BioCryst Pharmaceuticals, Inc.

BCRX Healthcare Drug Manufacturers Specialty & Generic

BioCryst Pharmaceuticals, Inc.’s revenue for fiscal 2025 (year ended December 2025) was $874.8 million, up 94.1% from fiscal 2024.

Revenue
+13.1%
EPS
+150.0%
Free cash flow
−18.7%
Total debt
+15.2%

Quarter to September 2026, against a year earlier

7.55 0.69 −8.37%
Market cap
$2.0B
P/E
0.0×
Fwd P/E
−3.7×
Dividend yield
—
F-score
7/9
Altman Z
1.83
Beneish M
−2.27
Dividend safety
n/a

BioCryst Pharmaceuticals, Inc. (BCRX) Operating margin

Alert me on Operating margin

BioCryst Pharmaceuticals, Inc.'s operating margin over the twelve months to 30 September 2026 was −30.1%, down 69.1 percentage points from fiscal 2025 (39.0%). Over the past ten years it has ranged from −981.1% (fiscal 2020) to 39.0% (fiscal 2025) — the current reading is the highest in ten years. That is below the Drug Manufacturers Specialty & Generic industry median of 0.00% and below the Healthcare sector median of 0.00%.

Operating margin, annual

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Annual newest first

Period Operating margin Change (points)
FY2025 39.0% 39.54
FY2024 −0.56% 30.73
FY2023 −31.3% 23.52
FY2022 −54.8% 58.27
FY2021 −113.1% 868.04
FY2020 −981.1% (777.46)
FY2019 −203.7% 252.54
FY2018 −456.2% (228.25)
FY2017 −228.0% (43.50)
FY2016 −184.5% (102.71)

Quarterly newest first

Period Operating margin Change (points)
Sep 2026 29.6% (15.54)
Jun 2026 45.1% 493.67
Mar 2026 −448.6% (512.60)
Dec 2025 64.1% 45.49
43 more quarters

Against its own ten years

Low −981.1% High 39.0%
Ten-year median −113.1%
Current reading's percentile 81

Operating margin against peers

Company Operating margin
PBH Prestige Consumer Healthcare Inc. compare 25.0%
ANIP ANI Pharmaceuticals, Inc. compare 16.0%
XERS Xeris Biopharma Holdings, Inc. compare 12.7%
TRLV Trulieve Cannabis Corp. compare 0.00%
HCM HUTCHMED (China) Limited Sponsored ADR compare 0.00%
BCRX BioCryst Pharmaceuticals, Inc. −30.1%
PRGO Perrigo Company plc compare −39.4%
ALVO Alvotech compare −42.4%
RGC Regencell Bioscience Holdings Limited compare —
Drug Manufacturers Specialty & Generic industry median 0.00%
Healthcare sector median 0.00%
Market median 0.00%

What Operating margin is

EBIT Margin tells an investor how much operating profit, before interest and taxes, a company keeps from each unit of revenue.

EBIT ÷ Revenue

The full definition of Operating margin →

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