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Spyre Therapeutics, Inc. (SYRE) vs Twist Bioscience Corporation (TWST)

Spyre Therapeutics, Inc. and Twist Bioscience Corporation are both Biotechnology companies. Spyre Therapeutics, Inc. is the larger, with a market value of $9.2B against $7.9B — 1.2× the size. Twist Bioscience Corporation grew revenue faster over the last twelve months: 19.2% against −81.8%. Spyre Therapeutics, Inc. has the higher net margin (0.00% vs −31.7%) and the higher return on invested capital (0.00% vs −30.8%). Across the 18 metrics below, Twist Bioscience Corporation leads on 10 and Spyre Therapeutics, Inc. on 8.

Valuation

Metric SYRE TWST Biotechnology median
P/E n/m n/m 10.26
P/S 8,159.98 17.60 9.18
P/B 9.50 17.05 2.05
Price to free cash flow n/m n/m 24.81
EV/EBITDA n/m n/m 0.65
EV/Sales 7,142.99 17.25 8.98
Earnings yield (3.16%) (1.82%) (34.89%)
Free cash flow yield (2.89%) (1.26%) (24.52%)

Profitability

Metric SYRE TWST Biotechnology median
Gross margin 100.00% 51.97% 65.16%
Operating margin 0.00% (33.58%) 0.00%
Net margin 0.00% (31.66%) 0.00%
Free cash flow margin 0.00% (22.15%) 0.00%
Return on equity (41.15%) (29.59%) (50.12%)
Return on assets (30.89%) (20.78%) (45.60%)
Return on invested capital 0.00% (30.83%) 0.00%

Growth

Metric SYRE TWST Biotechnology median
Revenue growth (TTM) (81.84%) 19.19% 6.26%
EPS growth (last fiscal year) 55.24% 63.89% 29.88%
Revenue growth, 5-year CAGR (28.15%) 33.11% 9.75%
Net income growth, 5-year CAGR 0.00% 0.00% 0.00%

Health

Metric SYRE TWST Biotechnology median
Debt to equity 0.00 0.03 0.00
Current ratio 27.40 2.67 4.89
Net debt to EBITDA 3.61 1.95 1.01

Dividend

Metric SYRE TWST Biotechnology median
Dividend yield — — 0.41%
Payout ratio — — —

Size

Metric SYRE TWST Biotechnology median
Market cap 9.17b 7.94b 172.11m

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