Upstream Bio, Inc.

UPB

Healthcare Biotechnology

Upstream Bio, Inc.’s revenue for fiscal 2025 (year ended December 2025) was $2.9 million, up 20.4% from fiscal 2024.

Revenue
−17.5%
EPS
+1.35%
Free cash flow
+9.33%

Quarter to June 2026, against a year earlier

3.23 0.02 +0.62%
Market cap
$176.9M
P/E
n/m
Fwd P/E
n/m
Dividend yield
—
F-score
2/9
Net debt / EBITDA
2.1×
Dividend safety
n/a
Older periods Sep '25 Dec '25 Mar '26 Jun '26
P/E ratio

+8 more quarters

0.00 0.00 0.00 0.00
P/S ratio
362.43 512.30 147.20 119.57
P/FCF ratio
0.00 0.00 0.00 0.00
P/Operating CF
(45.61) (47.73) (10.22) (10.60)
P/B ratio
2.68 4.30 1.61 1.39
EV/Sales
229.37 392.64 58.52 36.83
EV/EBITDA
0.00 0.00 0.00 0.00
EV/FCF
(5.22) (8.39) (1.39) (0.85)
Current Ratio
32.67 26.15 23.14 27.99
Net Debt/EBITDA
9.82 7.63 6.65 6.17
Debt/Equity
0.00 0.00 0.00 0.00
Earnings Yield
(12.53%) (9.83%) (32.33%) (41.91%)
Free Cash Flow Yield
(12.11%) (9.14%) (28.69%) (36.20%)
Free Cash Flow per Share
(0.41) (0.57) (0.88) (0.65)
Book value per Share
7.02 6.31 5.60 4.97
Free Cash Flow
(22.30) (30.68) (47.85) (35.62)
EV/EBIT
0.00 0.00 0.00 0.00
Other line items

Show all line items

Columns are period end dates · fundamentals updated 26 Oct 2026