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Arrowhead Pharmaceuticals, Inc. (ARWR) vs Spyre Therapeutics, Inc. (SYRE)

Arrowhead Pharmaceuticals, Inc. and Spyre Therapeutics, Inc. are both Biotechnology companies. Spyre Therapeutics, Inc. is the larger, with a market value of $9.2B against $8.1B — 1.1× the size. Arrowhead Pharmaceuticals, Inc. grew revenue faster over the last twelve months: 16.1% against −81.8%. Spyre Therapeutics, Inc. has the higher net margin (0.00% vs −47.8%) and the higher return on invested capital (0.00% vs 0.00%). Across the 16 metrics below, Arrowhead Pharmaceuticals, Inc. leads on 8 and Spyre Therapeutics, Inc. on 8.

Valuation

Metric ARWR SYRE Biotechnology median
P/E n/m n/m 10.26
P/S 12.34 8,159.98 9.18
P/B 17.73 9.50 2.05
Price to free cash flow n/m n/m 24.81
EV/EBITDA n/m n/m 0.65
EV/Sales 11.24 7,142.99 8.98
Earnings yield (3.90%) (3.16%) (34.89%)
Free cash flow yield (0.91%) (2.89%) (24.52%)

Profitability

Metric ARWR SYRE Biotechnology median
Gross margin 100.00% 100.00% 65.16%
Operating margin (33.82%) 0.00% 0.00%
Net margin (47.79%) 0.00% 0.00%
Free cash flow margin (11.22%) 0.00% 0.00%
Return on equity (64.91%) (41.15%) (50.12%)
Return on assets (18.32%) (30.89%) (45.60%)
Return on invested capital 0.00% 0.00% 0.00%

Growth

Metric ARWR SYRE Biotechnology median
Revenue growth (TTM) 16.13% (81.84%) 6.26%
EPS growth (last fiscal year) 99.80% 55.24% 29.88%
Revenue growth, 5-year CAGR 56.63% (28.15%) 9.75%
Net income growth, 5-year CAGR 0.00% 0.00% 0.00%

Health

Metric ARWR SYRE Biotechnology median
Debt to equity 1.85 0.00 0.00
Current ratio 5.90 27.40 4.89
Net debt to EBITDA (5.70) 3.61 1.01

Dividend

Metric ARWR SYRE Biotechnology median
Dividend yield — — 0.41%
Payout ratio — — —

Size

Metric ARWR SYRE Biotechnology median
Market cap 8.12b 9.17b 172.11m

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