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Vertex Pharmaceuticals Incorporated

VRTX Healthcare Biotechnology

Vertex Pharmaceuticals Incorporated’s revenue for fiscal 2025 (year ended December 2025) was $12.0 billion, up 8.90% from fiscal 2024.

Revenue
+11.9%
EPS
−39.2%
Free cash flow
−52.1%

Quarter to September 2026, against a year earlier

547.43 4.93 +0.91%
Market cap
$137.5B
P/E
34.6×
Fwd P/E
33.2×
Dividend yield
—
F-score
8/9
Altman Z
12.06
Beneish M
−2.17
Dividend safety
n/a
Overview Business Profile Earnings & Analysis
Financials
Income Statement Balance Sheet Cash Flow Metrics & Ratios
Segments Valuation Filings

Vertex Pharmaceuticals Incorporated (VRTX) valuation and DCF model

What the price implies · reverse DCF

At $547.43 the price implies free cash flow after share-based pay growing 18.9% a year for ten years.

Free cash flow after share-based pay grew −34.6% a year over the last five years. The price asks for 53.4 points a year more than its five-year rate. The industry’s median company is priced for 27.5%.

In December 2017 the price assumed 25.4% a year; Vertex Pharmaceuticals Incorporated went on to grow free cash flow after share-based pay 23.9% a year to FY2025.

Price implies
18.9%
Last 5 years, reported
−34.6%
Industry median implies
27.5%

The headline discounts the last twelve months’ free cash flow after share-based pay at 9.0% for ten years and grows it 2.5% a year after that, the same for every company, so the figure compares across the market (how a reverse DCF works).

The other way round · DCF
The price needs
18.9% a year for ten years
$547.43
today’s price
Its base case
−10.0% a year for five years, then −6.0%
$80.82
85.2% below today’s price

Both are growth in free cash flow after share-based pay, discounted at 9.0%, with 2.5% a year after year ten.

Base case on its own ten-year record Vertex Pharmaceuticals Incorporated’s own growth, carried forward

Its assumptions

Powerpack lets you start from a scenario and type over any of them.

The base case’s inputs, which Powerpack lets you change
1 · Cash flow to equity
the four quarters to September 2026, from the 10-Q and 10-K filings, before share-based pay

Yearly growth in cash flow. It usually slows as the company matures.

Today’s price implies free cash flow after share-based pay growing 18.9% a year for ten years.

2 · Rates

Cost of equity is the yearly return shareholders require, typically 8–11%. Terminal growth is growth forever after year 10, usually near long-run inflation, 2–3%.

3 · Per share

Diluted shares outstanding. Net debt, under Advanced inputs, is taken off before dividing.

Advanced inputs
Free cash flow Revenue and margin
negative is net cash
new shares the cash flow does not pay for

Against Vertex Pharmaceuticals Incorporated’s own cost of capital: risk-free 4.3% + beta 0.28 × equity premium 4.5% = 5.6% cost of equity; weighted, 5.6%.

Use 5.6%
Equity value $20.70b ▼ below market cap $140.24b
Base case value per share $80.82 equity value ÷ 256.18m shares
Current price $547.43 market price per share
Below today’s price 85.2% downside at the base case’s assumptions

How we got there$10.58b 10 years of cash to equity+$7.31b terminal value+$2.81b net cash=$20.70b equity value÷256.18m shares=$80.82 per share

Valuation against its own history

Today’s multiple against its 5- and 10-year averages and the industry median (Biotechnology).

Multiple Current 5Y avg 10Y avg vs 10Y avg Industry median vs industry 10Y range
P/E 34.57× 27.86× 41.43× 17% below 10.26× 237% above
P/FCF 42.87× 30.61× 40.02× 7% above 24.81× 73% above
P/B 6.57× 6.08× 8.04× 18% below 2.05× 220% above
EV/EBITDA 29.68× 21.96× 67.29× 56% below 0.65× 4459% above
EV/Sales 10.41× 9.04× 10.14× 3% above 8.98× 16% above
P/E P/FCF P/B EV/EBITDA EV/Sales
22.46×90.32×158.19×226.06×10Y avg 67.29×2016201720182019202020212022202320252026

VRTX trades at 29.68× EV/EBITDA, against a 10-year average of 67.29× (range 14.18×–247.62×). That is dearer than 56% of the last 9 year-end readings; re-rating to the average implies $1,227.13 per share.

Every growth rate on this page is the business’s — its cash flow, FFO or dividend — never its share price’s. A discounted-cash-flow model is only as good as its assumptions. Figures from the 10-K and 10-Q filings. Not investment advice.