Amylyx Pharmaceuticals, Inc. (AMLX) vs Kiniksa Pharmaceuticals International, plc (KNSA)

Amylyx Pharmaceuticals, Inc. and Kiniksa Pharmaceuticals International, plc are both Drug Manufacturers Specialty & Generic companies. Kiniksa Pharmaceuticals International, plc is the larger, with a market value of $5.9B against $3.8B — 1.6× the size. Amylyx Pharmaceuticals, Inc. has negative trailing earnings, so its P/E is not meaningful; Kiniksa Pharmaceuticals International, plc trades at 70.2×. Kiniksa Pharmaceuticals International, plc grew revenue faster over the last twelve months: 58.9% against −77.1%. Kiniksa Pharmaceuticals International, plc has the higher net margin (9.59% vs 0.00%) and the higher return on invested capital (48.9% vs 0.00%). Across the 16 metrics below, Kiniksa Pharmaceuticals International, plc leads on 15 and Amylyx Pharmaceuticals, Inc. on 1.

Valuation

Metric AMLX KNSA Drug Manufacturers Specialty & Generic median
P/E n/m 70.17 20.14
P/S 37.53 6.93 2.25
P/B 13.71 8.90 1.90
Price to free cash flow n/m 31.84 16.54
EV/EBITDA n/m 51.93 12.29
EV/Sales 34.68 6.30 2.56
Earnings yield (4.85%) 1.43% (2.99%)
Free cash flow yield (3.99%) 3.14% 0.00%

Profitability

Metric AMLX KNSA Drug Manufacturers Specialty & Generic median
Gross margin (42.65%) 89.82% 53.94%
Operating margin 0.00% 11.92% 0.00%
Net margin 0.00% 9.59% 0.00%
Free cash flow margin 0.00% 21.74% 0.00%
Return on equity (74.73%) 14.04% (0.40%)
Return on assets (66.25%) 10.36% (3.32%)
Return on invested capital 0.00% 48.87% 0.00%

Growth

Metric AMLX KNSA Drug Manufacturers Specialty & Generic median
Revenue growth (TTM) (77.06%) 58.85% 10.01%
EPS growth (last fiscal year) 65.46% 225.00% —
Revenue growth, 5-year CAGR — — 6.74%
Net income growth, 5-year CAGR 0.00% 0.00% 0.00%

Health

Metric AMLX KNSA Drug Manufacturers Specialty & Generic median
Debt to equity 0.00 0.00 0.05
Current ratio 12.12 3.90 2.31
Net debt to EBITDA 2.00 (5.26) 0.85

Dividend

Metric AMLX KNSA Drug Manufacturers Specialty & Generic median
Dividend yield — — 1.70%
Payout ratio 0.00 0.00 0.00

Size

Metric AMLX KNSA Drug Manufacturers Specialty & Generic median
Market cap 3.78b 5.90b 337.35m

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