CRISPR Therapeutics AG

CRSP Healthcare Biotechnology

CRISPR Therapeutics AG’s revenue for fiscal 2025 (year ended December 2025) was $3.5 million, down 90.6% from fiscal 2024. In the quarter to June 2026, revenue grew 1,041.4%, EPS grew 60.8% and free cash flow grew 26.2%, each against the same quarter a year earlier.

49.30 2.22 −4.31%
Market cap
$5.0B
P/E
0.0×
Fwd P/E
−10.8×
Dividend yield
—
F-score
2/9
Altman Z
7.04
Beneish M
n/a
Dividend safety
n/a

Insider Decisions trades per month

Total sells 14.84
Totals in millions of $.
Dec 25 Mar 26 Jun 26 Sep 26
Buy — — — — — — — — — — — —
Sell — 1 3 2 9 — 1 — — — 2 3
Insider Ownership 6.99%

Capital & Financial Ratios $m

Market Cap 4,980.00
Revenue 13.39
Net Income (451.14)
Free Cash Flow (371.32)
Net Debt (1,778.15)
Current Ratio 17.85 (at or above 1.5: strong)
Debt/Equity 0.34 (at or below 0.5: strong)
P/E ratio 0.00
Fwd P/E (10.80) (negative: loss-making)
P/S ratio 355.30 (above 10: high)
P/B ratio 2.72
Past 5Y EPS Growth —
This Y EPS Growth 32.31% (at or above 15%: strong)
Next Y EPS Growth 23.48% (at or above 15%: strong)
Next Y revenue growth 1,052.14% (at or above 10%: strong)
Next 5Y EPS Growth 32.04% (at or above 15%: strong)

Green and red mark values outside typical ranges. How we judge →

Valuation vs history

P/S against its own 10 years 75.34%
10-year low 10-year high
P/B against its own 10 years 41.65%
10-year low 10-year high
EV/Sales against its own 10 years 74.33%
10-year low 10-year high

Dividends

Payout Ratio —
Annual Dividend Rate —
Annual Dividend Yield —
total individual payouts
2025 Powerpack
2024 Powerpack
2023 Powerpack
2022 Powerpack
2021 Powerpack
2020 Powerpack
2019 Powerpack
2017 Powerpack
predictions special payouts not included in total or ratios

Assets vs Liabilities $m

2023 2024 2025 Q'26
Cash 1,694 1,904 1,976 2,364
Receivables 200 25 — —
Inventory — — — —
Other — — — —
1,908 1,937 1,986 2,372
2023 2024 2025 Q'26
Payables 38 15 11 11
ST’ Debt — — — —
Other 5 10 13 17
109 88 149 133

Compound Annual Growth %

10y 5y 3y
Sales 30.40% 37.31% 43.09%
Cash Flow 0.00% 0.00% 0.00%
Earnings 0.00% 0.00% 0.00%
Book Value 0.00% 2.92% 0.82%

Revenue $m

Mar Jun Sep Dec Year
’26 1 10 — — —
’25 1 1 1 1 4
’24 1 1 1 36 37
’23 100 70 — 201 371
’22 1 0 0 0 1
’21 1 901 1 13 915
’20 0 0 0 0 1
Fiscal quarters ending in the months shown.

Operating Cash Flow $m

Mar Jun Sep Dec Year
’26 (109) (83) — — —
’25 (54) (114) (85) (93) (345)
’24 110 (96) (107) (50) (143)
’23 9 (133) (40) (96) (260)
’22 (135) (142) (105) (113) (496)
’21 (101) 807 (81) (86) 539
’20 (52) (29) (76) (81) (238)
Fiscal quarters ending in the months shown.

Free Cash Flow $m

Mar Jun Sep Dec Year
’26 (109) (84) — — —
’25 (54) (114) (85) (93) (346)
’24 109 (96) (107) (50) (145)
’23 6 (137) (42) (97) (270)
’22 (151) (152) (111) (120) (533)
’21 (108) 779 (118) (95) 457
’20 (55) (33) (81) (87) (257)
Fiscal quarters ending in the months shown.

EPS $

Mar Jun Sep Dec Year
’26 (1.28) (0.94) — — —
’25 (1.58) (2.40) (1.17) (1.37) (6.47)
’24 (1.43) (1.49) (1.01) (0.44) (4.34)
’23 (0.67) (0.98) (1.41) 1.10 (1.94)
’22 (2.32) (2.40) (2.24) (1.41) (8.36)
’21 (1.51) 9.44 (1.67) (1.84) 4.70
’20 (1.15) (1.30) (1.32) (1.50) (5.29)
Fiscal quarters ending in the months shown.

Target Price Range

Analyst price targets

Recommendation Rating

1.9
1Buy 2 3Hold 4 5Sell

Ten years at a glance Fiscal years to December

Group Line 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 Trend 2026e 2027e 2028e
Price, $
Price, $ Low 13.75 11.63 22.22 27.15 32.30 67.15 38.94 37.55 38.20 30.04

Analyst estimates 2026–2028

Powerpack
High 23.97 25.00 73.90 74.00 181.42 220.20 86.95 76.97 91.10 78.48
People
People Employees 93 127 188 304 410 473 458 407 393 0
Revenue/emp, $m 0.06 0.32 0.02 0.95 0.00 1.93 0.00 0.91 0.09 0.00
Income, $m
Income, $m Revenue 5 41 3 290 1 915 1 371 37 4
Gross margin, % 100.00 100.00 100.00 100.00 100.00 100.00 100.00 100.00 100.00 100.00
EBT (23) (67) (164) 67 (348) 380 (650) (151) (363) (578)
EBT margin, % (439.93) (162.47) (5,263.38) 23.24 (48,408.34) 41.48 (54,298.83) (40.60) (971.93) (16,466.24)
Net income (23) (68) (165) 67 (349) 378 (650) (154) (366) (582)
Depreciation 1 3 4 5 11 18 24 20 19 19
Per share, $
Per share, $ Revenue 0.42 1.02 0.07 5.32 0.01 12.05 0.02 4.69 0.44 0.04
Earnings (1.89) (1.71) (3.44) 1.23 (5.29) 4.97 (8.36) (1.94) (4.34) (6.47)
Cash flow (4.51) (1.75) (2.01) 1.04 (3.61) 7.10 (6.38) (3.29) (1.69) (3.84)
Capex (0.25) (0.20) (0.06) (0.12) (0.28) (1.08) (0.48) (0.12) (0.02) (0.01)
Free cash flow (4.76) (1.94) (2.06) 0.92 (3.89) 6.02 (6.85) (3.41) (1.71) (3.85)
Book value 19.00 4.69 8.18 17.27 25.23 31.59 24.12 23.77 22.90 21.37
Shares, m 12 40 48 54 66 76 78 79 84 90
Valuation, ×
Valuation, × P/E 0.00 0.00 0.00 54.87 0.00 15.19 0.00 0.00 0.00 0.00
P/S 53.41 24.59 438.65 11.44 14,043.96 6.29 2,660.79 14.10 88.98 1,343.49
P/B 1.18 5.37 3.49 3.53 6.07 2.40 1.70 2.78 1.72 2.45
EV/Sales (7.69) 18.74 292.47 8.33 11,762.55 3.92 1,335.82 10.15 44.05 845.25
EV/FCF 0.68 (9.86) (9.23) 48.27 (32.94) 7.85 (3.00) (13.96) (11.36) (8.58)
Cash, $m
Cash, $m Operating cash flow (55) (70) (96) 57 (238) 539 (496) (260) (143) (345)
Capex (3) (8) (3) (7) (18) (82) (37) (9) (2) (1)
Free cash flow (58) (78) (99) 50 (257) 457 (533) (270) (145) (346)
Balance, $m
Balance, $m Working capital 298 234 439 930 1,622 2,298 1,732 1,799 1,849 1,837
Total debt — — — 44 50 213 228 — — —
Net debt (316) (240) (457) (944) (1,690) (2,379) (1,815) (1,694) (1,904) (1,976)
Shareholders’ equity 233 188 392 939 1,664 2,399 1,875 1,883 1,932 1,922
Returns, %
Returns, % ROA (9.19) (22.18) (43.40) 8.59 (24.10) 16.49 (26.03) (6.87) (16.38) (25.81)
ROIC 0.00 0.00 0.00 0.00 0.00 1,148.27 (699.33) (73.55) (1,032.08) 0.00
ROE (22.75) (32.50) (56.89) 10.04 (26.80) 18.59 (30.42) (8.17) (19.20) (30.18)
Negative figures in brackets.

All 10 years →

Fiscal years to Dec 2025 · latest quarter Jun 2026

Charts ten years each

CRISPR Therapeutics AG vs peers in Biotechnology (Q) = latest quarter vs a year earlier

Company Market cap P/E Fwd P/E Revenue growth (Q) EPS growth (Q) FCF growth (Q) Gross margin (Q) EBIT margin (Q) Compare
MIRM Mirum Pharmaceuticals, Inc. $5.4B — (loss-making) — (loss-making) +37.92% (above 0%: growing) n/m −681.46% (below 0%: shrinking) 82.78% (24.14%) Compare
ERAS Erasca, Inc. $5.2B — (loss-making) — — n/m −4.67% (below 0%: shrinking) 0.00% 0.00% Compare
COGT Cogent Biosciences, Inc. $5.1B — (loss-making) — (loss-making) −69.41% (below 0%: shrinking) n/m −42.01% (below 0%: shrinking) 0.00% 0.00% Compare
PTCT PTC Therapeutics, Inc. $5.1B — (loss-making) 110× +101.55% (above 0%: growing) n/m +295.69% (above 0%: growing) 94.47% 41.32% Compare
CRSP CRISPR Therapeutics AG $5.0B — (loss-making) — (loss-making) +1,041.37% (above 0%: growing) n/m +26.19% (above 0%: growing) 100.00% (1,151.84%)
TVTX Travere Therapeutics, Inc. $5.0B — (loss-making) 196× +48.17% (above 0%: growing) n/m +604.22% (above 0%: growing) 98.72% 2.33% Compare
SRRK Scholar Rock Holding Corporation $5.0B — (loss-making) — (loss-making) +605.03% (above 0%: growing) n/m +8.88% (above 0%: growing) 0.00% 0.00% Compare
ORKA Oruka Therapeutics, Inc. $4.9B — (loss-making) — — n/m −43.00% (below 0%: shrinking) 0.00% 0.00% Compare
DFTX Definium Therapeutics, Inc. $4.6B — (loss-making) — — n/m −78.31% (below 0%: shrinking) 0.00% 0.00% Compare
Median of peers $5.0B — — +48.17% — −23.34% 0.00% 0.00%

All 614 Biotechnology stocks →

CRISPR Therapeutics AG (CRSP) key facts

  • Concern: CRISPR Therapeutics AG’s revenue for fiscal 2025 (year ended December 2025) was $3.5 million, down 90.6% from fiscal 2024.
  • Concern: CRISPR Therapeutics AG reported a net loss of $581.6 million, or a loss of $6.47 per share, for fiscal 2025.
  • CRISPR Therapeutics AG (CRSP) is a Biotechnology company in the Healthcare sector, listed on Nasdaq.
  • As of October 16, 2026, CRSP traded at $49.30, a market capitalization of $5.0 billion.
  • Trailing earnings are negative, so a P/E ratio is not meaningful; the stock trades at 355× sales.
  • Return on equity was −30.2% and debt-to-equity 0.34.
  • Its Piotroski F-score is 2 out of 9 and its Altman Z-score is 7.04 (safe zone) for fiscal 2025.

Source: company filings (standardised) and stockrow calculations.

CRISPR Therapeutics AG (CRSP) Latest News

stockrow.com/CRSP · Data as of Jun 30, 2026 · For information only; not investment advice. · © 2026 stockrow.com