ProQR Therapeutics N.V.

PRQR Healthcare Biotechnology

ProQR Therapeutics N.V.’s revenue for fiscal 2025 (year ended December 2025) was $18.0 million, down 12.0% from fiscal 2024. In the quarter to June 2026, revenue grew 135.0%, EPS grew 28.6%, free cash flow fell 1.06% and total debt rose 8.71%, each against the same quarter a year earlier. Insiders bought in the last twelve months.

1.31 0.14 −9.66%
Market cap
$204.6M
P/E
0.0×
Fwd P/E
−2.5×
Dividend yield
—
F-score
1/9
Altman Z
−4.43
Beneish M
n/a
Dividend safety
n/a

Insider Decisions trades per month

Total buys 1.34
Totals in millions of $.
Dec 25 Mar 26 Jun 26 Sep 26
Buy — — — — — — — 1 4 — — —
Sell — — — — — — — — — — — —
Insider Ownership 10.65%

Capital & Financial Ratios $m

Market Cap 204.63
Revenue 21.47
Net Income (48.17)
Free Cash Flow (57.39)
Net Debt (130.35)
Current Ratio 3.49 (at or above 1.5: strong)
Debt/Equity 0.06 (at or below 0.5: strong)
P/E ratio 0.00
Fwd P/E (2.51) (negative: loss-making)
P/S ratio 6.71
P/B ratio 1.56
Past 5Y EPS Growth —
This Y EPS Growth (6.47%) (below 0%: weak)
Next Y EPS Growth (16.17%) (below 0%: weak)
Next Y revenue growth 13.80% (at or above 10%: strong)
Next 5Y EPS Growth 10.96%

Green and red mark values outside typical ranges. How we judge →

Valuation vs history

P/S against its own 10 years 1.40%
10-year low 10-year high
P/B against its own 10 years 14.63%
10-year low 10-year high
EV/Sales against its own 10 years 3.21%
10-year low 10-year high

Dividends

Payout Ratio —
Annual Dividend Rate —
Annual Dividend Yield —
total individual payouts
2025 Powerpack
2024 Powerpack
2023 Powerpack
2022 Powerpack
2021 Powerpack
2020 Powerpack
2019 Powerpack
2017 Powerpack
predictions special payouts not included in total or ratios

Assets vs Liabilities $m

2023 2024 2025 Q'26
Cash 129 162 105 136
Receivables — — 8 5
Inventory — — — —
Other 1 1 1 1
131 166 113 141
2023 2024 2025 Q'26
Payables 2 0 0 —
ST’ Debt — 5 6 6
Other 11 12 9 12
37 42 37 41

Compound Annual Growth %

10y 5y 3y
Sales — — 61.74%
Cash Flow 0.00% 0.00% 0.00%
Earnings 0.00% 0.00% 0.00%
Book Value (5.63%) (2.86%) (6.62%)

Revenue $m

Mar Jun Sep Dec Year
’26 2 10 — — —
’25 5 4 3 6 18
’24 5 7 4 5 20
’23 1 1 1 4 7
’22 1 1 1 1 4
Fiscal quarters ending in the months shown.

Operating Cash Flow $m

Mar Jun Sep Dec Year
’26 (13) (14) — — —
’25 (17) (14) (15) (14) (60)
’24 (16) (7) (7) (10) (39)
’23 48 (11) (8) (6) 23
’22 (23) (15) (13) (21) (72)
’21 (14) (12) (9) 4 (31)
’20 (17) (12) (13) (12) (54)
Fiscal quarters ending in the months shown.

Free Cash Flow $m

Mar Jun Sep Dec Year
’26 (13) (15) — — —
’25 (17) (14) (15) (14) (61)
’24 (17) (7) (7) (10) (41)
’23 48 (11) (9) (7) 30
’22 (23) (15) (14) (21) (73)
’21 (14) (12) (9) 4 (31)
’20 (17) (12) (14) (13) (55)
Fiscal quarters ending in the months shown.

EPS $

Mar Jun Sep Dec Year
’26 (0.15) (0.10) — — —
’25 (0.11) (0.14) (0.12) (0.09) (0.45)
’24 (0.10) (0.03) (0.11) (0.10) (0.35)
’23 (0.12) (0.11) (0.08) (0.08) (0.38)
’22 (0.22) (0.22) (0.34) (0.16) (0.96)
’21 (0.30) (0.29) (0.26) (0.30) (1.14)
’20 (0.35) (0.09) (0.36) (0.31) (1.06)
Fiscal quarters ending in the months shown.

Target Price Range

Analyst price targets

Recommendation Rating

1
1Buy 2 3Hold 4 5Sell

Ten years at a glance Fiscal years to December

Group Line 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 Trend 2026e 2027e 2028e
Price, $
Price, $ Low 3.48 2.75 2.80 5.49 3.40 4.00 0.53 1.11 1.61 1.07

Analyst estimates 2026–2028

Powerpack
High 8.96 6.90 24.00 18.94 10.09 9.46 8.60 3.85 4.62 3.10
People
People Employees 133 130 118 154 150 182 130 156 166 187
Revenue/emp, $m 0.00 0.00 0.00 0.00 0.00 0.01 0.03 0.05 0.12 0.10
Income, $m
Income, $m Revenue — — — — — 2 4 7 20 18
Gross margin, % 0.00 0.00 0.00 0.00 0.00 100.00 100.00 100.00 100.00 100.00
EBT (43) (49) (44) (63) (53) (73) (68) (30) (30) (48)
EBT margin, % 0.00 0.00 0.00 0.00 0.00 (4,546.80) (1,605.02) (426.97) (147.90) (265.09)
Net income (43) (49) (44) (64) (53) (73) (68) (30) (30) (48)
Depreciation 1 1 1 2 3 3 3 3 3 3
Per share, $
Per share, $ Revenue 0.00 0.00 0.00 0.00 0.00 0.03 0.06 0.09 0.24 0.17
Earnings (1.85) (1.94) (1.29) (1.55) (1.06) (1.14) (0.96) (0.38) (0.35) (0.45)
Cash flow (1.62) (1.56) (0.99) (1.20) (1.07) (0.48) (1.01) 0.29 (0.46) (0.57)
Capex (0.12) (0.01) (0.01) (0.02) (0.02) (0.01) (0.01) 0.09 (0.02) (0.01)
Free cash flow (1.74) (1.56) (1.00) (1.22) (1.09) (0.49) (1.02) 0.38 (0.48) (0.58)
Book value 2.52 1.75 3.21 2.56 1.29 2.09 0.96 0.55 1.11 0.53
Shares, m 23 25 34 41 50 64 72 81 86 105
Valuation, ×
Valuation, × P/E — — — — — 0.00 0.00 0.00 0.00 0.00
P/S — — — — — 0.00 57.44 23.90 11.15 11.82
P/B — — — — — 3.84 3.56 3.76 2.38 3.81
EV/Sales — — — — — 0.00 35.64 6.66 3.72 6.58
EV/FCF — — — — — (11.01) (2.08) 2.15 (1.86) (1.94)
Cash, $m
Cash, $m Operating cash flow (38) (40) (34) (49) (54) (31) (72) 23 (39) (60)
Capex (3) 0 0 (1) (1) (1) (1) 7 (2) (1)
Free cash flow (41) (40) (34) (50) (55) (31) (73) 30 (41) (61)
Balance, $m
Balance, $m Working capital 61 48 118 116 80 194 140 94 124 77
Total debt 6 8 11 15 20 52 7 5 5 6
Net debt (59) (46) (114) (111) (67) (170) (93) (124) (157) (99)
Shareholders’ equity 59 44 109 105 65 134 69 45 96 56
Returns, %
Returns, % ROA (47.11) (74.42) (45.82) (48.55) (43.52) (40.42) (32.02) (18.46) (18.15) (30.86)
ROIC 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
ROE (54.60) (95.54) (56.62) (59.24) (62.69) (73.43) (67.73) (53.67) (42.73) (62.93)
Negative figures in brackets.

All 10 years →

Fiscal years to Dec 2025 · latest quarter Jun 2026

Charts ten years each

ProQR Therapeutics N.V. vs peers in Biotechnology (Q) = latest quarter vs a year earlier

Company Market cap P/E Fwd P/E Revenue growth (Q) EPS growth (Q) FCF growth (Q) Gross margin (Q) EBIT margin (Q) Compare
IFRX InflaRx N.V. $212.2M — (loss-making) — (loss-making) −128.93% (below 0%: shrinking) n/m +69.33% (above 0%: growing) 14,029.95% 0.00% Compare
ZNTL Zentalis Pharmaceuticals, Inc. $212.1M — (loss-making) — (loss-making) — n/m −9.06% (below 0%: shrinking) 100.00% 0.00% Compare
LRMR Larimar Therapeutics, Inc. $206.7M — (loss-making) — — n/m −127.63% (below 0%: shrinking) 0.00% 0.00% Compare
PRQR ProQR Therapeutics N.V. $204.6M — (loss-making) — (loss-making) +135.03% (above 0%: growing) n/m −1.06% (below 0%: shrinking) 100.00% (100.72%)
NAGE Niagen Bioscience, Inc. $204.2M 12.5× 15.0× −4.28% (below 0%: shrinking) −80.00% (below 0%: shrinking) +140.63% (above 0%: growing) 64.84% 2.35% Compare
LYEL Lyell Immunopharma, Inc. $200.7M — (loss-making) — (loss-making) −50.00% (below 0%: shrinking) n/m +1.31% (above 0%: growing) 100.00% (1,183,425.00%) Compare
RNAC Cartesian Therapeutics, Inc. $199.1M — (loss-making) — (loss-making) −92.91% (below 0%: shrinking) −7.84% (below 0%: shrinking) −6.15% (below 0%: shrinking) 100.00% 0.00% Compare
IVVD Invivyd, Inc. $197.1M — (loss-making) — (loss-making) +21.20% (above 0%: growing) n/m −226.89% (below 0%: shrinking) 91.09% (320.76%) Compare
CGEN Compugen Ltd. $197.0M 5.2× — (loss-making) +107.00% (above 0%: growing) n/m −155.42% (below 0%: shrinking) (3.54%) (339.62%) Compare
Median of peers $202.4M — — −27.14% — −7.60% 95.55% 0.00%

All 614 Biotechnology stocks →

ProQR Therapeutics N.V. (PRQR) key facts

  • Concern: ProQR Therapeutics N.V.’s revenue for fiscal 2025 (year ended December 2025) was $18.0 million, down 12.0% from fiscal 2024.
  • Concern: ProQR Therapeutics N.V. reported a net loss of $47.7 million, or a loss of $0.45 per share, for fiscal 2025.
  • ProQR Therapeutics N.V. (PRQR) is a Biotechnology company in the Healthcare sector, listed on Nasdaq.
  • As of October 16, 2026, PRQR traded at $1.31, a market capitalization of $204.6 million.
  • Trailing earnings are negative, so a P/E ratio is not meaningful; the stock trades at 6.7× sales.
  • Return on equity was −62.9% and debt-to-equity 0.06.
  • Its Piotroski F-score is 1 out of 9 and its Altman Z-score is −4.43 (distress zone) for fiscal 2025.

Source: company filings (standardised) and stockrow calculations.

ProQR Therapeutics N.V. (PRQR) Latest News

8 Aug

Impact 3 ·
stockrow.com/PRQR · Data as of Jun 30, 2026 · For information only; not investment advice. · © 2026 stockrow.com