Saturday 17 October 2026
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CRISPR Therapeutics AG
CRSP Healthcare Biotechnology
CRISPR Therapeutics AG’s revenue for fiscal 2025 (year ended December 2025) was $3.5 million, down 90.6% from fiscal 2024. In the quarter to June 2026, revenue grew 1,041.4%, EPS grew 60.8% and free cash flow grew 26.2%, each against the same quarter a year earlier.
49.30
2.22
−4.31%
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Target Price Range
Analyst price targets
Free accountTen years at a glance Fiscal years to December
| Group | Line | 2016 | 2017 | 2018 | 2019 | 2020 | 2021 | 2022 | 2023 | 2024 | 2025 | Trend | 2026e | 2027e | 2028e |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Price, $ | |||||||||||||||
| Price, $ | Low | 13.75 | 11.63 | 22.22 | 27.15 | 32.30 | 67.15 | 38.94 | 37.55 | 38.20 | 30.04 |
Analyst estimates 2026–2028 Powerpack |
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| High | 23.97 | 25.00 | 73.90 | 74.00 | 181.42 | 220.20 | 86.95 | 76.97 | 91.10 | 78.48 | |||||
| People | |||||||||||||||
| People | Employees | 93 | 127 | 188 | 304 | 410 | 473 | 458 | 407 | 393 | 0 | ||||
| Revenue/emp, $m | 0.06 | 0.32 | 0.02 | 0.95 | 0.00 | 1.93 | 0.00 | 0.91 | 0.09 | 0.00 | |||||
| Income, $m | |||||||||||||||
| Income, $m | Revenue | 5 | 41 | 3 | 290 | 1 | 915 | 1 | 371 | 37 | 4 | ||||
| Gross margin, % | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | |||||
| EBT | (23) | (67) | (164) | 67 | (348) | 380 | (650) | (151) | (363) | (578) | |||||
| EBT margin, % | (439.93) | (162.47) | (5,263.38) | 23.24 | (48,408.34) | 41.48 | (54,298.83) | (40.60) | (971.93) | (16,466.24) | |||||
| Net income | (23) | (68) | (165) | 67 | (349) | 378 | (650) | (154) | (366) | (582) | |||||
| Depreciation | 1 | 3 | 4 | 5 | 11 | 18 | 24 | 20 | 19 | 19 | |||||
| Per share, $ | |||||||||||||||
| Per share, $ | Revenue | 0.42 | 1.02 | 0.07 | 5.32 | 0.01 | 12.05 | 0.02 | 4.69 | 0.44 | 0.04 | ||||
| Earnings | (1.89) | (1.71) | (3.44) | 1.23 | (5.29) | 4.97 | (8.36) | (1.94) | (4.34) | (6.47) | |||||
| Cash flow | (4.51) | (1.75) | (2.01) | 1.04 | (3.61) | 7.10 | (6.38) | (3.29) | (1.69) | (3.84) | |||||
| Capex | (0.25) | (0.20) | (0.06) | (0.12) | (0.28) | (1.08) | (0.48) | (0.12) | (0.02) | (0.01) | |||||
| Free cash flow | (4.76) | (1.94) | (2.06) | 0.92 | (3.89) | 6.02 | (6.85) | (3.41) | (1.71) | (3.85) | |||||
| Book value | 19.00 | 4.69 | 8.18 | 17.27 | 25.23 | 31.59 | 24.12 | 23.77 | 22.90 | 21.37 | |||||
| Shares, m | 12 | 40 | 48 | 54 | 66 | 76 | 78 | 79 | 84 | 90 | |||||
| Valuation, × | |||||||||||||||
| Valuation, × | P/E | 0.00 | 0.00 | 0.00 | 54.87 | 0.00 | 15.19 | 0.00 | 0.00 | 0.00 | 0.00 | ||||
| P/S | 53.41 | 24.59 | 438.65 | 11.44 | 14,043.96 | 6.29 | 2,660.79 | 14.10 | 88.98 | 1,343.49 | |||||
| P/B | 1.18 | 5.37 | 3.49 | 3.53 | 6.07 | 2.40 | 1.70 | 2.78 | 1.72 | 2.45 | |||||
| EV/Sales | (7.69) | 18.74 | 292.47 | 8.33 | 11,762.55 | 3.92 | 1,335.82 | 10.15 | 44.05 | 845.25 | |||||
| EV/FCF | 0.68 | (9.86) | (9.23) | 48.27 | (32.94) | 7.85 | (3.00) | (13.96) | (11.36) | (8.58) | |||||
| Cash, $m | |||||||||||||||
| Cash, $m | Operating cash flow | (55) | (70) | (96) | 57 | (238) | 539 | (496) | (260) | (143) | (345) | ||||
| Capex | (3) | (8) | (3) | (7) | (18) | (82) | (37) | (9) | (2) | (1) | |||||
| Free cash flow | (58) | (78) | (99) | 50 | (257) | 457 | (533) | (270) | (145) | (346) | |||||
| Balance, $m | |||||||||||||||
| Balance, $m | Working capital | 298 | 234 | 439 | 930 | 1,622 | 2,298 | 1,732 | 1,799 | 1,849 | 1,837 | ||||
| Total debt | — | — | — | 44 | 50 | 213 | 228 | — | — | — | |||||
| Net debt | (316) | (240) | (457) | (944) | (1,690) | (2,379) | (1,815) | (1,694) | (1,904) | (1,976) | |||||
| Shareholders’ equity | 233 | 188 | 392 | 939 | 1,664 | 2,399 | 1,875 | 1,883 | 1,932 | 1,922 | |||||
| Returns, % | |||||||||||||||
| Returns, % | ROA | (9.19) | (22.18) | (43.40) | 8.59 | (24.10) | 16.49 | (26.03) | (6.87) | (16.38) | (25.81) | ||||
| ROIC | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1,148.27 | (699.33) | (73.55) | (1,032.08) | 0.00 | |||||
| ROE | (22.75) | (32.50) | (56.89) | 10.04 | (26.80) | 18.59 | (30.42) | (8.17) | (19.20) | (30.18) | |||||
Negative figures in brackets.
Fiscal years to Dec 2025 · latest quarter Jun 2026
Charts ten years each
CRISPR Therapeutics AG vs peers in Biotechnology (Q) = latest quarter vs a year earlier
| Company | Market cap | P/E | Fwd P/E | Revenue growth (Q) | EPS growth (Q) | FCF growth (Q) | Gross margin (Q) | EBIT margin (Q) | Compare |
|---|---|---|---|---|---|---|---|---|---|
| MIRM Mirum Pharmaceuticals, Inc. | $5.4B | — (loss-making) | — (loss-making) | +37.92% (above 0%: growing) | n/m | −681.46% (below 0%: shrinking) | 82.78% | (24.14%) | Compare |
| ERAS Erasca, Inc. | $5.2B | — (loss-making) | — | — | n/m | −4.67% (below 0%: shrinking) | 0.00% | 0.00% | Compare |
| COGT Cogent Biosciences, Inc. | $5.1B | — (loss-making) | — (loss-making) | −69.41% (below 0%: shrinking) | n/m | −42.01% (below 0%: shrinking) | 0.00% | 0.00% | Compare |
| PTCT PTC Therapeutics, Inc. | $5.1B | — (loss-making) | 110× | +101.55% (above 0%: growing) | n/m | +295.69% (above 0%: growing) | 94.47% | 41.32% | Compare |
| CRSP CRISPR Therapeutics AG | $5.0B | — (loss-making) | — (loss-making) | +1,041.37% (above 0%: growing) | n/m | +26.19% (above 0%: growing) | 100.00% | (1,151.84%) | |
| TVTX Travere Therapeutics, Inc. | $5.0B | — (loss-making) | 196× | +48.17% (above 0%: growing) | n/m | +604.22% (above 0%: growing) | 98.72% | 2.33% | Compare |
| SRRK Scholar Rock Holding Corporation | $5.0B | — (loss-making) | — (loss-making) | +605.03% (above 0%: growing) | n/m | +8.88% (above 0%: growing) | 0.00% | 0.00% | Compare |
| ORKA Oruka Therapeutics, Inc. | $4.9B | — (loss-making) | — | — | n/m | −43.00% (below 0%: shrinking) | 0.00% | 0.00% | Compare |
| DFTX Definium Therapeutics, Inc. | $4.6B | — (loss-making) | — | — | n/m | −78.31% (below 0%: shrinking) | 0.00% | 0.00% | Compare |
| Median of peers | $5.0B | — | — | +48.17% | — | −23.34% | 0.00% | 0.00% |
CRISPR Therapeutics AG (CRSP) key facts
- Concern: CRISPR Therapeutics AG’s revenue for fiscal 2025 (year ended December 2025) was $3.5 million, down 90.6% from fiscal 2024.
- Concern: CRISPR Therapeutics AG reported a net loss of $581.6 million, or a loss of $6.47 per share, for fiscal 2025.
- CRISPR Therapeutics AG (CRSP) is a Biotechnology company in the Healthcare sector, listed on Nasdaq.
- As of October 16, 2026, CRSP traded at $49.30, a market capitalization of $5.0 billion.
- Trailing earnings are negative, so a P/E ratio is not meaningful; the stock trades at 355× sales.
- Return on equity was −30.2% and debt-to-equity 0.34.
- Its Piotroski F-score is 2 out of 9 and its Altman Z-score is 7.04 (safe zone) for fiscal 2025.