Karyopharm Therapeutics Inc. KPTI

1.62 (0.11) (6.36%) as of 25 Sep
Market cap
$39.2M
P/E
0.0×

Insider Decisions

Total sells 0.25
in millions of $
Nov 25 Feb 26 May 26 Aug 26
Buy — — — — — — — — — — — —
Sell — — — 2 2 3 1 6 — 1 — 1
Insider Ownership 36.59%

Capital & Financial Ratios

Market Cap 39.24
Revenue 146.62
Net Income (224.74)
Free Cash Flow (65.35)
Net Debt 184.84
Current Ratio 0.79
Debt/Equity (0.76)
P/E ratio 0.00
P/S ratio 0.32
P/B ratio 0.00
Past 5Y EPS Growth 27.91%
This Y EPS Growth 72.99%
Next Y EPS Growth 53.13%
Next 5Y EPS Growth 60.92%
in millions of $

Dividends

Payout Ratio 0.00
Annual Dividend Rate —
Annual Dividend Yield —
total individual payouts
2023 Powerpack
2022 Powerpack
2021 Powerpack
2020 Powerpack
2019 Powerpack
2017 Powerpack
predictions in italic, special payouts not included in total or ratios

Assets vs Liabilities

2023 2024 2025 Q'26
Cash 192 109 64 65
Receivables 27 31 26 30
Inventory 3 5 4 4
Other — — — —
234 156 103 106
2023 2024 2025 Q'26
Payables 3 5 4 8
ST’ Debt — 24 21 40
Other 2 2 2 6
69 92 92 134
in millions of $

Compound Annual Growth

10y 5y 3y
Sales 89.09% 6.21% (2.39%)
Cash Flow 0.00% 0.00% 0.00%
Earnings 0.00% 0.00% 0.00%
Book Value 0.00% 0.00% 0.00%

Revenue

Mar Jun Sep Dec Year
’26 35 33 — — —
’25 30 38 44 34 146
’24 33 43 39 31 145
’23 39 38 36 34 146
’22 48 40 36 34 157
’21 23 23 38 126 210
’20 18 34 21 35 108
in millions of $ · fiscal quarters ending in the months shown

Operating Cash Flow

Mar Jun Sep Dec Year
’26 (23) (25) — — —
’25 (39) (19) (6) (12) (75)
’24 (44) (38) (19) (26) (127)
’23 (19) (26) (30) (19) (93)
’22 (59) (35) (28) (27) (150)
’21 (53) (56) (24) 25 (107)
’20 (45) (40) (44) (31) (160)
in millions of $ · fiscal quarters ending in the months shown

Free Cash Flow

Mar Jun Sep Dec Year
’26 (23) (25) — — —
’25 (39) (19) (6) (12) (75)
’24 (44) (38) (19) (26) (128)
’23 (19) (26) (30) (19) (93)
’22 (59) (35) (28) (27) (150)
’21 (53) (56) (24) 25 (107)
’20 (45) (40) (44) (31) (160)
in millions of $ · fiscal quarters ending in the months shown

EPS

Mar Jun Sep Dec Year
’26 (0.91) (2.32) — — —
’25 (2.77) (4.32) (3.82) (7.01) (17.93)
’24 (4.80) 2.31 (3.90) (3.60) (9.04)
’23 (4.50) (4.35) (4.50) (5.40) (18.74)
’22 (7.95) (9.30) (6.75) (6.45) (30.28)
’21 (11.54) (10.64) (10.34) 6.90 (24.74)
’20 (11.69) (9.45) (10.94) (8.85) (40.78)
fiscal quarters ending in the months shown

Target Price Range

Analyst price targets

Recommendation Rating

1.3
1Buy 2 3Hold 4 5Sell
2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 2026 2027 2028
72.45 112.20 120.15 58.80 200.85 66.30 36.75 9.26 8.72 3.51

Analyst estimates 2026–2028

Powerpack
Low Price
209.55 219.45 325.65 300.00 444.15 270.00 220.95 73.05 29.25 12.45
High Price
108 154 332 347 432 442 385 325 279 228
Employees
0 0 0 0 0 0 0 0 1 1
Revenue/Emp
0 2 30 41 108 210 157 146 145 146
Revenue
100.00% 100.00% 100.00% 94.11% 97.50% 98.38% 96.68% 96.62% 95.86% 95.93%
Gross Margin
(109) (129) (178) (200) (196) (124) (165) (143) (76) (196)
EBT
(71,063.64%) (8,032.46%) (588.02%) (487.98%) (181.31%) (59.01%) (105.00%) (97.77%) (52.58%) (134.18%)
EBT Margin
(110) (129) (178) (200) (196) (124) (165) (143) (76) (196)
Net Income
2 2 2 7 10 3 1 (3) 4 10
Depreciation
0.06 0.52 8.01 9.90 22.49 41.82 28.76 19.17 17.88 13.36
Revenue/Sh
(43.78) (42.13) (47.08) (48.28) (40.78) (24.74) (30.28) (18.74) (9.45) (17.93)
Earnings/Sh
(33.72) (24.08) (42.01) (46.18) (33.35) (21.35) (27.39) (12.17) (15.69) (6.89)
Cash Flow/Sh
(0.03) (0.02) (0.62) (0.05) (0.03) (0.04) (0.02) 0.00 (0.02) 0.00
Capex/Sh
(33.75) (24.10) (42.64) (46.23) (33.38) (21.39) (27.41) (12.17) (15.71) (6.89)
Free CF/Sh
64.82 42.29 48.37 12.04 10.52 (15.88) (3.05) (17.88) (22.89) (26.79)
Book Value/Sh
3 3 4 4 5 5 5 8 8 11
Shares
0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
PE Ratio
2,021.82 275.76 17.55 29.06 10.32 2.31 1.70 0.71 0.57 0.55
PS Ratio
2.23 3.52 2.91 23.87 22.07 0.00 0.00 0.00 0.00 0.00
PB Ratio
1,298.06 186.97 10.11 25.35 9.10 2.00 1.02 0.58 1.11 1.67
EV/Sales
(2.75) (4.19) (1.90) (5.43) (6.13) (3.91) (1.08) (0.92) (1.26) (3.23)
EV/FCF
(84) (74) (159) (191) (160) (107) (150) (93) (127) (75)
Op' Cash Flow
0 0 (2) 0 0 0 0 — 0 —
Capex
(84) (74) (161) (191) (160) (107) (150) (93) (128) (75)
FCF
115 99 288 232 216 202 284 164 64 11
Working Cap'
— — 103 112 120 172 173 171 187 227
Total Debt
(130) (147) (226) (152) (132) (63) (106) (21) 79 163
Net Debt
162 129 183 50 51 (80) (17) (136) (186) (293)
Sh' Equity
(55.37%) (71.52%) (68.42%) (62.75%) (64.56%) (40.13%) (49.83%) (47.81%) (37.75%) (143.71%)
ROA
(211.70%) 0.00% 0.00% 0.00% 0.00% 0.00% 0.00% 0.00% 0.00% 0.00%
ROIC
(60.77%) (88.43%) (114.13%) (171.36%) (391.29%) 852.05% 343.18% 187.23% 47.43% 81.86%
ROE
predictions in italic, sparklines do not include predictions

All 10 years →

Fiscal years to Dec 2025 · latest quarter Jun 2026

Karyopharm Therapeutics Inc. peers in Biotechnology

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Karyopharm Therapeutics Inc. (KPTI) key facts

  • Karyopharm Therapeutics Inc. (KPTI) is a Biotechnology company in the Healthcare sector, listed on Nasdaq.
  • Karyopharm Therapeutics Inc.’s revenue for fiscal 2025 (year ended December 2025) was $146.1 million, up 0.57% from fiscal 2024.
  • As of September 25, 2026, KPTI traded at $1.62, a market capitalization of $39.2 million.
  • Return on equity was 81.9% and debt-to-equity -0.76.

Source: company filings (standardised) and stockrow calculations.

Karyopharm Therapeutics Inc. (KPTI) Latest News

News by impact score

Fine-tune

10 Sep

4

Phase III myelofibrosis results open new commercial opportunities for selinexor, driving market growth and sales forecasts through 2034 for Karyopharm Therapeutics. Positive Phase III myelofibrosis data directly expands selinexor addressable market and revenue trajectory.

4 Sep

3

Karyopharm Therapeutics stock fair value fell after analysts issued split opinions on recent trial updates. Analyst revisions on trial data can move near-term valuation and sentiment for the company.

31 Aug

4

Karyopharm submits supplemental new drug application to FDA for XPOVIO plus ruxolitinib to treat myelofibrosis patients. sNDA submission for XPOVIO plus ruxolitinib advances pipeline toward potential approval and market expansion.

21 Aug

4

Karyopharm Therapeutics faces mounting pressure on its lead cancer drug candidate as critical deadlines approach, threatening development timelines and commercialization prospects. Approaching deadlines directly threaten Karyopharm's primary cancer asset and could materially shift its competitive and financial trajectory.

20 Aug

3 transcript

Karyopharm Therapeutics Inc. released its Q2 2026 earnings call transcript detailing financial results, operational updates, and future outlook. Earnings transcripts deliver financial metrics and guidance that typically produce moderate short-term effects on stock price and sentiment.

14 Aug

3 transcript

Karyopharm Therapeutics Inc. held its Q2 2026 earnings call covering financial results, operational updates, and forward guidance. Quarterly earnings call provides financial metrics and outlook that can moderately shift near-term stock sentiment and valuation.

13 Aug

4 transcript

Karyopharm Therapeutics Inc. Q2 2026 earnings call highlighted success in the SENTRY Trial. SENTRY Trial success marks a major strategic advance that can shift company trajectory and investor sentiment.

4

Karyopharm Therapeutics reported second quarter 2026 financial results and highlighted continued progress toward myelofibrosis sNDA submission. Quarterly results paired with sNDA advancement signal major strategic and regulatory developments likely to shift company trajectory.

31 Jul

4

Karyopharm Therapeutics' XPORT-EC-042 study failed to meet its primary endpoint. XPORT-EC-042 study failure represents a major setback for Karyopharm's clinical pipeline and market position.

30 Jul

4

Karyopharm Therapeutics Inc. (KPTI) stock plunged 69% in after-hours trading on negative developments affecting its operations and outlook. 69% after-hours plunge reflects major adverse events with strong potential to alter company trajectory and investor sentiment.

4

Karyopharm Therapeutics plans to submit an sNDA for selinexor plus ruxolitinib in myelofibrosis under the accelerated approval pathway. sNDA filing plan for selinexor-ruxolitinib in myelofibrosis positions the company for potential accelerated approval and expanded revenue.

4

Karyopharm Therapeutics Inc. announced topline results from its Phase 3 XPORT-EC-042 trial in endometrial cancer. Phase 3 trial topline results directly determine regulatory path and commercial prospects for Karyopharm's lead endometrial cancer candidate.

25 Jun

3

Karyopharm Therapeutics (KPTI) stock sees split analyst revisions after Phase 3 trial update. Phase 3 trial update triggers split revisions likely producing moderate effects on performance and sentiment.

14 Jun

4

Menarini Group presented Phase 3 SENTRY trial data on selinexor plus ruxolitinib in myelofibrosis at the EHA 2026 Congress. Phase 3 selinexor combination data in myelofibrosis advances a major new indication with direct revenue and pipeline implications for KPTI.

4

Menarini Group presented Phase 3 SENTRY trial data showing selinexor plus ruxolitinib efficacy in myelofibrosis at EHA 2026 Congress. Phase 3 data readout for selinexor combination directly advances Karyopharm's lead asset toward potential regulatory and commercial milestones.

4

Menarini Group presented Phase 3 SENTRY trial results for selinexor plus ruxolitinib in myelofibrosis at the EHA 2026 Congress. Phase 3 data readout for selinexor in myelofibrosis can materially expand addressable market and drive KPTI valuation via Menarini partnership.

7 Jun

3

Karyopharm Therapeutics (KPTI) investment narrative continues to shift amid ongoing developments in its business and market positioning. Evolving investment story may moderately affect market sentiment and company trajectory.

2 Jun

4

Karyopharm Therapeutics will present Phase 3 SENTRY trial results for selinexor plus ruxolitinib in myelofibrosis as a late-breaking oral at ASCO 2026, with simultaneous publication in the Journal of Clinical Oncology. Phase 3 trial data presentation at ASCO directly affects Karyopharm's clinical credibility, potential approvals, and investor valuation.

3

Karyopharm's Phase 3 SENTRY Trial of Selinexor Plus Ruxolitinib in Myelofibrosis selected for late-breaking oral presentation at EHA 2026. Trial presentation selection provides moderate visibility boost for Karyopharm's key pipeline asset.

26 May

4

Karyopharm Therapeutics highlights Selinexor milestones, ASCO data, and cancer trial readouts. Selinexor milestones and cancer trial data readouts signal major strategic and clinical developments likely to shift company trajectory.

4

Karyopharm Therapeutics teases upcoming ASCO SENTRY trial data as its FDA approval pathway clarifies. SENTRY data tease plus clarifying FDA path signals potential pivotal regulatory and clinical progress for KPTI.

25 May

3

Menarini Group will present new clinical data at the ASCO 2026 Annual Meeting involving Karyopharm Therapeutics Inc. (KPTI) assets under their existing partnership. New ASCO data on partnered assets may moderately affect KPTI sentiment and pipeline visibility without immediate financial or regulatory shifts.

14 May

4

Karyopharm Therapeutics Inc. (KPTI) highlighted strong revenue growth in its Q1 2026 earnings call. Strong revenue growth indicates significant positive impact on financial performance and investor sentiment.

4

Karyopharm Therapeutics Inc. (KPTI) reported first quarter 2026 financial results and completed enrollment in its Phase 3 endometrial cancer trial. Phase 3 trial enrollment completion advances potential approval of endometrial cancer treatment, significantly boosting KPTI's pipeline and market prospects.

3

Karyopharm Therapeutics Inc. (KPTI) released Q1 2026 earnings call summary highlighting quarterly financial results, operational updates, and future outlook. Quarterly earnings summaries provide insights into financial health and guidance, moderately influencing stock performance and investor sentiment.

3

Karyopharm Therapeutics Inc. (KPTI) released Q1 earnings call highlights, detailing financial results, pipeline updates on oncology drugs like selinexor, clinical trial progress, revenue figures, cash position, and future guidance amid competitive biotech landscape. Q1 earnings highlights reveal financial health and pipeline status, moderately influencing investor sentiment and short-term stock performance.

3

Menarini Group announces presentation of new data at the 2026 American Society of Clinical Oncology (ASCO) Annual Meeting, relevant to Karyopharm Therapeutics Inc. (KPTI) partnered product. Partner Menarini's new data presentation at ASCO 2026 offers moderate validation for KPTI's selinexor, potentially boosting short-to-medium term market sentiment.

21 Apr

4

Karyopharm Therapeutics Inc. (KPTI) announced its Phase 3 SENTRY trial in myelofibrosis selected for late-breaking oral presentation at ASCO 2026 Annual Meeting. Phase 3 trial selection for prestigious ASCO late-breaking oral presentation signals strong data likely boosting KPTI stock and regulatory prospects.

25 Mar

4

Karyopharm Therapeutics Inc. (KPTI) shares declined after mixed results from a Phase III combination study in myelofibrosis patients. Mixed Phase III data signals potential regulatory hurdles and pipeline setbacks for KPTI's myelofibrosis therapy, significantly impacting investor sentiment and future performance.

24 Mar

4

Karyopharm Therapeutics Inc. (KPTI) reported positive topline results from the Phase 3 SENTRY trial of selinexor in myelofibrosis, achieving the primary endpoint of spleen volume reduction and showing an early overall survival signal versus standard of care. Phase 3 trial success in myelofibrosis with primary endpoint met and survival signal positions selinexor for potential approval and significantly enhances KPTI's pipeline value.

stockrow.com/KPTI · Data as of Jun 30, 2026 · For information only; not investment advice. · © 2026 stockrow.com