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Agenus Inc. (AGEN) vs Fulcrum Therapeutics, Inc. (FULC)

Agenus Inc. and Fulcrum Therapeutics, Inc. are both Biotechnology companies. Agenus Inc. and Fulcrum Therapeutics, Inc. are of similar size ($301.7M and $280.0M). Fulcrum Therapeutics, Inc. has negative trailing earnings, so its P/E is not meaningful; Agenus Inc. trades at 2.3×. Fulcrum Therapeutics, Inc. grew revenue faster over the last twelve months: 1,939.8% against 30.5%. Agenus Inc. has the higher net margin (69.2% vs 0.00%) and the higher return on invested capital (0.00% vs 0.00%). Across the 16 metrics below, Agenus Inc. leads on 8 and Fulcrum Therapeutics, Inc. on 8.

Valuation

Metric AGEN FULC Biotechnology median
P/E 2.28 n/m 8.50
P/S 1.88 3.37 9.71
P/B n/m 0.90 2.13
Price to free cash flow n/m n/m 20.82
EV/EBITDA 6.95 0.43 0.64
EV/Sales 2.14 (0.49) 9.21
Earnings yield 43.81% (33.15%) (33.15%)
Free cash flow yield (39.31%) (23.60%) (25.50%)

Profitability

Metric AGEN FULC Biotechnology median
Gross margin 99.52% 100.00% 65.16%
Operating margin 27.28% 0.00% 0.00%
Net margin 69.18% 0.00% 0.00%
Free cash flow margin (73.97%) 0.00% 0.00%
Return on equity (33.86%) (32.38%) (56.36%)
Return on assets 51.30% (30.75%) (48.04%)
Return on invested capital 0.00% 0.00% 0.00%

Growth

Metric AGEN FULC Biotechnology median
Revenue growth (TTM) 30.47% 1,939.80% 6.02%
EPS growth (last fiscal year) 100.00% (637.50%) 30.26%
Revenue growth, 5-year CAGR 5.31% — 9.41%
Net income growth, 5-year CAGR 0.00% 0.00% 0.00%

Health

Metric AGEN FULC Biotechnology median
Debt to equity (0.15) 0.00 0.00
Current ratio 0.34 31.35 4.72
Net debt to EBITDA (4.10) 4.23 0.96

Dividend

Metric AGEN FULC Biotechnology median
Dividend yield — — 0.09%
Payout ratio — — —

Size

Metric AGEN FULC Biotechnology median
Market cap 301.68m 280.01m 135.18m

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