Karyopharm Therapeutics Inc. KPTI
- Market cap
- $39.2M
- P/E
- 0.0×
Follow KPTI
Target Price Range
Analyst price targets
Free account| 2016 | 2017 | 2018 | 2019 | 2020 | 2021 | 2022 | 2023 | 2024 | 2025 | 2026 | 2027 | 2028 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 72.45 | 112.20 | 120.15 | 58.80 | 200.85 | 66.30 | 36.75 | 9.26 | 8.72 | 3.51 |
Analyst estimates 2026–2028 Powerpack |
Low Price
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| 209.55 | 219.45 | 325.65 | 300.00 | 444.15 | 270.00 | 220.95 | 73.05 | 29.25 | 12.45 |
High Price
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| 108 | 154 | 332 | 347 | 432 | 442 | 385 | 325 | 279 | 228 |
Employees
|
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| 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Revenue/Emp
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| 0 | 2 | 30 | 41 | 108 | 210 | 157 | 146 | 145 | 146 |
Revenue
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| 100.00% | 100.00% | 100.00% | 94.11% | 97.50% | 98.38% | 96.68% | 96.62% | 95.86% | 95.93% |
Gross Margin
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| (109) | (129) | (178) | (200) | (196) | (124) | (165) | (143) | (76) | (196) |
EBT
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| (71,063.64%) | (8,032.46%) | (588.02%) | (487.98%) | (181.31%) | (59.01%) | (105.00%) | (97.77%) | (52.58%) | (134.18%) |
EBT Margin
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| (110) | (129) | (178) | (200) | (196) | (124) | (165) | (143) | (76) | (196) |
Net Income
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| 2 | 2 | 2 | 7 | 10 | 3 | 1 | (3) | 4 | 10 |
Depreciation
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| 0.06 | 0.52 | 8.01 | 9.90 | 22.49 | 41.82 | 28.76 | 19.17 | 17.88 | 13.36 |
Revenue/Sh
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| (43.78) | (42.13) | (47.08) | (48.28) | (40.78) | (24.74) | (30.28) | (18.74) | (9.45) | (17.93) |
Earnings/Sh
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| (33.72) | (24.08) | (42.01) | (46.18) | (33.35) | (21.35) | (27.39) | (12.17) | (15.69) | (6.89) |
Cash Flow/Sh
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| (0.03) | (0.02) | (0.62) | (0.05) | (0.03) | (0.04) | (0.02) | 0.00 | (0.02) | 0.00 |
Capex/Sh
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| (33.75) | (24.10) | (42.64) | (46.23) | (33.38) | (21.39) | (27.41) | (12.17) | (15.71) | (6.89) |
Free CF/Sh
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| 64.82 | 42.29 | 48.37 | 12.04 | 10.52 | (15.88) | (3.05) | (17.88) | (22.89) | (26.79) |
Book Value/Sh
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| 3 | 3 | 4 | 4 | 5 | 5 | 5 | 8 | 8 | 11 |
Shares
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| 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
PE Ratio
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| 2,021.82 | 275.76 | 17.55 | 29.06 | 10.32 | 2.31 | 1.70 | 0.71 | 0.57 | 0.55 |
PS Ratio
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| 2.23 | 3.52 | 2.91 | 23.87 | 22.07 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
PB Ratio
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| 1,298.06 | 186.97 | 10.11 | 25.35 | 9.10 | 2.00 | 1.02 | 0.58 | 1.11 | 1.67 |
EV/Sales
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| (2.75) | (4.19) | (1.90) | (5.43) | (6.13) | (3.91) | (1.08) | (0.92) | (1.26) | (3.23) |
EV/FCF
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| (84) | (74) | (159) | (191) | (160) | (107) | (150) | (93) | (127) | (75) |
Op' Cash Flow
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| 0 | 0 | (2) | 0 | 0 | 0 | 0 | — | 0 | — |
Capex
|
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| (84) | (74) | (161) | (191) | (160) | (107) | (150) | (93) | (128) | (75) |
FCF
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| 115 | 99 | 288 | 232 | 216 | 202 | 284 | 164 | 64 | 11 |
Working Cap'
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| — | — | 103 | 112 | 120 | 172 | 173 | 171 | 187 | 227 |
Total Debt
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| (130) | (147) | (226) | (152) | (132) | (63) | (106) | (21) | 79 | 163 |
Net Debt
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| 162 | 129 | 183 | 50 | 51 | (80) | (17) | (136) | (186) | (293) |
Sh' Equity
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| (55.37%) | (71.52%) | (68.42%) | (62.75%) | (64.56%) | (40.13%) | (49.83%) | (47.81%) | (37.75%) | (143.71%) |
ROA
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| (211.70%) | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% |
ROIC
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| (60.77%) | (88.43%) | (114.13%) | (171.36%) | (391.29%) | 852.05% | 343.18% | 187.23% | 47.43% | 81.86% |
ROE
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Karyopharm Therapeutics Inc. peers in Biotechnology
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|---|---|---|---|
| IMMP Prima BioMed Ltd | $38.5M | 0.0× | Compare |
| CELU Celularity, Inc. | $38.2M | 0.0× | Compare |
| CRVO CervoMed Inc. | $38.1M | 0.0× | Compare |
| NNVC NanoViricides, Inc. | $38.0M | 0.0× | Compare |
| Company | Market cap | P/E | Compare |
|---|---|---|---|
| FLNA Cassava Sciences, Inc. | $37.8M | 0.0× | Compare |
| ATNM Actinium Pharmaceuticals, Inc. | $37.4M | 3.3× | Compare |
| BCTX BRIACELL THERAP | $37.2M | 1.9× | Compare |
| LBPS 4D pharma PLC Sponsored ADR | $37.2M | 0.0× | Compare |
Karyopharm Therapeutics Inc. (KPTI) key facts
- Karyopharm Therapeutics Inc. (KPTI) is a Biotechnology company in the Healthcare sector, listed on Nasdaq.
- Karyopharm Therapeutics Inc.’s revenue for fiscal 2025 (year ended December 2025) was $146.1 million, up 0.57% from fiscal 2024.
- As of September 25, 2026, KPTI traded at $1.62, a market capitalization of $39.2 million.
- Return on equity was 81.9% and debt-to-equity -0.76.
Karyopharm Therapeutics Inc. (KPTI) Latest News
10 Sep
Phase III myelofibrosis results open new commercial opportunities for selinexor, driving market growth and sales forecasts through 2034 for Karyopharm Therapeutics. Positive Phase III myelofibrosis data directly expands selinexor addressable market and revenue trajectory.
4 Sep
Karyopharm Therapeutics stock fair value fell after analysts issued split opinions on recent trial updates. Analyst revisions on trial data can move near-term valuation and sentiment for the company.
31 Aug
Karyopharm submits supplemental new drug application to FDA for XPOVIO plus ruxolitinib to treat myelofibrosis patients. sNDA submission for XPOVIO plus ruxolitinib advances pipeline toward potential approval and market expansion.
21 Aug
Karyopharm Therapeutics faces mounting pressure on its lead cancer drug candidate as critical deadlines approach, threatening development timelines and commercialization prospects. Approaching deadlines directly threaten Karyopharm's primary cancer asset and could materially shift its competitive and financial trajectory.
20 Aug
Karyopharm Therapeutics Inc. released its Q2 2026 earnings call transcript detailing financial results, operational updates, and future outlook. Earnings transcripts deliver financial metrics and guidance that typically produce moderate short-term effects on stock price and sentiment.
14 Aug
Karyopharm Therapeutics Inc. held its Q2 2026 earnings call covering financial results, operational updates, and forward guidance. Quarterly earnings call provides financial metrics and outlook that can moderately shift near-term stock sentiment and valuation.
13 Aug
Karyopharm Therapeutics Inc. Q2 2026 earnings call highlighted success in the SENTRY Trial. SENTRY Trial success marks a major strategic advance that can shift company trajectory and investor sentiment.
Karyopharm Therapeutics reported second quarter 2026 financial results and highlighted continued progress toward myelofibrosis sNDA submission. Quarterly results paired with sNDA advancement signal major strategic and regulatory developments likely to shift company trajectory.
31 Jul
Karyopharm Therapeutics' XPORT-EC-042 study failed to meet its primary endpoint. XPORT-EC-042 study failure represents a major setback for Karyopharm's clinical pipeline and market position.
30 Jul
Karyopharm Therapeutics Inc. (KPTI) stock plunged 69% in after-hours trading on negative developments affecting its operations and outlook. 69% after-hours plunge reflects major adverse events with strong potential to alter company trajectory and investor sentiment.
Karyopharm Therapeutics plans to submit an sNDA for selinexor plus ruxolitinib in myelofibrosis under the accelerated approval pathway. sNDA filing plan for selinexor-ruxolitinib in myelofibrosis positions the company for potential accelerated approval and expanded revenue.
Karyopharm Therapeutics Inc. announced topline results from its Phase 3 XPORT-EC-042 trial in endometrial cancer. Phase 3 trial topline results directly determine regulatory path and commercial prospects for Karyopharm's lead endometrial cancer candidate.
25 Jun
Karyopharm Therapeutics (KPTI) stock sees split analyst revisions after Phase 3 trial update. Phase 3 trial update triggers split revisions likely producing moderate effects on performance and sentiment.
14 Jun
Menarini Group presented Phase 3 SENTRY trial data on selinexor plus ruxolitinib in myelofibrosis at the EHA 2026 Congress. Phase 3 selinexor combination data in myelofibrosis advances a major new indication with direct revenue and pipeline implications for KPTI.
Menarini Group presented Phase 3 SENTRY trial data showing selinexor plus ruxolitinib efficacy in myelofibrosis at EHA 2026 Congress. Phase 3 data readout for selinexor combination directly advances Karyopharm's lead asset toward potential regulatory and commercial milestones.
Menarini Group presented Phase 3 SENTRY trial results for selinexor plus ruxolitinib in myelofibrosis at the EHA 2026 Congress. Phase 3 data readout for selinexor in myelofibrosis can materially expand addressable market and drive KPTI valuation via Menarini partnership.
7 Jun
Karyopharm Therapeutics (KPTI) investment narrative continues to shift amid ongoing developments in its business and market positioning. Evolving investment story may moderately affect market sentiment and company trajectory.
2 Jun
Karyopharm Therapeutics will present Phase 3 SENTRY trial results for selinexor plus ruxolitinib in myelofibrosis as a late-breaking oral at ASCO 2026, with simultaneous publication in the Journal of Clinical Oncology. Phase 3 trial data presentation at ASCO directly affects Karyopharm's clinical credibility, potential approvals, and investor valuation.
Karyopharm's Phase 3 SENTRY Trial of Selinexor Plus Ruxolitinib in Myelofibrosis selected for late-breaking oral presentation at EHA 2026. Trial presentation selection provides moderate visibility boost for Karyopharm's key pipeline asset.
26 May
Karyopharm Therapeutics highlights Selinexor milestones, ASCO data, and cancer trial readouts. Selinexor milestones and cancer trial data readouts signal major strategic and clinical developments likely to shift company trajectory.
Karyopharm Therapeutics teases upcoming ASCO SENTRY trial data as its FDA approval pathway clarifies. SENTRY data tease plus clarifying FDA path signals potential pivotal regulatory and clinical progress for KPTI.
25 May
Menarini Group will present new clinical data at the ASCO 2026 Annual Meeting involving Karyopharm Therapeutics Inc. (KPTI) assets under their existing partnership. New ASCO data on partnered assets may moderately affect KPTI sentiment and pipeline visibility without immediate financial or regulatory shifts.
14 May
Karyopharm Therapeutics Inc. (KPTI) highlighted strong revenue growth in its Q1 2026 earnings call. Strong revenue growth indicates significant positive impact on financial performance and investor sentiment.
Karyopharm Therapeutics Inc. (KPTI) reported first quarter 2026 financial results and completed enrollment in its Phase 3 endometrial cancer trial. Phase 3 trial enrollment completion advances potential approval of endometrial cancer treatment, significantly boosting KPTI's pipeline and market prospects.
Karyopharm Therapeutics Inc. (KPTI) released Q1 2026 earnings call summary highlighting quarterly financial results, operational updates, and future outlook. Quarterly earnings summaries provide insights into financial health and guidance, moderately influencing stock performance and investor sentiment.
Karyopharm Therapeutics Inc. (KPTI) released Q1 earnings call highlights, detailing financial results, pipeline updates on oncology drugs like selinexor, clinical trial progress, revenue figures, cash position, and future guidance amid competitive biotech landscape. Q1 earnings highlights reveal financial health and pipeline status, moderately influencing investor sentiment and short-term stock performance.
Menarini Group announces presentation of new data at the 2026 American Society of Clinical Oncology (ASCO) Annual Meeting, relevant to Karyopharm Therapeutics Inc. (KPTI) partnered product. Partner Menarini's new data presentation at ASCO 2026 offers moderate validation for KPTI's selinexor, potentially boosting short-to-medium term market sentiment.
21 Apr
Karyopharm Therapeutics Inc. (KPTI) announced its Phase 3 SENTRY trial in myelofibrosis selected for late-breaking oral presentation at ASCO 2026 Annual Meeting. Phase 3 trial selection for prestigious ASCO late-breaking oral presentation signals strong data likely boosting KPTI stock and regulatory prospects.
25 Mar
Karyopharm Therapeutics Inc. (KPTI) shares declined after mixed results from a Phase III combination study in myelofibrosis patients. Mixed Phase III data signals potential regulatory hurdles and pipeline setbacks for KPTI's myelofibrosis therapy, significantly impacting investor sentiment and future performance.
24 Mar
Karyopharm Therapeutics Inc. (KPTI) reported positive topline results from the Phase 3 SENTRY trial of selinexor in myelofibrosis, achieving the primary endpoint of spleen volume reduction and showing an early overall survival signal versus standard of care. Phase 3 trial success in myelofibrosis with primary endpoint met and survival signal positions selinexor for potential approval and significantly enhances KPTI's pipeline value.