Castle Biosciences, Inc.

CSTL Healthcare Diagnostics & Research

Castle Biosciences, Inc.’s revenue for fiscal 2025 (year ended December 2025) was $344.2 million, up 3.66% from fiscal 2024.

Revenue
+23.9%
EPS
−550.0%
Free cash flow
+56.8%
Total debt
−59.9%

Quarter to September 2026, against a year earlier

32.65 1.55 −4.53%
Market cap
$1.0B
P/E
0.0×
Fwd P/E
−29.8×
Dividend yield
—
F-score
3/9
Altman Z
6.70
Beneish M
−3.49
Dividend safety
n/a
Dec '25 Dec '24 Dec '23 Dec '22 Dec '21 Dec '20 Dec '19 Dec '18 Dec '17
P/E ratio
0.00 41.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
Piotroski F-Score
3 7 5 2 1 4 — — —
Altman Z-Score
6.70 6.74 5.56 7.59 13.21 33.28 6.15 — —
P/S ratio
3.28 2.23 2.68 4.33 11.45 20.29 5.69 1.70 1.70
Altman Z″-Score (non-manufacturers)
6.15 9.07 7.63 10.19 11.93 24.00 7.12 (6.93) —
P/FCF ratio
39.74 20.25 0.00 0.00 0.00 248.40 48.54 0.00 0.00
Beneish M-Score
(3.49) (2.58) (2.37) (2.41) 11.61 (2.38) (2.01) — —
P/Operating CF
41.87 30.38 31.67 (98.92) (387.49) (2,956.01) 65.66 95.59 95.59
P/B ratio
2.39 1.62 1.50 1.49 2.62 3.06 3.47 0.00 0.00
EV/Sales
2.44 1.38 1.64 2.54 8.04 14.11 4.27 1.96 1.96
EV/EBITDA
0.00 25.44 0.00 0.00 0.00 0.00 23.03 0.00 0.00
EV/FCF
29.55 12.51 (18.72) (7.39) (33.67) 172.70 36.41 (13.90) (13.90)
Current Ratio
5.26 7.29 6.20 8.09 14.21 20.58 7.63 2.69 1.28
Net Debt/EBITDA
46.20 (15.73) 3.98 3.85 8.77 78.35 (7.67) (6.79) (1.78)
Debt/Equity
0.02 0.02 0.00 0.03 0.02 0.00 0.30 (0.43) (1.27)
ROE
(5.21%) 4.31% (14.54%) (16.56%) (7.56%) (4.11%) 20.95% 19.02% 28.65%
ROA
(4.35%) 3.71% (12.76%) (14.76%) (6.94%) (3.68%) 4.21% (90.72%) (95.00%)
ROIC
(14.72%) 3.13% (28.67%) (29.60%) (27.78%) (70.02%) 40.21% 0.00% 0.00%
Return on Tangible Assets
(6.20%) 5.04% (21.02%) (24.82%) (9.25%) (2.47%) 2.89% (78.67%) (521.83%)
Average Days of Receivables
46.00 56.30 63.61 62.53 67.05 74.34 103.09 193.67 123.46
Earnings Yield
(2.16%) 2.44% (9.84%) (11.33%) (2.89%) (0.76%) (3.52%) (24.42%) (24.42%)
Free Cash Flow Yield
2.52% 4.94% (3.27%) (7.93%) (2.08%) 0.40% 2.06% (8.33%) (8.33%)
Free Cash Flow per Share
0.98 1.32 (0.72) (1.81) (0.89) 0.27 0.71 (6.60) (0.73)
Book value per Share
16.24 16.41 14.60 15.32 16.38 21.96 9.92 (29.68) (0.95)
Free Cash Flow
28.37 36.56 (19.23) (47.09) (22.46) 5.12 6.08 (12.57) (12.23)
EV/EBIT
0.00 52.76 0.00 0.00 0.00 0.00 30.20 0.00 0.00
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Columns are period end dates · fundamentals updated 5 Nov 2026