Alnylam Pharmaceuticals, Inc. (ALNY) vs Insmed, Inc. (INSM)

Alnylam Pharmaceuticals, Inc. and Insmed, Inc. are both Biotechnology companies. Alnylam Pharmaceuticals, Inc. is the larger, with a market value of $31.2B against $26.8B — 1.2× the size. Insmed, Inc. has negative trailing earnings, so its P/E is not meaningful; Alnylam Pharmaceuticals, Inc. trades at 43.6×. Insmed, Inc. grew revenue faster over the last twelve months: 185.8% against 95.1%. Alnylam Pharmaceuticals, Inc. has the higher net margin (16.1% vs −76.9%) and the higher return on invested capital (0.00% vs −329.2%). Across the 18 metrics below, Alnylam Pharmaceuticals, Inc. leads on 14 and Insmed, Inc. on 4.

Valuation

Metric ALNY INSM Biotechnology median
P/E 43.62 n/m 7.88
P/S 7.12 22.51 11.47
P/B 25.25 33.81 2.52
Price to free cash flow 41.71 n/m 21.16
EV/EBITDA 30.25 n/m 0.74
EV/Sales 6.64 22.18 10.73
Earnings yield 2.29% (3.49%) (28.84%)
Free cash flow yield 2.40% (3.15%) (23.03%)

Profitability

Metric ALNY INSM Biotechnology median
Gross margin 79.65% 83.46% 65.16%
Operating margin 20.81% (73.89%) 0.00%
Net margin 16.13% (76.94%) 0.00%
Free cash flow margin 17.07% (71.00%) 0.00%
Return on equity 96.55% (87.22%) (57.72%)
Return on assets 15.30% (38.20%) (49.22%)
Return on invested capital 0.00% (329.22%) 0.00%

Growth

Metric ALNY INSM Biotechnology median
Revenue growth (TTM) 95.14% 185.76% 5.64%
EPS growth (last fiscal year) 206.88% (15.26%) —
Revenue growth, 5-year CAGR 49.77% 29.83% 8.40%
Net income growth, 5-year CAGR 0.00% 0.00% 0.00%

Health

Metric ALNY INSM Biotechnology median
Debt to equity 0.75 0.74 0.00
Current ratio 3.05 3.72 4.73
Net debt to EBITDA (3.41) 0.71 0.96

Dividend

Metric ALNY INSM Biotechnology median
Dividend yield 2.52% — 2.10%
Payout ratio 0.00 0.00 0.00

Size

Metric ALNY INSM Biotechnology median
Market cap 31.16b 26.84b 162.10m

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