Septerna, Inc. (SEPN) vs Vericel Corporation (VCEL)

Septerna, Inc. and Vericel Corporation are both Biotechnology companies. Vericel Corporation is the larger, with a market value of $2.7B against $2.2B — 1.2× the size. Septerna, Inc. has negative trailing earnings, so its P/E is not meaningful; Vericel Corporation trades at 77.8×. Septerna, Inc. grew revenue faster over the last twelve months: 13,520.1% against 25.3%. Vericel Corporation has the higher net margin (10.3% vs −24.5%) and the higher return on invested capital (7.88% vs −189.0%). Across the 17 metrics below, Vericel Corporation leads on 10 and Septerna, Inc. on 7.

Valuation

Metric SEPN VCEL Biotechnology median
P/E n/m 77.80 10.26
P/S 21.84 8.11 9.18
P/B 5.58 6.84 2.05
Price to free cash flow 18.36 45.40 24.81
EV/EBITDA n/m 79.14 0.65
EV/Sales 18.07 7.64 8.98
Earnings yield (1.13%) 1.29% (34.89%)
Free cash flow yield 5.45% 2.20% (24.52%)

Profitability

Metric SEPN VCEL Biotechnology median
Gross margin 100.00% 74.47% 65.16%
Operating margin (44.04%) 8.32% 0.00%
Net margin (24.51%) 10.27% 0.00%
Free cash flow margin 118.93% 17.86% 0.00%
Return on equity (6.34%) 9.44% (50.12%)
Return on assets (4.94%) 6.86% (45.60%)
Return on invested capital (189.01%) 7.88% 0.00%

Growth

Metric SEPN VCEL Biotechnology median
Revenue growth (TTM) 13,520.11% 25.30% 6.26%
EPS growth (last fiscal year) 84.85% 60.00% 29.88%
Revenue growth, 5-year CAGR — 17.34% 9.75%
Net income growth, 5-year CAGR — 41.97% 0.00%

Health

Metric SEPN VCEL Biotechnology median
Debt to equity 0.00 0.00 0.00
Current ratio 4.99 5.13 4.89
Net debt to EBITDA 5.86 (6.08) 1.01

Dividend

Metric SEPN VCEL Biotechnology median
Dividend yield — — 0.41%
Payout ratio — — —

Size

Metric SEPN VCEL Biotechnology median
Market cap 2.21b 2.65b 172.11m

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