Septerna, Inc.

SEPN Healthcare Biotechnology

Septerna, Inc.’s revenue for fiscal 2025 (year ended December 2025) was $46.0 million, up 4,174.5% from fiscal 2024. In the quarter to June 2026, revenue grew 22,375.6%, EPS grew 48.2% and free cash flow fell 9.01%, each against the same quarter a year earlier.

36.05 1.40 −3.74%
Market cap
$1.8B
P/E
0.0×
Fwd P/E
−17.5×
Dividend yield
—
F-score
5/9
Altman Z
3.41
Beneish M
32.85
Dividend safety
n/a
Dec '23 Dec '24 Dec '25
Piotroski F-Score
— — 5
P/E ratio
0.00 0.00 0.00
Altman Z-Score
— 3.68 3.41
P/S ratio
58.37 210.70 26.85
Altman Z″-Score (non-manufacturers)
4.01 14.99 3.75
P/FCF ratio
0.00 0.00 10.10
Beneish M-Score
— 2.67 32.85
P/Operating CF
(3.11) (10.81) (82.33)
P/B ratio
0.00 0.54 3.23
EV/Sales
(87.31) (115.74) 18.34
EV/EBITDA
1.17 1.57 0.00
EV/FCF
2.21 2.65 6.90
Current Ratio
16.30 27.77 4.73
Net Debt/EBITDA
(30.27) 4.42 5.86
Debt/Equity
0.00 0.00 0.00
ROE
0.00% (37.62%) (12.19%)
ROA
0.00% (24.45%) (9.29%)
ROIC
0.00% (73.08%) 0.00%
Return on Tangible Assets
0.51% (20.57%) (14.88%)
Average Days of Receivables
55,054.57 58.06 82.26
Earnings Yield
(127.24%) (97.90%) (3.98%)
Free Cash Flow Yield
(67.71%) (20.73%) 9.90%
Free Cash Flow per Share
(8.61) (4.75) 2.76
Book value per Share
(19.89) 42.47 8.63
Free Cash Flow
(16.60) (46.95) 122.17
EV/EBIT
1.15 1.54 0.00
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Columns are period end dates