Protagonist Therapeutics, Inc. (PTGX) vs Twist Bioscience Corporation (TWST)

Protagonist Therapeutics, Inc. and Twist Bioscience Corporation are both Biotechnology companies. Protagonist Therapeutics, Inc. is the larger, with a market value of $8.8B against $7.9B — 1.1× the size. Twist Bioscience Corporation has negative trailing earnings, so its P/E is not meaningful; Protagonist Therapeutics, Inc. trades at 111×. Protagonist Therapeutics, Inc. grew revenue faster over the last twelve months: 34.8% against 19.2%. Protagonist Therapeutics, Inc. has the higher net margin (29.4% vs −31.7%) and the higher return on invested capital (61.8% vs −30.8%). Across the 18 metrics below, Protagonist Therapeutics, Inc. leads on 13 and Twist Bioscience Corporation on 5.

Valuation

Metric PTGX TWST Biotechnology median
P/E 110.95 n/m 10.26
P/S 31.65 17.60 9.18
P/B 10.61 17.05 2.05
Price to free cash flow 68.35 n/m 24.81
EV/EBITDA 144.60 n/m 0.65
EV/Sales 28.91 17.25 8.98
Earnings yield 0.90% (1.82%) (34.89%)
Free cash flow yield 1.46% (1.26%) (24.52%)

Profitability

Metric PTGX TWST Biotechnology median
Gross margin 100.00% 51.97% 65.16%
Operating margin 20.69% (33.58%) 0.00%
Net margin 29.40% (31.66%) 0.00%
Free cash flow margin 46.31% (22.15%) 0.00%
Return on equity 10.98% (29.59%) (50.12%)
Return on assets 10.34% (20.78%) (45.60%)
Return on invested capital 61.84% (30.83%) 0.00%

Growth

Metric PTGX TWST Biotechnology median
Revenue growth (TTM) 34.81% 19.19% 6.26%
EPS growth (last fiscal year) (148.46%) 63.89% 29.88%
Revenue growth, 5-year CAGR 9.96% 33.11% 9.75%
Net income growth, 5-year CAGR 0.00% 0.00% 0.00%

Health

Metric PTGX TWST Biotechnology median
Debt to equity 0.00 0.03 0.00
Current ratio 21.71 2.67 4.89
Net debt to EBITDA 3.49 1.95 1.01

Dividend

Metric PTGX TWST Biotechnology median
Dividend yield — — 0.41%
Payout ratio — — —

Size

Metric PTGX TWST Biotechnology median
Market cap 8.75b 7.94b 172.11m

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