Spyre Therapeutics, Inc. (SYRE) vs Bio-Techne Corp (TECH)

Spyre Therapeutics, Inc. and Bio-Techne Corp are both Biotechnology companies. Bio-Techne Corp is the larger, with a market value of $11.4B against $9.2B — 1.2× the size. Spyre Therapeutics, Inc. has negative trailing earnings, so its P/E is not meaningful; Bio-Techne Corp trades at 66.2×. Bio-Techne Corp grew revenue faster over the last twelve months: 0.94% against −81.8%. Bio-Techne Corp has the higher net margin (14.0% vs 0.00%) and the higher return on invested capital (8.29% vs 0.00%). Across the 18 metrics below, Bio-Techne Corp leads on 16 and Spyre Therapeutics, Inc. on 2.

Valuation

Metric SYRE TECH Biotechnology median
P/E n/m 66.17 10.60
P/S 8,738.76 9.29 9.40
P/B 10.18 5.27 2.13
Price to free cash flow n/m 37.03 25.18
EV/EBITDA n/m 33.40 0.66
EV/Sales 7,721.78 9.18 9.02
Earnings yield (2.95%) 1.51% (32.88%)
Free cash flow yield (2.70%) 2.70% (23.13%)

Profitability

Metric SYRE TECH Biotechnology median
Gross margin 100.00% 65.75% 68.51%
Operating margin 0.00% 19.61% 0.00%
Net margin 0.00% 14.00% 0.00%
Free cash flow margin 0.00% 25.09% 0.00%
Return on equity (41.15%) 8.32% (51.96%)
Return on assets (30.89%) 6.66% (46.06%)
Return on invested capital 0.00% 8.29% 0.00%

Growth

Metric SYRE TECH Biotechnology median
Revenue growth (TTM) (81.84%) 0.94% 6.76%
EPS growth (last fiscal year) 55.24% 152.17% 29.88%
Revenue growth, 5-year CAGR (28.15%) 5.47% 9.75%
Net income growth, 5-year CAGR 0.00% 5.31% 0.00%

Health

Metric SYRE TECH Biotechnology median
Debt to equity 0.00 0.00 0.00
Current ratio 27.40 2.28 4.97
Net debt to EBITDA 3.61 (0.19) 1.01

Dividend

Metric SYRE TECH Biotechnology median
Dividend yield — 0.44% 0.41%
Payout ratio — 0.29 —

Size

Metric SYRE TECH Biotechnology median
Market cap 9.17b 11.41b 161.82m

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