| Period | P/E ratio | Change |
|---|---|---|
| FY2025 | 9.4× | 88.89% |
| FY2024 | 5.0× | (49.23%) |
| FY2023 | 9.8× | (99.50%) |
| FY2022 | 1,967× | — |
| FY2021 | 0.0× | — |
| FY2020 | 0.0× | — |
| FY2019 | 0.0× | — |
| FY2018 | 0.0× | — |
| FY2017 | 0.0× | — |
Quarterly newest first
| Period | P/E ratio | Change |
|---|---|---|
| Jun 2026 | 15.0× | 17.52% |
| Mar 2026 | 12.8× | 35.32% |
| Dec 2025 | 9.4× | 33.40% |
| Sep 2025 | 7.1× | 102.29% |
| 32 more quarters | Free account |
Against its own ten years
P/E ratio against peers
| Company | P/E ratio |
|---|---|
| CTMX CytomX Therapeutics, Inc. compare | n/m |
| STTK Shattuck Labs, Inc. compare | n/m |
| FTH Faeth Therapeutics, Inc. compare | n/m |
| DBVT DBV Technologies S.A. compare | n/m |
| VECT VectivBio Holding AG compare | n/m |
| CYVNY Ceryvyn Therapeutics Ltd. - Unsponsored ADR compare | n/m |
| DRUG Bright Minds Biosciences Inc. compare | n/m |
| PBYI Puma Biotechnology, Inc. | 18.2× |
| VALN Valneva SE Sponsored ADR compare | 59.7× |
| Biotechnology industry median | 8.5× |
| Healthcare sector median | 23.0× |
| Market median | 18.1× |
What P/E ratio is
Price to Earnings Ratio shows how much investors pay for each dollar of a company’s annual profit per share.
Stock Price ÷ EPS (Basic) (TTM)