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PolyPid Ltd. PYPD

We limit data available in the Overview Report for users who do not have Powerpack

Get access to target analyst prices, predictions, compound annual growth rates and more than four years of historical data.

Insider Decisions

in millions of $
Nov 25 Feb 26 May 26 Aug 26
Buy
Sell
Insider Ownership
67.62%

Capital & Financial Ratios

Market Cap
101.56
Revenue
Net Income
(31.50)
Free Cash Flow
(76.90)
Net Debt
(6.77)
Current Ratio
1.35
Debt/Equity
0.00
P/E ratio
0.00
P/S ratio
0.00
P/B ratio
21.89
Past 5Y EPS Growth
(37.40%)
This Y EPS Growth
19.86%
Next Y EPS Growth
26.68%
Next 5Y EPS Growth
41.71%
in millions of $

Dividends

Payout Ratio
0.00
Annual Dividend Rate
Annual Dividend Yield
total individual payouts
2023 ‡‡‡
2022 ‡‡‡
2021 ‡‡‡
2019 ‡‡‡
predictions in italic, special payouts not included in total or ratios

Assets vs Liabilities

2023 2024 2025 Q'26
Cash 5.61 15.81 13.13 6.77
Receivables
Inventory
Other 1.11 1.36
6.07 16.57 15.23 8.89
2023 2024 2025 Q'26
Payables 0.77 2.41 2.86 1.66
ST’ Debt 4.00 6.79 0.99
Other
7.29 12.68 7.74 6.60
in millions of $

Compound Annual Growth

10y 5y 3y
Sales
Cash Flow ‡‡‡ ‡‡‡
Earnings ‡‡‡ ‡‡‡
Book Value ‡‡‡‡‡ ‡‡‡‡‡

Revenue

Year
in millions of $

Operating Cash Flow

Mar Jun Sep Dec Year
’26 (13.83)
’25 (12.71) (27.88)
(27.88)
’24 (8.49) (21.96)
(21.96)
’23 (8.28) (17.24)
(17.24)
’22 (20.34) (34.32)
(34.32)
’21 (13.55) (32.39)
(32.39)
’20 (4.69) (2.76) (21.60)
(21.60)
in millions of $

Free Cash Flow

Mar Jun Sep Dec Year
’26 (14.04)
’25 (12.73) (28.09)
(28.09)
’24 (8.51) (22.04)
(22.04)
’23 (8.48) (17.43)
(17.43)
’22 (21.53) (36.08)
(36.08)
’21 (13.94) (35.04)
(35.04)
’20 (5.16) (2.90) (22.38)
(22.38)
in millions of $

EPS

Mar Jun Sep Dec Year
’26 (0.35) (0.35)
’25 (0.70) (0.78) (0.37) (0.41)
(2.09)
’24 (1.37) (1.25) (1.22) (1.13)
(4.91)
’23 (8.41) (3.90) (3.40) (3.97)
(16.93)
’22 (18.92) (18.32) (14.41) (9.61)
(60.96)
’21 (14.11) (16.82) (15.92) (21.32)
(67.87)
’20 (0.59) (759.76) (10.51) (12.31)
(122.22)

Target Price Range

High
‡‡‡‡‡
‡‡‡‡
Average
‡‡‡‡‡
‡‡‡‡
Low
‡‡‡‡‡
‡‡‡

Recommendation Rating

1
1
Buy
2
3
Hold
4
5
Sell
2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 2026 2027 2028
‡‡‡‡‡ ‡‡‡‡‡ 19.50 3.57 2.37 2.30
Low Price
‡‡‡‡‡ ‡‡‡‡‡ 207.00 38.70 9.20 4.63
High Price
‡‡‡‡ ‡‡‡‡ ‡‡‡‡ 69 79 61 62
Employees
‡‡‡ ‡‡‡ ‡‡‡ 0.00 0.00 0.00 0.00
Revenue/Emp
‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡
Revenue
‡‡‡ ‡‡‡ ‡‡‡ ‡‡‡ ‡‡‡ ‡‡‡ 0.00%
Gross Margin
‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ (39.43) (23.80) (28.98) (34.16)
EBT
‡‡‡ ‡‡‡ ‡‡‡ ‡‡‡ ‡‡‡ ‡‡‡ 0.00% 0.00% 0.00% 0.00% ‡‡‡ ‡‡‡ ‡‡‡
EBT Margin
‡‡‡‡‡ ‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ (39.56) (23.86) (29.02) (34.17) ‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡
Net Income
‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ 1.72 1.82 1.62 1.46
Depreciation
‡‡‡ ‡‡‡ ‡‡‡ ‡‡‡ ‡‡‡ ‡‡‡ 0.00 0.00 0.00 0.00 ‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡
Revenue/Sh
‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡ ‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ (60.96) (16.99) (4.91) (2.09) ‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡
Earnings/Sh
‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ (52.99) (12.27) (3.71) (1.70)
Cash Flow/Sh
‡‡‡ ‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ (2.73) (0.14) (0.01) (0.01) ‡‡‡ ‡‡‡ ‡‡‡
Capex/Sh
‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ (55.72) (12.41) (3.73) (1.72)
Free CF/Sh
‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ 9.00 (1.49) 1.30 0.67
Book Value/Sh
‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ 0.65 1.40 5.91 16.35 ‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡
Shares
‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡
PE Ratio
‡‡‡ ‡‡‡ ‡‡‡
PS Ratio
‡‡‡ ‡‡‡ ‡‡‡
PB Ratio
‡‡‡‡ ‡‡‡‡ ‡‡‡‡
EV/Sales
EV/FCF
‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ (34.32) (17.24) (21.96) (27.88) ‡‡‡ ‡‡‡ ‡‡‡
Op' Cash Flow
‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ (1.77) (0.20) (0.08) (0.21)
Capex
‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ (36.08) (17.43) (22.04) (28.09)
FCF
‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ 5.64 (1.22) 3.89 7.49
Working Cap'
11.60 10.38 7.42 0.99
Total Debt
‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ (1.51) 4.77 (8.39) (12.14)
Net Debt
‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ 5.83 (2.10) 7.68 10.97
Sh' Equity
‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ (112.69%) (115.45%) (142.99%) (143.79%)
ROA
‡‡‡ ‡‡‡ ‡‡‡ ‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ (562.36%) (533.88%) 0.00% 0.00%
ROIC
‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ (189.32%) (1,278.60%) (1,038.73%) (366.29%)
ROE
predictions in italic, sparklines do not include predictions

Analyst Commentary (Summary)

PolyPid Ltd. (PYPD), an Israeli biotech pioneer in polymer-based drug delivery implants like PLEXZ for surgical pain and ONYX for infection prevention, embodies the rollercoaster of pre-revenue investing. Over the past decade, it’s battled heavy R&D cash burn, aggressive share dilution (up 123%), and a stock plunge of 98% from pandemic highs, mirroring many speculative biotechs. Cumulative losses top $200 million, but recent narrowing deficits—EBT improved 22% to -$29 million in 2024—and a healthier balance sheet with positive equity and slashed debt offer glimmers of stability.

Analysts forecast a game-changer: $23.4 million in revenue for 2025-2026 from PLEXZ’s U.S. launch, slashing losses by 69% initially and paving a path to breakeven, with price targets implying 100-220% upside from current levels. Insider silence adds caution, but improving metrics and a $12 million net cash runway fuel optimism amid a massive surgical market.

Yet risks loom large—execution delays, trial failures (90% Phase 3 odds), geopolitical tensions, and dilution history could derail progress. Like past winners such as Pacira, PolyPid teeters at an inflection point: transformative gains for patient investors, or more pain? Dive into the full analysis for the numbers and parallels that could make or break this high-stakes bet.

PolyPid Ltd. (PYPD) Latest News

News by impact score

Fine-tune

19 Aug

3 transcript www.fool.com, 11:27 AM
PolyPid Ltd. (PYPD) Q2 2026 earnings call transcript details the company's financial results, operational progress, and management commentary on future outlook. Quarterly earnings transcript reveals financial metrics and outlook that may shift near-term investor sentiment and valuation.

12 Aug

4 transcript , 7:03 PM
PolyPid Ltd's Q2 2026 earnings call highlighted FDA Priority Review and a $30M Azurity deal. FDA Priority Review and $30M Azurity deal accelerate approval path and add substantial funding for PolyPid.

3 transcript app.moby.co, 5:07 PM
PolyPid Ltd. held its Q2 2026 earnings call covering quarterly financial results, operational updates and forward-looking guidance. Earnings call details provide financial metrics and outlook that moderately affect near-term stock valuation and investor sentiment.

3 transcript www.marketbeat.com, 12:04 PM
PolyPid Ltd. presented Q2 earnings highlights covering financial results, clinical trial progress and cash position updates. Quarterly earnings data and pipeline updates can shift near-term investor views but rarely alter long-term company trajectory alone.

3 , 7:30 AM
PolyPid Ltd. issued a corporate update alongside its second quarter 2026 financial results. Quarterly financial results and corporate updates supply performance data that shape near-term valuation and sentiment.

29 Jul

4 , 8:30 AM
PolyPid Ltd. announced FDA acceptance of its NDA for D-PLEX₁₀₀ with Priority Review. FDA acceptance with priority review advances D-PLEX₁₀₀ toward potential accelerated approval and commercialization.

21 Jul

4 , 9:15 AM
Azurity will commercialize D-PLEX100 exclusively in the U.S. and Canada through a partnership with PolyPid. Exclusive North American commercialization rights for D-PLEX100 represent a major strategic expansion of PolyPid's market reach and revenue potential.

4 , 7:30 AM
PolyPid enters exclusive partnership with Azurity Pharmaceuticals to commercialize D-PLEX100 in the US and Canada. Exclusive North American commercialization deal for D-PLEX100 expands PolyPid market access and revenue potential substantially.

1 Jun

4 GlobeNewswire, 8:30 AM
PolyPid Ltd. completes New Drug Application submission to FDA for D-PLEX100. NDA submission for lead candidate D-PLEX100 marks major regulatory milestone that can significantly shift company trajectory and investor sentiment.

13 May

4 app.moby.co, 4:58 PM
PolyPid Ltd. (PYPD) Q1 2026 earnings call summary covers quarterly financial results, operational updates, and forward-looking guidance. Q1 2026 earnings summary details financial performance and strategic updates with potential to significantly sway investor sentiment and stock trajectory.

4 transcript www.fool.com, 3:01 PM
PolyPid Ltd. (PYPD) released its Q1 2026 earnings call transcript, detailing first-quarter financial results, operational updates, and management's outlook. Q1 2026 earnings transcript discloses financial performance, pipeline progress, and guidance that could significantly sway investor sentiment and stock trajectory.

4 transcript Benzinga, 9:24 AM
PolyPid Ltd. (PYPD) released the complete transcript of its Q1 2026 earnings call, detailing financial results, operational updates, and forward-looking statements. Q1 2026 earnings call transcript reveals financial performance, pipeline progress, and guidance that could significantly sway investor sentiment and stock trajectory.

4 GlobeNewswire, 7:30 AM
PolyPid Ltd. (PYPD) provided a corporate update and reported first quarter 2026 financial results. Quarterly financial results and corporate updates drive significant shifts in investor sentiment and stock trajectory.

3 GuruFocus.com, 7:01 PM
PolyPid Ltd. (PYPD) Q1 2026 earnings call highlights strategic advances amid financial challenges. Strategic advances signal moderate progress in key operations, tempered by financial challenges limiting broader trajectory shifts.

3 www.marketbeat.com, 2:09 PM
PolyPid Ltd. shared Q1 earnings call highlights covering financial results, clinical pipeline progress including D-PLEX updates, cash position, and upcoming milestones. Q1 earnings highlights detail financial performance and pipeline status with moderate potential to influence investor sentiment and short-term trajectory.

28 Apr

4 GlobeNewswire, 8:30 AM
PolyPid Ltd. (PYPD) will present data from its SHIELD II Phase 3 trial at the Surgical Infection Society 2026 Annual Meeting, demonstrating reduced severity of surgical site infections. Positive Phase 3 trial data on reduced surgical site infection severity could significantly advance regulatory approval prospects and enhance market valuation for PolyPid.

13 Apr

4 GlobeNewswire, 9:15 AM
PolyPid Ltd. (PYPD) will present new Phase 3 SHIELD II data at ESCMID Global 2026, demonstrating D-PLEX₁₀₀'s sustained local release. Presentation of new Phase 3 data on D-PLEX₁₀₀ at a major conference signals progress toward potential approval and enhances investor sentiment.

31 Mar

5 GlobeNewswire, 8:30 AM
PolyPid Ltd. initiates New Drug Application (NDA) submission for D-PLEX₁₀₀ to the U.S. FDA, advancing its lead product candidate for postoperative incisions toward potential approval. Initiating NDA submission for D-PLEX₁₀₀ to FDA is a transformative regulatory milestone poised to redefine PolyPid's competitive position and long-term commercial prospects.

17 Mar

3 GlobeNewswire, 8:30 AM
PolyPid Ltd. (PYPD) received a PDUFA fee waiver from the FDA for the New Drug Application of D-PLEX₁₀₀. PDUFA fee waiver saves PolyPid significant NDA submission costs, providing moderate financial relief and positive regulatory signal during approval process.

13 Feb

3 Simply Wall St., 5:24 AM
PolyPid Ltd. is facing challenges in achieving profitability as it navigates the complexities of the pharmaceutical market. The company is focused on advancing its product pipeline, particularly its lead candidate, D-PLEX100, which is aimed at preventing surgical site infections. Despite promising clinical results, the path to commercialization remains uncertain, with ongoing financial losses and the need for additional funding. Investors are keenly watching for updates on regulatory approvals and market strategies that could influence the company's future performance. The ongoing development of D-PLEX100 and the need for funding could moderately influence PolyPid's financial performance and market positioning.

12 Feb

3 app.moby.co, 8:30 AM
PolyPid Ltd. (PYPD) released Q4 2025 earnings call summary covering financial results, clinical updates, and strategic outlook. Q4 earnings call summary provides key financials and guidance likely to moderately influence investor sentiment and stock performance.

11 Feb

3 GuruFocus.comCoinMarketCapReuters VideosCoinDeskYahoo FinanceThe Daily Upside99bitcoinsThe Block, 4:03 PM
PolyPid Ltd. reported its Q4 2025 earnings, highlighting strategic advances in product development and ongoing financial challenges. The company is focusing on enhancing its pipeline and addressing market needs, while also navigating obstacles that could impact its growth trajectory. Investors are keenly observing these developments as they may influence future performance. Strategic advances and financial challenges are expected to moderately influence PolyPid's financial performance and competitive positioning.

3 transcript www.fool.com, 1:49 PM
PolyPid Ltd. reported its Q4 2025 earnings, highlighting key financial metrics and operational updates. The company discussed its ongoing projects, product pipeline, and strategic initiatives aimed at enhancing market presence. Management provided insights into revenue performance and future growth prospects, addressing investor questions regarding market challenges and competitive positioning. Financial performance and strategic initiatives may moderately influence the company's trajectory.

3 transcript www.marketbeat.com, 9:52 AM
PolyPid Ltd. reported its Q4 earnings, highlighting key financial metrics and strategic initiatives. The company discussed its product pipeline and ongoing clinical trials, emphasizing advancements in its lead product, D-PLEX100. Management provided insights into market opportunities and competitive positioning, while also addressing challenges faced during the quarter. Overall, the call underscored PolyPid's commitment to innovation and growth in the biopharmaceutical sector. The earnings call revealed important updates on product development and market strategy that could moderately influence PolyPid's financial performance.

3 GlobeNewswire, 7:30 AM
PolyPid Ltd. reported its fourth quarter and full-year 2025 financial results, providing a corporate update that highlights key developments and performance metrics. The company outlined its strategic initiatives and financial performance, indicating progress in its operational goals and future outlook. The financial results and corporate update suggest moderate influence on PolyPid's future performance and market sentiment.

28 Jan

3 GlobeNewswire, 8:00 AM
PolyPid Ltd. (PYPD) is scheduled to report its fourth quarter 2025 financial results and operational highlights on February 11, 2026. The announcement is expected to provide insights into the company's performance and strategic direction. The upcoming financial results may influence investor sentiment and provide insights into the company's operational performance.

16 Dec

4 GlobeNewswire, 8:30 AM
PolyPid Ltd. has appointed Brooke Story, a seasoned leader in the MedTech industry, as the new Chairman of the Board of Directors. Story brings extensive experience in the medical technology sector, having held various leadership roles in prominent companies. Her appointment is expected to enhance PolyPid's strategic direction and governance as the company continues to develop its innovative products. The appointment of a veteran leader like Brooke Story is likely to significantly influence PolyPid's strategic direction and governance.

3 Dec

4 GlobeNewswire, 8:30 AM
PolyPid Ltd. announced that it received positive feedback from the FDA regarding the pre-New Drug Application (NDA) meeting for D-PLEX100. The meeting minutes indicate that the FDA is supportive of the data presented, which strengthens the company's position for the upcoming NDA submission. This development is a significant step towards advancing D-PLEX100 in the regulatory process. Positive FDA feedback can significantly influence the company's trajectory and investor sentiment regarding D-PLEX100's market potential.

12 Nov

3 , 4:01 PM
PolyPid Ltd. reported its Q3 2025 earnings, highlighting strategic advances in product development alongside ongoing financial challenges. The company is focusing on enhancing its pipeline and addressing market needs, but it faces hurdles that may impact its growth trajectory. Investors are keenly observing these developments as they could influence future performance. Strategic advances and financial challenges may moderately influence PolyPid's financial performance and competitive positioning.

3 GlobeNewswire, 7:30 AM
PolyPid Ltd. provided a corporate update alongside its financial results for the third quarter of 2025, highlighting key developments and performance metrics. The company reported progress in its product pipeline and strategic initiatives aimed at enhancing market presence. Financial results indicated fluctuations in revenue and expenses, reflecting ongoing investments in research and development. PolyPid remains focused on advancing its innovative solutions in the healthcare sector, aiming to address unmet medical needs and improve patient outcomes. The financial results and corporate update indicate moderate changes in performance and strategy that could influence investor sentiment and operational focus.