ProQR Therapeutics N.V. PRQR

1.65 (0.06) (3.51%) as of 25 Sep
Market cap
$236.1M
P/E
0.0×
Insider Buys alert about insiders buying in the last 12 month

Insider Decisions

Total buys 1.34
in millions of $
Nov 25 Feb 26 May 26 Aug 26
Buy — — — — — — — — 1 4 — —
Sell — — — — — — — — — — — —
Insider Ownership 10.65%

Capital & Financial Ratios

Market Cap 236.13
Revenue 21.47
Net Income (48.17)
Free Cash Flow (57.39)
Net Debt (130.35)
Current Ratio 3.49
Debt/Equity 0.06
P/E ratio 0.00
P/S ratio 8.45
P/B ratio 1.96
Past 5Y EPS Growth 25.70%
This Y EPS Growth (7.20%)
Next Y EPS Growth (16.11%)
Next 5Y EPS Growth (6.45%)
in millions of $

Dividends

Payout Ratio 0.00
Annual Dividend Rate —
Annual Dividend Yield —
total individual payouts
2025 Powerpack
2024 Powerpack
2023 Powerpack
2022 Powerpack
2021 Powerpack
2020 Powerpack
2019 Powerpack
2017 Powerpack
predictions in italic, special payouts not included in total or ratios

Assets vs Liabilities

2023 2024 2025 Q'26
Cash 129 162 105 136
Receivables — — 8 5
Inventory — — — —
Other 1 1 1 1
131 166 113 141
2023 2024 2025 Q'26
Payables 2 0 0 —
ST’ Debt — 5 6 6
Other 11 12 9 12
37 42 37 41
in millions of $

Compound Annual Growth

10y 5y 3y
Sales — — 61.74%
Cash Flow 0.00% 0.00% 0.00%
Earnings 0.00% 0.00% 0.00%
Book Value (5.63%) (2.86%) (6.62%)

Revenue

Mar Jun Sep Dec Year
’26 2 10 — — —
’25 5 4 3 6 18
’24 5 7 4 5 20
’23 1 1 1 4 7
’22 1 1 1 1 4
in millions of $ · fiscal quarters ending in the months shown

Operating Cash Flow

Mar Jun Sep Dec Year
’26 (13) (14) — — —
’25 (17) (14) (15) (14) (60)
’24 (16) (7) (7) (10) (39)
’23 48 (11) (8) (6) 23
’22 (23) (15) (13) (21) (72)
’21 (14) (12) (9) 4 (31)
’20 (17) (12) (13) (12) (54)
in millions of $ · fiscal quarters ending in the months shown

Free Cash Flow

Mar Jun Sep Dec Year
’26 (13) (15) — — —
’25 (17) (14) (15) (14) (61)
’24 (17) (7) (7) (10) (41)
’23 48 (11) (9) 2 30
’22 (23) (15) (14) (21) (73)
’21 (14) (12) (9) 4 (31)
’20 (17) (12) (14) (13) (55)
in millions of $ · fiscal quarters ending in the months shown

EPS

Mar Jun Sep Dec Year
’26 (0.15) (0.10) — — —
’25 (0.11) (0.14) (0.12) (0.09) (0.45)
’24 (0.10) (0.03) (0.11) (0.10) (0.35)
’23 (0.12) (0.11) (0.08) (0.08) (0.38)
’22 (0.22) (0.22) (0.34) (0.16) (0.96)
’21 (0.30) (0.29) (0.26) (0.30) (1.14)
’20 (0.35) (0.09) (0.36) (0.31) (1.06)
fiscal quarters ending in the months shown

Target Price Range

Analyst price targets

Recommendation Rating

1
1Buy 2 3Hold 4 5Sell
2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 2026 2027 2028
3.48 2.75 2.80 5.49 3.40 4.00 0.53 1.11 1.61 1.07

Analyst estimates 2026–2028

Powerpack
Low Price
8.96 6.90 24.00 18.94 10.09 9.46 8.60 3.85 4.62 3.10
High Price
133 130 118 154 150 182 130 156 166 187
Employees
0 0 0 0 0 0 0 0 0 0
Revenue/Emp
— — — — — 2 4 7 20 18
Revenue
0.00% 0.00% 0.00% 0.00% 0.00% 100.00% 100.00% 100.00% 100.00% 100.00%
Gross Margin
(43) (49) (44) (63) (53) (73) (68) (30) (30) (48)
EBT
0.00% 0.00% 0.00% 0.00% 0.00% (4,546.80%) (1,605.02%) (426.97%) (147.90%) (265.09%)
EBT Margin
(43) (49) (44) (64) (53) (73) (68) (30) (30) (48)
Net Income
1 1 1 2 3 3 3 3 3 3
Depreciation
0.00 0.00 0.00 0.00 0.00 0.03 0.06 0.09 0.24 0.17
Revenue/Sh
(1.85) (1.94) (1.29) (1.55) (1.06) (1.14) (0.96) (0.38) (0.35) (0.45)
Earnings/Sh
(1.62) (1.56) (0.99) (1.20) (1.07) (0.48) (1.01) 0.29 (0.46) (0.57)
Cash Flow/Sh
(0.12) (0.01) (0.01) (0.02) (0.02) (0.01) (0.01) 0.09 (0.02) (0.01)
Capex/Sh
(1.74) (1.56) (1.00) (1.22) (1.09) (0.49) (1.02) 0.38 (0.48) (0.58)
Free CF/Sh
2.52 1.75 3.21 2.56 1.29 2.09 0.96 0.55 1.11 0.53
Book Value/Sh
23 25 34 41 50 64 72 81 86 105
Shares
— — — — — 0.00 0.00 0.00 0.00 0.00
PE Ratio
— — — — — 0.00 57.44 23.90 11.15 11.82
PS Ratio
— — — — — 3.84 3.56 3.76 2.38 3.81
PB Ratio
— — — — — 0.00 35.64 6.66 3.72 6.58
EV/Sales
— — — — — (11.01) (2.08) 2.15 (1.86) (1.94)
EV/FCF
(38) (40) (34) (49) (54) (31) (72) 23 (39) (60)
Op' Cash Flow
(3) 0 0 (1) (1) (1) (1) 7 (2) (1)
Capex
(41) (40) (34) (50) (55) (31) (73) 30 (41) (61)
FCF
61 48 118 116 80 194 140 94 124 77
Working Cap'
6 8 11 15 20 52 7 5 5 6
Total Debt
(59) (46) (114) (111) (67) (170) (93) (124) (157) (99)
Net Debt
59 44 109 105 65 134 69 45 96 56
Sh' Equity
(47.11%) (74.42%) (45.82%) (48.55%) (43.52%) (40.42%) (32.02%) (18.46%) (18.15%) (30.86%)
ROA
0.00% 0.00% 0.00% 0.00% 0.00% 0.00% 0.00% 0.00% 0.00% 0.00%
ROIC
(54.60%) (95.54%) (56.62%) (59.24%) (62.69%) (73.43%) (67.73%) (53.67%) (42.73%) (62.93%)
ROE
predictions in italic, sparklines do not include predictions

All 10 years →

Fiscal years to Dec 2025 · latest quarter Jun 2026

ProQR Therapeutics N.V. (PRQR) key facts

  • ProQR Therapeutics N.V. (PRQR) is a Biotechnology company in the Healthcare sector, listed on Nasdaq.
  • ProQR Therapeutics N.V.’s revenue for fiscal 2025 (year ended December 2025) was $18.0 million, down 12.0% from fiscal 2024.
  • ProQR Therapeutics N.V. reported a net loss of $47.7 million, or a loss of $0.45 per share, for fiscal 2025.
  • As of September 25, 2026, PRQR traded at $1.65, a market capitalization of $236.1 million.
  • Trailing earnings are negative, so a P/E ratio is not meaningful; the stock trades at 8.5× sales.
  • Return on equity was −62.9% and debt-to-equity 0.06.

Source: company filings (standardised) and stockrow calculations.

ProQR Therapeutics N.V. (PRQR) Latest News

News by impact score

Fine-tune

23 Sep

4

ProQR Therapeutics named Chris Hart as Chief Data and AI Officer and Thomas Wolf as strategic AI advisor to scale AI across its RNA editing discovery and development programs. Hart, formerly Lilly’s VP of Data Science and AI/ML, will lead AI strategy and execution for the Axiomer platform to speed EON design and clinical decisions. Wolf, co-founder/CSO of Hugging Face, will advise on technology strategy and AI scaling. AX-0811, the first AI-identified program, is in clinical testing with target engagement data expected in early January 2027; AX-0422 and AX-2911 are progressing toward clinic. ProQR expects up to five clinical data readouts across four programs in the next 12 months. The company’s partnership with Ginkgo Bioworks supports faster data generation and learning cycles. High-profile AI leadership and collaborations could significantly accelerate discovery and development across multiple programs.

9 Sep

3

ProQR Therapeutics dosed the first participant in its Phase 1 study of AX-0811 and set a virtual investor and analyst educational event for September 30, 2026. First-in-human dosing for AX-0811 advances an early pipeline candidate with moderate effect on near-term development progress.

13 Aug

3

ProQR Therapeutics N.V. announced second quarter 2026 operating and financial results. Quarterly results release influences near-term stock valuation and sentiment for ProQR.

25 Jun

5

ProQR Therapeutics reported positive Phase 1 target engagement data for AX-0810, delivering the first clinical validation of its Axiomer RNA editing platform. First clinical validation of the Axiomer platform in Phase 1 directly strengthens ProQR's technology credibility and long-term pipeline potential.

3

ProQR Therapeutics prices $50.0 million underwritten registered direct offering and concurrent private placement to raise capital. Financing strengthens cash position for operations but causes shareholder dilution without altering core business trajectory.

14 May

4

Analysts slashed ProQR Therapeutics N.V. (NASDAQ:PRQR) this year's revenue estimates by 22%. A 22% reduction in revenue estimates signals weaker financial outlook, likely driving down stock price and investor sentiment.

12 May

4

ProQR Therapeutics N.V. announced its participation in two upcoming scientific conferences: the ASGCT 28th Annual Meeting in New Orleans and the TIDES USA 2025 Conference in San Diego. Presentations will focus on the company's Axiomer RNA editing technology, including oral and poster presentations by Chief Scientific Officer Gerard Platenburg and Chief ADAR Scientist Peter A. Beal. The data shared at these conferences aim to support ProQR's vision of advancing RNA editing therapies for various diseases. Presentation materials will be available on the ProQR website after the events. The presentations at major scientific conferences could significantly enhance ProQR's visibility and credibility in the RNA therapy market, potentially impacting future collaborations and investments.

3

ProQR Therapeutics N.V. (PRQR) announced first quarter 2026 operating and financial results. Quarterly operating and financial results affect cash runway, pipeline updates, and investor sentiment without fundamentally altering long-term trajectory.

11 May

3

ProQR Therapeutics N.V. (PRQR) announces multiple upcoming scientific conference presentations highlighting the breadth of its Axiomer™ RNA Editing Platform. Multiple conference presentations on the Axiomer RNA Editing Platform will showcase technological breadth, moderately boosting visibility and investor sentiment without transformative results.

8 Apr

4

ProQR Therapeutics expands pipeline and highlights multiple upcoming clinical catalysts at investor and analyst event. Pipeline expansion and upcoming clinical catalysts indicate major strategic advancements poised to significantly influence ProQR's trajectory and investor sentiment.

4

ProQR Therapeutics unveiled new RNA editing programs targeting undisclosed indications and announced Phase 1 target engagement data for AX-0810 expected this quarter. New RNA editing programs expand the pipeline strategically while near-term Phase 1 data for AX-0810 serves as a key catalyst for investor sentiment and valuation.

4

ProQR Therapeutics announces strategic partnership with Ginkgo Bioworks to accelerate RNA therapeutics development and forms AI Advisory Board with experts to integrate AI into drug discovery pipeline. Partnership with Ginkgo Bioworks and AI Advisory Board formation enable major advancements in AI-driven biotech innovation, potentially transforming ProQR's competitive edge and investor appeal.

25 Mar

4

Growing optimism surrounds ProQR Therapeutics' RNA editing platform and upcoming clinical catalysts, highlighting potential advancements in their therapeutic pipeline. Optimism for the RNA editing platform and clinical catalysts could significantly enhance investor sentiment and alter the company's market trajectory.

12 Mar

4

ProQR Therapeutics N.V. (PRQR) announced year-end 2025 operating and financial results, highlighting key pipeline progress, cash position, and strategic updates. Year-end financial results reveal cash runway, R&D expenses, and clinical milestones that significantly influence investor sentiment and stock trajectory.

3

ProQR Therapeutics N.V. (PRQR) reported a Q4 loss and revenue below analyst estimates. Q4 loss and revenue miss highlight financial underperformance with moderate potential to affect stock sentiment and near-term trajectory.

3

ProQR Therapeutics N.V. (PRQR) reported Q4 net loss of €13.2 million ($14.4 million), or €0.32 per share, versus €17.4 million, or €0.48 per share, prior year. Revenue increased to €1.2 million from collaborations, up from €0.4 million. Full-year net loss narrowed to €55.6 million from €74.5 million. Cash and equivalents stood at €75.1 million at year-end. Q4 results show revenue growth and reduced losses but persistent unprofitability typical for biotech, exerting moderate influence on financial outlook and investor sentiment.

9 Feb

3

ProQR Therapeutics N.V. announced planned changes to its board composition, including the appointment of new members and the resignation of others. These changes aim to enhance the company's strategic direction and governance as it continues to focus on developing RNA therapies for genetic diseases. Board composition changes can moderately influence the company's strategic direction and governance, impacting its future performance.

8 Jan

4

ProQR Therapeutics N.V. announced positive Phase 1 safety and pharmacokinetic data for AX-0810, alongside the selection of new development candidates. The company provided an optimistic outlook for 2026, highlighting advancements in its pipeline and potential for future growth. Positive Phase 1 data and new candidate selections indicate significant advancements that could enhance the company's market position and investor sentiment.

6 Nov

3

ProQR Therapeutics N.V. reported a loss for Q3, falling short of revenue estimates. The company's financial performance continues to raise concerns among investors as it navigates challenges in its product pipeline and market conditions. The missed revenue estimates indicate potential challenges in financial performance and market sentiment.

3

ProQR Therapeutics N.V. reported its Q3 earnings, highlighting key financial metrics and developments in its pipeline. The company continues to focus on advancing its RNA-based therapies, with updates on clinical trials and collaborations. Financial results indicate progress, but challenges remain in achieving long-term goals. Investors are closely monitoring the company's strategic direction and upcoming milestones. The earnings report reflects moderate progress in financial performance and product development, which may influence investor sentiment but is not expected to drastically change the company's trajectory.

3

ProQR Therapeutics N.V. reported its operating and financial results for the third quarter of 2025, highlighting key metrics and developments in its pipeline. The company continues to advance its innovative therapies targeting genetic diseases, with updates on clinical trials and collaborations. Financial performance reflects ongoing investments in research and development, alongside strategic initiatives aimed at enhancing shareholder value. The financial results and pipeline updates indicate a moderately noticeable influence on the company's future performance and market positioning.

9 Aug

3

ProQR Therapeutics N.V. reported its second quarter 2025 earnings, which fell short of market expectations. The company's financial performance was impacted by lower-than-anticipated revenue and increased expenses, raising concerns among investors about its future growth prospects. Despite ongoing developments in its pipeline, the disappointing results have led to a decline in stock value and heightened scrutiny from analysts. Earnings miss may affect investor sentiment and financial performance, but the overall impact is expected to be limited.

8 Aug

3

ProQR Therapeutics N.V. reported its Q2 earnings, highlighting key financial metrics and developments in its pipeline. The company continues to focus on advancing its RNA-based therapies, with updates on clinical trials and collaborations. Financial results indicate a strategic positioning for future growth despite ongoing challenges in the biotech sector. The earnings report reflects moderate developments in financial performance and product pipeline that may influence investor sentiment.

7 Aug

3

ProQR Therapeutics N.V. reported its operating and financial results for the second quarter of 2025, highlighting key metrics such as revenue, expenses, and advancements in its clinical programs. The company continues to focus on developing RNA therapies for genetic diseases, with updates on ongoing trials and collaborations. Financial performance showed trends that may influence future operations and strategic decisions. The reported results and updates on clinical programs may moderately influence financial performance and market positioning.

28 Jul

3

ProQR Therapeutics N.V. announced its upcoming presentation at the RNA Editing Summit, highlighting its commitment to advancing RNA editing technologies. The presentation is expected to showcase the company's innovative approaches and research developments in this field, potentially attracting interest from investors and industry peers. The presentation may enhance ProQR's visibility and influence in the RNA editing space, but its immediate impact on financial performance is expected to be limited.

21 Jul

3

Institutional ownership in ProQR Therapeutics N.V. (NASDAQ: PRQR) has reached 32%, indicating significant interest from institutional investors. This level of ownership may reflect confidence in the company's potential and future performance in the biotechnology sector. Increased institutional ownership can positively influence market sentiment and stability, but its overall impact on the company's trajectory remains limited.

26 Jun

4

ProQR Therapeutics N.V. has submitted a Clinical Trial Application (CTA) to the European Medicines Agency for a Phase 1 study of AX-0810, an investigational RNA editing oligonucleotide targeting NTCP to treat cholestatic liver diseases. The trial will assess safety, tolerability, pharmacokinetics, and target engagement in healthy volunteers, with initial data expected in Q4 2025. This marks the first advancement of ProQR's Axiomer™ RNA editing platform into clinical development, aiming to address high unmet medical needs in liver health. The submission of the CTA represents a significant strategic move for ProQR, potentially altering its trajectory and investor sentiment.

9 May

3

Analysts have provided new forecasts for ProQR Therapeutics N.V. (NASDAQ: PRQR), indicating potential growth and developments in the company's pipeline. The insights reflect expectations regarding the company's future performance and market positioning, particularly in relation to its innovative therapies targeting genetic disorders. Investors are advised to consider these forecasts when evaluating ProQR's stock. Analyst forecasts suggest a moderately noticeable influence on ProQR's financial performance and market positioning.

8 May

4

ProQR Therapeutics N.V. reported its Q1 2025 results, highlighting a strong cash position of €132.4 million and progress in its Axiomer RNA editing pipeline, particularly the lead program AX-0810 targeting NTCP for cholestatic diseases, with a CTA filing expected in Q2 2025. The company appointed Dennis Hom as CFO and Dr. Cristina Lopez Lopez as CMO to bolster its leadership. R&D costs increased to €12.3 million, while the net loss for the quarter was €10.1 million. ProQR anticipates key milestones in 2025, including clinical data readouts and potential updates from its partnership with Eli Lilly. The anticipated CTA filing and leadership changes are significant strategic moves that could enhance ProQR's market position and investor sentiment.

2 May

3

ProQR Therapeutics N.V. announced that its management will present at the Citizens Life Sciences Conference in New York City on May 8, 2025, at 11:30 AM EDT. A live webcast of the presentation will be available on the company's website, with a replay accessible for 30 days. ProQR is focused on developing RNA therapies using its Axiomer™ RNA editing technology, which aims to correct disease-causing mutations and modulate protein expression. The company emphasizes its commitment to creating transformative medicines for various diseases. The presentation at a significant conference may enhance visibility and interest in ProQR's innovative RNA therapies, potentially influencing market sentiment and future performance.

stockrow.com/PRQR · Data as of Jun 30, 2026 · For information only; not investment advice. · © 2026 stockrow.com