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Synlogic, Inc.

SYBX Healthcare Biotechnology

Synlogic, Inc.’s revenue for fiscal 2024 (year ended December 2024) was $8,000.00, down 99.8% from fiscal 2023. In the quarter to June 2026, EPS was flat and free cash flow fell 277.9%, each against the same quarter a year earlier. Operating cash flow growth for three consecutive years.

1.00 0.08 −7.41%
Market cap
$6.7M
P/E
0.0×
Fwd P/E
−2.8×
Dividend yield
—
F-score
3/9
Altman Z
−35.79
Beneish M
n/a
Dividend safety
n/a
Overview Business Profile Financial Analysis Income Statement Balance Sheet Cash Flow Metrics & Ratios 10-Q 10-K

Insider Decisions trades per month

Dec 25 Mar 26 Jun 26 Sep 26
Buy — — — — — — — — — — — —
Sell — — — — — — — — — — — —
Insider Ownership 42.83%

Capital & Financial Ratios $m

Market Cap 6.68
Revenue 3.21
Net Income (0.65)
Free Cash Flow (3.84)
Net Debt (13.18)
Current Ratio 9.19 (at or above 1.5: strong)
Debt/Equity 0.00 (at or below 0.5: strong)
P/E ratio 0.00
Fwd P/E (2.80) (negative: loss-making)
P/S ratio 3.87
P/B ratio 1.03
Past 5Y EPS Growth —
This Y EPS Growth 85.81% (at or above 15%: strong)
Next Y EPS Growth 82.66% (at or above 15%: strong)
Next Y revenue growth 55,875.00% (at or above 10%: strong)
Next 5Y EPS Growth —

Green and red mark values outside typical ranges. How we judge →

Valuation vs history

EV/Sales, ten years
EV/Sales is −0.2×, against a ten-year median of −2.0×; over the ten years it ranged from −42.6× in 2019 to 253× in 2018.
P/S against its own 10 years 7.19%
10-year low 10-year high
P/B against its own 10 years 57.32%
10-year low 10-year high
EV/FCF against its own 10 years 22.73%
10-year low 10-year high

Dividends

Payout Ratio —
Annual Dividend Rate —
Annual Dividend Yield —
total individual payouts
2023 Powerpack
2022 Powerpack
2021 Powerpack
2020 Powerpack
2019 Powerpack
2017 Powerpack
special payouts not included in total or ratios

Assets vs Liabilities $m

2023 2024 2025 Q'26
Cash 48 19 15 13
Receivables — — — —
Inventory — — — —
Other — 0 — —
50 20 15 13
2023 2024 2025 Q'26
Payables 1 0 0 0
ST’ Debt — — — —
Other — — — —
30 7 4 1

Compound Annual Growth %

10y 5y 3y
Sales — (67.55%) (83.42%)
Cash Flow 0.00% 0.00% 0.00%
Earnings 0.00% 0.00% 0.00%
Book Value (17.88%) (36.53%) (47.63%)

Revenue $m

Mar Jun Sep Dec Year
’26 — — — — —
’24 0 — — — 0
’23 0 0 0 3 3
’22 0 0 1 0 1
’21 — 0 1 1 2
’20 0 0 — 0 1
’19 0 0 0 1 2
Fiscal quarters ending in the months shown.

Operating Cash Flow $m

Mar Jun Sep Dec Year
’26 (1) (1) — — —
’25 (2) 0 (1) (1) (4)
’24 (15) (15) (1) (1) (32)
’23 (22) (12) (13) (6) (52)
’22 (15) (14) (15) (12) (57)
’21 (14) (11) (14) (13) (52)
’20 (12) (9) (8) (10) (40)
Fiscal quarters ending in the months shown.

Free Cash Flow $m

Mar Jun Sep Dec Year
’26 (1) (1) — — —
’25 (2) 0 (1) (1) (4)
’24 (16) (14) (1) (1) (30)
’23 (22) (12) (13) (6) (52)
’22 (16) (14) (16) (12) (58)
’21 (14) (11) (14) (13) (53)
’20 (13) (9) (8) (10) (40)
Fiscal quarters ending in the months shown.

EPS $

Mar Jun Sep Dec Year
’26 0.05 (0.04) — — —
’25 0.03 (0.04) (0.19) 0.12 (0.08)
’24 (2.60) 0.25 (0.01) (0.06) (1.92)
’23 (3.45) (3.15) (2.57) (1.71) (8.81)
’22 (3.30) (3.30) (3.75) (3.60) (13.79)
’21 (5.40) (4.20) (4.35) (3.15) (16.34)
’20 (6.90) (6.60) (5.40) (5.85) (24.74)
Fiscal quarters ending in the months shown.

Target Price Range

Analyst price targets

Recommendation Rating

3
1Buy 2 3Hold 4 5Sell

Ten years at a glance Fiscal years to December

Group Line 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 Trend 2026e 2027e 2028e
Price, $
Price, $ Low 117.60 131.40 86.25 28.65 20.25 32.25 8.25 1.61 1.22 0.90

Analyst estimates 2026–2028

Powerpack
High 698.25 345.00 225.00 171.41 59.85 76.65 39.75 16.50 5.12 1.96
People
People Employees 9 63 74 76 72 84 72 6 1 1
Revenue/emp, $m 0.05 0.04 0.03 0.03 0.01 0.02 0.02 0.56 0.01 0.00
Income, $m
Income, $m Revenue 0 2 3 2 1 2 1 3 0 —
Gross margin, % 100.00 100.00 100.00 100.00 100.00 100.00 100.00 100.00 100.00 —
EBT (21) (40) (48) (51) (59) (61) (66) (61) (23) (1)
EBT margin, % (4,719.37) (1,652.09) (1,922.02) (2,309.94) (10,857.43) (3,452.74) (5,605.68) (1,817.24) (291,925.00) 0.00
Net income (21) (40) (48) (51) (59) (61) (66) (61) (23) (1)
Depreciation 1 2 1 1 3 3 2 1 0 —
Per share, $
Per share, $ Revenue 4.22 5.45 1.58 1.10 0.23 0.48 0.25 0.52 0.00 0.00
Earnings (199.34) (89.95) (30.43) (25.49) (24.74) (16.34) (13.79) (8.81) (1.92) (0.08)
Cash flow (194.18) (69.23) (26.66) (37.36) (16.55) (14.14) (11.90) (7.94) (2.60) (0.35)
Capex (17.44) (5.72) (3.55) (0.62) (0.17) (0.18) (0.15) (0.03) 0.11 0.01
Free cash flow (211.62) (74.95) (30.21) (37.98) (16.71) (14.33) (12.05) (7.97) (2.49) (0.34)
Book value 128.48 189.56 77.90 77.68 48.17 39.90 17.28 5.04 1.05 0.96
Shares, m 0 0 2 2 2 4 5 7 12 12
Valuation, ×
Valuation, × P/E 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 —
P/S 0.00 29.74 66.47 35.15 43.61 76.38 45.10 8.62 5.33 —
P/B 0.00 0.85 1.35 0.50 0.67 0.91 0.64 0.89 1.34 —
EV/Sales 0.00 (5.68) 17.85 (18.61) (1.53) 3.08 (20.68) (5.54) (0.56) —
EV/FCF (0.25) 0.41 (0.93) 0.54 0.07 (0.10) 0.42 0.36 0.06 —
Cash, $m
Cash, $m Operating cash flow (20) (31) (42) (75) (40) (52) (57) (52) (32) (4)
Capex (2) (3) (6) (1) 0 (1) (1) 0 1 0
Free cash flow (22) (34) (48) (77) (40) (53) (58) (52) (30) (4)
Balance, $m
Balance, $m Working capital 12 80 116 124 99 123 68 20 13 12
Total debt 0 0 0 0 20 0 0 — — —
Net debt (14) (87) (123) (120) (80) (129) (78) (48) (19) (15)
Shareholders’ equity 14 85 124 157 115 147 83 33 13 12
Returns, %
Returns, % ROA (37.77) (67.44) (40.36) (31.24) (35.60) (38.02) (46.32) (65.74) (48.98) (5.70)
ROIC 0.00 0.00 (2,027.79) (91.08) (108.09) (203.14) (845.27) 0.00 0.00 0.00
ROE (77.09) (148.49) (46.32) (36.56) (43.50) (46.16) (57.55) (106.21) (102.63) (8.17)
Negative figures in brackets.

All 10 years →

Fiscal years to Dec 2024 · latest quarter Mar 2024

Charts ten years each

Synlogic, Inc. vs peers in Biotechnology (Q) = latest quarter vs a year earlier

Company Market cap P/E Fwd P/E Revenue growth (Q) EPS growth (Q) FCF growth (Q) Gross margin (Q) EBIT margin (Q) Compare
SKYE Skye Bioscience, Inc. $7.0M — (loss-making) — −34.71% (below 0%: shrinking) n/m +34.84% (above 0%: growing) 72.71% 0.00% Compare
BCLI Brainstorm Cell Therapeutics Inc. $7.0M — (loss-making) — — n/m +74.44% (above 0%: growing) 0.00% 0.00% Compare
CLGN CollPlant Biotechnologies Ltd. Sponsored ADR $7.0M — (loss-making) — (loss-making) −39.66% (below 0%: shrinking) n/m +5.08% (above 0%: growing) (422.22%) (2,437.96%) Compare
NIKI Niki BioSolutions, Inc. $6.9M — (loss-making) 31.9× −32.36% (below 0%: shrinking) +69.51% (above 0%: growing) +58.14% (above 0%: growing) (154.22%) 0.00% Compare
AIM AIM ImmunoTech Inc. $6.8M — (loss-making) — (loss-making) +4.00% (above 0%: growing) n/m −167.46% (below 0%: shrinking) 80.77% (13,511.54%) Compare
SYBX Synlogic, Inc. $6.7M — (loss-making) — (loss-making) −95.40% (below 0%: shrinking) n/m −277.87% (below 0%: shrinking) 100.00% 0.00%
FBLG FibroBiologics Inc. $6.7M — (loss-making) — — n/m +21.59% (above 0%: growing) — 0.00% Compare
ACXP Acurx Pharmaceuticals, Inc. $6.5M — (loss-making) — — n/m −2.36% (below 0%: shrinking) — 0.00% Compare
TCRT Alaunos Therapeutics, Inc. $6.4M — (loss-making) — (loss-making) +200.00% (above 0%: growing) n/m +57.20% (above 0%: growing) 100.00% 0.00% Compare
Median of peers $6.9M — — −32.36% — +28.22% 36.36% 0.00%

All 614 Biotechnology stocks →

Synlogic, Inc. (SYBX) key facts

  • Concern: Synlogic, Inc.’s revenue for fiscal 2024 (year ended December 2024) was $8,000.00, down 99.8% from fiscal 2023.
  • Synlogic, Inc. (SYBX) is a Biotechnology company in the Healthcare sector.
  • As of October 16, 2026, SYBX traded at $1.00, a market capitalization of $6.7 million.
  • Return on equity was −8.17% and debt-to-equity 0.00.
  • Its Piotroski F-score is 3 out of 9 and its Altman Z-score is −35.79 (distress zone) for fiscal 2024.

Source: company filings (standardised) and stockrow calculations.

Synlogic, Inc. (SYBX) Latest News

30 Jul

Impact 5 ·

29 Jul

Impact 5 ·
stockrow.com/SYBX · Data as of Mar 31, 2024 · For information only; not investment advice. · © 2026 stockrow.com