Alto Neuroscience, Inc. (ANRO) vs MeiraGTx Holdings PLC (MGTX)

Alto Neuroscience, Inc. and MeiraGTx Holdings PLC are both Biotechnology companies. Alto Neuroscience, Inc. and MeiraGTx Holdings PLC are of similar size ($1.1B and $1.1B). Alto Neuroscience, Inc. has negative trailing earnings, so its P/E is not meaningful; MeiraGTx Holdings PLC trades at 14.4×. MeiraGTx Holdings PLC has the higher net margin (19.9% vs 0.00%) and the higher return on invested capital (66.6% vs 0.00%). Across the 13 metrics below, MeiraGTx Holdings PLC leads on 11 and Alto Neuroscience, Inc. on 2.

Valuation

Metric ANRO MGTX Biotechnology median
P/E n/m 14.36 7.88
P/S n/m 2.51 11.47
P/B 5.17 4.62 2.52
Price to free cash flow n/m 98.53 21.16
EV/EBITDA n/m 4.83 0.74
EV/Sales n/m 2.40 10.73
Earnings yield (9.14%) 6.97% (28.84%)
Free cash flow yield (6.07%) 1.01% (23.03%)

Profitability

Metric ANRO MGTX Biotechnology median
Gross margin — 97.95% 65.16%
Operating margin 0.00% 46.30% 0.00%
Net margin 0.00% 19.87% 0.00%
Free cash flow margin 0.00% 2.55% 0.00%
Return on equity (49.17%) 72.22% (57.72%)
Return on assets (40.90%) 26.54% (49.22%)
Return on invested capital 0.00% 66.60% 0.00%

Growth

Metric ANRO MGTX Biotechnology median
Revenue growth (TTM) — 948.35% 5.64%
EPS growth (last fiscal year) 12.40% 33.02% —
Revenue growth, 5-year CAGR — 39.22% 8.40%
Net income growth, 5-year CAGR — 0.00% 0.00%

Health

Metric ANRO MGTX Biotechnology median
Debt to equity 0.09 0.46 0.00
Current ratio 14.85 3.76 4.73
Net debt to EBITDA 2.40 0.18 0.96

Dividend

Metric ANRO MGTX Biotechnology median
Dividend yield — — 2.10%
Payout ratio — 0.00 0.00

Size

Metric ANRO MGTX Biotechnology median
Market cap 1.07b 1.06b 162.10m

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