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CG Oncology, Inc. (CGON) vs Ionis Pharmaceuticals, Inc. (IONS)

CG Oncology, Inc. and Ionis Pharmaceuticals, Inc. are both Biotechnology companies. Ionis Pharmaceuticals, Inc. is the larger, with a market value of $6.5B against $5.7B — 1.1× the size. CG Oncology, Inc. grew revenue faster over the last twelve months: 840.8% against −7.41%. Ionis Pharmaceuticals, Inc. has the higher net margin (−64.7% vs −3,602.7%) and the higher return on invested capital (0.00% vs −4,111.6%). Across the 17 metrics below, Ionis Pharmaceuticals, Inc. leads on 10 and CG Oncology, Inc. on 7.

Valuation

Metric CGON IONS Biotechnology median
P/E n/m n/m 10.26
P/S 918.54 7.36 9.18
P/B 5.56 14.62 2.05
Price to free cash flow n/m n/m 24.81
EV/EBITDA n/m n/m 0.65
EV/Sales 755.35 7.05 8.98
Earnings yield (4.15%) (8.90%) (34.89%)
Free cash flow yield (3.14%) (8.83%) (24.52%)

Profitability

Metric CGON IONS Biotechnology median
Gross margin (85.20%) 98.17% 65.16%
Operating margin (4,056.18%) (68.00%) 0.00%
Net margin (3,602.68%) (64.66%) 0.00%
Free cash flow margin (2,879.62%) (64.93%) 0.00%
Return on equity (26.41%) (105.50%) (50.12%)
Return on assets (25.11%) (18.90%) (45.60%)
Return on invested capital (4,111.64%) 0.00% 0.00%

Growth

Metric CGON IONS Biotechnology median
Revenue growth (TTM) 840.79% (7.41%) 6.26%
EPS growth (last fiscal year) (47.52%) 21.71% 29.88%
Revenue growth, 5-year CAGR — 5.29% 9.75%
Net income growth, 5-year CAGR — 0.00% 0.00%

Health

Metric CGON IONS Biotechnology median
Debt to equity 0.00 3.07 0.00
Current ratio 22.22 7.89 4.89
Net debt to EBITDA 3.88 2.39 1.01

Dividend

Metric CGON IONS Biotechnology median
Dividend yield — — 0.41%
Payout ratio — — —

Size

Metric CGON IONS Biotechnology median
Market cap 5.74b 6.45b 172.11m

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