Upstream Bio, Inc.

UPB

Healthcare Biotechnology

Upstream Bio, Inc.’s revenue for fiscal 2025 (year ended December 2025) was $2.9 million, up 20.4% from fiscal 2024.

Revenue
−17.5%
EPS
+1.35%
Free cash flow
+9.33%

Quarter to June 2026, against a year earlier

3.23 0.02 +0.62%
Market cap
$176.9M
P/E
n/m
Fwd P/E
n/m
Dividend yield
—
F-score
2/9
Net debt / EBITDA
2.1×
Dividend safety
n/a
Dec '23 Dec '24 Dec '25
Piotroski F-Score
— — 2
P/E ratio
0.00 0.00 0.00
Altman Z-Score
— 11.46 60.99
P/S ratio
27.97 317.02 512.30
Altman Z″-Score (non-manufacturers)
12.38 45.58 25.63
P/FCF ratio
0.00 0.00 0.00
Beneish M-Score
— 6.55 (2.81)
P/Operating CF
(4.76) (38.31) (47.73)
P/B ratio
0.00 1.60 4.30
EV/Sales
(64.82) 118.52 392.64
EV/EBITDA
2.44 0.00 0.00
EV/FCF
2.77 (4.69) (8.39)
Current Ratio
17.96 44.63 26.15
Net Debt/EBITDA
2.66 5.93 2.11
Debt/Equity
0.00 0.00 0.00
ROE
0.00% (44.07%) (35.43%)
ROA
0.00% (25.51%) (34.34%)
ROIC
0.00% 0.00% 0.00%
Return on Tangible Assets
(34.58%) (16.29%) (42.33%)
Average Days of Receivables
15.03 94.41 85.43
Earnings Yield
(92.05%) (113.24%) (9.83%)
Free Cash Flow Yield
(83.71%) (7.96%) (9.14%)
Free Cash Flow per Share
(12.89) (4.36) (2.48)
Book value per Share
36.50 34.34 6.31
Free Cash Flow
(38.07) (59.68) (133.44)
EV/EBIT
2.53 0.00 0.00
Other line items

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Columns are period end dates · fundamentals updated 26 Oct 2026