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Instil Bio, Inc. TIL

Growth Flags show if company had growth for consecutive years

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Get access to target analyst prices, predictions, compound annual growth rates and more than four years of historical data.

Insider Decisions

in millions of $
Nov 25 Feb 26 May 26 Aug 26
Buy
Sell
Insider Ownership
38.51%

Capital & Financial Ratios

Market Cap
48.90
Revenue
0.14
Net Income
(30.28)
Free Cash Flow
(23.61)
Net Debt
15.26
Current Ratio
21.67
Debt/Equity
0.79
P/E ratio
0.00
P/S ratio
348.44
P/B ratio
0.45
Past 5Y EPS Growth
(62.10%)
This Y EPS Growth
89.07%
Next Y EPS Growth
52.06%
Next 5Y EPS Growth
10.08%
in millions of $

Dividends

Payout Ratio
0.00
Annual Dividend Rate
Annual Dividend Yield
total individual payouts
2023 ‡‡‡
2022 ‡‡‡
2021 ‡‡‡
2019 ‡‡‡
2018 ‡‡‡
2017 ‡‡‡
predictions in italic, special payouts not included in total or ratios

Assets vs Liabilities

2023 2024 2025 Q'26
Cash 151.86 115.15 76.30 69.93
Receivables
Inventory
Other 112.10
160.76 124.47 191.43 71.61
2023 2024 2025 Q'26
Payables 1.21 0.66 0.78 0.80
ST’ Debt
Other
10.56 7.90 4.84 3.31
in millions of $

Compound Annual Growth

10y 5y 3y
Sales
Cash Flow ‡‡‡ ‡‡‡
Earnings ‡‡‡ ‡‡‡
Book Value ‡‡‡ ‡‡‡‡‡

Revenue

Mar Jun Sep Dec Year
’26
in millions of $

Operating Cash Flow

Mar Jun Sep Dec Year
’26 (1.34) (4.64)
’25 (4.19) (14.79) (10.56) (7.08)
(36.62)
’24 (14.39) (10.61) (20.13) (10.56)
(55.70)
’23 (34.66) (19.56) (14.43) (13.38)
(82.03)
’22 (55.05) (47.26) (40.88) (36.98)
(180.16)
’21 (17.73) (32.22) (29.39) (42.79)
(122.14)
’20 (2.28) (3.28) (7.23) (16.82)
(29.62)
in millions of $

Free Cash Flow

Mar Jun Sep Dec Year
’26 (1.34) (4.64)
’25 (4.19) (14.79) (10.56) (7.08)
(36.62)
’24 (14.39) (10.61) (20.13) (10.56)
(55.70)
’23 (43.13) (26.54) (19.58) (13.44)
(102.69)
’22 (75.29) (73.40) (66.08) (49.99)
(264.75)
’21 (26.86) (40.72) (51.14) (61.25)
(179.97)
’20 (3.25) (3.55) (11.54) (62.09)
(80.43)
in millions of $

EPS

Mar Jun Sep Dec Year
’26 (0.62) (0.63)
’25 (4.32) (3.24) (2.01) (1.21)
(10.70)
’24 (3.74) (2.29) (3.54) (1.82)
(11.39)
’23 (8.80) (2.80) (10.40) (1.99)
(24.00)
’22 (8.40) (9.20) (8.60) (8.20)
(34.40)
’21 (13.20) (5.40) (6.60) (8.60)
(29.60)
’20 (0.24) (0.07) (0.06)
(5.89)

Target Price Range

High
‡‡‡‡‡
‡‡‡
Average
‡‡‡‡‡
‡‡‡
Low
‡‡‡‡‡
‡‡‡

Recommendation Rating

3
1
Buy
2
3
Hold
4
5
Sell
2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 2026 2027 2028
‡‡‡‡‡ 9.42 6.08 7.28 10.17
Low Price
‡‡‡‡‡ 379.40 18.54 92.00 42.79
High Price
‡‡‡‡‡ ‡‡‡‡‡ 192 49 14 17
Employees
‡‡‡‡‡ ‡‡‡ 0.00 0.00 0.00 0.00
Revenue/Emp
‡‡‡‡‡ ‡‡‡‡‡
Revenue
‡‡‡ ‡‡‡ ‡‡‡ 0.00%
Gross Margin
‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ (225.25) (156.09) (74.13) (71.37)
EBT
‡‡‡ ‡‡‡‡‡ ‡‡‡ 0.00% 0.00% 0.00% 0.00% ‡‡‡ ‡‡‡ ‡‡‡
EBT Margin
‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ (223.18) (156.09) (74.13) (71.37) ‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡
Net Income
‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ 21.81 4.76 3.61 0.53
Depreciation
‡‡‡ ‡‡‡‡‡ ‡‡‡ 0.00 0.00 0.00 0.00 ‡‡‡ ‡‡‡ ‡‡‡
Revenue/Sh
‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ (34.40) (24.00) (11.39) (10.70) ‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡
Earnings/Sh
‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ (27.82) (12.61) (8.56) (5.49)
Cash Flow/Sh
‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ (13.06) (3.18) 0.00 0.00 ‡‡‡ ‡‡‡ ‡‡‡
Capex/Sh
‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ (40.88) (15.79) (8.56) (5.49)
Free CF/Sh
‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ 56.15 34.72 26.03 17.08
Book Value/Sh
‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ 6.48 6.50 6.51 6.67 ‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡
Shares
‡‡‡ ‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡
PE Ratio
‡‡‡‡‡ ‡‡‡ ‡‡‡ ‡‡‡
PS Ratio
‡‡‡ ‡‡‡ ‡‡‡ ‡‡‡
PB Ratio
‡‡‡‡‡ ‡‡‡‡‡
EV/Sales
‡‡‡‡‡
EV/FCF
‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ (180.16) (82.03) (55.70) (36.62) ‡‡‡ ‡‡‡ ‡‡‡
Op' Cash Flow
‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ (84.59) (20.66)
Capex
‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ (264.75) (102.69) (55.70) (36.62)
FCF
‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ 236.59 150.20 116.57 186.59
Working Cap'
74.73 81.43 84.19 84.81
Total Debt
‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ (186.19) (70.43) (30.96) 8.51
Net Debt
‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ 363.61 225.83 169.44 113.87
Sh' Equity
‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ (40.87%) (38.65%) (25.16%) (30.56%)
ROA
‡‡‡ ‡‡‡ ‡‡‡‡‡ (79.78%) (64.02%) (33.19%) (40.13%)
ROIC
‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ (48.58%) (52.96%) (37.51%) (50.39%)
ROE
predictions in italic, sparklines do not include predictions

Analyst Commentary (Summary)

Instil Bio (TIL), a trailblazing clinical-stage biotech harnessing tumor infiltrating lymphocyte (TIL) therapies for tough solid tumors like colorectal cancer, trades at multi-year lows around $8 after a staggering 98% plunge from its 2021 SPAC-fueled peak of $590. Yet, this depressed valuation screams opportunity: analysts’ mean price target implies a whopping 540% upside, with the high-end forecasting over 1,460% gains, far outpacing minimal downside risk. TIL’s razor-sharp pivot to its next-gen lead asset, ITIL-306, amid aggressive cost-cutting—slashing headcount 96% to just 14 employees and halting capex—has tamed cash burn by up to 46% while preserving a 12-18 month runway, setting the stage for explosive value creation if clinical catalysts deliver.

With zero revenue today but projections for $1.93 million in 2025 (a 14x leap), TIL mirrors the high-stakes biotech playbook where losses are narrowing dramatically—net income improved 52% to -$74 million in 2024, EPS less dilutive at -$11.39—and efficiency metrics like ROA and ROIC are ticking higher. Validated by peer successes like Iovance’s 2024 TIL approval that ignited sector rallies, TIL’s CRC focus taps an underserved market ripe for disruption, trading at a steep discount to $26 book value and lofty EV/Sales multiples that scream growth repricing.

Bottom line: TIL is a high-conviction speculative gem for oncology optimists, with Q1 2026 Phase 1 ITIL-306 data as the pivotal spark. Breakthrough here could catapult shares skyward; even modest milestones curb dilution fears in this binary bet poised for outsized returns.

Instil Bio, Inc. (TIL) Latest News

News by impact score

Fine-tune

15 May

3 GlobeNewswire, 7:00 AM
Instil Bio, Inc. (TIL) reported first quarter 2026 financial results and provided a corporate update. Q1 2026 financial results and corporate update affect financial performance and investor sentiment but are balanced by ongoing clinical developments.

27 Mar

3 GlobeNewswire, 7:00 AM
Instil Bio, Inc. (TIL) reported fourth quarter and full-year 2025 financial results, alongside a corporate update. Quarterly financial results and corporate updates often moderately affect biotech investor sentiment and stock performance.

6 Jan

3 GlobeNewswire, 7:00 AM
Instil Bio, Inc.'s subsidiary has discontinued the clinical development of AXN-2510 and terminated its license and collaboration agreement with ImmuneOnco. This decision marks a significant shift in the company's strategic direction regarding this particular asset. Discontinuing clinical development of AXN-2510 may moderately affect Instil Bio's product pipeline and investor sentiment.

13 Nov

4 GlobeNewswire, 7:00 AM
Instil Bio, Inc. reported third quarter 2024 financial results and provided a corporate update, including licensing SYN-2510 for global development, clinical data updates, and initiation of Phase 1b/2 studies in China. The potential best-in-class asset, SYN-2510, and strategic moves in China trials are expected to significantly impact Instil Bio's future performance and market positioning.

3 GlobeNewswire, 7:00 AM
Instil Bio, Inc. reported its financial results for the third quarter of 2025, highlighting key metrics and developments in its operations. The company provided updates on its ongoing clinical trials and strategic initiatives aimed at advancing its product pipeline. Financial performance showed trends that may influence future growth, while management outlined plans for upcoming milestones and potential market opportunities. The financial results and updates on clinical trials indicate a moderately noticeable influence on the company's future performance and market positioning.

10 Sep

4 , 7:00 AM
Instil Bio, Inc. announced that ImmuneOnco presented data on the ‘2510 monotherapy for patients with second-line or greater squamous non-small cell lung cancer (NSCLC) at the 2025 World Conference on Lung Cancer (WCLC). The presentation highlights the potential of ‘2510 as a treatment option in this patient population, contributing to the ongoing research and development efforts in oncology. The presentation of promising monotherapy data at a major conference could significantly enhance Instil Bio's competitive positioning and investor sentiment.

16 Aug

3 Simply Wall St., 8:23 AM
Instil Bio, Inc. (NASDAQ:TIL) has garnered attention from institutional investors, who collectively own 36% of the company. This significant ownership stake indicates a growing interest in Instil Bio's potential and future performance in the market. Institutional ownership suggests moderate confidence in the company's future prospects and may influence market sentiment.

13 Aug

3 GlobeNewswire, 6:00 AM
Instil Bio, Inc. reported its financial results for the second quarter of 2025, highlighting key metrics and developments in its operations. The company provided updates on its ongoing clinical trials and strategic initiatives aimed at advancing its product pipeline. Management emphasized their commitment to innovation and growth in the biopharmaceutical sector, while also addressing challenges faced during the quarter. Overall, the report reflects the company's efforts to enhance shareholder value and position itself for future success. The financial results and corporate updates indicate moderate influences on the company's performance and market positioning.

2 Jul

4 GlobeNewswire, 6:00 AM
Instil Bio, Inc. announced that the U.S. FDA has cleared its Investigational New Drug application for AXN-2510, a PD-L1xVEGF bispecific antibody. A Phase 1 trial for relapsed/refractory solid tumors is expected to begin before the end of 2025. Additionally, initial safety and efficacy results from a Phase 2 trial of AXN-2510 in combination with chemotherapy for first-line NSCLC in China are anticipated to be shared in the second half of 2025. The Chief Medical Officer emphasized the importance of evaluating AXN-2510 in a global population for its clinical development. The FDA clearance and upcoming trials represent significant strategic moves that could alter Instil's trajectory and investor sentiment.

20 Jun

3 , 12:00 PM
Instil Bio, Inc. (TIL) has experienced a 4.07% increase in its stock price over the past week. The company continues to focus on its innovative cell therapy treatments for cancer, which are currently in various stages of clinical trials. Investors are closely monitoring the company's progress and upcoming announcements that could influence its market position and financial performance. The recent stock price increase reflects moderate investor interest, but significant changes in the company's trajectory are not yet evident.

16 Jun

4 Zacks, 9:55 AM
Instil Bio, Inc. (TIL) closed at $34.23, up 134% in four weeks, with Wall Street analysts setting a mean price target of $118.67, indicating a potential upside of 246.7%. Price targets range from $51 to $180, with a standard deviation of $64.73. Analysts show strong agreement on earnings estimates, with a Zacks Rank #2 (Buy) suggesting positive sentiment. However, caution is advised as price targets can be misleading and overly optimistic. Recent upward revisions in earnings estimates correlate with potential stock price increases, reinforcing the outlook for TIL. Strong agreement among analysts on earnings revisions indicates significant potential for stock price movement.

11 Jun

4 , 7:00 AM
Instil Bio, Inc. has appointed John Maraganore, Ph.D., to its board to support the advancement of its PD-L1xVEGF bispecific antibody program. Maraganore brings extensive experience in biotechnology and drug development, which is expected to enhance the company's strategic initiatives in this area. The appointment of a seasoned expert like Maraganore is likely to significantly impact the advancement of a key therapeutic program.

4 Jun

4 , 12:00 PM
Instil Bio, Inc. (TIL) is highlighted as a strong momentum pick due to its innovative approaches in cell therapy and promising clinical trial results. The company is focused on developing TILs (tumor-infiltrating lymphocytes) for cancer treatment, which have shown potential in improving patient outcomes. Recent advancements and strategic partnerships are expected to enhance its market position and attract investor interest, making it a compelling choice for those seeking growth opportunities in the biotech sector. Significant advancements in TIL's product development and strategic partnerships are likely to impact its market performance and investor sentiment.

2 Jun

4 GlobeNewswire, 7:00 AM
Instil Bio, Inc. has appointed Jamie Freedman, M.D., Ph.D., as Chief Medical Officer. Dr. Freedman, an experienced oncologist with over 20 years in biopharmaceuticals, will lead the development of AXN-2510, a PD-L1xVEGF bispecific antibody aimed at treating solid tumors. CEO Bronson Crouch expressed enthusiasm for Dr. Freedman's leadership, highlighting the potential of AXN-2510 to redefine cancer treatment standards. Freedman has a history of successful drug approvals and is committed to health equity, having pioneered inclusive trials for underserved populations. Instil Bio focuses on innovative cancer therapies, with AXN-2510 as its lead asset. The appointment of a seasoned executive like Dr. Freedman and the focus on a promising therapy like AXN-2510 are likely to significantly impact the company's future trajectory and market perception.

29 May

4 Zacks, 12:00 PM
Instil Bio, Inc. (TIL) has been upgraded to a Zacks Rank #2 (Buy) due to an upward trend in earnings estimates, indicating a positive earnings outlook. The Zacks rating system, based on earnings estimate revisions, suggests that the stock may experience buying pressure and price increases. Analysts have raised their earnings estimates for Instil Bio, with a projected loss of -$7.71 per share for the fiscal year ending December 2025, reflecting a year-over-year change of 32.3%. The upgrade positions Instil Bio in the top 20% of Zacks-covered stocks, suggesting potential for market-beating returns in the near term. The upgrade reflects significant improvements in earnings estimates, which could lead to increased investor interest and stock price appreciation.

4 Zacks, 9:55 AM
Instil Bio, Inc. (TIL) closed at $26.75, up 108.2% in four weeks, with Wall Street analysts setting a mean price target of $118.67, suggesting a 343.6% upside. The lowest estimate is $51 (90.7% increase), while the highest is $180 (572.9% increase). Analysts show agreement on improved earnings estimates, with a 7.2% increase in the Zacks Consensus Estimate for the current year. TIL holds a Zacks Rank #2 (Buy), indicating strong potential for upside despite skepticism about the reliability of price targets. Investors are advised to consider earnings revisions as a more reliable indicator of stock performance. Analysts' optimism regarding earnings revisions suggests significant potential for stock price movement.

23 May

4 , 7:00 AM
Instil Bio, Inc. and ImmuneOnco will host an investor and analyst breakfast during the 2025 ASCO Annual Meeting in Chicago. The event will focus on the evolving landscape of PD-(L)1xVEGF bispecific antibodies and provide updates on clinical trials. This gathering aims to engage stakeholders and discuss advancements in cancer treatment. The event is likely to significantly impact investor sentiment and strategic positioning in the competitive landscape of cancer therapies.

22 May

4 GlobeNewswire, 6:00 AM
Instil Bio, Inc. and ImmuneOnco announced that the Phase 2 trial of ‘2510, a PD-L1xVEGF bispecific antibody, in combination with chemotherapy for first-line NSCLC in China is on track to complete enrollment by Q3 2025, with initial results expected in the second half of 2025. Instil plans to initiate a Phase 3 trial in mid-2026, pending regulatory discussions, and is also preparing for a Phase 1b/2 trial in the U.S. for relapsed/refractory solid tumors. Initial safety and efficacy results from the ongoing trial in China are anticipated in late 2025. The ongoing trials and potential Phase 3 initiation represent significant strategic moves that could alter the company's trajectory and investor sentiment.

13 May

4 , 7:00 AM
Instil Bio, Inc. reported its financial results for the first quarter of 2025, highlighting key metrics and developments in its corporate strategy. The company continues to advance its pipeline of cell therapies and is focused on expanding its clinical trials. Management provided insights into future plans and anticipated milestones, aiming to enhance shareholder value and drive growth in the competitive biotech landscape. The financial results and corporate updates indicate significant strategic moves that could alter the company's trajectory and investor sentiment.

4 Mar

3 , 7:09 AM
Instil Bio, Inc. reported its financial results for the fourth quarter and full year of 2024, highlighting key metrics and developments in its operations. The company provided updates on its clinical programs and strategic initiatives aimed at advancing its pipeline and enhancing shareholder value. Financial performance showed trends that may influence future growth and market positioning. The financial results and corporate updates indicate moderate influences on the company's future performance and market sentiment.

2 Mar

4 TipRanks, 6:15 AM
Instil Bio, Inc. is shifting focus from tumor-infiltrating lymphocyte therapies to bispecific antibodies, partnering with ImmuneOnco Biopharmaceuticals to develop SYN2510 and IMM27M. A Phase 1b/2 trial for SYN2510 in advanced non-small cell lung cancer (NSCLC) is set to begin in China, with initial data expected in late 2025. Jefferies analyst Kelly Shi rates TIL a Buy with a $52 price target, indicating a potential 158% upside. The stock holds a Strong Buy consensus rating, with an average price target suggesting a 467% upside from its current price of $20.10. The strategic pivot towards bispecific antibodies and upcoming clinical trials could significantly alter Instil Bio's market position and investor sentiment.

20 Feb

3 Simply Wall St., 5:11 AM
Private equity firms hold a 38% stake in Instil Bio, Inc. (NASDAQ:TIL), gaining 34% from recent price increases, while institutional ownership stands at 27%. The top four shareholders control 50% of the company, indicating significant influence over management decisions. Hedge funds own 18%, and insiders hold 1.9%. The general public owns 15%, allowing for some influence but not control. Insider ownership is noted at $4.1 million, which is relatively low compared to the company's market cap of $163 million. The article suggests that while institutional ownership adds credibility, it is essential to consider other factors for future performance. The significant ownership by private equity and institutional investors indicates potential influence on company strategy and market sentiment.

14 Jan

4 GlobeNewswire, 7:00 AM
Instil Bio, Inc. has announced clinical progress in China for its bispecific antibody IMM2510/SYN-2510, which targets PD-L1 and VEGF. The company is advancing its clinical trials, aiming to enhance treatment options for patients with cancer. This development is part of Instil Bio's broader strategy to expand its product pipeline and improve patient outcomes in oncology. The clinical progress in China for a bispecific antibody could significantly enhance Instil Bio's product offerings and market position in the competitive oncology landscape.

15 Nov

4 , 2:38 PM
Merck signs $3.3B licensing deal with Chinese biotech for cancer therapy. The significant licensing deal with Merck is expected to have a major impact on Instil Bio's future and market performance.

14 Nov

3 Zacks, 10:45 AM
BioNTech SE announced its acquisition of China-based Biotheus to enhance its oncology pipeline, gaining full global rights to the investigational bispecific antibody BNT327/PM8002. The deal, valued at $800 million, is expected to close in Q1 2025 and includes performance-based payments of up to $150 million. This acquisition aims to expand BioNTech's capabilities in developing bispecific antibodies and initiate multiple registrational studies for various solid tumors starting in 2024. Following the announcement, BioNTech's shares rose 4.9%. The acquisition of Biotheus could moderately influence Instil Bio's competitive positioning in the bispecific antibody market.

23 Oct

3 Zacks, 9:41 AM
Shares of Summit Therapeutics (SMMT) have surged 689% year to date, outperforming the industry and S&P 500, following positive results from the phase III HARMONi-2 study of its drug ivonescimab against Merck's Keytruda for non-small cell lung cancer. Despite this success, SMMT faces challenges, including a lack of marketed products, significant cash burn, and intense competition from established pharmaceutical companies and other developing therapies, including Instil Bio's SYN-2510. The stock is considered overvalued, and analysts advise caution until further data from SMMT's own studies is available. Instil Bio faces competition from Summit's promising drug, which could influence its market positioning.

25 Sep

4 www.fool.com, 4:56 AM
Shares of Summit Therapeutics and Instil Bio have surged over 700% in 2024 due to promising cancer drug candidates that could outperform Keytruda. Summit's ivonescimab showed positive results in a phase 3 trial, while Instil's SYN-2510 is in development with a similar approach. Both companies are focusing on lung cancer treatments with potential for significant market success. The article highlights potential game-changing impact on Instil Bio's future and market performance with the development of SYN-2510 and its potential to outperform Keytruda.

17 Sep

4 www.fool.com, 4:24 AM
Summit Therapeutics' lead candidate, ivonescimab, shows promising results in a clinical trial for frontline lung cancer patients, potentially competing with Merck's Keytruda. Instil Bio and BioNTech are also developing similar candidates. The article discusses potential competition in the cancer drug market, which could significantly impact Instil Bio's future and market performance.

16 Sep

4 Zacks, 11:23 AM
Instil Bio stock surged 641% in a week due to positive data on ivonescimab compared to Keytruda. TIL acquired rights to develop two antibody treatments targeting cancer indications. Positive data on ivonescimab and potential to replace Keytruda could significantly impact Instil Bio's future and market performance.

4 GlobeNewswire, 6:00 AM
Instil Bio and ImmuneOnco announce global registrational strategy for SYN-2510/IMM2510 in NSCLC and TNBC, with Phase 1b/2 trials in China and US IND submission targeted for late 2024. The announcement of a global registrational strategy and Phase 1b/2 trials for SYN-2510/IMM2510 in NSCLC and TNBC is a significant move that could have a major impact on Instil Bio's future and market performance.

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