Iovance Biotherapeutics, Inc. (IOVA) vs Rhythm Pharmaceuticals, Inc. (RYTM)

Iovance Biotherapeutics, Inc. and Rhythm Pharmaceuticals, Inc. are both Biotechnology companies. Iovance Biotherapeutics, Inc. is the larger, with a market value of $6.7B against $6.1B — 1.1× the size. Rhythm Pharmaceuticals, Inc. grew revenue faster over the last twelve months: 53.5% against 34.6%. Rhythm Pharmaceuticals, Inc. has the higher net margin (−87.6% vs −89.1%) and the higher return on invested capital (0.00% vs −43.0%). Across the 16 metrics below, Rhythm Pharmaceuticals, Inc. leads on 9 and Iovance Biotherapeutics, Inc. on 7.

Valuation

Metric IOVA RYTM Biotechnology median
P/E n/m n/m 8.50
P/S 18.81 24.64 9.71
P/B 8.31 57.39 2.13
Price to free cash flow n/m n/m 20.82
EV/EBITDA n/m n/m 0.64
EV/Sales 17.90 23.26 9.21
Earnings yield (5.38%) (3.61%) (33.15%)
Free cash flow yield (4.85%) (2.55%) (25.50%)

Profitability

Metric IOVA RYTM Biotechnology median
Gross margin 48.40% 89.00% 65.16%
Operating margin (92.72%) (83.62%) 0.00%
Net margin (89.09%) (87.62%) 0.00%
Free cash flow margin (91.21%) (43.91%) 0.00%
Return on equity (40.36%) (461.65%) (56.36%)
Return on assets (31.76%) (51.91%) (48.04%)
Return on invested capital (42.96%) 0.00% 0.00%

Growth

Metric IOVA RYTM Biotechnology median
Revenue growth (TTM) 34.55% 53.51% 6.02%
EPS growth (last fiscal year) 14.84% 28.34% 30.26%
Revenue growth, 5-year CAGR — — 9.41%
Net income growth, 5-year CAGR 0.00% 0.00% 0.00%

Health

Metric IOVA RYTM Biotechnology median
Debt to equity 0.00 0.00 0.00
Current ratio 4.35 3.45 4.72
Net debt to EBITDA 0.82 2.04 0.96

Dividend

Metric IOVA RYTM Biotechnology median
Dividend yield — — 0.09%
Payout ratio — — —

Size

Metric IOVA RYTM Biotechnology median
Market cap 6.67b 6.06b 135.18m

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