Annexon, Inc.

ANNX Healthcare Biotechnology

EPS
+17.7%
Free cash flow
−26.4%

Quarter to June 2026, against a year earlier

4.21 0.20 +4.99%
Market cap
$759.3M
P/E
0.0×
Fwd P/E
—
Dividend yield
—
F-score
n/a
Altman Z
n/a
Beneish M
n/a
Dividend safety
n/a

Insider Decisions last twelve months

Bought, $m 3.58
Sold, $m 0.31
Trades a month
Jan 26 Apr 26 Jul 26 Oct 26
Buy 1 — — 1 1 2 — — — 1 — —
Sell — — 5 5 — — — — — — — —
Insider Ownership 17.95%

Capital & Financial Ratios $m

Size
Market Cap 759.27
Revenue ttm —
Net income ttm (202.67)
Free cash flow ttm (193.23)
Net debt Q (209.24)
Valuation
P/E 0.00
Forward P/E —
Price / sales 0.00
Forward P/S Powerpack
Price / FCF 0.00
Price / book 4.55
Financial health
Current ratio Q 5.53 (at or above 1.5: strong)
Debt / equity Q 0.00 (at or below 0.5: strong)
Interest coverage Q —
Growth
Revenue growth Q —
Operating income growth Q −10.63% (below 0%: shrinking)
EPS, this year +21.53% (at or above 15%: strong)
EPS, next year A +5.92%
Revenue, next year A —
EPS, past 5 yrs —
EPS, next 5 yrs A +46.41% (at or above 15%: strong)

Green and red mark values outside typical ranges; (Q) is the latest quarter, (A) analysts’ estimates. How we judge →

Valuation vs history

P/B against its own 10 years 91.46%
10-year low 10-year high

Dividends

Yield
—
Annual rate
—
Payout ratio
—

Assets vs Liabilities $m

2023 2024 2025 Q'26
Cash 260 312 238 209
Receivables — — — —
Inventory — — — —
Other — — — —
264 316 242 213
2023 2024 2025 Q'26
Payables 5 10 15 16
ST’ Debt — — — —
Other — — — —
18 31 43 38

Compound Annual Growth %

10y 5y 3y
Sales — — —
Cash Flow — 0.00% 0.00%
Earnings — 0.00% 0.00%
Book Value — (9.27%) (2.90%)

Earnings Trends EPS, adjusted, against the consensus

EPS $

Mar Jun Sep Dec Year
’26 (0.23) (0.28) — — —
’25 (0.37) (0.34) (0.37) (0.28) (1.34)
’24 (0.21) (0.23) (0.25) (0.33) (1.01)
’23 (0.52) (0.47) (0.43) (0.36) (1.77)
’22 (0.92) (0.96) (0.51) (0.48) (2.60)
’21 (0.68) (0.82) (0.93) (0.97) (3.40)
’20 (28.45) (28.87) (0.77) (0.61) (4.15)
Fiscal quarters ending in the months shown.

Revenue $m

Year
Fiscal quarters ending in the months shown.

Operating Cash Flow $m

Mar Jun Sep Dec Year
’26 (47) (48) — — —
’25 (50) (38) (52) (46) (186)
’24 (28) (22) (32) (36) (118)
’23 (33) (36) (28) (23) (121)
’22 (30) (28) (31) (27) (116)
’21 (23) (25) (30) (28) (106)
’20 (10) (10) (14) (19) (53)
Fiscal quarters ending in the months shown.

Free Cash Flow $m

Mar Jun Sep Dec Year
’26 (47) (48) — — —
’25 (50) (38) (52) (46) (186)
’24 (28) (22) (32) (36) (118)
’23 (33) (36) (28) (23) (121)
’22 (36) (29) (31) (27) (123)
’21 (23) (25) (30) (29) (108)
’20 (10) (10) (14) (19) (54)
Fiscal quarters ending in the months shown.

Target Price Range

Analyst price targets

Recommendation Rating

1.4
1Buy 2 3Hold 4 5Sell

Ten years at a glance

Ten-year view Analyst estimates Powerpack
Group Line 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 TTM Jun ’26 Trend 10 yrs 2026e 2027e 2028e Next 3/yr
Income, $m
Income, $m Revenue — — — — — — — — — — — — 35 35 266 +174.3%
Gross margin, % — 0.00 0.00 0.00 0.00 0.00 0.00 — — — 0.00 0.0 pt
EBT — (19) (18) (37) (63) (130) (142) (134) (138) (207) (203) +35.0%
EBT margin, % — 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.0 pt
Net income — 0 (18) (37) (63) (130) (142) (134) (138) (207) (203) n/m
Per share, $
Per share, $ Revenue — 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 n/m
Earnings — (0.49) (45.45) (85.78) (4.15) (3.40) (2.60) (1.77) (1.01) (1.34) (1.16) +13.4%
Cash flow — (0.50) (42.69) (65.42) (3.13) (2.77) (2.13) (1.60) (0.86) (1.20) (0.96) +11.5%
Capex — 0.00 (0.04) (0.62) (0.03) (0.04) (0.12) 0.00 0.00 0.00 0.00 n/m
Free cash flow — (0.50) (42.73) (66.03) (3.16) (2.81) (2.25) (1.60) (0.86) (1.20) (0.96) +11.5%
Book value — (1.21) (159.43) (231.73) 20.30 6.05 4.23 3.31 2.13 1.36 0.93 n/m
Shares, m — 38 0 0 17 38 55 76 137 155 175 +19.1%
Valuation, ×
Valuation, × P/E — — — — — — — — — — 0 —
P/S — — — — — — — — — — 0 —
P/B — — — — — — — — — — 0 —
EV/Sales — — — — — — — — — — 0 —
EV/FCF — — — — — — — — — — 0 —
Cash, $m
Cash, $m Operating cash flow — (19) (17) (28) (53) (106) (116) (121) (118) (186) (193) +32.8%
Capex — (1) 0 0 0 (2) (7) 0 0 0 0 (16.3%)
Free cash flow — (19) (17) (29) (54) (108) (123) (121) (118) (186) (193) +32.8%
Balance, $m
Balance, $m Working capital — 2 42 40 343 226 226 246 286 200 174 +78.0%
Net debt — 46 (44) (44) (351) (243) (243) (260) (312) (238) (209) n/m
Shareholders’ equity — (46) (64) (100) 344 232 231 251 293 212 186 n/m
Returns, %
Returns, % ROA — (67.16) (76.76) (78.08) (34.66) (40.54) (49.62) (46.07) (42.67) (66.45) (79.38) +0.7 pt
ROIC — 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.0 pt
ROE — 34.04 33.47 46.49 (57.69) (45.24) (61.30) (55.73) (50.84) (82.63) (105.26) (116.7) pt
People
People Employees — — — 30 48 61 80 71 100 96 — +21.4%
Revenue/emp, $m — — — 0.00 0.00 0.00 0.00 0.00 0.00 0.00 — n/m
Negative figures in brackets.
estimates

All 10 years →

Annexon, Inc. vs peers in Biotechnology (Q) = latest quarter vs a year earlier

Company Market cap P/E Fwd P/E Revenue growth (Q) EPS growth (Q) FCF growth (Q) Gross margin (Q) EBIT margin (Q) Compare
CRVS Corvus Pharmaceuticals, Inc. $818.5M — (loss-making) — — n/m −171.31% (below 0%: shrinking) 0.00% 0.00% Compare
MGTX MeiraGTx Holdings PLC $817.3M 11.8× 30.3× +8,608.59% (above 0%: growing) n/m +13.06% (above 0%: growing) 97.77% 76.04% Compare
PRME Prime Medicine, Inc. $807.1M — (loss-making) — (loss-making) +3.50% (above 0%: growing) n/m +4.40% (above 0%: growing) 100.00% (3,750.87%) Compare
ALMS Alumis Inc. $780.9M — (loss-making) — (loss-making) −37.66% (below 0%: shrinking) n/m +23.59% (above 0%: growing) 100.00% (8,956.38%) Compare
ANNX Annexon, Inc. $759.3M — (loss-making) — — n/m −26.41% (below 0%: shrinking) 0.00% 0.00%
ARDX Ardelyx, Inc. $751.6M — (loss-making) — (loss-making) +15.70% (above 0%: growing) n/m +938.76% (above 0%: growing) 96.44% 3.15% Compare
LXRX Lexicon Pharmaceuticals, Inc. $716.4M — (loss-making) — (loss-making) −20.67% (below 0%: shrinking) n/m +66.10% (above 0%: growing) 99.30% (128.84%) Compare
OABI OmniAb, Inc. $704.5M — (loss-making) — (loss-making) +78.34% (above 0%: growing) n/m +206.33% (above 0%: growing) 92.26% (409.92%) Compare
SANA Sana Biotechnology, Inc. $700.5M — (loss-making) — — n/m −5.46% (below 0%: shrinking) 0.00% 0.00% Compare
Median of peers $766.3M — — +9.60% — +18.33% 97.11% (64.42%)

All 621 Biotechnology stocks →

Pay and ownership Proxy statement filed 27 April 2026

Chief executive’s pay

Year Total pay Actually paid $100 invested
2025 3.58m 5.08m 20.06
2024 3.67m 4.37m 20.50
2023 2.45m 1.20m 18.14

Ownership

Directors and executive officers, together 10.31%
Redmile Group, LLC 9.99%
Trusts and other entities affiliated with Muneer A. Satter 6.40%
FMR LLC 6.29%
Muneer A. Satter 6.05%
BVF Partners L.P. 5.49%
BlackRock, Inc. 5.46%
Total pay is as the Summary Compensation Table states it; actually paid revalues the year’s share awards at its end, as the SEC’s pay-versus-performance rule asks. $100 invested is what $100 in the company’s shares at the start of the earliest year shown was worth at each year’s end. Ownership is the proxy’s own table: the directors and officers as a group, and every holder of 5% or more. Read the proxy statement

Annexon, Inc. (ANNX) Latest News

19 Aug

Impact 3 · · The Motley Fool transcript

15 Dec

Impact 4 · · Simply Wall St.
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