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Werewolf Therapeutics, Inc. HOWL

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Get access to target analyst prices, predictions, compound annual growth rates and more than four years of historical data.

Insider Decisions

Total sells
8.67
in millions of $
Nov 25 Feb 26 May 26 Aug 26
Buy
Sell 6 18 8 4 2 7 7 1
Insider Ownership
12.63%

Capital & Financial Ratios

Market Cap
45.44
Revenue
24.39
Net Income
(34.61)
Free Cash Flow
(29.87)
Net Debt
(21.99)
Current Ratio
2.91
Debt/Equity
0.00
P/E ratio
0.00
P/S ratio
1.93
P/B ratio
2.89
Past 5Y EPS Growth
(20.76%)
This Y EPS Growth
33.08%
Next Y EPS Growth
33.71%
Next 5Y EPS Growth
0.72%
in millions of $

Dividends

Payout Ratio
0.00
Annual Dividend Rate
Annual Dividend Yield
total individual payouts
2025 ‡‡‡
2024 ‡‡‡
2023 ‡‡‡
2022 ‡‡‡
2021 ‡‡‡
2020 ‡‡‡
2019 ‡‡‡
predictions in italic, special payouts not included in total or ratios

Assets vs Liabilities

2023 2024 2025 Q'26
Cash 134.34 111.00 57.05 21.99
Receivables 1.35
Inventory
Other
138.37 113.07 58.59 22.89
2023 2024 2025 Q'26
Payables 1.34 3.04 0.75 1.94
ST’ Debt
Other
19.38 15.18 36.15 7.86
in millions of $

Compound Annual Growth

10y 5y 3y
Sales
Cash Flow ‡‡‡ ‡‡‡
Earnings ‡‡‡ ‡‡‡
Book Value ‡‡‡ ‡‡‡‡‡

Revenue

Mar Jun Sep Dec Year
’26 21.00
’24 0.74 1.14
1.89
’23 4.46 8.08 5.90 1.50
19.94
in millions of $

Operating Cash Flow

Mar Jun Sep Dec Year
’26 (10.60) 6.63
’25 (18.95) (15.16) (15.16) (11.02)
(60.29)
’24 (15.30) (14.18) (12.46) (14.25)
(56.19)
’23 (9.90) (10.92) (7.21) (4.58)
(32.61)
’22 (13.95) (0.30) (14.47) (11.87)
(40.60)
’21 (7.33) (10.46) (12.42) (12.67)
(42.88)
’20 (3.40) (4.29) (4.92) (6.01)
(18.62)
in millions of $

Free Cash Flow

Mar Jun Sep Dec Year
’26 (10.60) 7.05
’25 (18.95) (15.16) (15.16) (11.02)
(60.29)
’24 (15.41) (14.19) (12.46) (14.37)
(56.44)
’23 (10.07) (11.10) (7.43) (4.78)
(33.38)
’22 (13.98) (1.41) (16.43) (12.39)
(44.21)
’21 (7.34) (10.57) (12.52) (12.94)
(43.37)
’20 (3.85) (4.34) (4.98) (6.02)
(19.18)
in millions of $

EPS

Mar Jun Sep Dec Year
’26 (0.28) 0.08
’25 (0.40) (0.40) (0.36) (0.20)
(1.33)
’24 (0.39) (0.43) (0.38) (0.46)
(1.63)
’23 (0.34) (0.14) (0.23) (0.33)
(1.05)
’22 (0.56) (0.53) (0.40) (0.39)
(1.86)
’21 (83.36) (3.82) (0.51) (0.66)
(10.94)
’20 (0.21)
(0.98)

Target Price Range

High
‡‡‡‡‡
‡‡‡
Average
‡‡‡‡‡
‡‡‡
Low
‡‡‡‡‡
‡‡‡

Recommendation Rating

1
1
Buy
2
3
Hold
4
5
Sell
2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 2026 2027 2028
‡‡‡‡‡ 1.39 1.57 1.38 0.56
Low Price
‡‡‡‡‡ 12.86 4.57 8.19 2.38
High Price
‡‡‡‡ ‡‡‡‡ 46 47 46 39
Employees
‡‡‡ ‡‡‡ 0.36 0.42 0.04 0.00
Revenue/Emp
16.40 19.94 1.89 ‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡
Revenue
‡‡‡ ‡‡‡ ‡‡‡ 100.00% 100.00% 100.00%
Gross Margin
‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ (53.81) (37.37) (70.51) (60.82)
EBT
‡‡‡ ‡‡‡ ‡‡‡ (328.09%) (187.37%) (3,740.85%) 0.00% ‡‡‡ ‡‡‡ ‡‡‡
EBT Margin
‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ (53.81) (37.37) (70.51) (60.82) ‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡
Net Income
‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ 1.31 1.82 1.81 1.63
Depreciation
‡‡‡ ‡‡‡ ‡‡‡ 0.57 0.56 0.04 0.00 ‡‡‡ ‡‡‡ ‡‡‡
Revenue/Sh
‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ (1.86) (1.05) (1.63) (1.32) ‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡
Earnings/Sh
‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ (1.41) (0.91) (1.30) (1.31) ‡‡‡‡‡
Cash Flow/Sh
‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ (0.13) (0.02) (0.01) 0.00 ‡‡‡ ‡‡‡ ‡‡‡
Capex/Sh
‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ (1.53) (0.94) (1.30) (1.31)
Free CF/Sh
‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ 4.24 3.12 1.69 0.54
Book Value/Sh
‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ 28.86 35.65 43.33 46.02 ‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡
Shares
0.00 0.00 0.00 ‡‡‡‡‡ ‡‡‡‡ ‡‡‡‡‡
PE Ratio
0.00 8.29 6.91 ‡‡‡ ‡‡‡ ‡‡‡
PS Ratio
0.48 1.49 0.87 ‡‡‡ ‡‡‡ ‡‡‡
PB Ratio
0.00 3.36 (1.88) ‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡
EV/Sales
1.25 (2.01) 0.31
EV/FCF
‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ (40.60) (32.61) (56.19) (60.29) ‡‡‡ ‡‡‡ ‡‡‡
Op' Cash Flow
‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ (3.61) (0.77) (0.25) ‡‡‡‡‡ ‡‡‡‡‡
Capex
‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ (44.21) (33.38) (56.44) (60.29) ‡‡‡‡‡
FCF
‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ 116.21 118.99 97.89 22.44
Working Cap'
‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ 14.68 32.66 26.10
Total Debt
‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ (114.63) (101.69) (84.90) (57.05)
Net Debt
‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ 122.34 111.37 73.39 24.81
Sh' Equity
‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ (31.70%) (22.30%) (46.74%) (61.96%)
ROA
‡‡‡ ‡‡‡ ‡‡‡‡‡ (454.65%) (261.32%) 0.00% 0.00%
ROIC
‡‡‡‡‡ ‡‡‡‡‡ ‡‡‡‡‡ (39.12%) (31.98%) (76.33%) (123.88%)
ROE
predictions in italic, sparklines do not include predictions

Analyst Commentary (Summary)

Werewolf Therapeutics (HOWL), a clinical-stage biotech innovating the INDUKINE platform for targeted immune activation in cancer and inflammatory diseases, trades at deeply depressed levels in mid-February 2026, down over 94% from its 2021 IPO peak amid biotech euphoria. The stock’s rollercoaster mirrors sector woes: early hype from cell therapy buzz gave way to trial delays, a 91% revenue plunge to $1.89 million in 2024, relentless dilution (shares up 134%), and worsening cash burn, with free cash flow per share dropping 42% YoY despite a solid $85 million net cash position.

Financials highlight classic pre-commercial risks—perfect gross margins but EBT margins cratering to -37% and net losses deepening 89%—yet analyst forecasts eye a 430% revenue rebound to $10 million in 2025, fueled by potential pipeline milestones like WTX-124 trials or autoimmune pivots. Insider activity leans bearish with $6.53 million in sells dwarfing a single $487k buy, but Wall Street remains cautiously optimistic, with mean price targets implying 515% upside (highs over 1,400%).

In this high-stakes biotech narrative, HOWL’s fortress balance sheet and immunotherapy tailwinds offer turnaround whispers, but execution on catalysts amid FDA risks and competition will determine if it howls back or fades—tempting for risk-tolerant investors eyeing historical survivors.

Werewolf Therapeutics, Inc. (HOWL) Latest News

News by impact score

Fine-tune

26 Aug

4 www.barchart.com, 11:47 AM
Werewolf Therapeutics secured a $150 million funding boost, strengthening its position as a penny stock with potential for substantial growth. The $150 million funding infusion supplies major capital to advance development and operations at Werewolf Therapeutics.

21 Aug

5 investorshub.advfn.com, 9:26 AM
Werewolf Therapeutics shares surge 120% after Ambros merger and $150 million financing. Merger with Ambros plus $150 million financing fundamentally redefine Werewolf Therapeutics competitive position and long-term prospects.

5 , 8:00 AM
Werewolf Therapeutics merges with Ambros Therapeutics under a merger agreement, accompanied by an oversubscribed $150 million private placement. Merger with Ambros Therapeutics and $150 million private placement fundamentally redefine Werewolf Therapeutics' competitive position and prospects.

5 , 8:00 AM
Werewolf Therapeutics merges with Ambros Therapeutics under agreement and raises $150 million via oversubscribed private placement. Merger with Ambros Therapeutics plus $150 million funding fundamentally redefines Werewolf Therapeutics competitive position and resources.

4 www.barchart.com, 1:51 PM
Werewolf Therapeutics, Inc. (HOWL) stock doubled in value after announcement of a biotech merger. Merger news drives 100% stock surge indicating major strategic development for the company.

31 Jul

3 , 7:00 AM
Werewolf Therapeutics reported second quarter 2026 financial results and recent corporate updates. Quarterly results with corporate updates typically produce moderate effects on biotech stock performance and sentiment.

14 May

3 Simply Wall St., 7:23 AM
Werewolf Therapeutics (NASDAQ:HOWL) burns cash rapidly, shortening its financial runway and raising sustainability concerns among investors. Cash burn issues threaten financial runway and could moderately impact stock performance and investor sentiment.

7 May

3 GlobeNewswire, 4:05 PM
Werewolf Therapeutics, Inc. (HOWL) reported first quarter 2026 financial results and recent corporate updates. Quarterly financial results and corporate updates affect key financial performance and investor sentiment.

27 Mar

4 GlobeNewswire, 7:00 AM
Werewolf Therapeutics, Inc. (HOWL) reported fourth quarter and full-year 2025 financial results alongside recent corporate updates. Full-year financial results and corporate updates directly influence investor sentiment, stock valuation, and strategic outlook for the biotech firm.

24 Feb

4 GlobeNewswire, 4:09 PM
Werewolf Therapeutics, Inc. (HOWL) announces plan to explore strategic alternatives, including potential mergers, acquisitions, partnerships, or other transactions to maximize shareholder value. Exploring strategic alternatives signals major potential shifts like sale or restructuring, likely causing significant volatility and trajectory changes for HOWL.

12 Jan

4 Insider Monkey, 4:23 AM
Werewolf Therapeutics, Inc. (HOWL) is preparing for significant developments in 2026 following positive FDA guidance and promising results from its INDUKINE program. The company is focusing on advancing its therapeutic candidates, which could lead to important milestones and potential market opportunities in the near future. Positive FDA guidance and encouraging clinical results are likely to significantly impact the company's future trajectory and investor sentiment.

18 Dec

4 GlobeNewswire, 8:00 AM
Werewolf Therapeutics, Inc. (HOWL) provided updates on its pipeline and business strategy, highlighting advancements in its therapeutic programs and ongoing collaborations. The company is focused on developing innovative treatments for cancer and autoimmune diseases, with several candidates in clinical trials. Additionally, Werewolf announced plans for future initiatives aimed at enhancing its market position and expanding its research capabilities. Significant advancements in therapeutic programs and strategic initiatives are likely to impact the company's future performance and market position.

15 Dec

4 Zacks, 12:00 PM
Werewolf Therapeutics, Inc. (HOWL) has been upgraded to a 'Buy' rating by analysts, reflecting positive sentiment regarding its future prospects. The upgrade is attributed to recent advancements in the company's therapeutic pipeline and promising clinical trial results. Investors are encouraged to consider the potential for growth as the company continues to innovate in the biotech sector. The upgrade to 'Buy' indicates significant investor confidence in the company's future performance and strategic direction.

7 Nov

4 GlobeNewswire, 9:00 AM
Werewolf Therapeutics, Inc. presented new data on its PREDATOR® platform at the Society for Immunotherapy of Cancer’s 40th Annual Meeting. The data highlights advancements in the company's immunotherapy research, showcasing the potential of its innovative approach to cancer treatment. This presentation aims to enhance understanding of the platform's capabilities and its implications for future therapeutic developments. The presentation of new data on the PREDATOR® platform could significantly influence investor sentiment and the company's strategic direction in immunotherapy.

4 Nov

3 GlobeNewswire, 7:00 AM
Werewolf Therapeutics, Inc. (HOWL) reported its financial results for the third quarter of 2025, highlighting key metrics and developments in its business operations. The company provided updates on its ongoing projects and strategic initiatives aimed at advancing its therapeutic pipeline. Management expressed optimism about future growth and the potential impact of their innovations in the biopharmaceutical sector. The financial results and business updates indicate moderate influence on the company's performance and market positioning.

31 Oct

3 Zacks, 8:58 AM
Insmed reported disappointing Q3 earnings, missing analyst expectations. Despite this, the company's stock rose due to strong uptake of its drug Brinsupri, indicating positive market sentiment and potential for future growth. Strong uptake of Brinsupri may positively influence Insmed's financial performance and market positioning.

29 Oct

3 Zacks, 1:45 PM
Alkermes reported Q3 earnings and revenues that exceeded analysts' estimates, prompting the company to raise its financial outlook for 2025. The positive results reflect strong performance in its key products and a favorable market environment, which may enhance investor confidence and support future growth initiatives. The earnings beat and raised outlook may positively influence investor sentiment and financial performance, but the overall effect on Werewolf Therapeutics is expected to be limited.

23 Oct

4 , 12:00 PM
Werewolf Therapeutics, Inc. (HOWL) has been upgraded to a Strong Buy rating due to promising developments in its pipeline and positive market sentiment. Analysts highlight the company's innovative approach to drug development and potential for significant growth in the biopharmaceutical sector. The upgrade reflects confidence in the company's strategic direction and its ability to deliver value to shareholders. The upgrade to Strong Buy indicates significant confidence in the company's future performance and market position.

8 Oct

4 GlobeNewswire, 8:00 AM
Werewolf Therapeutics, Inc. has received Fast Track Designation from the U.S. FDA for WTX-124, an investigational therapy aimed at treating cancer. This designation is intended to expedite the development and review process for drugs that address unmet medical needs, potentially allowing for quicker access to the therapy for patients. Fast Track Designation can significantly enhance the development timeline and market potential for WTX-124, impacting the company's future performance.

3 Oct

3 GlobeNewswire, 9:00 AM
Werewolf Therapeutics, Inc. (HOWL) announced its participation in the Society for Immunotherapy of Cancer’s (SITC) 40th Annual Meeting, where it will present posters detailing its innovative approaches in immunotherapy. The presentations aim to showcase the company's advancements and research findings in the field, potentially attracting interest from investors and industry peers. Presenting at a significant industry conference can enhance visibility and credibility, impacting investor sentiment and future opportunities.

25 Sep

3 , 2:05 PM
Werewolf Therapeutics, Inc. (HOWL) is highlighted as one of three promising penny stocks with market caps under $700 million. The company focuses on developing innovative therapies for cancer and autoimmune diseases, leveraging its proprietary platform to create targeted treatments. Investors are encouraged to consider its potential for growth in the biotech sector, especially given the increasing demand for novel therapeutics. The company's focus on innovative therapies may moderately influence its market performance and investor sentiment.

8 Sep

3 Zacks, 5:03 PM
Werewolf Therapeutics, Inc. (HOWL) has recently signaled a 'Golden Cross,' a technical indicator suggesting potential upward momentum in its stock price. This pattern occurs when a short-term moving average crosses above a long-term moving average, often interpreted as a bullish signal by traders. Investors are now considering whether to buy into the stock based on this development, which may indicate a positive shift in market sentiment towards the company. The Golden Cross signal may influence market sentiment and trading activity, but its overall impact on the company's long-term trajectory remains uncertain.

14 Aug

3 GlobeNewswire, 7:00 AM
Werewolf Therapeutics, Inc. (HOWL) reported its financial results for the second quarter of 2025, highlighting key metrics and developments in its business operations. The company provided updates on ongoing projects and strategic initiatives aimed at enhancing its market position and product pipeline. Financial performance indicators showed trends that may influence future growth and investor sentiment. The financial results and business updates indicate moderate influence on the company's performance and market positioning.

29 Jul

3 Exec Edge, 12:30 PM
ReAlta Life Sciences has appointed Ellen Lubman as Chief Business Officer, bringing extensive experience in business development and commercialization in the life sciences sector. Lubman previously held leadership roles at various biotech companies, where she successfully advanced product pipelines and strategic partnerships. Her appointment is expected to enhance ReAlta's operational capabilities and drive growth as the company focuses on developing innovative therapies. The appointment of a seasoned executive like Lubman may positively influence ReAlta's operational effectiveness and strategic direction, but its overall impact on Werewolf Therapeutics is expected to be limited.

9 Jul

4 GlobeNewswire, 8:00 AM
Werewolf Therapeutics, Inc. announced that Dr. Randi Isaacs will present at the KidneyCAN 7th Annual Kidney Cancer Research Summit on July 18, 2025, discussing the company's WTX-124, a tumor-activated IL-2 INDUKINE molecule. The presentation will highlight early clinical findings and the strategy to improve therapeutic outcomes for renal cell carcinoma while minimizing toxicity. The company is also conducting a national awareness campaign, 'Full Moon Moment,' to support ongoing trials for WTX-124, which is currently enrolling patients with advanced or metastatic renal cell carcinoma and other solid tumors. The presentation at a significant cancer research summit and ongoing clinical trials could significantly impact investor sentiment and the company's future trajectory.

12 Jun

4 GlobeNewswire, 8:00 AM
Werewolf Therapeutics, Inc. announced that Dr. Randi Isaacs will participate in a panel discussion at the BIO International Convention from June 16-19, 2025, in Boston. The panel will focus on conditionally activated biologics, which aim to enhance anti-tumor activity while reducing systemic toxicity. This event coincides with the launch of Werewolf's 'Full Moon Moment' initiative, promoting awareness of its clinical trials, including WTX-124, an IL-2 INDUKINE molecule showing promising results in patients with cancer. Werewolf's therapeutics are designed to activate selectively in the tumor microenvironment, potentially redefining cancer treatment. The company is advancing multiple product candidates for solid tumors and Non-Hodgkin Lymphoma. Participation in a major convention and the launch of a significant awareness initiative could significantly influence investor sentiment and market positioning.

29 May

4 Zacks, 12:00 PM
Werewolf Therapeutics, Inc. (HOWL) has been upgraded to a Zacks Rank #2 (Buy) due to an upward trend in earnings estimates, indicating a positive earnings outlook that could lead to increased stock prices. The Zacks rating system, which correlates earnings estimate revisions with stock movements, suggests that the upgrade reflects an improvement in the company's underlying business. For the fiscal year ending December 2025, the company is expected to earn -$1.80 per share, a 10.4% decline from the previous year, but analysts have raised their estimates by 6.6% over the past three months. The upgrade positions Werewolf Therapeutics in the top 20% of Zacks-covered stocks, suggesting potential for market-beating returns. The upgrade indicates significant positive changes in earnings estimates, likely influencing investor sentiment and stock performance.

20 May

4 GlobeNewswire, 4:01 PM
A patient with advanced cutaneous squamous cell carcinoma has been in remission for over a year after participating in a clinical trial for Werewolf Therapeutics' investigational drug WTX-124. The drug, designed to activate in the tumor microenvironment, significantly reduced the patient's tumor within eight weeks. The trial is evaluating WTX-124 as a monotherapy and in combination with pembrolizumab for patients with advanced solid tumors that have failed standard treatments. The incidence of this type of skin cancer has tripled in the last three decades, highlighting the need for effective therapies. The successful trial results for WTX-124 could significantly enhance Werewolf Therapeutics' market position and investor sentiment.

13 May

4 GlobeNewswire, 8:00 AM
Werewolf Therapeutics, Inc. announced that Sameer Chopra, M.D., Ph.D., will present at the Hanson Wade Cytokine-Based Drug Development Summit on May 15-16, 2025, in Boston. The presentation will focus on data from first-in-human clinical trials of IL-2 and IL-12 INDUKINE molecules, which validate the company's approach to tumor-activated immunotherapies. Werewolf's INDUKINE molecules aim to activate selectively in the tumor microenvironment while remaining inactive in peripheral tissue. The company is advancing its product candidates, WTX-124 and WTX-330, for the treatment of solid tumors and Non-Hodgkin Lymphoma, respectively. The presentation at a significant summit and validation of innovative therapies could enhance investor sentiment and market positioning.

10 May

3 Simply Wall St., 10:52 AM
Werewolf Therapeutics (NASDAQ:HOWL) reported a net loss of US$18.1 million for Q1 2025, widening by 12% from Q1 2024, with a loss per share of US$0.40 compared to US$0.39 in the previous year. Despite this, revenue is forecasted to grow at an average of 56% annually over the next three years, outpacing the 18% growth expected for the US biotech industry. The company's shares have declined by 12% in the past week, and there are five warning signs identified that could pose risks to the company. The widening losses and declining share price indicate potential challenges, but strong revenue growth forecasts suggest a balanced outlook.

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